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해송의 leucine aminopeptidase 와 glutamate - oxalate transaminase 동위효소 유전
정경호,박용구 한국유전학회 1986 Genes & Genomics Vol.8 No.3
Starch gel electrophoresis was used to examine inheritance of leucine aminopeptidase (LAP) and glutamate-oxalate transaminase (GOT) isozyme in megagametophytes of Pinus thunbergii. There were three zones of activity on gels stained for LAP. Only two zones (LAP-B, LAP-C) showed remarkable variability with different migration rate in many trees. The segregation ratio of these phenotypes in heterozygous trees did not show any significant deviations from 1:1 in both zones. It was suggested that LAP-B locus was controlled by three alleles (B₁, B₂, B_0), and LAP-C two alleles (C₁, C₂). In GOT activity only GOT-E zone revealed variation. It was assumed that GOT-E would be controlled by two alleles (E₁, E₂). Nine mother heterozygous for two loci showed independent segregation indicating that the three loci were not linked.
폐루프 광섬유자이로의 불감응 영역 감소를 위한 모델링 시뮬레이션
정경호,정길도 제어로봇시스템학회 2013 제어로봇시스템학회 각 지부별 자료집 Vol.2013 No.12
Due to electrical cross-coupling between modulation voltage and photodetector current in closed loop fiber optic gyro, deadzone is inevitably occurred. In this paper, electrical cross-coupling signal is modeled and the reason and overcoming method are investigated. The cross-coupling model is composed of high pass filter, coupling gain, and current adder and square-wave digital dithering model is used in overcoming method. Simulation results show that the main reason of deadzone is directly related to electrical cross-coupling and deadzone is eliminated by dithering method.
Molecular Imaging in the Era of Personalized Medicine
정경호,이경한 대한병리학회 2015 Journal of Pathology and Translational Medicine Vol.49 No.1
Clinical imaging creates visual representations of the body interior for disease assessment. The role of clinical imaging significantly overlaps with that of pathology, and diagnostic workflows largely depend on both fields. The field of clinical imaging is presently undergoing a radical change through the emergence of a new field called molecular imaging. This new technology, which lies at the intersection between imaging and molecular biology, enables noninvasive visualization of biochemical processes at the molecular level within living bodies. Molecular imaging differs from traditional anatomical imaging in that biomarkers known as imaging probes are used to visualize target molecules-of-interest. This ability opens up exciting new possibilities for applications in oncologic, neurological and cardiovascular diseases. Molecular imaging is expected to make major contributions to personalized medicine by allowing earlier diagnosis and predicting treatment response. The technique is also making a huge impact on pharmaceutical development by optimizing preclinical and clinical tests for new drug candidates. This review will describe the basic principles of molecular imaging and will briefly touch on three examples (from an immense list of new techniques) that may contribute to personalized medicine: receptor imaging, angiogenesis imaging, and apoptosis imaging.