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Formulation of Calcium Phosphate Ceramic Particles for Bone Replacement
임예람,김정헌,박이안,조가은,서종휘,남지현,이우걸 한국공업화학회 2019 한국공업화학회 연구논문 초록집 Vol.2019 No.1
Recently, the growth of the elderly population increases the number of patients suffering from osteoporosis. Accordingly, it becomes an immediate need to develop bone grafts for bone replacement. Human bone is composed of 35% organic components, 45% inorganic components, and 20% moisture. Among them, the inorganic component accounts for a large proportion of calcium and phosphate as well as trace elements, such as magnesium, fluorine, sodium, and zinc. In this study, we synthesized phosphate-based inorganic ceramic particles with various chemical states for the use of bone substitutes. The chemical composition, size, surface charge, and degradation pattern are evaluated using SEM, FTIR, zeta potential, and EDX. Biocompatibility of these ceramic particles were examined via cell assays using osteoblastic MG63 cells.
Trace element-incorporated CaP scaffold to improve its function as a bone substitute
임예람,박선호,이우걸 한국공업화학회 2020 한국공업화학회 연구논문 초록집 Vol.2020 No.-
Bone substitutes for the treatment of bones of aging and various causes are important biomaterials. Trace elements together with calcium and phosphate are known to contribute to the formation of HA. In this study, the effects of the combination of CaP with trace elements on the proliferation and differentiation of osteoblastic MG63 cells were analyzed. Morphological changes in CaP particle and resulting effect on pore shape were observed using a SEM, and the constituent elements were confirmed by an EDX. Then, changes in water uptake, decomposition, and pH due to changes in pores and chemical composition were investigated. In addition, qualitative analysis of elements was performed using an FTIR. Growth and differentiation of MG63 cells were evaluated.
스마트폰을 이용한 원격 독화 중재가 청년층 청각장애인의 독화 능력에 미치는 영향
임예람(Lim, Ye-Ram),심현섭(Sim, Hyun-Sub) 이화여자대학교 특수교육연구소 2016 특수교육 Vol.15 No.3
연구목적: 스마트폰을 이용한 원격 독화 중재가 청년층 청각장애인의 독화 능력에 미치는 영향 및 대상일반화, 반응일반화, 유지 효과를 살펴보고자 하였다. 연구방법: 이 연구에는 고도에서 최고도의 감각신경성 난청을 가진 청년층 청각장애인 5명이 참여하였다. 연구설계는 대상자간 중다간헐기초선설계를 적용하였다. 평가는 기초선, 중재, 일반화, 유지 단계에서 문장과 단어 독화 검사를 이용하여 매 회기 5분씩 이루어졌으며, 기초선과 동일한 조건을 적용하여 실시하였다. 독화 중재는 주 5회, 총 4주 동안 실시되었고, 음절 변별 과제, 단어 변별과제, 문장 이해 과제, 문단 이해 과제를 순서대로 진행하였다. 모든 평가와 중재는 온라인상에서 이루어졌으며, 대상자들은 스마트폰을 이용하여 장소나 시간에 관계없이 연구에 사용되는 사이트에 접속하여 훈련에 참여하였다. 연구결과: 첫째, 대상자 모두 문장 독화 능력이 향상된 것으로 나타났지만, 단어 수준에서는 대상자 모두 중재 효과 크기가 작거나 거의 없는 것으로 나타났다. 둘째, 문장 수준에서는 대상일반화와 반응일반화에서 대상자 모두 효과가 있는 것으로 나타났으나, 단어수준에서는 대상자의 일부만 대상일반화와 반응일반화를 보인 것으로 나타났다. 셋째, 문장 수준에서는 모두 독화 능력이 유지되었지만, 단어 수준에서는 대상자 중 4명만이 유지 효과를 보인 것으로 나타났다. 결론: 전통적인 독화 지도나 컴퓨터 혹은 비디오를 이용한 독화 지도에 관한 선행 연구와 마찬가지로 스마트폰을 이용한 원격 독화 중재 또한 청각장애인의 독화 능력 향상에 효과적이었다. 따라서 스마트폰은 독화 중재의 효과성을 극대화시키는 도구로서 의미가 있으며, 스마트폰을 이용한 원격 중재에서의 언어치료사의 역할 또한 대상자들의 독화 능력을 향상시키는데 필수적인 것으로 나타났다. Purpose: The purpose of this study was to determine the effect of speechreading telepractice intervention using smartphone on speechreading ability of young deaf adults. Method: Multiple probe design across subject was applied to determine the effect of speechreading training. Five young deaf adults were trained and tested online. Participants were tested on words and sentences in baseline, intervention, generalization, and maintenance phase. After baseline tests, participants received training on syllable, word, sentence, and story task for 4 weeks. Results: Improvements were seen in sentences after training. However, small or little improvements were seen in words. Generalization and maintenance effect were also found in sentences improvement. However, not all participants were improved in words. Conclusion: The results from this study suggest that smartphone-based telepractice intervention can improve the speechreading ability of young deaf adults.
Improvement of Osteoconductivity of Biodegradable PLCL Bone Cement
박진우,김정헌,박이안,임예람,홍재윤,이우걸 한국공업화학회 2019 한국공업화학회 연구논문 초록집 Vol.2019 No.1
Human bone-related disease, such as osteoporosis and arthritis, is continuously increasing problem in elderly population. This illness is caused due to the lack of calcium arising from demineralization of bone tissue and brings about serious deterioration of physical structure of bone. In this investigation, we synthesized PLCL(5:5) via copolymerization of lactide and caprolactone monomers. highly porous PLCL scaffolds combined with ceramic particles were fabricated to use as bone cement possessing improved physical and biological properties. Various properties including mechanical strength, chemical state, hydrophilicity, and water uptake were examined using SEM, EDX, and FT-IR. The biological property of the scaffold was evaluated with regard to proliferation of osteoblastic sarcoma cells. Results demonstrate that both mechanical and biological functionality were significantly improved, suggesting the developed scaffold can be potentially applied for the preparation of bone grafts.
김정헌,박선호,이상헌,임예람,이우걸 한국공업화학회 2019 한국공업화학회 연구논문 초록집 Vol.2019 No.1
Chitosan (CHN) is a biodegradable natural polymer which has excellent biocompatibility. It has been widely used as bone tissue substitute grafts. Usage of CHN microsphere has various advantages to be used as biomaterials and drug delivery carrier. Hyaluronic acid (HA) is polysaccharide found rich where cell proliferation is actively taking place. Combination of HA with CHN can be possibly improve the biological properties, biocompatibility and biodegradation, in particular. This study investigated the modulation of CHN microsphere using a synthetic organic component enabling controlled drug release. The physicochemical properties of the fabricated modified CHN microspheres were analyzed using SEM and zeta potential. Their chemical state was evaluated by FTIR. Biodegradation pattern and drug release were analyzed by weight reduction measurement and HPLC analysis. Cytotoxicity of the microspheres was examined via cell assays using osteoblastic MG63 cells.
Characterization of Physicochemical Properties of COL/CHN Complex
김정헌,김민정,박은현,송민주,이민선,이병학,임예람,오지영,이우걸 한국공업화학회 2018 한국공업화학회 연구논문 초록집 Vol.2018 No.0
Chitosan (CHN) is a natural polymer derived by deacetylation of chitin which is external skeletal compound of crustaceans. CHN is reported to be highly positively charged, biocompabitible and biodegradable. Therefore, CHN is widely used for medical applications including artificial replacement of skin, cartilage, and bone tissues. In addition, collagen (COL) is a major protein constituting human body. COL possess RGD seqeuence which interacts with integrin embedded in cellar membrane and stimulates cell adhesion and differentiation. In this study, we prepared CHN/COL complex film and examined the effect of the complexation on the surface properties of the CHN/ COL-complexed film on the chemical state, morphology, and hydrophilicity using FT-IR, SEM, and goniometer.
Chitosan Scaffold Supported by Collagen Incorporation for the Improvement of Bioactivity
김정헌,김민정,박은현,송민주,이민선,이병학,임예람,오지영,이우걸 한국공업화학회 2018 한국공업화학회 연구논문 초록집 Vol.2018 No.0
In tissue engineering, 3D porous scaffold is essential for the regeneration of damaged tissue. To do so, materials used to prepare the scaffold need to satify prerequisites including biocompatibility, biodegradability, porosity, hydrophilicity, so that the scaffold can promote cell adhesion, proliferation, and differentiation. In this study, we performed feasibility study whether the bioactivity of chitosan (CHN) scaffold can be supported by collagen (COL) incorporation. COL incorporation into CHN scaffold was made at various COL concentrations and the mechanical properties of the scaffold were thoroughly examined. The porosity and degradation behavior of CHN/COL scaffold were analyzed. The bioactivity of the scaffold was evaluated using fibroblast and found that fibroblast proliferation and differentiation were improved.