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In vitro and in vivo Biological Responses of Proton Irradiation from MC-50 Cyclotron
정우희,엄현수,정권,박혜란,조성기 한국방사선산업학회 2012 방사선산업학회지 Vol.6 No.3
In this study, we investigated the biological damage and stress responses induced byion beam (proton beam) irradiation as a basis for the development of protective measures againstspace radiation. We examined the biological effects of proton beam produced by MC-50 cyclotronat KIRAMS on the cultured cells and mice. The proton beam energy used in this study was 34.9MeV and the absorption dose rate for cells and mice were 0.509 Gy sec-1 and 0.65 Gy sec-1, respectively. The cell survival rates measured by plating efficiency showed the different sensitivity anddose-relationship between CHO cells and Balb/3T3 cells. HGPRT gene mutation frequency in Balb/3T3 was 15×10-6 Gy-1, which was similar to the reported value of X-ray. When stress signalingproteins were examined in Balb/3T3 cells, IκB-α decreased markedly whereas p53, phospho-p53,and Rb increased after proton beam irradiation, which implied that the stress signaling pathwayswere activated by proton beam irradiation. In addition, cellular senescence was induced in IMR-90 cells. In the experiments with C57BL/6 mouse, the immune cells (white blood cells, lymphocytes)in the peripheral blood were greatly reduced following proton beam irradiation whereas red bloodcells and platelets showed relatively little change. These results can be utilized as basic data forstudying the biological effects of proton beam using MC-50 cyclotron with respect to proton therapyresearch as well as space radiation research.
정우희,구자승,김민정,김은경 한국유방암학회 2010 Journal of breast cancer Vol.13 No.2
Purpose: Our purpose was to identify the factors in a breast core needle biopsy (CNB) of atypical ductal hyperplasia (ADH) that are predictive for carcinoma in the subsequent excision specimens. Methods: We performed a retrospective pathologic review of 50 cases that were diagnosed as ADH via the CNB and that had the corresponding excision specimens. Results: The size of the largest ADH foci in the CNBs was 0.8±0.6 mm (mean±SD) for benign proliferative disease (BPD, n=12), 1.0±0.5 mm (mean±SD) for ADH (n=9) and 1.3±0.8 mm (mean±SD) for malignant lesions (n=29) in excision specimens (p=0.105). Among the 30 cases showing stromal alterations around the ducts with ADH in the CNBs, 9 cases (30.0%) were BPD or ADH and 21 cases (70.0%) were malignant lesions in the excision specimens (p=0.004). Conclusion: As the stromal alterations around the ADH were noted in the CNB, there was an increased likelihood that more advanced lesions would be identified in the surgical excision specimens.