백서두개골 결손부에서 BMP전달체의 골재생효과분석

정성원,정지희,채경준,정의원,김창성,조규성,채중규,김종관,최성호,Jung, Sung-Won,Jung, Jee-Hee,Chae, Gyung-Joon,Jung, Ui-Won,Kim, Chang-Sung,Cho, Kyoo-Sung,Chai, Jung-Kiu,Kim, Chong-Kwan,Choi, Seong-Ho 대한치주과학회 2007 Journal of Periodontal & Implant Science Vol.37 No.4

Bone morphogenetic proteins have been shown to possess significant osteoinSductive potential, but in order to take advantage of this effect for tissue engineering, carrier systems are essential. Successful carrier systems must enable vascular and cellular invasion, allowing BMP to act as a differentiation factor. The carrier should be reproducible, non-immunogenic, moldable, and space-providing, to define the contours of the resulting bone. The purpose of this study was to review available literature, in comparing various carriers of BMP on rat calvarial defect model. The following conclusions were deduced. 1. Bone regeneration of ACS/BMP, ${\beta}-TCP/BMP$, FFSS/BMP, $FFSS/{\beta}-TCP/BMP$, MBCP/BMP group were significantly greater than the control groups. 2. Bone density in the ACS/BMP group was greater than that in ${\beta}-TCP$, FFSS, $FFSS/{\beta}-TCP$ carrier group. 3. Bone regeneration in FFSS/BMP group was less than in ACS/BMP, ${\beta}-TCP/BMP$, MBCP/BMP group. However, New bone area of $FFSS/{\beta}-TCP/BMP$ carrier group were more greater than that of FFSS/BMP group. ACS, ${\beta}-TCP$, FFSS, $FFSS/{\beta}-TCP$, MBCP were used for carrier of BMP. However, an ideal carrier which was reproducible, non-immunogenic, moldable, and space-providing did not exist. Therefore, further investigation are required in developing a new carrier system.

Protein transduction domain을 이용한 recombinant human bone morphogenetic protein-2의 골재생효과

정성원,김남희,육종인,김창성,김형준,조규성,Jung, Sung-Won,Kim, Nam-Hee,Yook, Jong-In,Kim, Chang-Sung,Kim, Hyung-Jun,Cho, Kyoo-Sung 대한치주과학회 2007 Journal of Periodontal & Implant Science Vol.37 No.3

Bone morphogenetic proteins(BMPs) are regarded as members of the transforming growth $factor-{\beta}$ superfamily with characteristic features in their amino acid sequences. A number of studies have demonstrated the biologic activities of BMPs, which include the induction of cartilage and bone formation. Recently there was a attempt to overcome a limitation of mass production, and economical efficieny of rh-BMPs. The method producing PTD by using bacteria have advantages of acquiry a mass of proteins. Hences, a new treatment which deliver protein employed by protein transduction domain(PTD) has been tried. The purpose of this study was to evaluate the bone regenerative effect of TATBMP-2 and TAT-HA2-BMP-2 employed by PTD from HlV-1 TAT protein for protein translocation in the rat calvarial model. An 8mm calvarial, critical size osteotomy defect was created in each of 32 male Spraque-Dawley rats(weight $250{\sim}300g$). The animals were divided into 4 groups of 32 animals each (4 animals/group/healing interval). The defect was treated with TATBMP-2/ACS(Absorbable collagen sponge) (TATBMP-2 0.1mg/ml), TAT-HA2-BMP-2/ACS(TAT-HA2-BMP-2 0.1mg/ml), ACS alone or left untreated for surgical control(negative control). The rats were sacrificed at 2 or 8 weeks postsurgery, and the results were evaluated histologically. The results were as follows: New bone formation were not significantly greater in the TATBMP-2/ACS group relative to negative, and positive control groups. New bone was evident at the defect sites in TAT-HA2-BMP-2/ACS group relative to negative, positive control and TATBMP-2 groups. There were a little bone regeneration in TATBMP-2 groups. While, enhanced local bone formation were observed in TAT-HA2-BMP-2 group. But, The results was not the same in all rat defects. Therefore, further investigations are required to develop a method. which disperse homogenously, and adhere to target cells.

한국적 특수성을 고려한 지역특성과 개인의 건강

정성원,조영태,Jung, Sung-Won,Cho, Young-Tae 대한예방의학회 2005 예방의학회지 Vol.38 No.3

Recently much attention has been paid to the effect of neighborhood characteristics on the health of individuals, independent of individual demographic and/or socioeconomic characteristics. Although many empirical studies of a kind, mostly based on Western society, have appeared on various international journals, few studies have shown empirical evidence of neighborhood characteristics as an independent and significant risk factor of ill health in Korea. This paper discusses possible reasons that neighborhood seems to be neither significant nor substantial regarding its impact on the health of Koreans. Addressing the uniqueness of Korean society regarding the concept of neighborhood, attributes of neighborhoods, and methodological challenges, authors suggest that more sophisticated conceptual and methodological approach, specific to Korean society, should enable to reveal the effect of neighborhood characteristics on individual health in Korea.

외측광근을 이용한 대전자부 피부결손의 치료

정성원,김종관,Jung, Sung-Weon,Kim, Chong-Kwan 대한미세수술학회 2006 Archives of reconstructive microsurgery Vol.15 No.2

Purpose: We performed vastus lateralis (VL) muslce or myocutaneous flap for close of the trochanteric skin defect usually happened in paraplegia and report our 6 cases. Materials and Methods: Between March 2004 and August 2005 we performed 4 cases of VL muscule flap with skin graft and 2 cases of VL myocutaneous flap for close of the trochanteric skin defect in 6 paraplegia patients. There were 5 men and 1 woman and mean age was 52.2 years and mean diameters of skin defect was $8.3{\times}8.3\;cm$. The mean follow up period was 18 months. The survival of flap, complications, healing time and patient's satisfaction were evaluated. Results: All flaps were survived except 1 case of margin necrosis. In 2 cases, blood-serous discharges were continued after operation which might be due to dead space and treated with $2{\sim}3$ times debridement and delayed close. Mean time to heal the skin defect was 7.6 weeks. No infection and recurrence in follow up periods. Cosmetic results judged by patients are that 3 cases are good and 3 cases are fair. Conclusion: VL muscle and myocutaneous flap is good treatment method among the numerous methods in treatment-failed cases of trochanteric skin defects of paraplegia patients. This surgical procedure is simple, constant blood supply, good pliability, cosmetic results and also appliable to other skin defect of pelvis girdle like sacrum and ischium.

플랜트 하부의 강파일 인접 토양의 부식성 평가

정성원,박경완,전재영,Jung, Sungwon,Park, Kyeong-Wan,Jeon, Jae-Young 한국플랜트학회 2016 플랜트 저널 Vol.12 No.1

플랜트 하부 강파일 기초 주변 토양의 부식성을 평가하기 위해서 현장조사, 현장 보링작업을 통한 시료 채취 및 실험실 분석을 거친 결과를 검토하였다. 토양 분석 결과 강관파일이 타설된 토양은 여러 개의 특성이 다른 토양층으로 구성되어 있었으며, 각 지층의 화학적, 물리적 성질이 다르므로 강관파일의 타설깊이에 따른 부식성의 차이가 발생할 것을 예상할 수 있었다. 분석 결과를 토대로 정성적인 부식성 평가, 평균부식속도 및 최대부식속도를 예측한 결과, 일부 지층에서는 일반적으로 강관파일 설계시 적용되는 부식속도인 0.01-0.02mm/y 이상의 평균부식속도를 보이고 있었다 (0.33mm/y). The corrosivity evaluations on soil surrounding the buried steel piles under manufacturing plants. It was proven that the soil structure of this sample area is composed of several soil layers, and that each layer show the different corrosivity. The predicted average corrosion rates of some layers are about 0.33mm/y, which is over than the general corrosion rate, 0.01-0.02mm/y.

WPAN에서 간섭을 피하기 위한 멀티모드 단말기 채널등급 방법

정성원,금동현,최승원,Jung, Sungwon,Kum, Donghyun,Choi, Seungwon 디지털산업정보학회 2015 디지털산업정보학회논문지 Vol.11 No.3

There is a new evolution in technological advancement taking place called the Internet of Things (IoT), The IoT enables physical world objects in our surrounding to be connected to the Internet. ISM (Industrial Scientific Medical) band that is 2.4GHz band authorized free of charge is being widely used for smart devices. Accordingly studies have been continuously conducted on the possibility of coexistence among nodes using ISM band. In particular, the interference of IEEE 802.11b based Wi-Fi devices using overlapping channel during communication among IEEE 802.15.4 based wireless sensor nodes suitable for low-power, low-speed communication using ISM band. Because serious network performance deterioration of wireless sensor networks. In this paper, we will propose an algorithm that identifies the possibility of using more accurate channels by mixing utilization of interference signal and RSSI (Received Signal Strength Indicator) Min/Max/Activity of Interference signal by wireless sensor nodes. In addition, it will verify our algorithm by using OPNET Network verification simulator.

신기능 저하 환자에서 위막성 대장염 발생의 임상적 특징

정성원 ( Sung Won Jung ),이유민 ( Yu Min Lee ),정덕은 ( Duk Eun Jung ),이재훈 ( Jae Hoon Lee ),김현정 ( Hyun Jung Kim ),이지은 ( Ji Eun Lee ),송주흥 ( Ju Hung Song ),박도심 ( Do Sim Park ),안선호 ( Seon Ho Ahn ) 대한신장학회 2009 Kidney Research and Clinical Practice Vol.28 No.2

목적: Clostridium difficile-associated diarrhea (CDAD)는 항생제 사용 후 장내세균 변화로 인해 C. difficile 독소 A에 의해 발생되는 위막성 대장염에 의한 것으로 알려져 있다. 본 연구는 대장내시경 후 조직검사를 통해 위막성 대장염으로 확진된 CDAD 환자에서 임상적 및 검사실적 소견의 분석을 통해 신기능의 저하가 CDAD 발생에 어떤 영향을 미치는지 알아보고자 하였다. 방법: 1998년 1월부터 2006년 12월까지 원광대학교 의과대학 병원에서 2일 이상 묽은 변과 고열이 발생한 환자에서 CDAD가 의심되어 C. difficile 독소 A를 시행하고 대장내시경을 통해 조직학적으로 CDCA로 확진된 환자 56명을 대상으로 신기능 저하, 당뇨 및 악성종양의 유무를 조사하여 항생제 투여 기간에 따른 CDAD 발생 빈도를 비교하였다. 결과: 연구 기간 동안 CDAD가 의심되어 C. difficile 독소 A를 검사한 환자는 452명이었으며, 이중 양성 환자 416명 (92.03%), 음성 환자 36명 (7.96%)이었다. 452명 중 대장내시경을 시행한 환자는 92명 (20.7%)이었고, 이중 조직검사에서 위막성 대장염으로 진단된 환자는 56명 (60.8%)이었다. 조직 검사로 진단된 위막성 대장염 환자 56명 (남자 26명; 여자 30명)이었고, 이중 신기능 저하 환자 8명 (14.2%), 당뇨환자 10명 (17.8%), 악성종양 환자 13명 (23.2%)이었다. 또한 독소 A가 음성인 환자는 36명 (64.3%)었다. 조직검사로 확진된 신기능 저하 환자 8명 중 5명 (62.5%)은 C. difficile 독소 A 검사에서 음성으로 신기능 저하 유무에 따른 독소 반응의 차이는 없었다 (62.5% vs. 64.6%). 신기능이 저하된 환자에서 당뇨 2명 (25%), 악성종양 환자 1명 (12.5%)이었다. CDAD 발생까지의 항생제 투여 기간은 신기능이 정상인 환자 보다 신기능이 저하된 환자에서 짧았고 (23.44±3.28일 vs. 11.13±2.386일, p=0.034), 당뇨 및 악성 종양 유무에 따른 비교에서 (20.85±2.221일 vs. 25.50±13.07일; 23.30±3.67일 vs. 16.31±2.31일) 차이가 없었다. 결론: 면역력이 저하된 당뇨 및 악성종양 환자에 비해 신기능이 저하된 환자에서 CDAD 발생까지의 항생제 투여 일수가 적어 신기능 저하 상태에서 특히 항생제 투여에 주의가 필요하다. 또한 항생제 투여 후 발생된 설사 환자에서 C. difficile 독소 A가 음성이라 할지라도 환자가 대장내시경을 시행할 수 있는 상태인 경우 반드시 대장내시경과 조직검사를 시행하여 CDAD를 감별해야 할 것으로 생각한다. Purpose: Clostridium difficile-associated diarrhea (CDAD) is a potentially life-threatening illness which has been shown to be more common and more severe in patient with chronic renal failure. The aim of this study was to investigate clinical characteristics of renal insufficiency patients with clostridium difficile-associated pseudomembranous colitis. Methods: We reviewed charts of fifty-six patients with clostridium difficile-associated pseudomembranous colitis, who have clostridial toxin A assay in stool and a diagnosis made on histology of colonic biopsies. Results: There was no difference in age, serum albumin, C-reactive protein (CRP) and negative incidence of clostridial toxin A between patients who had renal insufficiency with serum creatinine more than 1.5 mg/dL and those who did not. But duration of antibiotic use administered prior to development of the clostridium difficile infection was more shorter in patients with impaired renal function than in patients with normal renal function. Conclusion: These data suggest that it may take a short period to development of the clostridium difficile infection in patients with impaired renal function, and histologic evaluation by sigmoidoscopy should be performed to make a diagnosis in CDAD-suggested patients, who have impaired renal function and even negative clostridial toxin A.

우울증의 진단평가 지침 -우울증 평가도구를 중심으로-

정성원 ( Sung Won Jung ),이은정 ( Eun Jung Lee ),최윤경 ( Yun Kyeung Choi ),성형모 ( Hyung Mo Sung ),김대현 ( Dae Hyeon Kim ),최정식 ( Jeong Shik Choi ),김정범 ( Jung Bum Kim ) 한국정신병리진단분류학회 2009 精神病理學 Vol.18 No.1

Depression is the second most common chronic disease in primary care. However, depression is commonly misdiagnosed, or though diagnosed properly, it is easy to treat inadequate doses or duration of antidepressants. It is of importance to diagnose and treat properly. Because of a wide range of symptoms and comorbidities, it is difficult to make a diagnosis of depression. Rating scales can be useful for the diagnosis of depression. It is feasible that the clinicians assess the patients with depression appropriately and determine therapeutic strategies by rating scales for depression. We have reviewed the purpose of rating scales for depression, including screening, ratings of symptoms, diagnosis, the progress, and the results of treatment. We also have described the actual condition of rating scales in Korea, which were performed by clinical research center for depression. It is restricted within marrow limits to select certain rating scale for depression and poorly known that some scales have been developed. Therefore, it is important task to announce the rating scales for depression so that the clinicians and researchers can be familiar with these scales. It is also important to develop a diversity of scales so that the clinicians can select appropriate scales.

대학생과 스마트폰 -스마트폰 이용수준, 스마트폰 중독과 삶의 질-

정성원 ( Jung Sungwon ),이영신 ( Lee Youngshin ) 극동대학교 사회복지연구소 2016 글로벌사회복지연구 Vol.6 No.2

본 연구의 목적은 일 대학교 학생의 스마트폰 이용수준, 스마트폰 중독과 삶의 질의관계를 확인하여 스마트폰 중독으로 인한 삶의 질 저하를 예방하기 위한 기초 자료를 마련하는 데 있다. 이 목적을 달성하기 위해 일 대학교에 재학 중인 201명을 대상으로 스마트 사용양상, 스마트폰 중독, 삶의 질을 측정하여 자료를 수집하였다. 연구 결과는 수업시간 스마트폰을 사용한 경험이 있는 경우 91.04%, 사용한 경험이 없는 경우 8.96%였다. 스마트폰 사용경험 여부에 따른 스마트폰 중독을 t-test로 확인 한 결과 스마트폰을 사용한 경험이 있는 경우가 유의미 하게 높았다(t = -2.09, p=.04). 스마트폰 이용수준, 스마트폰 중독, 삶의 질의 관계를 살펴 본 결과 스마트폰 이용량은 삶의 질과 통계적으로 유의미한 부적 관계를 나타냈다(r=-.18, p=.01). Purpose: The development and innovation of information and communication technology has caused a substantial change in the personal life. This study investigates the impact of smartphone on the life of university student users by identifying the degree of smartphone addiction and the quality of life. Method: A total of 219 nursing students from a university was randomly collected, and 201 students responded to a survey specifically designed for the current study. SPSS (version 20.0) was used to perform descriptive analysis, T-test, ANOVA, post-test Scheffe, and Pearson correlation. Result: Most students used their smartphone in the class (91%). The use of smartphone in class and smartphone addiction was highly associated (t= -2.09, p=.04). The level of smartphone use and the quality of life was also significantly correlated (r = -.18, p = .01). Conclusion:. Smartphone use in class is an indirect measure of smartphone addiction and low quality of life among university students. Students need to use smartphone in class as little as possible to decrease the risk of addiction and to increase the quality of life on campus.

클러스터링과 유전자 알고리즘을 이용한 대규모 S-system 모델의 효율적 학습 방법

정성원(Sungwon Jung),이광형(Kwang H. Lee),이도헌(Doheon Lee) 한국정보과학회 2005 한국정보과학회 학술발표논문집 Vol.32 No.2

S-System 모델은 동적 시스템을 기술하기 위한 여러 모델 중의 하나로서, 높은 표현력으로 인해 다양한 분야에서 사용되어져 오고 있다. 하지만 S-System 모델이 갖고 있는 많은 매개변수는 목표 시스템을 모델링하는 데에 있어 고려해야 할 탐색 공간의 넓이를 크게 증가시키는 단점을 갖고 있으며 그로 인해 고려될 수 있는 변수의 수는 극히 적은 수로 제한되어져 왔다. 일반적인 S-System 모델의 경우, n개의 변수로 이루어진 시스템을 모델링하는 데 결정되어져야 할 매개변수의 수는 O(n²)이다. 본 논문에서는 시스템 내의 변수들을 서로간의 연관 정도에 따라 클러스터링하고, 클러스터 사이의 동적 모델링을 통해 고려하는 매개변수의 수를 O(kn) ( k≤n)으로 줄이는 방법을 제안한다. 매개변수 값의 탐색을 위해 유전자 알고리즘을 사용하며, 제안된 방법이 기존의 방법으로는 학습할 수 없었던 규모의 S-System 모델을 학습할 수 있는 가능성을 지님을 보인다.