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인체 Endostatin의 신생혈관 형성에 대한 억제효과
정성필,이민혁 순천향의학연구소 2000 Journal of Soonchunhyang Medical Science Vol.6 No.2
Background : Angiogenesis is a critical determinant of tumor growth and the development of metastrasis. Endostatin have been used in a variety of in vitro and in vivo animal models as effective inhibitors of angiogenesis. However, human endostatin have not tested against an intact human tissue target in vitro to determine its ability of antiangiogenic response. Purpose : We performed our study to determine that human endostatin would inhibit the development of an angiogenic response (initiation) and the subsequent growth (angiogenic index) of the human vessels in a dose-dependent manner with a human placental vein angiogenesis model(HPVAM). Methods : We used full thickness human placental vein discs cultured in three-dimensional fibrin-thrombin clots with an overlay of liquid media. Human endostatin were evaluated in concentrations ranging from 1x10^(-9)M/L to 1x10^(-4)M/L. A positive control containing 20% fetal bovine serum and a negative control using heparin and hydrocortisone 21-phosphate were also tested. Results : Human endostatin significantly inhibited the initiation rate of an angiogenic response at concentration of 1x10^(-4)M/L(p<0.001) and the subsequent development of the angiogenic response (angiogenic index) at concentrations of 1x10^(-5)M/L and 1x10^(-4)M/L(p<0.001, p<0.001 respectively). Conclusions : We concluded that the very high concentration of human endostatin can inhibit the angiogenic response in the human blood vessels in vitro. These results suggest that human endostatin has a powerful antiangiogenic effect against an intact human tissue target.
정성필,이석우,양영모,하영록,김승환,유인술 대한응급의학회 2001 대한응급의학회지 Vol.12 No.3
Background: This study was designed to review the cases of patients who had undergone diffusion-weighted magnetic resonance imaging(DWI) in the emergency department(ED), and to investigate its clinical usefulness and current indications. Methods: We analyzed the cases of 152 consecutive patients who underwent DWI in the ED from Jan to Mar 2001. DWI was obtained with the use of a multislice, single-shot, spin-echo plana imaging technique(GE SignaR). Imaging time was less than one minute. The medical records, the DWI films and the computed topography results were reviewed. We investigated the chief complaint, initial findings of physical examination, final diagnosis, decision-making department, interval from admission to imaging, and DWI findings. Results: DWI showed positive findings of high signal intensity in 84 patients(55.3%). Among the 68 patients who yielded a negative result, false negative occurred with 12 patients(17.6%): 10 lacunar infarctions, a pons infarction, and a brainstem infarction. Eleven patients were determined as having a cerebral hemorrhage, all of whom showed the abnormal finding of a mixed signal in DWI. The sensitivity and the specificity of DWI to rule out stroke were 85.5% and 98%, respectively. Current indications for DWI in our ED are age older than 60, alert mental status, and one of the symptoms or signs among lateralyzing sign, language disturbance, and dizziness/vertigo. Conclusion: DWI was highly specific to rule out stroke, so emergency care professionals should be familiar with this new technology. Further prospective study is required to determine the proper indications and clinical usefulness of DWI in the ED.
정성필,조경진,서승범,박석호,윤홍식,민태진,박준우 대한상하수도학회 2022 상하수도학회지 Vol.36 No.6
Due to the rapid growth of electrical vehicle and portable electronics markets, huge amount of the rare earth elements(REEs) and lithium have been required for the manufacturers globally. Moreover, after life time of the battery pass, the waste batteries containing valuable metal resources should be recycled due to competitions between the countries who manufacturing the batteries. Therefore, the REEs and lithium recoveries from the e-waste and wastewaters become issue recently. However, the commercialized technology for the valuable metal recovery is limited. In this study, the uses of the REEs and other valuable metal resources such as lithium, uranium, and gold and there recoverying methods according to the different water conditions were investigated and summarized. Moreover, the possible expectations and suggestions for the future application of the valuable resource recovery were conducted as a review.
학생들에 대한 심폐소생술 수업방식의 비교: CPR Anytime과 Little Anne
정성필,조준호,박유석,김의중,김찬웅,이경룡,이미진,임훈,장문준,이진희 대한응급의학회 2008 대한응급의학회지 Vol.19 No.6
Purpose: We compared the effectiveness of CPR Anytime and Little Anne for instructing schoolchildren in CPR. Methods: We gave CPR instructions to 774 school children (24 classes) from the fifth to the eighth grade in 12 schools. We randomly selected two classes of the same grade from each school. Each class was given two hours of CPR instruction using either the Korean version of CPR Anytime or Little Anne . The number of CPR Anytime per student was 1:1 and Little Anne was 1:6. The lesson consisted of didactic lecture, skill practice, and skill test. We compared the skill performance of students according to the instruction method. Results: Three hundred ninety-seven (51%) students were taught using CPR Anytime and 377 (49%) with Little Anne . There was no difference in the compression depth, hand position, adequacy of chest recoil, volume of ventilation, self-confidence, and willingness to do CPR between the two instructional methods. The average compression depth was less than 40~50 mm. Elementary school students showed more confidence and willingness to do CPR than middle school students. Conclusion: There was no difference in CPR skill performance after instruction using either Anytime CPR or Little Anne .