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전상우,김호,정민정,장인수,Jeon, Sang-woo,Kim, Ho,Jeong, Min-jeong,Jang, In-soo 대한한방내과학회 2017 大韓韓方內科學會誌 Vol.38 No.4
Objectives: The purpose of this study was to assess the effectiveness of acupuncture for the treatment of Raynaud's disease. Methods: This review was conducted using nine electronic databases (CINAHL, CiNii, CNKI, EMBASE, J-STAGE, NDSL, OASIS, PubMed, and WANFANG) and the keywords "Raynaud's disease", "Raynaud disease", "acupuncture", and "needling". Only randomized controlled trials (RCTs) using acupuncture for Raynaud's disease were included, and the methodological quality of the trials was assessed using the Cochrane risk-of-bias tool. Results: After screening, six RCTs were selected among 67, and the total effective rate and peripheral blood flow were used as evaluation methods. In five studies, the total effective rate was significantly higher in the intervention group than in the control group. In three studies, peripheral blood flow was higher in the intervention group than in the control group, with two studies being statistically significant and the remaining study not being statistically significant. Conclusions: Acupuncture could be a suitable treatment without adverse effects for Raynaud's disease because it improves peripheral blood flow. However, further studies, including randomized, placebo-controlled, double-blind methods, and clear evaluation criteria are needed.
전상우,이희영,용석중 한국웰니스학회 2017 한국웰니스학회지 Vol.12 No.2
The effects of inhaling controlled amounts, achieved through adequate training, of electronic cigarettes and conventional cigarettes have on the cardiovascular system were compared from the standpoints of the absorbed amount of nicotine in arterial blood and the saturation amount of carbon monoxide in arterial blood. Thirty healthy adults who have been adequately trained on the inhaling methods of electronic cigarettes and conventional cigarettes were used as the study subjects and then experiments were carried out using a fixed nicotine content of the same concentration. The carbon monoxide hemoglobin was quantified using ABL 800 Flex of Radiometer, nicotine concentration in hemoglobin using Waters 1450, No C18 column and HPLC grade acetonitrile as spreading agent. The mixing ratio of acetonitrile:H2O(1:9), flow rate(0.2㎖/min). Conc-HCL dichloromathane, and NaOH are used in preprocessing. Calibration curve was prepared basing on 1,2,4,8,16(ng/㎖). The r2 value between the electronic cigarette group and the conventional cigarette group was >0.0001. HPLC(261㎚) and was (r2)>0.9998. The limit of quantization was 0.4(㎍/㎏). The recovery rate and coefficient of variation satisfied the standards of the Codex Alimentarius Committee. The arterial plasma nicotine concentration of conventional cigarettes was 6.28±3.31(ng/㎖) before smoking and 6.64±3.31(ng/㎖) after inhaling 6 times. The arterial plasma nicotine concentration of electronic cigarettes was 4.1±0.81(ng/㎖) before smoking and 4.28±1.05(ng/㎖) after inhaling 6 times. There are differences in the accumulated nicotine in arterial blood and carbon monoxide hemoglobin concentration. Thus this study can be concluded to provide a indicator on how effectively electronic cigarettes can be used as an alternative to conventional cigarettes.