녹내장과 정상안의 중심망막혈관 직경 비교

장민욱,김용연 대한안과학회 2009 대한안과학회지 Vol.50 No.5

Purpose: To compare the diameter of central retinal vessels between patients with normal-tension glaucoma, primary open-angle glaucoma and healthy (control) eyes. Methods: The authors reviewed 30 eyes of 30 normal-tension glaucoma patients, 20 eyes of 20 primary open-angle glaucoma patients and 30 eyes of normal persons who had no systemic vascular diseases. The diameters of the central retinal arteries and veins were measured and calculated using a revised Parr-Hubbard formula, and results were compared between the groups. Results: The diameter of the central retinal vessel showed no statistical differences between the eyes with normal-tension glaucoma and primary-open angle glaucoma. However, there were significant differences between the eyes of patients with glaucoma and the normal control eyes (p<0.05). Conclusion: The diameter of the central retinal vessels in glaucoma patients were narrower than that in the control group. Our results suggest that the diameter of the central retinal vessels may affect the development of glaucoma both in normal tension and primary open-angle types, or that glaucomatous damage may influence the diameter of the central retinal vessels. 목적: 정상안압녹내장 환자와 원발개방각녹내장 환자 및 정상인을 대상으로 중심망막혈관 직경을 구하여 비교하고자 하였다. 대상과 방법: 고혈압, 당뇨 및 심혈관계 질환이 없으며 본원에서 처음으로 진단받은 정상안압녹내장 환자 30명, 원발개방각녹내장 환자 20명 그리고 정상인 30명을 대상으로 망막동맥 및 정맥의 직경을 측정하고 이 값을 토대로 변형된 Parr-Hurbard 공식을 이용하여 중심망막동맥 및 정맥의 직경을 구하여 비교하였다. 결과: 정상안압녹내장 환자에서 중심망막동맥 및 정맥의 직경은 원발개방각녹내장 환자와의 비교에서 유의한 차이를 보이지 않았으나 (p>0.05) 두 녹내장 군 모두 정상안과의 비교에서는 혈관직경이 유의하게 좁았다(p<0.05). 결론: 녹내장 환자의 중심망막혈관 직경은 정상인에 비해 좁았다. 이는 정상안압녹내장 및 원발개방각녹내장의 발생 및 진행에 혈관직경 혹은 혈역학적 요인이 영향을 미칠 가능성 혹은 녹내장의 진행이 혈관직경에 영향을 미칠 가능성을 시사한다.

당뇨황반부종에서 안구내 트리암시놀론 단독주입과 베바시주맙 병합주입의 단기 효과 비교

장민욱,김성우,오인경,오재령,허걸.Min Wook Chang. M.D.. Seoung Woo Kim. M.D.. In Kyung Oh. M.D.. Jae Ryung Oh. M.D.. Kuhl Huh. M.D.. Ph.D. 대한안과학회 2008 대한안과학회지 Vol.49 No.8

Purpose: To compare the effect of intravitreal triamcinolone injection with and without bevacizumab for diabetic macular edema. Methods: Of 69 patients (69 eyes) diagnosed with diabetic macular edema without any history of other intraocular disease or intraocular operation, 45 eyes (45 patients) were injected with intravitreal triamcinolone (4 mg) and the remaining eyes (24 patients) were injected with triamcinolone (2 mg) and bevacizumab (1.25 mg). The visual acuity and central macular thickness of treated eyes from both groups was measured using OCT, and these measurements were compared between the two groups. Results: There were no statistical differences between the two groups with respect to baseline data. Central macular thickness (CMT) was reduced in both groups, and BCVA improved in both groups. No significant differences were detected in changes in CMT or BCVA between the two groups. Conclusions: Intravitreal injection of triamcinolone had a beneficial effect on DME in terms of CMT reduction and BCVA improvement. Addition of three consecutive intravitreal bevacizumab injections, however, did not show any significant addictive effect during the follow-up period. J Korean Ophthalmol Soc 49(8):1269-1274, 2008

Nerve Growth Factor and Sensory Neuropeptide Levels in Plasma and Saliva of Various Orofacial Pain Patients

장민욱,정성창,정진우,Jang, Min-Uk,Chung, Sung-Chang,Chung, Jin-Woo Korean Academy of Orofacial Pain and Oral Medicine 2009 Journal of Oral Medicine and Pain Vol.34 No.4

Nerve growth factor (NGF) and sensory neuropeptides are involved in the process of nociception at peripheral nerve fibers and wide spread in central nervous system. The aims of this study were to investigate NGF and sensory neuropeptides (substance P [SP] and calcitonin gene-related peptide [CGRP]) levels in human plasma and saliva, and the associations between these sensory neuropeptides levels and chronic orofacial pain symptoms. NGF, SP, and CGRP levels in plasma and resting whole saliva samples collected from 67 orofacial pain patients (joint pain, dental or periodontal pain, mucosal pain) and 36 pain free control subjects were measured by enzyme immunoassay. The characteristic pain intensity of each subject was measured using the Graded Chronic Pain Scale and the flow rate of resting whole saliva was measured. Joint pain patients group showed significantly higher plasma NGF level compared to each of dental pain patients (p<0.01), mucosal pain patients (p<0.01), and control group (p<0.01). Plasma NGF level of dental pain patients group was significantly higher than that of control group (p<0.01). Saliva SP level of dental pain patients group (p<0.05) and saliva CGRP level of mucosal pain group (p<0.05) were significantly higher than that of control group. Plasma and saliva SP levels of joint pain patients was significantly associated with pain intensity (plasma: standardized coefficient=0.599, p<0.01, saliva: standardized coefficient=0.504, p=0.05). In dental pain patients group, plasma SP (standardized coefficient=0.559, p<0.01), saliva SP (standardized coefficient=0.520, p<0.01) and saliva CGRP (standardized coefficient=0.599, p<0.01) levels were significantly associated with age. In mucosal pain patients group, plasma SP (standardized coefficient=0.495, p<0.05), saliva SP (standardized coefficient=0.500, p<0.05), and saliva CGRP (standardized coefficient=0.717, p<0.01) levels were significantly associated with age. NGF and neuropeptides may play a role in the maintenance of various orofacial pain symptoms. The examination of those levels in plasma and saliva helps understanding the mechanism of orofacial pain, and furthermore, can be applied to the diagnosis and therapy of orofacial pain.

In-Hospital and Post-Discharge Recovery after Acute Ischemic Stroke: a Nationwide Multicenter Stroke Registry-base Study

장민욱,강지훈,김범준,홍정호,여민주,한문구,이병철,유경호,오미선,최경찬,이상화,홍근식,조용진,박종무,차재관,김대현,박태환,이경복,이수주,이준,김준태,김동억,최재철,이준영,이지성,Philip B. Gorelick,배희준 대한의학회 2019 Journal of Korean medical science Vol.34 No.36

Background: Using data from a large national stroke registry, we aimed to investigate the incidence and determinants of in-hospital and post-discharge recovery after acute ischemic stroke and the independence of their occurrence. Methods: In-hospital recovery was defined as an improvement of 4 points or > 40% in the National Institutes of Health Stroke Scale (NIHSS) score from admission to discharge. Post- discharge recovery was defined as any improvement in the modified Rankin Scale (mRS) score from discharge to 3 months after stroke onset. Two analytic methods (multivariate and multivariable logistic regression) were applied to compare the effects of 18 known determinants of 3-month outcome and to verify whether in-hospital and post-discharge recovery occur independently. Results: During 54 months, 11,088 patients with acute ischemic stroke meeting the eligibility criteria were identified. In-hospital and post-discharge recovery occurred in 36% and 33% of patients, respectively. Multivariate logistic regression with an equality test for odds ratios showed that 7 determinants (age, onset-to-admission time, NIHSS score at admission, blood glucose at admission, systolic blood pressure, smoking, recanalization therapy) had a differential effect on in-hospital and post-discharge recovery in the way of the opposite direction or of the same direction with different degree (all P values < 0.05). Both in-hospital and post-discharge recovery occurred in 12% of the study population and neither of them in 43%. The incidence of post-discharge recovery in those with in-hospital recovery was similar to that in those without (33.8% vs. 32.7%, respectively), but multivariable analysis showed that these 2 types of recovery occurred independently. Conclusion: Our findings suggest that, in patients with acute ischemic stroke, in-hospital and post-discharge recovery may occur independently and largely in response to different factors.

아메드 밸브 삽입술 후 발생한 전방소실이 수술 예후에 미치는 영향

장민욱,김용연,Min Wook Chang,Yong Yeon Kim 대한안과학회 2008 대한안과학회지 Vol.49 No.8

Purpose: To evaluate the outcome following Ahmed valve implantation in patients who developed flat anterior chamber. Methods: The authors reviewed 60 eyes of 60 patients who underwent Ahmed valve implantation and divided these patients into the flat anterior chamber group (18 eyes) and the control group (42 eyes). The influence of clinical variables on the development of flat anterior chamber and the effect of flat anterior chamber on the success of Ahmed valve implantation were evaluated. Results: The preoperative intraocular pressure, age, and the incidence of neovascular glaucoma as a preoperative diagnosis were higher in the flat anterior chamber group than in the control group (p<0.05). The overall success rates for the mean follow-up period of 12 months were similar between the two groups (p>0.05). Conclusions: The development of a flat anterior chamber after Ahmed valve implantation appeared not to affect the outcome of the surgery. J Korean Ophthalmol Soc 49(8):1297-1302, 2008

CEM 기법을 이용한 RAS 구조의 RCS 해석

장민욱,A. Chaudhuri,명노신,이원준 한국항공우주학회 2013 한국항공우주학회 학술발표회 논문집 Vol.2013 No.11

디지털 무전기 국내 표준화 현황

장민욱,김대중,김남경 한국통신학회 2018 정보와 통신 Vol.35 No.10

우리나라의 아날로그 무전기의 디지털 무전기로의 사용 정책이 변환되는 현 시점에, 국내 디지털 무전기의 표준화 현황을 소개하고 앞으로의 표준화 방향을 검토해보고자 한다.

Specific Visual Symptoms and Signs of Meares-Irlen Syndrome in Korean

장민욱,김성현,김주영,조윤애 대한안과학회 2014 Korean Journal of Ophthalmology Vol.28 No.2

Purpose: To discriminate the visual symptoms and signs of Meares-Irlen syndrome (MIS) and nonspecific dyslexiafrom other ophthalmologic diseases (NODs). Methods: Forty-five patients were enrolled. Thirty four of the patients with MIS whose symptoms improved withtinted lenses comprised MIS group. The other 11 patients whose reading difficulty improved with other oculartherapy and did not require tinted lenses comprised NODs group. The main symptoms causing dyslexia andassociated ocular diseases were evaluated. Results: The mean age was 17.9 ± 9.5 years in MIS group, and 19.3 ± 11.0 years in NODs group. In MIS group,the most common symptoms while reading were difficulty to move lines (85%), doubling (53%), and difficulty inbright condition (27%). On the other hand, blurring was the most common symptom in NODs group (45%). Theassociated ocular diseases in the two groups were refractive error (79% and 73%), dry eye (29% and 18%),and exophoria (6% and 27%), respectively. Conclusions: Doubling, difficulty to move lines, and difficulty in bright condition while reading are main specificsymptoms in MIS compared to nonspecific dyslexia from other ophthalmologic disorders.

Psychological Characteristics Related to Subjective Satisfaction Level of Oral Malodor Treatment Outcome

장민욱,한송,김영구,Jang, Min-Wook,Han, Song,Kim, Young-Ku The Korean Academy of Orofacial Pain and Oral Medi 1999 Journal of Oral Medicine and Pain Vol.24 No.4

구취를 주소로 내원한 환자 중 구취의 치료 후 객관적인 구취의 감소가 인정되는 데도 불구하고, 계속해서 구취를 호소하며 만족해 하지 못하는 환자들의 심리적 특성을 알아보고자 하였다. 구취를 주소로 서울대학교 치과병원 구강진단과 구취클리닉에 내원하여 검사 및 치료를 시행한 환자 중, 치료 전 객관적 구취의 소견을 보였으나, 치료 후 할리미터 수치의 객관적인 감소를 보이는 40명의 구취 환자를 대상으로 하였다. 치료 전, 모든 환자들은 자신의 주관적 구취 심도 및 그로 인한 불편감 정도를 표시하였고, 간이정신진단검사 (SCL-90-R)를 시행하였으며 할리미터를 이용하여 구강내 휘발성황화합물의 농도를 측정하였다. 치료 후, 구강내 휘발성황화합물의 농도, 주관적 구취 심도 및 불편감 정도를 재측정하였다. 주관적 구취 심도의 감소 정도에 따라 환자들을 두 군으로 분류하여 할리미터 수치와 불편감 정도 및 간이정신진단검사항목을 비교, 분석하였다; A군-주관적 구취 심도가 평균값 이상으로 감소한 환자군; B군-주관적 구취 심도가 평균값 이하로 감소한 환자군. 1. 치료 전후 모두에서 주관적 구취 심도와 휘발성황화합물 농도 사이에는 유의한 상관관계가 없었으며 주관적 구취 심도의 감소 정도 또한 휘발성황화합물의 감소 정도와 상관관계가 없었다. 2. 치료 전 휘발성황화합물의 농도는 치료 후 휘발성황화합물의 감소치와 유의한 상관관계를 보였다 (p < 0.01). 3.구취로 인한 불편감 정도는 주관적 구취 심도와 유의한 상관관계를 보였으며 (p < 0.01), 치료 후 A군에서는 유의하게 감소 (p < 0.01) 하였으나, B군에서는 유의한 감소를 보이지 않았다. 4. B군은 A군에 비하여 간이정신진단검사 항목 중 대인예민성과 우울증의 항목에서 유의하게 높은 수치를 보였다 (p < 0.05).

열정 넘치는 ‘록커 마이클’

장민욱 샘터사 2021 월간 샘터 Vol.613 No.-