한국인 쯔쯔가무시병 환자에서 사이토카인 유전자의 다양성 조사

장우임,김수연,위성헌,김태규 대한감염학회 2010 Infection and Chemotherapy Vol.42 No.1

Background: Scrub typhus is caused by Orientia tsutsugamushi and can become severe and potentially life-threatening. It is suggested that specific host factors can modify the host response during O. tsutsugamushi infection. It is known that susceptibility and outcome of infectious disease are associated with genetic polymorphisms of some cytokines. Materials and Methods: Peripheral blood of 144 patients who were diagnosed with scrub typhus and of 311 unrelated healthy subjects were collected. A diagnosis of scrub typhus was made upon demonstration of a fourfold rise in antibody titer to O. tsutsugamushi in paired serum specimens in an indirect immunofluorescent (IFA) test. Genomic DNAs were extracted from peripheral mononuclear cells and genotypings for IL-1 (-511C/T), IL-1β (+3953T/C), IL-2 (-330T/G), IL-4 (-590C/T), IL-4R(-1902G/A), IL-10 (-1082G/A), IL-10 (-819C/T), TNF-α (-238G/A) and TNF-α (-308G/A) were performed simultaneously using PCR-SSP (sequence specific polymorphisms) assay. Results: The frequency of IL-1 (-511T/T) (OR=0.53, P<0.01) and IL-2 (-330T/T) (OR=0.56, P<0.01) were significantly decreased, but that of IL-2(-330G/G) (OR=4.49, P<0.01) was increased, in the scrub typhus patients compared to the healthy controls. And, there were no statistically significant differences in the genetic polymorphisms of IL-4 (-590C/T), IL-4Rα (-1902G/A), IL-10 (-1082G/A), IL-10 (-819C/T), TNF-α (-238G/A), TNF-α (-308G/A) genes, in the scrub typhus patients compared to the unrelated healthy controls. Conclusions: Cytokine polymorphisms in the IL-1 (-511T/T) and the IL-2 genes may influence the host response to O. tsutsugamushi. Background: Scrub typhus is caused by Orientia tsutsugamushi and can become severe and potentially life-threatening. It is suggested that specific host factors can modify the host response during O. tsutsugamushi infection. It is known that susceptibility and outcome of infectious disease are associated with genetic polymorphisms of some cytokines. Materials and Methods: Peripheral blood of 144 patients who were diagnosed with scrub typhus and of 311 unrelated healthy subjects were collected. A diagnosis of scrub typhus was made upon demonstration of a fourfold rise in antibody titer to O. tsutsugamushi in paired serum specimens in an indirect immunofluorescent (IFA) test. Genomic DNAs were extracted from peripheral mononuclear cells and genotypings for IL-1 (-511C/T), IL-1β (+3953T/C), IL-2 (-330T/G), IL-4 (-590C/T), IL-4R(-1902G/A), IL-10 (-1082G/A), IL-10 (-819C/T), TNF-α (-238G/A) and TNF-α (-308G/A) were performed simultaneously using PCR-SSP (sequence specific polymorphisms) assay. Results: The frequency of IL-1 (-511T/T) (OR=0.53, P<0.01) and IL-2 (-330T/T) (OR=0.56, P<0.01) were significantly decreased, but that of IL-2(-330G/G) (OR=4.49, P<0.01) was increased, in the scrub typhus patients compared to the healthy controls. And, there were no statistically significant differences in the genetic polymorphisms of IL-4 (-590C/T), IL-4Rα (-1902G/A), IL-10 (-1082G/A), IL-10 (-819C/T), TNF-α (-238G/A), TNF-α (-308G/A) genes, in the scrub typhus patients compared to the unrelated healthy controls. Conclusions: Cytokine polymorphisms in the IL-1 (-511T/T) and the IL-2 genes may influence the host response to O. tsutsugamushi.

최근 10년간 화농성 간농양 141예의 임상적 특성 및 원인균의 항균제 감수성 양상

장우임,위성헌,김진동,이정록,곤덕승,최상욱,남순우,양진모 대한간학회 2008 Clinical and Molecular Hepatology(대한간학회지) Vol.14 No.3(S)

《文筆眼心抄》考論

張宇超(장우초) 한국교통대학교 동아시아연구소 2020 동아문헌연구 Vol.- No.-

《문필안심초(文筆眼心抄)》는 일반적으로 《문경비부론(文鏡秘府論)》의 축약본으로 인식되고 있다. 《문경비부론》은 일본 승려 편조 금강(遍照金剛, 속명은 좌백 공해/佐伯空海:774 ~ 835)이 편찬한 중국문론사 저서이다. 남북조에서 중당시기에 이르기까지 시가 작법이라거나 시가 이론에 관한 저작을 모은 것인데, 이들 중 다수가 이미 중국에서는 실전되어 문학연구에서 자료 가치가 높은 책이다. 그러나 《문필안심초》는 현존본 《문경비부론》과 완전히 포함관계에 있지 않다. 대표적으로, 《문경비부론》에 보이지 않는 시가작품으로 5언시 15수 (행 수는 30구), 7언시 1수(행은 2구)가 수록되어 있다. 때문에 진충(陳翀) 같은 경우는 《문필안심초》가 위서(僞書)라고까지 하였는데 자세히 관찰 해 보면 이것은 《문필안심초》가 완성 된 뒤 후세 사람들이 끊임없이 수정하였기 때문임을 알 수 있다. 한편, 진충은 《문필안심초》의 저본이 일본의 와카(和歌) 창작 지도를 위한 교재라고도 하였다. 이것은 겸창(가마쿠라:鐮倉)막부 시대의 《화원천황신기(하나조노텐노신키:花園天皇宸記》에 《문필안심초》가 언급되어 있다는 것에 근거를 두고 있다. 그러나 이것은 원문에 보이는 “兼”자를 일본어 훈독으로 보아 “予て(かねて)”, 즉 “애당초부터, 처음 시작할 때부터 이미”의 의미로 본 것인데, 이 부분에서 “爲兼”은 인명으로 보는 것이 타당하다. 그래서 와카 창작의 지도용 서적 같은 것은 아니며, 《시인옥설(詩人玉屑)》 같은 시론, 시화서의 성질을 갖는 것이고, 아울러 일본 평안(헤이안:平安)시대 한시학(漢詩學)가 밀접한 관련을 갖는다. Wenbiyanxinchao is generally considered to be the abridged version of Wenjingmifulun, in which poems not quoted in Wenjingmifulun are retained, including, 15 poems 30 sentences of five characters poem, 1 poem 2 sentences of seven characters poem. Almost all of them come from the newly added contents of Wenbiyanxinchao, which reflects that the appearance of Wenbiyanxinchao is constantly modified by later generations, rather than the original appearance of Konghai at that time. At the same time, Wenbiyanxinchao is not a guide book for Waka writing. Its nature is similar to Shirenyuxie, and it is still closely related to the Chinese character poetics in the Heian era of Japan.

반도체 옥외 등기구에 적용되는 FTE

장우진(張禹鎭),전용석(全容奭) 한국조명·전기설비학회 2010 조명.전기설비 Vol.24 No.2

제 11 차 춘계학술대회 : 포스터 / 연제 2 ; 바렛식도와 역류성식도염 환자의 임상적 특징

장우임,박수헌,이태규,김성수,김진일,채현석,정인식,선희식 대한소화관운동학회 2001 대한소화관운동학회 춘계학술대회 Vol.11 No.-

A comparison of the clinical characteristics of elderly and non-elderly women with communityonset, non-obstructive acute pyelonephritis

장우임,김형욱,노용선,위성헌 대한내과학회 2015 The Korean Journal of Internal Medicine Vol.30 No.3

Background/Aims: Acute pyelonephritis (APN) is the most common cause of community-onset bacteremia in hospitalized elderly patients. The objectives of this study were to investigate the differences in the clinical and microbiological data of hospitalized elderly and non-elderly women with community-onset APN. Methods: Women with community-onset APN as a discharge diagnosis were identified from January 2004 to December 2013 using an electronic medical records system. We compared the clinical and microbiologic data in elderly and non-elderly women with community-onset APN due to Enterobacteriaceae. Results: Of the 1,134 women with community-onset APN caused by Enterobacteriaceae, 443 were elderly and 691 were non-elderly women. The elderly group had a lower frequency of upper and lower urinary tract symptoms/signs than the non-elderly. The incidence of bacteremia, extended-spectrum β-lactamase (ESBL)- producing Enterobacteriaceae, patients with a C-reactive protein (CRP) level ≥ 15 mg/dL, and patients with a leukocyte count ≥ 15,000/mm3 in the blood, were significantly higher in the elderly group than in the non-elderly group. The proportion of patients requiring hospitalization for 10 days or more was significantly higher in the elderly group compared to the non-elderly group (51.5% vs. 26.2%, p < 0.001). The clinical cure rates at 4 to 14 days after the end of therapy were 98.3% (338/344) and 97.4% (519/533) in the elderly and non-elderly groups, respectively (p = 0.393). Conclusions: Elderly women with APN exhibit higher serum CRP levels, a higher frequency of bacteremia, a higher proportion of ESBL-producing uropathogens, and require a longer hospitalization than non-elderly women, although these patients may not complain of typical urinary symptoms.

초록집 : 구연 ; 선택적 COX-2 억제제인 NS398의 간암 세포주 성장억제 기전

장우임,백지연,배시현,최종영,윤승규,조세현,양진모,안병민,이영석,차상복,김부성 대한간학회 2005 춘계 학술대회 Vol.11 No.-

한국인 쯔쯔가무시병 환자에서 사이토카인 유전자의 다양성 조사

장우임,김수연,위성헌,김태규 대한감염학회 2010 감염과 화학요법 Vol.42 No.1

Background: Scrub typhus is caused by Orientia tsutsugamushi and can become severe and potentially life-threatening. It is suggested that specific host factors can modify the host response during O. tsutsugamushi infection. It is known that susceptibility and outcome of infectious disease are associated with genetic polymorphisms of some cytokines. Materials and Methods: Peripheral blood of 144 patients who were diagnosed with scrub typhus and of 311 unrelated healthy subjects were collected. A diagnosis of scrub typhus was made upon demonstration of a fourfold rise in antibody titer to O. tsutsugamushi in paired serum specimens in an indirect immunofluorescent (IFA) test. Genomic DNAs were extracted from peripheral mononuclear cells and genotypings for IL-1 (-511C/T), IL-1β (+3953T/C), IL-2 (-330T/G), IL-4 (-590C/T), IL-4R(-1902G/A), IL-10 (-1082G/A), IL-10 (-819C/T), TNF-α (-238G/A) and TNF-α (-308G/A) were performed simultaneously using PCR-SSP (sequence specific polymorphisms) assay. Results: The frequency of IL-1 (-511T/T) (OR=0.53, P<0.01) and IL-2 (-330T/T) (OR=0.56, P<0.01) were significantly decreased, but that of IL-2(-330G/G) (OR=4.49, P<0.01) was increased, in the scrub typhus patients compared to the healthy controls. And, there were no statistically significant differences in the genetic polymorphisms of IL-4 (-590C/T), IL-4Rα (-1902G/A), IL-10 (-1082G/A), IL-10 (-819C/T), TNF-α (-238G/A), TNF-α (-308G/A) genes, in the scrub typhus patients compared to the unrelated healthy controls. Conclusions: Cytokine polymorphisms in the IL-1 (-511T/T) and the IL-2 genes may influence the host response to O. tsutsugamushi.

행정관리의 이론적 틀 - 지적행정을 중심으로

장우진(張祐珍),유근환(劉根煥) 영남대학교 한국균형발전연구소(구 지역혁신연구소) 2006 한국지역혁신논집 Vol.1 No.1

  본 연구에서는 행정관리의 필요성과 함께 기준이 될 수 있는 지적행정의 이론적 틀을 선정, 검토하였다. 지적행정관리의 필요성은 대내적인 측면과 대외적인 측면으로 구분할 수 있으며, 특히, 지적행정의 경쟁력 확보 차원에서 절대적으로 요구되어지는 사항이라 할 수 있다. 이러한 관점 하에서 지적행정관리의 이론적 틀로서는 행정개혁, 행정서비스마케팅, 그리고 신공공관리 등의 3개 측면에서 논의를 진행하였다. 즉 각각의 이론적 틀의 개념과 주요 대상과 내용, 그리고 이를 토대로 지적행정관리에의 시사점 등을 중점적으로 검토하였다. 이러한 연구는 지적행정관리 방향을 새로이 설정하거나 수정이 요구되는 경우, 명확한 기준과 근거를 마련해 줄 수 있을 것으로 기대된다.   The purpose of this study was to discuss a theoretical framework of the public management on the Cadastral Civil Affairs Administration. For the purpose, the previous studies and theories concerning the public management and administrative reform, public sector marketing, new public management were reviewed. Next to examine whether the cadastral civil affairs administration han been discussed in the aspect of administrative reform, public sector marketing, new public management, and concept, main object and substance have been suggestive on the basic of this, the framework of the cadastral civil affairs administration. This study will be helpful in understanding of the public management on the Cadastral Civil Affairs Administration. specially, it any understand why public management orientation as they do and why they are so very hard to change in any fundamental way.

춘계학술대회 : 구연 ; 선택적 COX-2 억제제인 NS398의 간암 세포주 성장억제 기전

장우임,백지연,배시현,최종영,윤승규,조세현,양진모,안병민,이영석,차상복,김부성 대한간학회 2005 Clinical and Molecular Hepatology(대한간학회지) Vol.11 No.3(S)

배경/목적: Cyclooxygenase-2 (COX-2)의 간세포암 세포주내에서의 발현과 NS398 투여 후의 억제효과는 여러 문헌들을 통해 기술되었다. 그러나 NS398의 억제 효과와 COX-2의 발현 정도와의 연관성, NS398의 성장억제 기전 등은 보고자에 따라 다양하다. 본 연구에서는 HepG2, HuH-7 세포주에서 COX-2 발현을 확인하고 NS398에 의한 성장억제 유도 기전을 알아보고자 하였다. 대상 및 방법: HepG, HuH-7 세포주