Cushing 증후군 2예 : 부신피질 선종으로 인한 due to Adrenocortical Adenoma

전영빈,이의용,김면호,박호진,유건,왕희정,이혁상,고일향 인제대학교 1984 仁濟醫學 Vol.5 No.3

Cushing's syndrome is the clinical and metabolic disorder resulting from a chronic excess of glucocorticoids. Approximately 20-25% of patients with Cushing's syndrome have primary overproduction of cortisol and other adrenal steroids due to an adrenal neoplasm. We recently experienced two cases of Cushing's syndrome due to adrenocortical adenoma. The diagnosis was confirmed by clinical features, biochemical, hormonal and radiological studies and finally pathologic examination. A brief review of literature was presented and our cases were reported.

Helicobacter Pylori 감염 진단에서 One Minute Urease Test의 임상적 유용성에 관한 연구

전영빈 인제대학교 1996 仁濟醫學 Vol.17 No.4

Helicobacter pylori 진단을 위한 여러 파지 검사법이 개발되어 있고, 각기 높은 민감도와 특이도가 보고되고 있지만 대부분의 검사법이 조작이 복잡하고 시간이 소요된다는 단점을 가지고 있다. 저자는 기존의 urease 검사의 배지조건을 변화시킴으로써 1분내 결과 판단이 가능하다는 최근의 보고에 근거하여 이러한 검사법이 소화성궤양 환자와 H. pylori 제균요법후에 H. pylori 진단에 유용한지를 연구조사하였다. Objective : There are several reliable methods for detecting Helicobacter pylori but all have as a major disadvantage the time required to yield a definitive result. Recent study indicates that the diagnosis can be made within one minute by the change of incubation condition. This study aimed to assess the diagnostic efficiency of one minute urease test in patients with peptic ulcer treated or not treated with the agents eradicating H. pylori. Methods : In 304 patients with peptic ulcer, antral biopsies were taken for histology (Hematoxylin & Eosin staining) and one minute urease test. Rebiopsies were done in 65 patients infected with H. pylori after a eradication therapy of H. pylori. The diagnostic efficiency of one minute urease test was compared with that of H&E staining. Results : The H&E staining revealed that 237 patients (78%) of 304 patients with peptic ulcer were infected with H. pylori. Among the 65 patients given H. pylori eradication therapy, H. pylori were eradicated in 44 (68%) patients. Assuming that the H&E staining is a 'gold standard', one minute urease test showed high sensitivity (88%) and specificity (85%) in the diagnosis of H. pylori infection. After H. pylori eradication therapy, one minute urease test showed sensitivity of 52% and specificity of 100% in evaluating the success of eradication. Conclusion : One minute urease test is a sensitive and specific method for the diagnosis of H. pylori infection in patients with peptic ulcer. Despite of low sensitivity for evaluation of the success of H. pylori eradication therapy, one minute urease test has the advantage that it takes low cost and short time.

특이한 형태를 취한 거대 위선종의 내시경적 절제 1예

전영빈,배원기,이승진,양대열,문정섭,유권 인제대학교 1998 仁濟醫學 Vol.19 No.2

위선종은 세포 이형성을 가진 선상피의 양성 종양으로, 대부분 2cm 미만의 편평한 융기 형태를 취하며 6∼75%에서 악성 변화가 보고되고 있다. 다양한 내시경적 절제술이 시도되고 있는데 고장식염수-에피네프린 국주를 병용한 점막절제술(ERHSE)은 병변의 가장자리를 미리 절개함으로써 정확하게 완전 절제가 가능하다는 장점이 있다. 저자들은 주름 형태의 거대 위 선종에서 이러한 방법으로 완전 절제가 가능하였던 1예를 경험하여 보고하는 바이다. The gastric adenoma is a benign tumor of glandular epithelium with varying degrees of cellular atypia and with papillary and/or tubular structures. Macroscopically, the gastric adenoma usually looks like a plaque or a polypoid protrusion. The gastric adenoma is considered as a precancerous condition and should be removed. Many techniques have been developed to remove the adenoma. The technique of endoscopic resection utilizing the local injection of hypertonic saline-epinephrine(ERHSE), has the advantage of accurate resection by marking and precutting the resection margin with a needle knife. We report a case of 4.5×1.5cm sized, thickened fold-like adenoma, in a 65 year-old woman, which was successfully reseated with endoscopy using ERHSE technique. Pathological examination of the resected adenoma showed tubular adenoma wish severe dysplasia and focal adenocarcinomatous transformation.

고립성 위정맥류 출혈의 내시경적 치료

전영빈,문정섭,유권 인제대학교 1999 仁濟醫學 Vol.20 No.1S

고립성 위정맥류는 혈류량이 많고 혈행동태가 복잡하여 일단 출혈하면 사망률이 높은 질환이다. 과거 이러한 질환의 내시경적 치료는 실패하는 경우가 많았으나 최근 Histoacryl 등의 조직접착제 주입요법이나 detachable snare를 이용한 결찰요법 등의 우수한 지혈효과가 보고되면서 적극적인 내시경적 치료가 시도되고 있다. 저자들은 9명의 고립성 위정맥류 출혈환자에서 경화요법, O형 고무밴드 결찰요법, Histoacryl 주입요법, detachable snare 결찰요법 등을 단독 또는 병합요법으로 시행하고 이들 방법의 치료효과, 부작용 등을 연구하였다. Background/Purpose : Gastric variceal bleeding, especially from the isolated gastric varices, is one of the most serious complications of portal hypertension and is difficult to control. Recently, various endoscopic techniques have been tried for the management of gastric variceal bleeding. We tried several techniques of endoscopic treatments in patients wish hemorrhage from the isolated gastric varices and assessed the efficacy of each method in achieving initial hemostasis and preventing early recurrent bleeding. Patients and methods: Between September 1996 and December 1998, 9 patients wish hemorrhage from the isolated gastric varices were treaded with endoscopic techniques. Emergency endoscopy showed active bleeding(n=6) or clot on the isolated gastric varlces(n=3). All patients had underlying cirrhosis and 3 patients had associated hepatocellular carcinoma. According to Child-Pugh's classification, 2 patients were class A, 3 patients class B, and 4 patients class C. The location of the gastric varices was cardia in 3 patients, fundus in 2 patients, cardia and fungus in 3 patients, and greater curvature side of the upper body in a patient. The methods of treatments are as follow; 1) sclerotherapy with 5% ethanolamine oleate(n=1), 2) variceal ligation with rubber band(n=1), 3) Histoacryl(n=4), 4) detachable snare and Histoacryl(n=2), 5) detachable snare and sclerotherapy with 5% ethanolamine oleate(n= 1). Results: Endoscopic sclerotherapy with 5% ethanolamine oleate failed to control bleeding in a patient. Initial hemostasis was achieved with endoscopic ligation with rubber band in a patient. but the bleeding recurred after a few days and was treated with Histoacryl. Endoscopic treatment with HistoaLryl(n = 4) achieved excellent Initial hemostasis, and rebleeding did not occur. Combination therapy of detachable snake with other methods(n = 3) also successfully controlled bleeding. There was no significant complication related with endoscopic treatments. Conclusion: These results suggest that endoscopic therapy wish Histoacryl or detachable snare is a safe and effective method of treatment in bleeding isolated gastric varices.

아세트아미노펜 정제의 제조 및 평가

전영빈,민병희,김승인,김영일,Jun, Young-Bin,Min, Byung-Hee,Kim, Seung-In,Kim, Young-Il 한국약제학회 1989 Journal of Pharmaceutical Investigation Vol.19 No.3

A study was made to investigate the effects of various binders on the physical properties of acetaminophen granules and tablets prepared by wet and fluidized bed granulation methods. The binders used were povidone (K-90), hydroxypropylcellulose (HPC-L) and gelatin. The fluidized bed granules were more porous than the wet massed, and the tablets prepared by fluidized system showed improved disintegration and dissolution characteristics. The dissolution rate was fast in the order of gelatin>povidone>hydroxypropylcellulose in tablets prepared by fluidized system, and povidone>hydroxypropylcellulose>gelatin in tablets prepared by wet granulation.

고립성 위정맥류 출혈을 내시경적 치료

전영빈,문정섭,유권 인제대학교 1999 仁濟醫學 Vol.20 No.1

Rat에 있어서 Norfloxacin의 체내동태에 미치는 제산제의 영향

전영빈,이광표 중앙대학교 약학연구소 1991 약학 논총 Vol.5 No.-

The effect of antacids on the pharmacokinetic parameters(mean±S.E.) was inverstigated in rats. The pharmacokinetic data were evaluated by the residual method assuming one compartment open model. K_ei, t_1/2β, K_a, t_1/2α and Cp^max in the oral administration of norfloxacin were 0.138hr^-1, 5.05hr, 1.356hr^-1, 0.61hr, 10.074㎍/㎖, respectively and these parameter values were significantly increased or decreased according to the type of antacids, when norfloxacin and antacids were concurrently administered. AUC in case of the administration of norfloxacin alone was 62.49㎍ · hr · ㎖^-1, and AUC was significantly decreased in case of the concurrent administration of norfloxacin and antacids(except magnesium oxide 1×0.5g/kg and aluminum hydroxide gel 2×0.3g/kg). The bioavailability of norfloxacin was generally decreased by the coadministration of antacids on the basis of Cp^max, T_max and AUC data.

Tripamide (Tripamol(r))가 본태성고혈압 환자의 혈청지질에 미치는 영향

전영빈,김면호,최석구,유원상 대한순환기학회 1985 Korean Circulation Journal Vol.15 No.3

메페남산 캅셀의 용출에 미치는 계면활성제의 영향

전영빈,김승인,김영일,Jun, Young-Bin,Kim, Seung-In,Kim, Young-Il 한국약제학회 1990 Journal of Pharmaceutical Investigation Vol.20 No.3

Mefenamic acid has been widely used clinically as an anti-inflammatory analgesic. It has poor solubility in water $(41\;{\mu}g/ml)$ and there is the difficulty of dissolution in the mefenamic acid capsules. A study was made to investigate the effect of various surfactants on the dissolution of mefenamic acid capsules. The surfactants used were sodium lauryl sulfate (SLS), Pluronic F-68, F-77, and F-127. Mefenamic acid capsule containing surfactant showed significantly improved dissolution characteristics. The dissolution rate was fast in the order of SLS > F-77 > F-68 > F-127 in mefenamic acid capsules containing 0.2 w/w % surfactant. SLS was selected for further study on the bioavailability in rabbits. The area under the plasma concentration-time curve $(AUC_{0-24})$ of mefenamic acid capsule containing SLS was higher than one of mefenamic acid capsule not containing surfactant.

콜레스테롤 담석형성의 병인론

전영빈,유권 인제대학교 1993 仁濟醫學 Vol.14 No.1

콜레스테롤담석 형성과정에 대한 이해를 돕고자 병인론에 관한 최신지견들을 요약 기술하였다. Cholesterol gallstone disease is extremely common. Three major stages are recognized for stone formation. namely supersaturated bile, cholesterol nucleation leading to crystal fomation and finally retention of the crystals in the gallbladder resulting in stone formation. Impaired motility of the gallbladder causes crystal retention and is probably very important in stone formation. For cholesterol gallstones formation all the above conditions must be achieved. In this review article, we summarized the recent concepts regarding the pathogenesis of cholesterol gallstone.