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이후장,김석,천명선,정원철,김동혁,임정주,손호영,김무석,김곤섭,정회식 한국식품위생안전성학회 2007 한국식품위생안전성학회지 Vol.22 No.2
test was performed to evaluate the skin iritation and sensitization of Creocomplex, disinfectant,containing 10% 4-chloro-m-cresol, 10% didecyl dimethyl ammonium chloride, and 10% glutaraldehyde. In primaryskin irritation test, rabbits were dermally treated with Creocomplex for 24 hrs. The disinfectant did not induce anyadverse reactions such as erythema and edema on intact skin sites, but on abraded skin sites, some rabbits showed veryslight erythema and edema 24hr after topical application. So, the disinfectant was clasified as a practically non-iri-tating material based on the score 0.13 of primary irritation index. In the skin sensitization test, guinea pigs were sen-of injection, and chalenged 2 weeks later. Creocomplex did not induce any allergic reactions. Therefore, 10% Creo-complex was graded as a weak material from 0 in both sensitization score and rate. From results of the present study,it is suggested that 10% Creocomplex does not cause contact irritation and sensitization.
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Awareness of Asbestos and Action Plans for Its Exposure can Help Lives Exposed to Asbestos
이후장,박은기,Donald Wilson,Engin Tutkun,옥철호 한국산업안전보건공단 산업안전보건연구원 2013 Safety and health at work Vol.4 No.2
Despite the fact that asbestos is a known carcinogen to humans, it is still used in industrialized countries, especially Asian countries. The global incidence of asbestos-related diseases (ARDs) due to the past use of asbestos, continues to increase, although many countries have adopted a total ban on asbestos use. The implementation of effective strategies to eliminate ARDs is therefore an important challenge in Asia, where asbestos is still mined and consumed. Collaborative efforts and strategies at the local and international levels are vital, in the pursuit toward the elimination of ARDs in this region.
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랫드의 스트레스성 위궤양에 대한 Opuntia dillenii Haw.(선인장)의 항궤양작용에 관한 연구
이후장,이용욱,김정현 한국식품위생안전성학회 1998 한국식품위생안전성학회지 Vol.13 No.1
본 연구는 스트레스에 의해 발생하는 위궤양에 대한 Opuntia dillenii Haw.(선인장)의 효과를 관찰하고자 시행되었다. 실험동물로는 Sprague-Dawley계 수컷 흰쥐 48마리를 사용하였며, 대조군(CO)과 3개의 투여군(E-1, E-2, E-3)으로 나누어 1996년 7월 29일부 1996년 8월 25일까지 4주간 실험을 수행하였다. Opuntia dillenii Saw.(선인장)는 1일 1회 경구투여하였으며, 각각 30 mg/kg BW(E-1) 및 120 Mg/kg BW(E-3)의 농도를 투여하였다. 결과느 s다음과 같다. 1. 체육은 전 군에 걸쳐서 고르게 증가되었으며, 특히 실험시작 후 13일째 체중증가량은 대조군에 비하여 Opuntia dillenii Haw.(선인장)를 투여한 실험군 실험군에서 유의한 차이는 관찰되지 않았다. 4. Alcian bule staining을 통한 위점액량 산출 결과 Opuntia dillenii Haw.(선인장)를 투여한 실험군이 대조군에 비해 전 농도에서 점액량이 높게 나타났으며, 실험군 E-1군은 유의하게 높았고(p<0.05), 실험군 E-2의 경우 그 증가가 현저하였다(p<0.01). 이로서 Opuntia dillenii Haw.(선인장)가 위의 점액생성을 촉진시키거나 위에 보호막을 형성함으로서 위궤양 발생저하에 기여하는 것으로 보여진다. 5. shear rate 11.25, 45.0, 90.0 및 225.0 sec^(-1)에서 전혈점도 및 혈장점도를 측정한 결과 모든 shear rate에서 C군>E-3군>E-1군>E-2군의 경향성을 보였다. E-1(30 mg/kg BW)군의 전혈점도는 대조군에 비하여 shear rate 11.25, 45.0 sec^(-1)에서는 매우 유의하게 감소하였고(p<0.01), shear rate 90.0, 225.0 sec^(-1)에서도 유의하게 감소되었다(p<0.05). E-2(60 mg/kg BW)군의 전혈점도는 대조군에 비하여 매우 유의하게 감소하였고(p<0.01). E-3(120 mg/kg BW)군의 전혈점도는 대조군에 비하여 shear rate 11.25 sec^(-1)에서 매우 유의하게 감소되었고 (p<0.01), shear rate 45.0, 225.0 sec^(-1)에서도 유의하게 감소되었다(p<0.5). 동일한 shear rate에서의 혈장점도는, E-1(30 mg/kg BW)군은 대조군에 비해서 shear rate 90.0 sec^(-1)에서 유의하게 감소되었다(p<0.05). E-2(60 mg/kg BW)군의 혈장점도는 대조군에 비해 shear rate 90.0, 225.0 sec^(-1)에서 유의하게 감소되었다(p<0.05). E-3(120 mg/kg BW)군은 대조군에 비해 전 shear rate에서 모두 감소하였으나 유의한 차이는 보이지 않았다. 이러한 결과로부터 Opuntia dillenii Haw.(선인장)가 스트레스하에서 발생하는 위의 미세혈관 협류흐름장애를 개선시켜 위게양 발생저하에 기여하는 것으로 보여진다. 6. 전 실험군의 위를 조사한 결과 출혈을 동바한 궤양이 형성되었음을 관찰할 수 있었다. Opuntia dillenii Haw.(선인장)투여군에서는 대조군에 비해서 궤양의 면적과 깊이가 다소 적은 경향을 나타내었다. 7. 위조직에 대한 병리조직학적 검사를 시행한 결과 Opuntia dillenii Haw.(선인장)을 투여한 실험군에 비하여 대조군의 궤양이 매우 심함을 관찰할 수 있었고, E-2군의 경우 궤양이 경미한 정도였다. 8. 위궤양의 지표로 사용한 pH, 위점액량, 전혈점도, 혈장점도, 조직병리학적소견 등을 종합한 결과, Opuntia dillenii Haw.(선인장)를 투여한 실험군이 대조군에 비해서 항궤양효과가 있는 것으로 나타났으며, 치료양의 2배를 투여한 E-2(60 mg/kg BW)군에서 효과가 가장 뛰어났다. This study was performed to investigate the antiulcer effect of Opuntia dillenii Haw. on the stomach ulcer induced by restraint and water-immersion stress in rats. For the experiment, 48 male Sprague-Dawley strain were used. The experimental groups were divided into four: a control (C) and 3 Opuntia dillenii Haw. treatment groups (E-1, E-2, E-3). Each dose of Opuntia dillenii Haw. was 30 mg/kg bw (E-1), 60 mg/kg bw (E-2) and 120 mg/kg bw (E-3). The ratswere allocated to each group by 12 and observed for 4 weeks. The results were as following: 1. The stomach surface pH in each group showed no significant difference, but the values of Opuntia dillenii Haw. treatment groups were higher than the value of the control group. 2. The gastric wall mucus was increased in all Opuntia dillenii Haw. treatment groups compared with the control group. Especially in E-1 difference was higher (p<0.05) and in E-2 difference was significantly higher (p<0.01). 3. At shear rate 11.25, 45.0, 90.0, 225.0 sec^(-1), whole blood viscosity and plasma viscosity were measured. Most of the values of the valuses of Opuntia dillenii Haw. treatment groups were low compared with that of the control group. At shear rate 90.0, 225.0 sec^(-1), the values of whole blood viscosity in E-1 were significantly low (p<0.05) and at shear rate 11.25, 45.0 sec^(-1), more significant p<0.01). At shear rate 11.25, 45.0, 90.0, 225.0 sec^(-1), the values of plasma viscosity in E-2 we resignificantly low (p<0.01). 4. Less severs ulcers were obsered in Opuntia dillenii Haw. treatment groups than in the control group. From the results of this study, it can be concluded that the oral administratio-n of Opuntia dillenii Haw. results in protection of stomach ulcer by stimulating the secretion of gastric mucus and improving the gastric mucosal microcirculation.
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동물병원 근로자에서의 알레르기 증상과 직업성 알레르기질환의 유병률
이후장,박은기,김희규,최길순 대한 소아알레르기 호흡기학회 2020 Allergy Asthma & Respiratory Disease Vol.8 No.4
Purpose: Veterinary clinic workers are frequently exposed to various animal allergens, increasing the possibility of occupational allergy. However, allergic symptoms in this group have not been studied extensively. We aim to investigate the prevalence of allergic symptoms and especially occupational allergic diseases in veterinary clinic workers. Methods: A questionnaire-based cross-sectional study was conducted. The questionnaire for allergic symptoms was sent to the veterinary clinic workers in the Gyeongsangnam-do region and was collected for statistical analysis. Occupational asthma, rhinitis, or dermatitis were defined as the new onset or worsening of each symptom at work and improvement in the condition while away from the work. Results: Ninety-five veterinary clinic workers participated in this study; 33.7% were male and their mean age was 33.7 years. Fifty-two subjects (54.7%) experienced conjunctivitis symptoms along with rhinitis symptoms. Fifty-seven subjects (60.0%) experienced rhinitis symptoms, but not cold or flu, and 40% of the subjects were suspected of having occupational rhinitis. Forty subjects reported that they had lower respiratory symptoms, while 11 (11.6%) and 4 subjects (4.2%) had asthma and occupational asthma, respectively. Twenty-two subjects with respiratory symptoms complained of symptom worsening upon contact with animals, especially cats. Of 95 subjects, 31 had skin itching, 11 reported skin rash, and 6 had occupational dermatitis. There was no significant difference in the type of work performed by the study participants. Conclusion: This study is the first to analyze the prevalence of allergic symptoms in veterinary clinic workers in Korea. The data can be employed for the prevention of occupational allergic diseases in veterinary clinic workers and can provide a basis for further studies. .
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