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외과환자에 있어서 Minocycline(Minocin) 정맥투여의 효과
鄭啓孝,黃圭哲 최신의학사 1975 最新醫學 Vol.18 No.12
Minocycline is a semi-synthetic new member of the tetracycline family which has a broader antibacterial spectrum and is more potent than tetracycline. Its chemical name is 7-dimethylamino-6-deoxy-6-demethyltetracycline. It has advantages compared with tetracycline; 1. Therapeutic dose is 8 to 31 times smaller and therapeutic blood concentration is 2 to 6 times lower and persists in plasma for relatively long periods in mice. 2. It is not only active against tetracycline-sensitive strains of staphylococcus aureus, but also is effective against tetracycline-resistant strains of staphylococci, E. coli, enterobacter, proteus and other gram negative bacilli isolated from hospital patients. 3. Bacteria resistence to Minocycline develops slowly in stepwise fashion and is of lower order of magnitude than resistence to tetracycline. 23 patients who had severely intrabdominal contamination, admitted to Department of Surgery, Yonsei University, College of Medicine, were intravenously injeded with Minocycline for 5 to 16 days. The therapeutic dose of Minocycline was about 10 times smaller than that of tetracycline against infections due to staphylococci, streptococci, E. coli, enterobacter, proteus and other gram negative bacilli. But, Minocycline had not singnificantly active against aerobacter, pseudomonas and klebsiella. Daily intravenous dose of 200 mg. of Minocycline had well tolerated, while dose in excess of 600 mg. had usually poorly tolerated. Diziness was always occurred Over-all cure rates was about 78% in our 23 patients. 9 out of 23 patients responded excellently, 9 out of them responded good, while remaining 5 patients responded poorly.
외과환자에 있어서 Sulbobenzylpenicillin(Sulbenicillin)의 효과
鄭啓孝,黃圭哲 中央醫學社 1975 中央醫學 Vol.29 No.5
Sulbenicillin is similar to ampicillin or carbenicillin in its chemical structure and its antibacterial activities. This compound is more effective against penicillinase producing organisms and gram negative organisms. In additions, it is effective against pseudomonas and proteus groups like carbenicillin. Our clinical studies were performed on 19 patients who admitted to our surgery department due to severe infection(Tab. 1). In this studies, the causative organisms were divided into 7 groups; E. coli (6), pseudomonas (5), klebsiella (4), coagulase positive staphylococus (4), preteus (3), gram negative bacilli (3) and flabobacter (1) (Tab. 2). Sulbenicillin was administered either I. M. or I. V. 2 to 4 gm per day for 3 to 14 days in these severely infected patients. Results are as following; 1) Infection due to E. coli, gram negative bacilli, and coagulase positive staphyl?ococci was well controlled with sulbenicillin administration within 1 week. Results were all excellent. 2) Infection due to pseudomonas and proteous groups were relatively well controlled within 7 to 14 days administration. Results were good in 6 cases and poor in 1 case. 3) Infection due to klebsiella was unfortunately resistant to the sulbenicillin. 4) Over-all cure rate was about 79%.