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김지수,양용석,김승영,부철수,이헌직,박병엽,조현장,양승호,김두형 대한내과학회 1998 대한내과학회지 Vol.55 No.5
Autoimmune neutropenia is characterized by severe neutropenia with cell-bound neutrophil antibodies or circulating antibodies for neutrophils. Diagnosis of disease is made of the basis of the presence of antibodies for neutrophil. Corticosteroid or rhG-CSF have been reported to be effective in some patients. Recently we experienced one case of autoimmune neutropenia patient who was admitted to our hospital in 1997 because of stomach cancer and degenerative joint disease. She had severe neutropenia without underlying autoimmune disease. And cell-bound neutrophil antibodies were detected by indirect immunofluorescence test. Treatments with rhG-CSF and steroid result in transient improvement of neutropenia and subtotal gastrectomy was done successfully. We herein report one case of autoimmune neutropenia patient, to our best knowledge, the first report in Korea, with a brief review of literature.
직접 항글로블린 시험에서 위양성을 보인 B형 전림프구성 백혈병 1 예
김지수,양용석,김승영,부철수,노성민,이헌직,박병엽 대한내과학회 2000 대한내과학회지 Vol.59 No.4
De novo B-cell prolymphocytic leukemia (B-PLL) is a distinct clinicopathologic entity that was first described in 1974 by Galton et al. B-PLL is characterized by marked lymphocytosis with predominance of prolymphocytes, often massive splenomegaly, minimal lymphadenopathy, often aggressive clinical course and frequently poor prognosis. We experienced a case of B-PLL associated with false-positive direct antiglobulin test. The patient was 52 year-old man who presented with marked leukocytosis (160.2x103/μL) and 60% of characteristic prolymphocytes in the peripheral blood. The bone marrow aspirate showed dry tap and the PAS stain of peripheral blood smear showed positivity of prolymphocytes. The immunophenotyping of the leukemic prolymphocytes revealed the positivity of surface immunoglobulin (IgM, lambda type), HLA-DR, CD19 and CD5.(Korean J Med 59:428-432, 2000)
류마치스성 관절염과 동반된 Ochronosis(조직갈변증) 1 예
김상현,이종수,김진도,문한규,최장락,강필중,이광욱,나하연,이헌직,여동승,윤영권,황병욱,곽임수 대한내과학회 1991 대한내과학회지 Vol.41 No.1
Ochronosis, which is autosomal recessive, results from a decreased amount of the enzyme homogentisic acid oxidase, due to which tyrosine and phenylalanine cannot be broken down via the normal pathway. The clinical manifestations of ochronosis usually appear after the age of 30 as a result of the deposition of pigment in the extracellular macromolecules of the connective tissue, particular of the skin and joints. The diagnosis is made by determination of urinary homogentisic acid excretion, and the clinical and radiological findings can help to diagnose this disease. We report a case of Ochronosis with Rheumatoid arthritis presented with skin pigmentation and migrating polyarthritis in a 57-year-old female patient who was managed with an antiinflammatory agent, steroids, and symptomatic care.