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정경환(Kyeong-Hwan Jeong),정동경(Dong-Kyung Jung),서정민(Jeong-Min Seo) 한국방사선학회 2021 한국방사선학회 논문지 Vol.15 No.6
방사선을 이용하는 관련 기관은 국내에 연구, 의료, 교육 등 다양하다. 최근에는 검진 및 의료기관의 방문 횟수가 증가하고 있다. 이로 인해 의료기관에서 방사선학적 검사 횟수가 증가하고 있다. 방사선작업종사자의 피폭뿐만 아니라 방사선 안전관리가 필요하다. 안전관리를 위해서 우선적으로 개인피폭선량계의 올바른 착용 및 착용 후 정확한 측정이 필요하다. 본 연구는 진단용 방사선발생장치의 방사선에 의한 PLD 소자의 계측 직선성을 평가하고 검증하려고 한다. 방사선 분할 조사 시간간격은 10, 30, 60 sec로 10회 조사와 거리에 따라 흡수선량 변화를 측정하기 위해서 조사거리를 30 ~ 100 cm까지 10 cm 간격으로 조사 후 측정하였다. 그 결과 시간 간격에 의한 흡수선량은 차이가 없었다. 이는 고흡수선량 연구에 진단용발생장치를 이용하여 다양한 연구에 도움이 될 것으로 여겨진다. Related institutions that use radiation are diverse in Korea, such as research, medical care, and education. Recently, the number of examinations and visits to medical institutions is increasing. As a result, the number of radiological examinations in medical institutions is increasing. Radiation safety management is necessary as well as exposure of radiation workers. For safety management, first of all, it is necessary to wear the personal exposure dosimeter correctly and measure it accurately after wearing it. This study tries to evaluate and verify the measurement straightness of PLD devices by radiation of a diagnostic generator. Radiation division irradiation time interval was measured after irradiating 10 times at 10, 30, and 60 sec and irradiating the irradiation distance from 30 to 100 cm at 10 cm intervals to measure the change in absorbed dose depending on the distance. As a result, there was no difference in absorbed dose by time interval. This is considered to be helpful in various studies by using a diagnostic generator for the study of high absorbed dose.
IgA 신증에서 spironolactone이 요중 TGF-β1 분비에 미치는 효과
정경환 ( Kyung Hwan Jeong ),박미나 ( Mi Na Park ),문주영 ( Joo Young Moon ),이상호 ( Sang Ho Lee ),이태원 ( Tae Won Lee ),임천규 ( Chun Gyoo Ihm ) 대한신장학회 2007 Kidney Research and Clinical Practice Vol.26 No.5
Purpose : Transforming growth factor-β1 (TGF-β1) has an important role in the pathogenesis of renal damage; it enhances extracellular matrix production. Urinary TGF-β1 excretion has been shown to be significantly increased in patients with IgA nephropathy. The aim of the present study was to evaluate the effect of spironolactone on urinary TGF-β1 levels in patients with IgA nephropathy. Methods : TGF-β1 was measured by enzyme-linked immunosorbent assay in random urine specimens from 35 patients with IgA nephropathy. The patients were assigned to a spironolactone group, prednisolone group or losartan group. They were treated over an 8-week period. Urine samples were tested at the beginning and the end of the treatment period. Results : The patients with IgA nephropathy (n=35) had a higher urinary excretion of TGF-β1 than normal controls (n=13). Urinary TGF-β1 excretion was positively correlated with proteinuria and pathological grading but not with serum creatinine. After 8 weeks of treatment, losartan (n=13) and prednisolone (n=11) therapy induced a significant reduction in both urinary protein and TGF-β1 excretion. After treatment with spironolactone (n=11), urinary protein and TGF-β1 excretion were decreased. However, the decrease was not statistically significant. There was a significant correlation between the urinary TGF-β1 excretion and the serum aldosterone (r=0.84; p<0.01); however, treatment with spironolactone abolished this correlation. Conclusion : This study provides evidence that endogenous aldosterone influences urinary TGF-β1 excretion in patients with IgA nephropathy.
정경환(Jeong Kyung-Hwan),김종훈(Kim Jong-Hun),김석근(Kim Seok-Keun),이정재(Yee Jurng-Jae) 한국건축친환경설비학회 2008 한국건축친환경설비학회 학술발표대회 논문집 Vol.- No.-
Recently, underground spaces is developed to heighten the utilization rate of city. However, this space exist danger about fire. The purpose of this study is to evaluate on evacuation safety in underground arcade. Particularly, this study focused on sprinkler, fire shutter, smoke control equipment because evacuation safety is changed by fire protection equipment. According to result of fire simulation, sprinkler is very effective to fire protection. Fire shutter is effective fire protection equipment which protected damage of other space by intercepting fire and smoke. Smoke and CO density was reduced by smoke control equipment but the effective control plan is necessary for it. In conclusion, when operating all fire protection equipment, evacuation safety is satisfied in underground arcade.
급성콩팥기능상실을 동반한 MRSA감염과 연관된 혈구탐식림프구조직구증: 증례보고 및 문헌조사
김진숙 ( Jin Sug Kim ),정경환 ( Kyung Hwan Jeong ),이태원 ( Tae Won Lee ),임천규 ( Chun Gyoo Ihm ),이상호 ( Sang Ho Lee ),문주영 ( Ju Young Moon ),김양균 ( Yang Gyun Kim ),박지윤 ( Ji Yoon Park ),김슬기 ( Seul Ki Kim ),이유호 ( Yu 전북대학교 의과학연구소 2014 全北醫大論文集 Vol.38 No.1
혈구탐식림프구조직구증은 드물지만 높은 치사율을 가지는 질환이다. 저자들은 급성신부전을 동반하여 혈액투석을 필요로 했던 메티실린 내성 황색포도구균에 의한 폐렴과 연관되어 발생한 혈구탐식구조직구증 환자를 경험하였기에 보고하는 바이다. 다기관장 기부전과 범혈구감소증을 동반한 급성신부전 환자에서는 혈구탐식림프구조직구증이 드물다 하더라도 의심해 보아야 한다. Hemophagocytic lymphohistiocytosis (HLH) is a rare disease with high mortality. Here we present the case of a 61-year-old woman suffering from HLH related to methicillin-resistant Staphylococcus aureus (MRSA) pneumonia that was accompanied by acute kidney injury (AKI) requiring hemodialysis. Despite treatment, the HLH led to a fatal outcome in this case. Although rare, HLH should be considered in patients with AKI accompanied by pancytopenia and signs of multi-organ failure.
IgA 신병증 환자에게 있어 ACE 유전자 다형성에 따른 Angiotensin receptor blocker의 치료 효과
박미나 ( Mi Na Park ),정경환 ( Kyung Hwan Jeong ),문주영 ( Joo Young Mon ),이태원 ( Tae Won Lee ),임천규 ( Chun Gyoo Ihm ),이상호 ( Sang Ho Lee ) 대한신장학회 2008 Kidney Research and Clinical Practice Vol.27 No.1
목적: IgA 신병증에 있어 ACE 억제제나 ARB에 대한 치료 반응은 개개인에 따라 다르며, 이는 ACE 유전자 다형성등 유전적 성향과 관련될 것이라 생각된다. 하지만 이전의 연구들은 IgA 신병증 환자에게 있어 ACE 다형성과 ACE 억제제 치료 반응의 관련성을 다양하게 보고하였으며, 현재까지 이는 명확히 규명되지 못한 상태이다. 본 저자들은 ACE 억제제의 불완전한 RAAS 차단이 이러한 결과를 산출 할 수 있을 것이라 가정하고, ARB 치료를 받은 IgA 신병증 환자를 대상으로 ACE 유전자 다형성과 RAAS 차단제 치료 반응의 연관성에 대해 살펴보았다. 방법: 경희대학교 병원에서 IgA 신병증을 진단 받은 환자들 중 24시간 요 단백량이 0.5 g/일 이상, 혈중 크레아티닌수치가 1.5 mg/dL 미만인 환자를 조사하였고, 그 중 첫 치료로 ARB를 약 6개월간 단독 사용한 40명의 환자를 선택하였다. 환자들의 말초 혈액에서 유전자 DNA를 추출하여 ACE 유전자 다형성을 분석하였다. 치료 도중 24시간 요 단백량이 0.3 g/일 미만으로 감소한 환자들을 완전 반응군 (Complete response), 단백뇨 감소정도가 50% 이상이지만 0.3 g/일 미만인 경우를 부분 반응군 (Partial response), 단백뇨 감소 정도가 50% 미만이거나 오히려 증가한 환자들을 비반응군 (Nonresponse)로 분류하였다. 결과: 대상 환자들의 진단 당시 평균 나이는 41.0±12.9세였고, 남:녀 비는 25:15 였다. 평균 혈중 크레아티닌은 1.2±0.6 mg/dL, 단백뇨는 1.6 g/일 (95% Cl, 1.4-2.3)이었다. 약 6개월을 (95% Cl, 5.5-7.9) ARB 치료하며 관찰 한결과, 완전 반응군은 총 15명 (38%), 부분 반응군은 11명 (27%), 비반응군은 14명 (35%)이었다. ACE 유전자 다형성에 따른 전체적인 치료 반응은 각 유전자형 별로 의미 있는 차이를 보이고 있었다 (p=0.02). 각 유전자형에 따라 완전 반응 또는 불완전 반응을 보인 환자들의 비율을 보면, Ⅱ:ID:DD=43%:68%:100% (p=0.03)였다. ID/DD 형과 Ⅱ형으로 나누어 살펴보아도 ID/DD 형이 Ⅱ형에 비해 ARB 치료에 반응할 확률이 통계학적으로 의미 있게 높았다 (p=0.01). 결론: 한국인 IgA 신병증 환자에게 있어 ACE 유전자 다형성은 ARB 치료 반응과 밀접한 연관성을 가지는 것으로 생각되며, 이의 명확한 규명을 위한 대단위 연구가 필요하다. Purpose: Each and every patients therapeutic response to ACE inhibitor in IgA nephropathy can be different. The diversity may be caused by ACE polymorphism. The previous studies did not reveal the consistency of relation between ACE polymorphism and ACE inhibitor. We consider the incomplete blockade of ACE inhibitor for RAAS is the one of various reasons. We evaluated the relation between ACE polymorphism and ARB in IgA nephropathy. Methods: Among patients confirmed in IgA nephropathy and treated with ARB, 40 patients with over 0.5 g/day proteinuria and less 1.5 mg/dL serum creatinine were reviewed. Genomic DNA was extracted from blood and PCR was performed. Complete response was defined that proteinuria was less than 0.3 g/day after treatment. Partial response was defined that proteinuria was decreased over than 50%, but more than 0.3 g/day. Non-response was defined that proteinuria was decreased less than 50%. Results: The median follow-up duration was 6 months (95% Cl, 5.5-7.9). The serum creatinine was 1.2±0.6 mg/dL and median proteinuria was 1.6 g/day (95% Cl, 1.4-2.3). 15 complete responses, 11 partial responses and 14 non-responses were observed. The differences in the therapeutic response to ARB were observed according to ACE polymorphism (p=0.02). The response rate among each group was Ⅱ:ID:DD=43%:68%:100% (p=0.03), and there was a significant difference in the therapeutic response to ARB between the DD/ID genotype and the Ⅱ genotype (p=0.01). Conclusion: In IgA nephropathy, there was a significant relation between the therapeutic response to ARB and the ACE polymorphism. Especially DD/ID genotype revealed better response to ARB than Ⅱ genotype.
유전자 재조합 Human Growth Hormone 의 성장촉진 효과에 관한 연구
정요찬(Yo Chan Jeong),송동호(Dong Ho Song),조명행(Myung Haing Cho),구본흔(Bon Heun Koo),정광회(Kwang Hoe Chung),김경연(Kyeong Yeon Kim),정경환(Kyung Hwan Jung),이은경(Eun Kyung Lee),박두홍(Doo Hong Park) 한국응용약물학회 1995 Biomolecules & Therapeutics(구 응용약물학회지) Vol.3 No.3
The growth effects of newly developed recombinant human growth hormone (rHGH), were compared with those of Biotropine. For the effective evaluation, we examined the increasing rate of body weight and the thicknes of tibial epiphysis as criteria of growth effects on hypophysectomised female rats treated with varing concentration of rHGH for 4 days. rHGH treated groups showed significant body weight gain which was less evident in Biotropine and vehicle treatment group. In tibial epiphyseal test, rHGH also showed clear effects compared to Biotropine and vehicle treatment group. Above findings indicate that newly developed rHGH has better effects of growth stimulation on female rats than Biotropine does.