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정신지체아동의 K-ABC와 K-SIB-R 결과 차이에 대한 비교 분석
정승희 ( Seung Hee Jung ),박원경 ( Won Kyung Park ),박찬영 ( Chan Yung Park ),최성규 ( Sung Kyu Choi ) 한국특수아동학회 2011 특수아동교육연구 Vol.13 No.2
이 연구는 정신지체아동의 K-ABC와 K-SIB-R의 하위요소에 대한 결과와 두 검사 간의 상관관계를 비교·분석하는데 목적이 있다. 부산과 대구 지역에 거주하며 치료실을 이용하고 있는 만 2세부터 만 12세 5개월까지의 정신지체아동 176명을 대상으로 K-ABC와 K-SIB-R 검사를 실시하였다. 연구 결과, K-ABC와 K-SIB-R의 하위요소에 대한 정신지체아동의 검사결과는 성별과 연령 집단별 간에 차이가 없었으며, 또한 두 검사의 하위요소 간에는 높은 상관관계가 나타났다. 즉 두 검사 도구는 정신지체아동 판별에 타당하며, 검사에 대한 결과들을 교육적 지원 등의 활용에 가능하다는 것을 이 연구에서는 시사하고 있다. The purpose of this study was compared and analyzed that Korean K-ABC and K-SIB-R results for sub-elements and the correlation between the two tests for mental retarded children. The K-ABC and K-SIB-R were examined for 176 mental retarded children who were 2 year to 12 years 5months and were studying at clinics in Busan and Daegu. The results of this study were that: (a) results of the subtests in the K-ABC for mental retarded children were no difference between gender and age; (b) the corellation of the subtests of the K-SIB-R was validated to test for mental retarded children; and (c) the correlation between K-ABC and K-SIB-R was meaningful, however the correlation of the K-ABC and the inappropriate test which was a part of the K-SIB-R was not suitable statistically. This study concluded that both of the two tests, K-ABC and K-SIB-R had to be tested to get validation to diagnosis and evaluation for mental retarded children.
담수산 양식어류의 혈액검사에 사용된 건식 자동생화학 분석기 (FUJIDRI-CHEM 3000) 의 활용 가능성
정승희 ( Sung Hee Jung ),서정수 ( Jung Soo Seo ),김진도 ( Jin Do Kim ),최혜승 ( Hye Sung Choi ),박명애 ( Myoung Ae Park ) 한국어병학회 2011 한국어병학회지 Vol.24 No.3
The purpose of this study was to obtain reference data of parameters for hematological health diagnosis in cultured freshwater fish and also evaluate application of automatic dry-type chemistry analyzer (FUJI DRI-CHEM 3000) used to those blood tests. A blood profile of total 200 fish for rainbow trout (Onchorhynchus mykiss), israel carp (Cyprinus carpio), tilapia (Oreochromis niloticus) and eel (Anguilla japonica) cultured in Inland Fisheries Research Institute of NFRDI was determined by hemoglobin (Hb) and plasma chemistry tests: total protein (TP), albumin (ALB), alkaline phosphatase (ALP), blood urea nitrogen (BUN), lactate dehydrogenase (LDH), triglyceride (TG), total cholesterol (TCHO), creatinine (CRE), aspartate aminotransferase (AST), alanine aminotransferase (ALT), glucose (GLU). The values of ALT, TG, LDH, ALB, TCHO, AST and ALP were outside from the minimum and/or maximum of the established detectable range of the analyzer. ALT and TG were not detectable in the range of 67%∼61.5%. LDH, ALB and TCHO were not detectable in the range of 36∼17%. AST and ALP were not detectable in the range of 5.5∼0.5%. However, the values of BUN, CRE, GLU, Hb and TP were below the detectable limits of the analyzer.
정승희 ( Seung Hee Jung ),최성규 ( Sung Kyu Choi ) 한국특수아동학회 2011 특수아동교육연구 Vol.13 No.4
청각장애유아의 출산과 양육은 건청부모의 건청유아를 위한 양육경험과는 다른 특성에 노출되며, 대부분의 건청부모는 자신의 유아가 청각에 문제가 있다는 사실을 인지하지 못한 상황에서 청각장애유아를 양육한다. 그러나 청각장애유아의 가족이 느끼는 양육경험과 그에 따른 가족기능의 양상은 가정마다 각기 다르게 나타나므로 만3세에서 초등학교 취학 전 어린이에 해당하는 청각장애유아의 부모를 대상으로 설문조사를 실시하여 청각장애유아 가족의 배경변인을 토대로 부모의 양육효능감 및 태도, 스트레스의 전반적인 양육경험과 가족기능의 특성과 관계를 분석하였다. 연구 결과, 청각장애유아 가족의 효율적인 양육과 원활한 가족기능을 위해서는 청각장애유아 가족의 긍정적인 양육효능감을 통한 양육스트레스의 감소와 바람직한 양육태도, 가족 간의 높은 결속·응집 및 적응을 통한 가족기능 강화의 필요성이 제기된다. 다시 말해 청각장애유아 가족의 안정적인 가족관계 및 삶을 위해서는 전반적으로 청각장애에 대한 가족의 긍정적인 양육효능감 및 태도 형성과 가족 간의 원활한 의사소통에 기초한 가족기능의 강화가 필요함을 알 수 있다. The purpose of this study was to suggest the situation and future direction for effective child rearing and family function of the family of young children with hearing impairment based on the correlation between child rearing experience and the characteristics of the family function. The 212 parents of young children with hearing impairment who were the age of three to five, and attending at the kindergarten in special schools, and nursery for children with disabilities or welfare institute for hearing impaired children were participated for this study. The questionnaire was divided into two parts, one was for child rearing experiencewith forty six questions, and the other one was for family function with seventeen questions. T-test, Pearson correlation, regression, and structure equation were utilized for this study. The results of this study were that: (a) the hearing impaired infants` sex, the degree of the hearing impairment, and the age of the parents of the hearing impaired infants were important factors to influence in child rearing attitudes and stress; (b) the hearing impaired infants` sex and the degree of the hearing impairment were main factors to effect in family function; and (c) the factors in the child rearing experience and the characteristics of the family function were indicated with correlation. Therefore this study concluded that positive child rearing experience of the family of young children with hearing impairments were influenced to the reinforcement for family function, and strengthen the solidarity for family members each others. Also this study suggested the systematic and professional programs, and financial supports were required to change the social attitudes and positive child rearing attitudes toward young children with hearing impairment, and to reinforce the family function with harmonious communication.
잔류 항균물질에 대한 미생물학적 간이검사법의 검출감도 비교
정승희(Sung Hee Jung),김진우(Jin Woo Kim),손상규(Sang Gyu Son) 한국수산과학회 1999 한국수산과학회지 Vol.32 No.3
Minimun-detectable levels to 28 antibacterial agents used for the prevention and the treatment of fish diseases were determined to establish optimal detective method of bioassay in fish by the EEC 4-plate method, the modified method of EEC 4-plate and the standard method of analysis in food safety regulation. The test organisms used in the methods of bioassay were as follows: Bacillus subtilis BGA(B. subtilis)and Micrococcus luteus ATCC 9341(M. luteus) in the EEC 4-plate method, B. subtilis, M. luteus, and Bacillus cereus var. mycoides ATCC 11778(B. cereus) in the EEC 4-plate and B. subtilis, M. luteus, B. cereus and Bacillus stearothermophilis var. calidolactis C-953 (B. starothermophilis)in the standard method. The standard method showed predominant sensitivity in the detection of penicillins(PCs), and was also highly sensitive to aminoglycosides (AGs). The sensitivity of standard method in the detection of tetracyclines (TCs), macrolides(MLs), nitrofuran derivatives(NFs) and quinolones(Qns) was very low, and against sulfonamides (SAs), however, was extremely low. The modified method of EEC 4-plate showed very high sensitivity to TCs. Both the EEC 4-plate and the modified method of EEC 4-plate showed competitively high sensitivity in the detection of PCs, MLs, NFs, QNs and SAs. All the methods studied in the experiment showed very low sensitivity against chloramphenicol (CMs). Consequently, the modified method of EEC 4-plate was the best bioassay method with a wide .range of sensitivity for the optimal detection of the residual antibacterial agents in fish.
넙치, Paralichthys olivaceus에 nalidixic acid, piromidic acid, oxolinic acid의 경구투여 약물동태에 미치는 수온의 영향
정승희 ( Sung Hee Jung ),김진우 ( Jin Woo Kim ),서정수 ( Jung Soo Seo ),최동림 ( Dong Lim Choi ),지보영 ( Bo Young Jee ),박명애 ( Myoung Ae Park ) 한국어병학회 2010 한국어병학회지 Vol.23 No.1
퀴놀론계 항균제인 nalidixic acid(OA), piromidic acid(PA), oxolinic acid(OA)를 사육수온(13±1.5℃, 23±1.5℃)에 따라서 넙치(평균체중 700g)에 60㎎/㎏의 농도로 1회 경구 투여한 다음, 경시적인 혈청내 잔류농도를 분석하였다. 수온이 23±1.5℃의 경우, 투여 후 NA는 10시간째 (11.55㎍/㎖), PA는 24시간째(3.79㎍/㎖), OA는 30시간째(1.12㎍/㎖)에 각각 최대혈중농도에 도달하였다. 수온이 13±1.5℃의 경우, 투여 후 NA는 10시간째(6.36㎍/㎖), PA는 15시간째(1.4㎍/㎖), OA는 30시간째(1.01㎍/㎖)에 각각 최대혈중농도에 도달하였다. NA와 PA의 넙치 혈중내 흡수정도는 수온 13±1.5℃보다 수온 23±1.5℃에서 매우 높게 나타났으며, NA의 넙치 혈중내 소실정도는 수온 13±1.5℃보다 수온 23±1.5℃에서 두드러지게 빨랐다. 한편 OA의 넙치 혈중내 흡수 및 소실정도는 사육수온에 크게 영향을 받지 않는 것으로 나타났다. NA 및 PA는 one-compartment model, OA는 two-compartment model로 해석하여 WinNonlin program을 이용, 약물동태학적 매개변수(parameter)를 조사하였다. 수온이 23±1.5℃의 경우, 혈장농도-시간곡선하 면적(AUC)은 NA, PA, OA가 각각 258.26, 248.12 및 138.20㎍?h/㎖, 혈중최고농도의 도달시간(Tmax)은 10.67, 21.15 및 23.95 h, 혈중최고농도(Cmax)는 8.91, 3.09 및 1.06㎍/㎖로 계산되었다. 수온이 13±1.5℃의 경우, AUC는 NA, PA, OA가 각각 341.45, 103.89 및 159.10㎍?h/㎖, 혈중최고농도의 도달시간은 7.72, 12.89 및 28.03 h, 혈중최고농도는 6.23, 1.22 및 1.02㎍/㎖로 계산되었다. Effects of temperature (13±1.5℃, 23±1.5℃) on the pharmacokinetic properties of nalidixic acid (NA), piromidic acid (PA) and oxolinic acid (OA) were studied after oral administration to cultured olive flounder, Paralichthys olivaceus. Serum concentrations of these antimicrobials were determined after oral administration of a single dosage of 60㎎/㎏body weight (average 700g). At 23±1.5℃, the peak serum concentrations of NA, PA and OA, which attained at 10 h, 24 h and 30 h post-dose, were 11.55, 3.79 and 1.12㎍/㎖, respectively. At 13±1.5℃, the peak serum concentrations of NA, PA and OA, which attained at 10 h, 15 h and 30 h post-dose, were 6.36, 1.4 and 1.01㎍/㎖, respectively. Better absorption of NA and PA was noted at 23±1.5℃ compared to 13±1.5℃. The elimination of NA from serum of olive flounder was considerably faster at 23±1.5℃ than at 13±1.5℃. However, both absorption and elimination of OA were not affected significantly by temperature. The kinetic profile of absorption, distribution and elimination of these antimicrobials in serum were analyzed by fitting to a one-and two compartment model, with WinNonlin program. In the one compartment model for NA, AUC, Tmax and Cmax at 23±1.5℃ were 258.26㎍·h/㎖, 10.67 h and 8.91㎍/㎖, respectively. The AUC, Tmax and Cmax at 13±1.5℃ were 341.45㎍·h/㎖, 7.72 h and 6.23㎍/ ㎖, respectively. In the one compartment model for PA, AUC, Tmax and Cmax at 23±1.5℃ were 248.12㎍·h/㎖, 21.15 h and 3.09㎍/㎖, respectively. The AUC, Tmax and Cmax at 13±1.5℃ were 103.89㎍·h/ ㎖, 12.89 h and 1.22㎍/㎖, respectively. In the two compartment model for OA, AUC, Tmax and Cmax at 23±1.5℃ were 138.20㎍·h/㎖, 23.95 h and 1.06㎍/㎖, respectively. The AUC, Tmax and Cmax at 13±1.5℃ were 159.10㎍·h/㎖, 28.03 h and 1.02㎍/㎖, respectively.