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허혈성뇌졸중과 출혈성뇌졸중에서 Apolipoprotein E 유전자의 다형성
이현아(Hyon-Ah Yi),임정근(Jeong-Geun Lim),권오대(Oh-Dae Kwon),조용원(Yong-Won Cho),이형(Hyung Lee),이상도(Sang-Doe Yi),김대광(Dae-Kwang Kim) 대한해부학회 2002 Anatomy & Cell Biology Vol.35 No.4
Apolipoprotein E (APOE) 대립유전자의 분포는 동맥경화증, 심장동맥질환 및 목동맥협착증 환자에서 일반 인구군에 비해 유의한 차이를 나타내는 것으로 알려져 있지만, 뇌졸중에서의 역할에 대해서는 명확하게 알려져 있지 않다. 이 연구는 뇌경색과 뇌출혈에서 APOE 유전자의 다형성을 조사하고 APOE 대립유전자와 뇌졸중의 발생 및 유형과의 상관관계를 알아 보기 위해 시행하였다. 113명의 뇌졸중 환자군과 111명의 대조군을 대상으로 APOE 대립유전자의 분포 및 유전자형을 조사하고 뇌혈관질환과 이들 사이의 상관관계를 분석하였다. 대상군과 대조군, 그리고 뇌출혈군과 뇌경색군 사이에 APOE 대립유전자와 APOE 유전자형의 분포는 유의한 차이가 없 었다. 따라서 뇌졸중 환자군에서 APOE의 다형성이 뇌졸중의 발생과 유형에 영향을 끼치지 않는 것으로 추정된다. 이는 지역적 차이와 표본 추출 상태 및 표본 수의 영향을 고려해야 함이므로 뇌졸중의 유전적 병태 생리를 이해하기 위해서 더 많은 표본을 대상으로 한 연구가 필요할 것이다. There is an evidence for a role of apolipoprotein E (APOE) in atherosclerosis, coronary heart disease and carotid artery stenosis. Morbidity of carotid artery atherosclerosis is higher in persons carrying an ε4 allele, but the association of cerebrovascular disease and apoE genotype is controversial. We studied the association between APOE genotype and allele (ε2, ε3, ε4) frequency and stroke. We evaluated APOE genotype in 133 first-ever stroke patients and 111 healthy controls. We also estimated the risk factors of stroke such as hypertension, diabetes and lipid profiles in both groups. APOE genotypes were analyzed by polymerase chain reaction. APOE genotypes and allele distributions were not different in patients and controls. There is also no difference of APOE allele frequencies between ischemic small artery occlusive disease and hypertensive subcortical intracerebral hemorrhage. We concluded that the APOE-ε4 allele is not associated with stoke including ischemic and hemorrhagic stroke.
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배한준 ( Han Jun Bae ),정창규 ( Chang Gyu Jung ),이주형 ( Ju Hyung Lee ),김태열 ( Tae Yul Kim ),이선영 ( Sun Young Lee ),채진녕 ( Jin Nyeong Chae ),장혁원 ( Hyuk Won Chang ),이현아 ( Hyon Ah Yi ),김상현 ( Sang Hyon Kim ) 대한류마티스학회 2012 대한류마티스학회지 Vol.19 No.1
Behcet`s disease (BD) is a multisystem disorder presenting recurrent oral and genital ulcerations as well as ocular lesions, involving the nervous system in a subgroup of patients. BD develops at a young age and is frequently presented with an acute or subacute brainstem syndrome or hemiparesis, as well as with other various neurological manifestations, the syndrome is often included in the differential diagnosis of multiple sclerosis, stroke of the young adult, and other neurological disorders. Transverse myelitis (TM) is a clinical syndrome in which an immune- mediated process causes neural injury to the spinal cord, resulting in varying degrees of weakness, sensory alterations and autonomic dysfunction. Spinal Neuro-behcet`s disease is rare case. We reported a 33 -year old man who had been treated for BD for 3 years.
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이장준,이현아,최종환,이형,임정근,이상도,박영춘 계명대학교 의과학연구소 2000 계명의대학술지 Vol.19 No.2
Cerebral small vessel disease is the most important cause of lacunar infarction (LI) and intracerebral hemorrhage (ICH). It is generally postulated that, in its early stages, the vascular lesion engenders vessel wall fragility and ICH. But if rupture dose not occur, segmental vessel occlusion evolves, producing LI. It may be a common aging phenomenon that is exacerbated by hypertension and diabetes mellitus. This study was performed to evaluate risk factors of LI and ICH. We reviewed retrospectively the medical records of 690 patients (254 LI, 436 ICH) with stroke who were admitted to Keimyung University Dongsan Medical Center from January 1995 to December 1998. The major risk factors including age, sex, hypertension, diabetes mellitus and several minor risk factors were analyzed in these patients. Older age (p<0.01), male sex(p<0.01), hypertension with treatment(p<0.01), hypertension with long duration(p<0.01) and hypertriglyceridemia(p<0.01), cigarette smoking(p<0.01) were significantly more frequent in LI. Younger age(p<0.01), female sex(p<0.01) and hypertension without treatment(p<0.01), hypertension with short duration(p<0.01) were more frequent in ICH. The prevalence, duration and treatment of diabetes mellitus were not different between these two groups. This study show that the age, sex, treatment of hypertension, duration of hypertension and cigarette smoking seem to be significant risk factors between LI and ICH.
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