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- 저자 : 전영우 ( Young Woo Jeon ) (검색결과 20 건)
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전영우(Young Woo Jeon) 상명대학교 조형예술연구소 1998 조형예술연구 Vol.3 No.-
As the Modern era began the exchanging goods between West and East has been increased. The European culture, included Jesuit of Catholic, was known to Chinese. The various types of western painting also known to Chinese and the representatives of Korean g
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전영우 ( Young Woo Jeon ),김재연 ( Jae Yun Kim ),박재석 ( Jae Seok Park ),박재만 ( Jae Man Park ),길효욱 ( Hyo Wook Gil ),양종오 ( Jong Oh Yang ),이은영 ( Eun Young Lee ),홍세용 ( Sae Yong Hong ) 대한내과학회 2011 대한내과학회지 Vol.81 No.2
목적: 칼슘 통로 차단제는 흔히 사용되는 항고혈압 약제이다. 전세계적으로 사용량 증가에 따른 과량 복용에 대한 보고가 증가 하고 있지만 국내 보고는 미흡하다. 칼슘 통로 차단제 중 암로디핀은 매우 흔히 사용되는 약제이나 과량복용에 대해서는 임상의에게는 익숙하지 않다. 따라서 본 연구는 암로디핀을 과다 복용한 환자들의 임상양상, 치료 경과, 합병증 및 예후에 대해 조사하였다. 방법: 2002년 1월부터 2010년 12월까지 순천향대학교 천안병원에 약물중독으로 내원한 환자 중 암로디핀을 과량복용한 환자를 대상으로 후향적 조사를 하였다. 약물 복용량은 환자나 보호자 진술에 근거하여 체표면적당 약물 복용량(Billy`s BSA formula)으로 계산하였고, 응급실 내원 당시의 초기 생징후, 혈액 검사, 심전도 검사 등을 조사하였으며, 심전도 이상은 서맥, 방실 전도장애, QT, QRS 간격의 증가 중1개 이상의 변화가 있을 경우로 정의하였다. 결과: 총 9명의 환자(남자 2명, 여자 7명)가 포함되었고, 체표면적당 암로디핀 복용량은 197.78±128.37 mg이었으며, 모든 환자에서 다른 종류의 약물을 같이 과량 복용했다. 9명의 환자 중 2명이 사망했고, 사망한 환자의 체표면적당 약물복용량은 343.5 mg/m2와 225.6 mg/m2이었고, 생존 환자 모두에서는 200 mg/m2 이하였다. 3명의 환자에서 glimepride를 같이 과량 복용했지만, 200 mg/dL 이상의 혈당 수치를 보였고, 이중에서 1명은 고혈당이 조절되지 않아 대사성 케톤산증이 진행되어 다장기 부전으로 사망하였다. 심전도 이상을 보인 환자의 평균 체표면적당 약물 복용량은 197.1±92.3 mg/m2이었고, 심전도 이상이 없는 환자에서는 58.5±27.1 mg/m2이었다. 결론: 비교적 안전하다고 알려진 non-dihydropyridine계인 암로디핀도 과량 복용 시 고혈당과 대사성 케톤산증 및 심장 전도이상이 유발되어 치명적인 결과를 보일 수 있다. 고혈당 발생은 나쁜 예후를 시사하므로 이에 대한 주의가 필요하다. Background/Aims: Calcium channel blockers (CCBs) are anti-hypertensive medications that are used worldwide. CCB overdose has increased in proportion to the use of these drugs. Although amlodipine is the most widely used CCB, many physicians are not familiar with amlodipine overdose. We report the clinical outcome in patients with an intentional amlodipine overdose. Methods: We retrospectively reviewed the medical records of the patients who visited Soonchunhyang University Cheonan Hospital with an amlodipine overdose from January 2002 through December 2010. We recorded the initial vital signs, blood chemistry, electrocardiography, and estimated amount of amlodipine ingested. Results: Nine patients were enrolled, of whom two patients died. Both patients who died had ingested more than 200 mg/m2 of amlodipine, while all of the patients who ingested less than 200 mg/m2 of amlodipine survived. Three patients had blood sugar levels exceeding 200 mg/dL and two of these died despite high-dose insulin therapy in combination with glucose infusion (hyperinsulinemia/euglycemia therapy). Although three patients also took a glimepiride overdose, none had hypoglycemia. The amount of amlodipine ingested relative to the body surfaced area (BSA) was 197.1±92.3 mg/m2 in patients with an abnormal ECG and 58.5±27.1 mg/m2 in patients with a normal ECG. Conclusions: Amlodipine overdose can induce hyperglycemia, resulting in lethal cardiogenic shock owing to the decreased calcium influx, inappropriate energy production, and weakened inotropic effect. Therefore, amlodipine-induced hyperglycemia indicates a poor prognosis. (Korean J Med 2011;81:208-214)
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Relaxin을 분비하는 아데노바이러스가 피판의 생존에 미치는 영향
윤인식,박용순,전영우,전여름,이원재,윤채옥,나동균,Yun, In-Sik,Park, Yong-Sun,Cheon, Young-Woo,Jeon, Yeo-Reum,Lee, Won-Jai,Yun, Chae-Ok,Rah, Dong-Kyun 대한성형외과학회 2010 Archives of Plastic Surgery Vol.37 No.5
Purpose: Of various effects of relaxin, we assumed that anti-fibrotic effects, neovascularization effects and vasodilatation effects of relaxin might enhance the survival rate of skin flap. In the current study, we used adenovirus expressing relaxin genes to examine whether these genes could enhance the survival rate of a skin flap. Methods: A total of 30 Sprangue-Dawley rats were divided into three groups: RLX group (10; relaxin virus injected group), CTR group (10; no gene coded virus injection group), and PBS group (10; PBS injected group). Each group was intradermally injected with the virus ($10^7$ PFU) and PBS 48 hours before and immediately before the flap elevation. A distally based flap $3{\times}9\;cm$ in size was elevated on the dorsal aspect of each rat. Following this, a flap was placed in the original location and then sutured using a #4-0 Nylon. A surviving area of the flap was measured and then compared on postoperative days 3, 7 and 10. Using a laser Doppler, the amount of blood flow was measured. On postoperative day 10, tissues were harvested for histologic examination and the number of blood vessels was counted. Results: There was a significant increase in the area of the flap survival in the RLX group on postoperative days 3 and 7. The Doppler measurement also showed significantly increased blood flow immediately after the operation and on postoperative days 7 and 10. The number of blood vessels was significantly greater in the RLX group in the tissue harvested on postoperative day 10. The VEGF concentration was significantly higher in the RLX group than others in the tissues harvested on postoperative day 10. Conclusion: Following an analysis of the effects of relaxin-secreting adenovirus on the survival of a flap, the surviving area of the flap and the blood flow also increased. A histopathology also showed an increase in the number of blood vessels and the concentration of VEGF.
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검사별 radioimmunoassay시약 조사 및 비교실험
김지나,안재석,전영우,윤상혁,김윤철,Kim, Ji-Na,An, Jae-seok,Jeon, Young-woo,Yoon, Sang-hyuk,Kim, Yoon-cheol 대한핵의학기술학회 2021 핵의학 기술 Vol.25 No.1
Purpose If a new test is introduced or reagents are changed in the laboratory of a medical institution, the characteristics of the test should be analyzed according to the procedure and the assessment of reagents should be made. However, several necessary conditions must be met to perform all required comparative evaluations, first enough samples should be prepared for each test, and secondly, various reagents applicable to the comparative evaluations must be supplied. Even if enough comparative evaluations have been done, there is a limit to the fact that the data variation for the new reagent represents the overall patient data variation, The fact puts a burden on the laboratory to the change the reagent. Due to these various difficulties, reagent changes in the laboratory are limited. In order to introduce a competitive bid, the institute conducted a full investigation of Radioimmunoassay(RIA) reagents for each test and established the range of reagents available in the laboratory through comparative evaluations. We wanted to share this process. Materials and Methods There are 20 items of tests conducted in our laboratory except for consignment tests. For each test, RIA reagents that can be used were fully investigated with the reference to external quality control report. and the manuals for each reagent were obtained. Each reagent was checked for the manual to check the test method, Incubation time, sample volume needed for the test. After that, the primary selection was made according to whether it was available in this laboratory. The primary selected reagents were supplied with 2kits based on 100tests, and the data correlation test, sensitivity measurement, recovery rate measurement, and dilution test were conducted. The secondary selection was performed according to the results of the comparative evaluation. The reagents that passed the primary and secondary selections were submitted to the competitive bidding list. In the case of reagent is designated as a singular, we submitted a explanatory statement with the data obtained during the primary and secondary selection processes. Results Excluded from the primary selection was the case where TAT was expected to be delayed at the moment, and it was impossible to apply to our equipment due to the large volume of reagents used during the test. In the primary selection, there were five items which only one reagent was available.(squamous cell carcinoma Ag(SCC Ag), β-human chorionic gonadotropin(β-HCG), vitamin B12, folate, free testosterone), two reagents were available(CA19-9, CA125, CA72-4, ferritin, thyroglobulin antibody(TG Ab), microsomal antibody(Mic Ab), thyroid stimulating hormone-receptor-antibody(TSH-R-Ab), calcitonin), three reagents were available (triiodothyronine(T3), Tree T3, Free T4, TSH, intact parathyroid hormone(intact PTH)) and four reagents were available are carcinoembryonic antigen(CEA), TG. In the secondary selection, there were eight items which only one reagent was available.(ferritin, TG, CA19-9, SCC, β-HCG, vitaminB12, folate, free testosterone), two reagents were available(TG Ab, Mic Ab, TSH-R-Ab, CA125, CA72-4, intact PTH, calcitonin), three reagents were available(T3, Tree T3, Free T4, TSH, CEA). Reasons excluded from the secondary selection were the lack of reagent supply for comparative evaluations, the problems with data reproducibility, and the inability to accept data variations. The most problematic part of comparative evaluations was sample collection. It didn't matter if the number of samples requested was large and the capacity needed for the test was small. It was difficult to collect various concentration samples in the case of a small number of tests(100 cases per month or less), and it was difficult to conduct a recovery rate test in the case of a relatively large volume of samples required for a single test(more than 100 uL). In addition, the lack of dilution solution or standard zero material for sensitivit [목 적] 의료기관의 핵의학 검사실에서 신규검사를 도입하거나 사용하던 시약을 변경하게 되는 경우 절차에 따라 검사의 특성이 분석되고 시약에 대한 평가가 이루어져야 한다. 그러나 요구되어지는 비교실험을 모두 수행하기 위해서는 몇 가지 필요한 조건이 충족되어야 하는데, 첫째 각 검사별로 수행하기에 충분한 검체량이 준비되어야하며, 둘째 비교실험에 적용 가능한 다양한 시약의 공급이 가능해야한다. 충분한 비교실험이 이루어졌다고 하더라도 변경된 시약에 의한 데이터 변동이 전체 환자데이터 변동을 의미하는 것에는 한계가 있으므로 검사실에서 시약이 변경되는 것에 대한 부담이 있다. 이러한 다양한 어려움으로 검사실에서의 시약변경은 제한적으로 이루어지고 있다. 본원에서는 원할한 경쟁 입찰을 도입하기 위하여 검사별로 radioimmunoassay(RIA)시약을 전수조사하고 비교실험을 통해 검사실에서 사용가능한 시약범위를 설정하였다. 이 과정을 공유하고자 하였다. [대상 및 방법] 본원 핵의학 검체 검사실에서 시행하고 있는 검사는 위탁검사를 제외하고 총 20종목이다. 각각의 검사별로 외부정도관리와 기관간 정도관리 결과보고서를 참고로 사용가능한 RIA시약을 전수 조사하였고, 각 시약에 대한 메뉴얼을 확보하였다. 각각의 시약마다 메뉴얼을 확인하여 검사 방법과 incubation시간, 검사 시 필요한 검체량, 시약량 등을 확인하여 본 검사실에서 사용가능한지 여부에 따라 시약 1차 선정을 하였다. 1차 선정된 시약을 100 test기준으로 2 kit씩 공급받아 데이터 상관성시험, 민감도, 회수율, 희석시험을 진행하였고, 비교실험 결과에 따라 시약을 2차 선정하였다. 1, 2차 선정을 통과한 시약을 경쟁 입찰리스트로 제출하였다. 검사 시약을 단수로 지정할 경우에는 1차, 2차 선정 과정에서 얻은 자료로 단수지정 사유서를 작성하였다. [결 과] 각각의 시약마다 매뉴얼을 확인하여 시약 1차 선정에서 제외되는 경우는 각 검사의 현재 Turn Around Time(TAT)보다 길어지는 경우와 검사 시 사용 시약량이 많아 장비사용이 불가능한 경우였다. 1차 선정에서 사용가능한 시약이 1개인 경우는 5종목 squamous cell carcinoma antigen(SCC Ag), 𝛽-human chorionic gonadotropin(𝛽-HCG), vitamin B12, folate, free testosterone 이었고, 2개인 경우는 8종목 (CA19-9, CA125, CA72-4, ferritin, thyroglobulin antibody(TG Ab), microsomal antibody(Mic Ab), thyroid stimulating hormone-receptor-antibody(TSH-R-Ab), calcitonin), 3개인 경우는 5종목(triiodothyronine(T3), Free T3, Free T4, TSH, intact parathyroid hormone(intact PTH)), 4개인 경우는 2종목(carcinoembryonic antigen(CEA), TG)이었다. 2차 최종 선정결과 사용가능한 시약이 3개인 것은 T3, Free T3, Free T4, TSH, CEA, 2개인 것은 TG Ab, Mic Ab, TSH-R-Ab, CA125, CA72-4, intact PTH, calcitonin이었다. 단수 지정된 종목은 ferritin, TG, CA19-9, SCC, 𝛽-HCG, vitamin B12, folate, free testosterone이었다. 2차 선정에서 제외된 사유에는 비교실험을 위한 시약공급이 안된 경우와 데이터 재현성에 문제가 있었던 경우, 데이터 변동에 대한 수용이 불가능하다고 판단되는 경우였다. 비교실험 시 가장 문제가 되는 부분은 검체 수집이었다. 검사건수가 많고 검사 시 필요한 검체량이 적은 경우에는 문제가 되지 않았지만, 검사건수가 적은 경우(월 100건 이하)에는 다양한 농도 검체를 수집하기가 어려웠으며, 한번 검사 시 필요한 검체량이 상대적으로 많은 경우(100 uL이상)에는 회수율시험을 진행하기가 어려웠다
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박재석 ( Jae Seok Park ),전영우 ( Young Woo Jeon ),김영일 ( Young Il Kim ),길효욱 ( Hyo Wook Gil ),양종오 ( Jong Oh Yang ),이은영 ( Eun Young Lee ),홍세용 ( Sae Yong Hong ) 대한임상독성학회 2011 대한임상독성학회지 Vol.9 No.1
Trichloroethylene (TCE, C2HCl3), which was introduced as a gas for general anesthesia and analgesia in early 1900’s has been widely used in industry as an organic solvent. Occupational exposure to TCE is an important med-ical problem. Manifestations of acute exposure to TCE include mucocutaneous irritation, hepatotoxicity, cognitive impairment, sleep, headache, respiratory insufficiency and death. We report a 38-year-old man who was admitted to a department of emergency medicine after occupational inhala-tion exposure to TCE. He rapidly developed semicoma and respiratory depression. After mechanical ventilation, hypercapnea and hypoxemia disappeared and his mental state again became alert. Careful evaluation and proper respiratory support are important for respiratory failure after occupational TCE inhala-tion.
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