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내배엽기원 태아장기에서 Carcinoembryonic Antigen 출현도에 관한 면역조직화학적 관찰
전행조,유재형,송계용,지제근 중앙대학교 의과대학 의과학연구소 1983 中央醫大誌 Vol.8 No.4
Since Gold and Freedman discovered the carcinoembryonic antigen (CEA) in 1965, CEA had been used as a tumor marker of gastrointestinal carcinoma for the evaluation of surgical treatment and prognosis. The CEA is also known to present in normal developing tissue. However, the knowledge on CEA in human fetal tissue is still incomplete. In this study CEA in the entoderm-derived fetal organs such as pancreas(22 cases), trachea(16 cases) and liver (10cases) was examined in the fetuses ranging in age from the 16th to the 39th week gestation by using immunoperoxidase (peroxidase-antiperoxidase) method. The results obtained were as follows: 1. CEA of the pancreas in the fetus' CEA of the luminal border and cytoplasm of the acinar epithelium and Langerhans' islets in pancreas was demonstrated by the 16th week of gestation. CEA positive reaction was gradually increased to the 19th and 20th week of gestation and was continued to present until the 33th week of gestation. 2. CEA of the trachea in the fetus CEA of the surface epithelium and glands of the trachea was demonstrated by the 17th week of gestation. Its activity was increased to reach the peak by the 20th week of gestation and gradually decreased by the 38th week of gestation. 3. CEA of the liver in the fetus CEA of the fetal liver was only demonstrated in the bile canaliculi without its positivity of the hepatocytes and intrahepatic bile ducts from the 19th to 30th week of gestation. Therefore it is assumed that the liver is not the site of CEA synthesis but is probably responsible for the degradation and excretion of CEA.
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쇠살무사독이 흰쥐 심장에 미치는 영향에 관한 혈액화학적 및 병리조직학적 연구
전행조,김형춘,박용욱,송계용 중앙대학교 의과대학 의과학연구소 1987 中央醫大誌 Vol.12 No.1
To observed the cardiotoxic effects on the mechanism of circulatory shock in actue venom intoxication, a diochemical and histopthological studies were carried out in the heart od rats using venom of Agkistrodon saxailis. The rat used were adults weighing between 200∼250gm. 32gm of freeze dried venom was diluted to 12ml of normal saline, and 0.4ml of this solution was administrated intravenously through tail vein to each rat. The rats were sacrificed serially with time interval; after venom adminstration 1 hour, 3 hours, 6 hours,1 day, 4days and 7 days, respectively. Additionally serum enzymes, namely glutamic oxaloacetic transaminase(GOT), lactic dehydrogenase(LDH) and creatinine phosphpkinase(CPK)were measures for the correlation. The results obtained were as follows: 1. Serum levels of GOT were significantly elevated in hours to 298.0±219.6IU/ℓ(p<0.05) until 6 hours 2. Serum levels of LDH were significantly reduced from 6 hours and lowest in 24 hours to 340.6±132.7IU/ℓ(p<0.01) until 4 days. 3. Serum levels of CPK were significantly reduced in 24 hours 543.4±469.4IU/ℓ(p<0.05). 4. Light microscopic changes in the heart revealed moderate to marked congestion, edema, hemorrhage in the ventricular and subendocardial myocardium with coagulation necrosis of myocardial muscles in the hemorrhagic areas in i hour after venom administration. Infiltreated of inflammatory cells were increased in 3∼6 hours. Later, fibrosis was due in the multiple areas of previous necrosis. 5. Early electronmicroscopic changes in the myocardium revealed marked intracellular edema with lifting, bleb formation and repture of sarcolemma as well as separation of myofilaments and focal random loss of myofilaments. Mitochondrial swelling and vacuolar changes were also noted. With above results, it was assumed that cardiotoxicity of the venom of Agkistrodon caliginosus, characterized by marked myocardial edema and hemorrhage with necrosis, could play a role in explaining acute cirulatory collapse in rats after venom intoxication. It was also interest to note that the extent of myocardial damage did not correlated with the levels of serum GOT,LDH, and CPK.
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고통판단과제에서 정신병질 경향성 집단의 고통공감: 사건관련전위연구
전행자,김영윤 한국사회및성격심리학회 2011 한국심리학회지 사회 및 성격 Vol.25 No.4
We examined empathy for pain in undergraduate students divided into psychopathic tendencies(n=15) and control(n=15) groups according to the scores of Psychopathic Personality Inventory-Revised. Event-related potentials were collected as participants performed a pain judgment task and a hand counting task. The participants were presented with pictures of hands that were in painful or neutral situations. The pain judgment task required attention to pain cues in the stimuli. The hand counting task withdrew their attention from these cues. The statistical analysis of P3 elicited by pain and neutral stimuli in the pain judgment task indicated that psychopathic tendencies group showed significantly higher P3 amplitudes than the control group at the frontocentral and central areas. Psychopathic tendency group responded less accurately than the control group. But both group did not show significant differences in accuracies. These results suggest that individuals with psychopathic tendencies are required more cognitive effort to empathize the others’ pain. 본 연구는 사건관련전위를 이용하여 정신병질 경향성을 가진 사람들이 타인의 고통공감에 어려움이 있는지 알아보기 위해 수행되었다. 일반 대학생들을 대상으로 정신병질적 성격 질문지 개정판의 점수에 의해 65점 이상을 받아 정신병질 경향성자로 분류된 15명이 실험집단으로 선발되었다. 정신병질적 성격 질문지 개정판에서 65점 이하를 받은 나머지 학생들 중에서 15명이 통제집단으로 선발되었다. 컬러 사진을 이용한 시각 과제를 실시하였는데, 모든 피험자는 일상생활에서 흔히 일어날 수 있는 손에 고통이 가해지는 상황의 사진(고통자극)과 같은 상황이지만 고통이 가해지지 않은 사진(중성자극)을 보게 된다. 피험자들은 고통판단과제에서 손에 고통이 있는 사진과 없는 사진을 구분하고, 손수세기과제에서는 손의 수를 구분하여 가능한 한 빠르고 정확하게 해당 버튼을 누르도록 지시받았다. 과제가 수행되는 동안 사건관련전위를 측정하였다. 사건관련전위 분석 결과, 고통판단과제에서 정신병질 경향성집단이 통제집단보다 전전두(prefrontal)영역에서 중심(central)영역까지 고통자극의 P3 진폭이 중성자극의 P3 진폭보다 크게 나타났고, 집단 간 유의미한 차이를 나타냈다. 행동데이터를 분석한 결과, 정신병질 경향성집단이 통제집단보다 더 낮은 과제수행 정확도 평균을 나타냈으나, 집단 간에 유의미한 차이를 보이지 않았다. 이러한 결과는 정신병질 경향성을 가지고 있는 대학생들이 타인의 고통을 공감하는데 더 많은 인지적인 노력을 요구하는 것으로 보여진다.
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