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임상연구 : 비뇨기과 수술을 받는 노인 환자의 척추마취 시 첨가된 Fentanyl의 용량에 따른 임상효과의 비교
김정은 ( Jeong Eun Kim ),문영은 ( Young Eun Moon ),홍상현 ( Sang Hyun Hong ),전준표 ( Joon Pyo Jeon ),장혜원 ( Hae Wone Chang ),김수진 ( Su Jin Kim ),고현정 ( Hyun Jung Koh ),유건희 ( Keon Hee Ryu ) 대한마취과학회 2008 Korean Journal of Anesthesiology Vol.55 No.5
Background: Spinal anesthesia for urologic surgery in elderly patients is preferred. The addition of opioids to local anesthetics reduces the side effects of spinal anesthesia. This study examined the effects of intrathecal fentanyl 10 μg and 20 μg when administered with hyperbaric 0.5% bupivacaine to elderly patients undergoing urologic surgery. Methods: Forty-five elderly patients undergoing urologic surgery were randomized into the following three groups: group 1, bupivacaine 7.5 mg; group 2, bupivacaine 5 mg + fentanyl 10 μg; and group 3, bupivacanie 5 mg + fentanyl 20 μg. The total volume of intrathecally injected was adjusted to 1.5 ml with sterile normal saline. Spinal anesthesia was administered with a 25 G Quincke needle at the L3-4 or L4-5 interspace in the lateral position. The neural block was assessed using a pinprick test and the Bromage scale. Results: There were no significant differences in the onset time of the T10 sensory block, peak level of the sensory block, and onset time of the peak level. The duration of the sensory block was significantly shorter in group 2 than in group 1 (P=0.017). The duration of the motor block was longer in group 1 than in groups 2 and 3 (P=0.016, P=0.04). Pruritus was observed more often in group 3 (37.5%) and shivering was more common in group 1 (P=0.005). Conclusions: The addition of fentanyl 10 μg and 20 μg to bupivacaine 5 mg provides adequate anesthesia for elderly patients undergoing urologic surgery with fewer side effects, and fentanyl 10 μg is recommended as outpatient anesthesia. (Korean J Anesthesiol 2008;55:579~84)
음이온 리빙중합에 의한 방향족 아민 양말단변성 폴리부타디엔의 합성
전준표,이범재,박상호 忠南大學校 産業技術硏究所 2002 산업기술연구논문집 Vol.17 No.2
Functionalization reaction of poly(butadienyl)lithium with 4,4'-bis(dimethylamino)-benzophenone, 4,4'-bis(diethylamino)benzophenone, 1,1'-bis[(4-dimethylamino)phenyl]ethylene, and 1,1'-bis[(4-diethylamino)phenyl]ethylene in n-heptane provide the corresponding ω-amine chain-end funstionalized polymers in 90∼95% yields. α-Functionalized polybutadienes were prepared by the polymerization using amine functional initiator, which was obtained by the stoichiometric reaction of sec-butyllithium and 1,1'-bis[(4-dimethylamino)phenyl]ethylene, or 1,1'-bis[(4-diethylamino)phenyl]ethylene. Utilizing these two reaction technologies, well-known α,ω-difunctionalized polybutadienes could be synthesized by the polymerization using amine functional initiator followed by chain-end functionalization.
복강내 온열 관류요법시 수액의 종류에 따른 산. 염기 균형의 변화
최종호,김성년,전준표,나애자 대한마취과학회 2001 Korean Journal of Anesthesiology Vol.40 No.2
Background: Continuous hyperthermic peritoneal perfusion (CHPP) has been introduced to improve the survival of cancer patients. However CHPP induced acute change of body temperature and intra-abdominal pressure could produce various abnormal physiologic responses, especially acid-base and electrolyte imbalance. The purpose of this study was to evaluate the effects of intravenous fluids, plasma solution and Hartman's solution on acid-base status and electrolyte concentrations during CHPP and to determine strategies for safer fluid management. Methods: Thirty five patients with ovarian cancer were divided into two groups; Group 1 (16 Patients) was supplied with plasma solution and Group 2 (19 patients) was supplied with a Hartman solution as the intravenous fluid. Closed peritoneal irrigation was done with perfusate at a temperature of 47˚C for 90 min under general anesthesia. Body temperature, hemodynamic parameters (mean arterial pressure MAP, heart rate HR), blood gas tensions (PaO2, PaCO2), acid-base parameters (pH, base deficit BD) and electrolytes (sodium, potassium, calcium) were measured at 10 min before CHPP, 30, 60, 90 min after the initiation of CHPP, and 30 min after the end of CHPP. Results: There were no significant changes in body temperature, MAP, HR, PaO2, PaCO2 during CHPP in both groups. pH measured at posfCHPP in group 2 was significantly lower than that measured in group 1. Base deficits measured at 30, 60, 90 min after the initiation of CHPP and 30 min after the end of CHPP in group 2 were significantly lower than those measured in group 1. Potassium and calcium ion concentations did not show statistical significance during CHPP in both groups. 7 patients in group 1 whose calcium ion level dropped by more than 20% of the initial value needed a calcium injection but but only 1 patient in group 2 needed a calcium injection. Conclusion: It appears that hemodynamic stability was maintained well during CHPP between the two group. A plasma solution may be more ideal in reducing acidic tendencies and base deficits than