둔부에 발생한 골수외 형질세포종 - 증례 보고 -

이형석,김정렬,Lee, Hyung-Seok,Kim, Jung-Ryul 대한근골격종양학회 2009 대한골관절종양학회지 Vol.15 No.1

골수외 형질세포종은 아주 드물게 발생하는 종양으로, 전체 형질 세포 종양의 3~5 %를 차지하며 상부 호흡기관에서 주로 발생한다. 그 외 드물게 위장관, 방광, 중추 신경계, 유방, 갑상선, 고환, 타액선, 임파선, 피부 등에서 발생한 증례보고가 있다. 저자들은 49세 남자의 대둔근에서 발생한 골수외 형질세포종 1예를 경험하였기에 이를 문헌 고찰과 함께 보고하는 바이다. Extramedullary plasmacytoma is extremely rare, constitute 3 to 5 % of plasma cell malignancies and commonly occur in the upper aerodigestive tract. Several case studies of extramedullary plasmacytoma occurring in unusual location are reported; stomach, bladder, central nervous system, breast, thyroid, testis, salivary gland and skin. Here, we present a case of an extramedullary plasmacytoma of the right gluteus maximus muscle in a 49-year-old man.

Sulfur Dioxide 가스 흡입 후 흰쥐 기관 점막에서 Laminin의 발현에 대한 연구

이형석,유연희,조석현,김경래,정호삼,Lee, Hyung-Seok,Yu, Yean-Hee,Cho, Seok-Hyun,Kim, Kyung-Rae,Chung, Ho-Sam 대한기관식도과학회 2000 大韓氣管食道科學會誌 Vol.6 No.1

Background and Objectives : The concentration of sulfur dioxide($SO_2$) gas in the ambient air appears increasing in the industry and urban area day by day. It was known that $SO_2$ is noxious gas. $SO_2$ can be irritating to the eyes, nose, throat, upper respiratory tract and skin. It produces sulfurous acid on contact with water and is extremely irritating to the nasopharynx and respiratory tract. Laminin is a family of extracellular matrix glycoproteins localized in the basement membrane that separates epithelial cells from the underlying stroma. The biological activities of laminin are to promote cell migration, wound healing, growth and differentiation. Meterials and Methods : The histologic changes and the expression of laminin in tracheal mucosa sacrificed at every weeks (to 7 weeks) after continued $SO_2$ exposure of 250ppm for 30 minutes a day were studied in rats. Results : Pathologic tissue was formed at the tracheal mucosa and the underlying tissue by the infiltration of monocytes and epithelium was transformed to the single cell layered epithelium above 5 weeks after exposure. At the 6 weeks after exposure, epithelial cells were partially lost and epithelial cell layer was transformed to be leaf-shaped. Submucosal tissue was transformed to be lymphatic tissue. An intense positive staining for laminin was found in apical cytoplasm and lateral surface of the normal epithelial cells and basement membrane but at the 5 and 6 weeks after exposure, laminin activity was decreased to the moderate activity. At the 7 weeks after exposure, laminin activity was decreased to the weak activity. Conclusion : Our finding suggests that $SO_2$ makes histologic damage on the tracheal mucosa and decreases immunoreactivity for laminin. Longer duration of the exposure of $SO_2$ makes more histologic damage on the tracheal mucosa and decreases immunoreactivity for laminin.

국방 핵심기술의 성숙도(Readiness Level)평가를 활용한 국방기술가치평가 방안 연구

이형석,신충진,강석중,Lee, Hyung-Seog,Shin, Chung-Jin,Kang, Seok-Joong 한국정보통신학회 2019 한국정보통신학회논문지 Vol.23 No.12

본 연구는 다양한 기술의 융합과 체계통합기술이 고도로 복잡하게 요구되는 국방기술을 이해하고, 분야별 특성이 반영된 가치평가방법을 제안하고자 한다. 가치평가 대상 무기체계의 기술 수준의 척도, 기술 간의 통합(체계통합기술)척도, 제조준비 및 성숙도 척도를 측정요소별 항목에 맞추어 측정하여 시스템성숙도를 확인하고, 시스템의 성숙도를 활용한 핵심기술의 계량적인 가치예측모형의 틀을 제시하고자 한다. 국방기술의 가치를 기술분야별 특성을 고려하여 이에 맞는 가치평가방법을 제안하는 연구이다. 각 분야의 역량있는 기술전문가들에 의해 분야별 기술적인 특성이 반영된 평가 기준에 따라 평가되고, 전체 시스템의 완성도를 정량적인 수치로 표현할 수 있는 시스템성숙도(SRL)를 활용하여 국방기술가치를 평가하는 방안을 제안한다. This study is intended to understand defense technologies that require the convergence of various technologies and the integration of systems, and to propose valuation methods that reflect the characteristics of each field. The measure of technology level, integration (system integration technology) between technologies, preparation of manufacturing, and maturity scale of the weapons system to be valued are measured according to the items of measurement factors to verify system performance, and to present a framework for estimating the quantitative values of core technologies using system maturity. Considering the characteristics of each technology field, the research suggests a proper valuation method. In evaluating the value of defense technologies, A proposal is made to evaluate the value of defense technology by competent technical experts in each field, using SRL, which can be evaluated according to the evaluation criteria reflecting the technical characteristics of each field, and to evaluate the completion of the entire system in quantitative terms.

악성 흑색종의 예후 인자에 대한 분석

이형석,박종혁,함동훈,김정렬,Lee, Hyung-Seok,Park, Jong-Hyuk,Ham, Dong-Hun,Kim, Jung-Ryul 대한근골격종양학회 2009 대한골관절종양학회지 Vol.15 No.2

목적: 최근 발생빈도가 증가하고 있는 악성 흑색종의 치료 결과를 분석하여 장기 예후에 영향을 미치는 인자를 알아보고자 하였다. 대상 및 방법: 1997년 3월부터 2004년 3월까지 악성 흑색종으로 진단 받았고 5년 이상 추시가 가능하였던 51예를 대상으로 후향성 연구를 하였으며, 평균연령은 49.4세였다. 연구 방법으로는 나이, 성별, 발생 부위, 종양의 두께, 주위 림프절 전이여부, 면역화학 요법의 시행 유무에 따른 5년 생존율을 비교하였고, 전이 및 국소재발 유무를 조사하였다. 결과: 발병 연령이 65세 미만인 경우 5년 생존율은 88.5%였고, 65세 이상에서는 88.0%였다. 남자의 5년 생존율은 62.5%였으며, 여자는 100%였다. 발생 부위에 따른 5년 생존율은 상지가 100%, 하지가 80.0%, 기타 부위가 100%였다. Clark stage III이하에서는 100% 5년 생존율을 보였고, IV이상에서는 79.3%였다. 주위 림프절로의 전이가 있었던 경우 5년 생존율은 66.7%였고, 림프절 전이가 없었던 경우는 94.9%였다. 결론: 악성흑색종의 예후에 영향을 미치는 인자로 성별(남자), 발생 부위(하지), 종양의 두께(Clark's stage IV이상), 주위 림프절 전이가 있는 경우에 나쁜 예후를 보였으나, 다른 연구와는 다르게 발병 연령은 예후에 큰 영향을 미치지 않는 것으로 조사되었다. Purpose: To evaluate treatment outcomes of malignant melanoma and to analyze the factors that contributes to outcomes. Materials and Methods: We reviewed the 51 cases of malignant melanoma from March, 1997 to March, 2004 and were followed up more than 5 years. Average age was 49.4. We compared 5-year survival rate for each age, gender, site of occurrence, depth of tumor, metastasis of regional lymph node and immuno-chemo therapy. Results: 5-year survival rate was 88.5% for the age group below 65, 88.0% for the age group 65 and above, 62.5% for male and 100% for female. 5-year survival rate for the site of occurrence showed 100% in upper extremities, and 80.0% in lower extremities and 100% in other sites. 5-year survival rate was 100% for the stage below Clark stage III and 79.3% for the stage above IV. In surgical resection, 5-year survival rate was 66.7% for lymph node metastasis group and 94.9% for non-lymph node metastasis group. Conclusion: The prognostic factors of malignant melanoma were gender, tumor site, depth of tumor (Clark's stage) and metastasis of regional lymph node. But, there was no relation between the age and the survival rate in our study.

봄철 크리핑 벤트그래스의 품종별 특성비교

이형석,홍범석,김경덕,태현숙,Lee, Hyung-Seok,Hong, Beom-Seok,Kim, Kyung-Duck,Tae, Hyun-Sook 한국잔디학회 2007 한국잔디학회지 Vol.21 No.2

본 연구는 봄철 크리핑 벤트그래스의 품종별 생육특성을 파악하고자 수행하였다. 먼저 그린업 조사결과, CY-2와 T-1의 초기 그린업이 가장 빨랐으며 이는 다른 품종들보다 2주정도 빨리 진행된 것으로 나타나 봄철 그린업 속도에 따른 품종별 별도의 관리 프로그램이 필요할 것으로 생각 되었다. 나머지 품종들의 그린업은 Penn A-4, Crenshaw, L-93 > 2 Penncross > Putter > Dominant > SR1020 순으로 조사되었다. 클로로필 함량은 T-1과 CY-2가 가장 높았고, Penncross는 현저히 낮은 수치를 보였다. 잔디 밀도가 가장 높았던 품종은 Crenshaw, Penn A-4이고, 다음으로 CY-2, L-93, T-1, Putter, Dominant, SR1020, Penncross 순으로 높게 나타났다. 봄철 뿌리생육이 가장 우수한 품종은 CY-2와 L-93이었고, 가장 불량한 품종은 Penncross였다. 시각적 품질은 CY-2가 가장 좋았으며, T-1과 Crenshaw도 우수한 품종으로 분류되었다. SR1020, Dominant 및 Penncross의 시각적 품질은 낮았으나 잔디생육이 활발한 6월에 접어들면서 품종별 차이는 없어졌다. 본 실험의 결과를 종합해 보면 봄철 생육이 가장 우수한 품종은 CY-2, T-1, Crenshaw이었으며, 가장 불량하였던 품종은 SR1020, Penncross였다. 조사된 다양한 결과들은 많은 골프장 그린의 품종 선택과 초기 관리에 유용한 정보가 될 것으로 생각된다. 앞으로 잔디병과 답압 스트레스를 포함한 다양한 항목에 대한 조사가 수행되어야 할 것이다. This study was initiated to evaluate the growth characteristics of creeping bentgrass cultivars during the sprlng season. The green-up of 'CY' and 'T-1' were about 2 weeks earlier than the other cultivars followed by 'Penn A' 'Crenshaw', 'L> 'Penncross' > 'Putter' > 'Dominant' > 'SR1020' in that order. 'T-1' and 'CY-2' had the highest chlorophyll content while 'Penncross' had the lowest during the spring. 'Crenshaw' and 'Penn A-4' showed the highest shoot density in this research, followed by 'CY-2', 'L-93', 'T-1', 'Putter', 'Dominant', 'SR1020', and 'Penncross' in that order. In case of root length, 'CY-2' and 'L-93' were the best cultivars, but 'Penncross' was worst during the spring. 'CY-2' had the best visual quality among the cultivars, 'T-1' and 'Crenshaw' also classified as high visual quality group whereas 'SR1020', 'Dominant' and 'Penncross' were grouped in relatively low quality. In conclusion, 'CY-2', 'T-1' and 'Crenshaw' were the best cultivars in terms of growth characteristics in spring. Conversely, 'SR1020' and 'Penncross' were the poorest cultivars. These results can be more useful for management or constructing of golf courses. However, this research was performed with little compaction stress. More information is needed on the tolerance to compaction stress of these bentgrass cultivars.

악성 골 종양으로 오인된 급속 파괴형 고관절증 - 증례 보고 -

이형석,김정렬,Lee, Hyung-Seok,Kim, Jung-Ryul 대한근골격종양학회 2008 대한골관절종양학회지 Vol.14 No.2

급속 파괴형 고관절증(Rapidly destructive coxarthrosis)은 고관절에 발생하여 급속한 골파괴를 일으키며 현재까지 확실한 원인이 밝혀지지 않은 드문 질환이다. 임상적으로 극심한 고관절 통증과 파행을 나타내며, 방사선학적으로 수개월 내에 급속한 대퇴골두의 파괴를 일으키므로 류마토이드 관절염, 세균성 관절염, 신경병성 관절증 및 골종양과 감별을 요한다. 저자들은 우측 대퇴골두에 발생하여 4개월만에 급속한 골파괴성 병변을 보여 악성 골종양으로 오인되어 타 병원으로부터 전원 되었던 80세 여자 환자의 급속 파괴형 고관절증을 보인 증례를 경험하였기에 이를 문헌 고찰과 함께 보고하는 바이다. Rapid destructive hip osteoarthritis is a rare subset of osteoarthritis with rapid destruction of the hip joint within months of the onset of symptoms. The entity simulates rheumatoid arthritis, septic arthritis, neuropathy or malignant bone tumor. We report a case of rapidly destructive coxarthrosis of the right hip joint initially misdiagnosed as a malignant bone tumor at outside hospital in a 80-year-old woman.

기관피부누공에 대한 임상적 고찰

이형석,김현수,심봉택,태경,박철원,Lee, Hyung-Seok,Kim, Hyun-Soo,Shim, Bong-Taek,Tae, Kyung,Park, Chul-Won 대한기관식도과학회 1995 大韓氣管食道科學會誌 Vol.1 No.1

The tracheocutaneous fistula(TCF) may develop infrequently as a complication after tracheostomy. Prolonged tracheostomy tube dependence increases the risk of TCF developing, and in growth of stratified squamous epithelium lines the furrow connecting the tracheal mucosa and the skin, accounting for persistence of the fistulous tract. Such fistulas are a nuisance and create nursing and social problems including poor hygiene, aspiration, difficulty with speech, and depletion of pulmonary reserve. Surgical closure has generally been successful by primary closure, fistulectomy with primary closure, and closure by secondary intention following excision of the tracheocutaneous fistula. No large series compares the efficacy of these techniques and each has its own merits. Recent literature has purposed to minimizing complications. For ten years, from January 1985 to December 1994, the authors experienced 25 cases of TCF which were analyzed in respect to incidence and interval of cannulation, duration between decanulation and fistular closure, precedent disease, closure methods, and complications of TCF repair.

백서 기관 점막의$SO_2$ 노출 후 회복과정의 조직학적 관찰 및 laminin의 발현에 관한 연구

이형석,태경,조석현,한장희,정진석,Lee, Hyung-Seok,Tae, Kyung,Cho, Seok-Hyun,Han, Jang-Hee,Jeong, Jin-Suck 대한기관식도과학회 2002 大韓氣管食道科學會誌 Vol.8 No.1

Background and Objectives : Sulfur dioxide gas is one of the major airborne Pollutants noxious to human in industrialized countries. The most vulnerable areas in the human respiratory system were the trachea and main bronchi and a gradient of decreasing damage was observed in the peripheral tracheobronchial tree. Induced functional alteration was increased mucosal permeability, and morphological changes were epithelial sloughing, intracellular edema, mitochondrial swelling, widened intercellular spaces, and ciliary cytoplamic extrusions. The laminins are a family of extracellular matrix glycoproteins localized in the basement membrane. Their primary role is cell-matrix attachment, but many additional biologic activities, including Promoting cell growth and migration, tumor growth and metastasis, wound repair, and graft survival, have been demonstrated. Materials and Methods : Histologic changes and expression of laminin in tracheal mucosa sacrificed at 1 day, 2 day, 3 day, 1 week, 2 weeks, and 3 weeks after continued SO2 exposure of 250 ppm for 30 minutes a day(to 7week) were studied in rats. In this study, mild immune reaction for laminin was noted at the apical cytoplasm of epithelial cells and basement membrane one day after a 7 week $SO_2$ exposure. The cilia and nucleoi of epithelial cells were normal and no immune reaction was noted in Goblet cells. The lamina propria of the tracheal tissue was infiltrated by monocytes and lymphocytes. Results : At 24 hours after exposure, all tracheal cells except Goblet cells revealed a mild immune reaction for laminin. No immune reactions were noted in the basement membrane. At 72 hours after exposure, mild or moderate immune reactions for laminin was seen in the tracheal cell cytoplasm. Irregular faint immune reaction for laminin was noted in the basement membrane. At 1 week after exposure, strong immune reaction for laminin was detected over all tracheal cells, and the basement membrane was seen clearly. At 2~3 weeks after exposure, strong immune reaction for laminin was seen in all tracheal epithelial cells except Goblet cells and a mild immune reaction was partly revealed in the basement membrane. Conclusion : Our study suggests that 502 produces histologic damage on the tracheal mucosa. Longer duration after exposure of $SO_2$ makes more progressive healing on the tracheal mucosa and increased immunoreactivity for laminin.

Dr. Speech Science를 이용한 정상 및 후두질환 환자의 음향분석

이형석,태경,장경진,김경우,김경래,박철원,Lee, Hyung-Seok,Tae, Kyung,Jang, Kyung-Jin,Kim, Kyung-Woo,Kim, Kyung-Rae,Park, Chul-Won 대한후두음성언어의학회 1997 대한후두음성언어의학회지 Vol.8 No.2

Background : For example, aerodynamic study, vibratory study, acoustic study, neuro-muscular test and psychoacoustic evaluation, a number of objective methods are now available for assessing pathologic voice change. They help to differentiate pathologic condition from normal condition and to monitor pathologic and aging change. These laboratory analyses are used commonly to monitor speech therapy and to follow a patient's recovery after surgery. Objectives : We investigated the values of jitter, shimmer and NNE of normal person and hoarseness patients in Korea. The values of Jitter and shimmer might be meaningful parameters distinguishing pathologic vibration from normal and recovery after surgery. Materials and Methods : Statistical significance between normal control and 48 subjects taken microlaryngeal surgery were compared with Dr. speech science program that is computerized system for acoustic analysis of voice production employed to determine vocal characteristics of pitch perturbation(jitter) and amplitude perturbation(shimmer). Results : The mean normal values of jitter and shimmer were 0.226${\pm}$0.110(%), 2.200${\pm}$0.421(%) in male and 0.164${\pm}$0.060(%), 2.063 ${\pm}$0.575(%) in female. In patients with vocal nodule, the preoperative and postoperative values of jitter and shimmer were valueless. In patients with vocal polyps, the preoperative and postoperative values of jitter and shimmer were valuable. Conclusion : Dr. speech science program was effective to monitor laryngeal disease and aging changes.

원위 비골에서 발생한 골막하 결절종 - 증례 보고 -

이형석,김정렬,Lee, Hyung-Seok,Kim, Jung-Ryul 대한근골격종양학회 2008 대한골관절종양학회지 Vol.14 No.2

In contrast to ganglion of the soft tissue, periosteal ganglion occurring within or beneath the periosteum is a rare disorder. The differential diagnosis includes periosteal chondroma, lipoma, giant cell tumor of tendon sheath and periosteal osteosarcoma. Most common location for periosteal ganglion is the tibia, followed by radius, femur and ulna. To our knowledge, only 1 case of periosteal ganglion of the fibula has been reported in the literature. We report a case of periosteal ganglion of the distal fibula in a thirty-year-old woman treated with excision of the cyst and the adjacent periosteum. 골막하에 발생하는 결절종은 매우 드물며, 골막 연골종, 지방종, 건초 거대 세포종, 혈종, 기타 염증 그리고 방골성 골육종 등과 감별이 필요하다. 현재까지 보고된 골막하 결절종의 발생 부위는 경골이 가장 흔하며, 요골, 척골, 대퇴골에서도 발생이 보고되었지만, 비골에 발생한 경우는 1예만 보고되어 있다. 이에 저자들은 30세 여자 환자의 우측 원위 비골 부위에 발생한 골막하 결절종을 경험하였기에 이를 문헌 고찰과 함께 보고하는 바이다.