쯔쯔가무시병에 의한 길랑-바레증후군

이학승,이영주,박현영 대한신경과학회 2007 대한신경과학회지 Vol.25 No.2

의과대학생에서 임상 수기 수행능력에 대한 자가평가 결과와 임상수행능력 평가시험(CPX) 결과의 비교

이학승 圓光大學校 醫科學硏究所 2008 圓光醫科學 Vol.23 No.2

본 연구는 의과대학생들이 한 학기 동안 임상실습을 마치고 난 후, 실습지침서에서 요구하고 있는 흔한 임상 증상을 얼마자 자주 경험하였는가를 조사해 보고, 흔한 임상 증상에 대한 학생들의 경험 빈도와 자가 평가한 염상수행능력과의 상관성을 조사해보는 것이었다. 둘째로, 시험문항으로 제시된 임상수기에 대한 의과대학생들의 주관적 자가평가 결과와 객관적 CPX 결과를 비교하여 주관적 평가 결과와 객관적 평가 결과의 상관성을 조사해 보는 것이었다. 그 결과는 다음과 같다. 1. 임상 증상에 대한 학생들의 경험 빈도와 자가평가한 임상수행능력과의 상관성은 경험 빈도가 많을수록 자가평가 점수도 높게 나오는 결과를 보였다. 2. 객관적 CPX 결과와 주관적 자가평가 결과는 상관성이 없는 것으로 나타났다. Purpose: The purpose of this study was to assess the clinical experience state of medical students 3-grade, and compare the self-assessment about their competency on clinical skills and the assessment of instructors through the Clinical Performance Examination(CPX). Methods: Fifty-two medical students who are in 3-grade were included. Their clinical experiences state and the self-assessment of their condidence on clinical skills were evaluated by questionnaires givend before the CPX. After completing the CPX, they evaluated their own performance state to 9 whole clinical skills of the CPX by self-assessment questionnaires, again. The correlation and comparison between self assessments' socre and instructor's score were analyzed. Results: For 19 of 28 clinical skills items listed in the questionnaires, self-assessment of competence by medical students correlated with the frequency of performance(p<0.05). For 9 clinical skills in the CPX, the self-assessment scores did not correlate significantly with the instructors' assessment scores(p>0.05). However, these 9 clinical skills scores from the instructors correlated significantly with the scores of clinical experienceand the final semester grade point averages(p<0.05). Conclusion: There was a significant association between frequency of performance and self-assessed competency. And there was no significant correlation between self-assessed score on competency with instructor's score in the CPX.

전자상거래 계약상의 법적 문제점에 관한 연구

이학승,정성훈 동국대학교 경제경영연구원 무역연구부 1999 國際貿易硏究 Vol.23 No.2

삼능(Scirpus Maritimus)의 항암성 연구

이학승,황우익 고려대학교 의과대학 1994 고려대 의대 잡지 Vol.31 No.3

This study was devised to observe the cytotoxic activities of the petroleum ether extract of Scirpus Maritimus (crude extract) and its partially purified fraction from silicic acid column chromatography (acetone fraction) against mouse leukemic cell (L_(1210)), hepatoma cell (Hep G2), human rectum (HRT-18) and colon (HT-29) cancer cells, in vitro. Each cell line was cultured in medium containing serial concentration of the crude extract or acetone fraction for 72 hours. And then the growth rate, dose-response and morphological change of each cell were determined. The results obtained are summarized as follows, 1. The doubling times of L_(1210), HRT-18, HT-29 and Hep G2 cells were about 12, 20, 22 and 40 hours, respectively, 2. The growth inhibition rates of L_(1210), HRT-18, HT-29 and Hep G2 cells were gradually increased in proportion to the concentration of the crude extract or acetone fraction in culture medium. 3. The cytotoxic activity of acetone fraction on the each cell line was more potent than that of the crude extract. 4. The growth inhibition rates of the cells treated with crude or acetone fraction were shown the difference among the each cell and greatest in the L_(1210) cell. 5. The numbers and size of HRT-18 cultured in medium containing acetone fraction were significantly reduced and deformed compared with the control group and the effect of actone fraction was more potent than that of the crude extract. In view of the results, there are contained the growth inhibitory substance on the several cancer cells in the acetone fraction of Scirpus Maritimus, it could be suggested that active compound is glycolipid.

원발성 유방암에서 p53 단백발현과 예후와의 상관성에 관한 연구

이학승,이광만,채권묵,문형배 圓光大學校 醫科學硏究所 1995 圓光醫科學 Vol.11 No.1

p53 is a nuclear phosphoprotein which is normally expressed at very low level in all mammalian cells and plays a role in the regulation of cell proliferation. It has also been suggested that normal p53(wild type) serves as a tumor suppressor gene, and inhibits the oncogene-mediated cellular transformation and the rate of cellular proliferation. But, wild type p53 is hardly stained by immunohistochemistry because of its low intracellular concentration and very short half-life. Mutant form of p53 protein is detectable in various human malignancies e.g. colon, stomach, lung and breast cancer by immunohistochemical stain because of its prolonged half-life. In breast cancer, p53 protein expression has been regarded as an unfavorable prognostic factor, but the results of studies about the relationship between the p53 protein expression and prognosis are equivocal. So, author performed this study to evaluate the prognostic significance of p53 expression in 54 patients with primary breast cancer who underwent surgical treatment at Wonkwang University Hospital from October 1985 to September 1991. Follow-up period was 24-91 months (mean: 54.7months). p53 protein was stained by immunohistochemical methods in formalin-fixed, paraffin-embedded tissues using monoclonal antibody(DAKO-p53, DO-7). The prognostic significance of p53 protein was evaluated by positivity and 5-year survival rate, and comparing with well-known prognostic factors of breast cancer. p53 protein was expressed 48.1%(26/54) of primary breast cancers. 5-year survival rate of patients with p53 protein expression was 42.0%, and that of patients without p53 protein expression was 76.4%(p = 0.0277) There was no relationship between p53 protein expression and tumor size, lymph node metastasis, histologic grade or vascular invasion. These results suggest that p53 protein expression is another independent prognostic factor in primary breast cancer.

Gender in Medical Training and Academic Medicine

이학승,이창우 연세대학교 의과대학 2013 의학교육논단 Vol.15 No.1

There has been an increase in the number of female doctors worldwide. Women now represent half of all medical students, with almost the same numbers of men and women becoming physicians. There is a pool of talented women in our midst, and it is our responsibility as leaders to find those individuals and groom them for progress. However, residency training and academic education still resemble the historical model when there were few women in medicine. Gender differences in medical specialty choices can cause a maldistribution of doctors by specialty and geographical area, which could cause significant problems at the national health care system level. Major challenges facing female physicians include gender discrimination and sexual harassment,and work/family conflicts. Women are largely under-represented in academic medicine and experience discrimination in the academic environments. Recent issues about related to the “feminization of medicine” raise important questions forabout how academic medicine deals with gender issues. To better accommodate the needs of female doctors and ensure that they will have successful careers, structural and cultural changes to medical educations are needed.

반신불완전마비로 발현된 전척수동맥경색

이학승,김영서,장혁,박현영 대한신경과학회 2015 대한신경과학회지 Vol.33 No.2

Infective Endocarditis Associated with Transcatheter Aortic Valve Replacement: Potential Importance of Local Trauma for a Deadly Nidus

이학승,이승표,정지현,김혜미,김지혜,박준빈,김형관,김용진,김효수,손대원 한국심초음파학회 2014 Journal of Cardiovascular Imaging (J Cardiovasc Im Vol.22 No.3

Recently, transcatheter aortic valve replacement (TAVR) has emerged as an alternative for the treatment of severe symptomaticaortic stenosis patients. Although experience with TAVR is increasing exponentially, few cases of post-TAVR endocarditis arereported. We present a case of 76-year-old man with infective endocarditis after TAVR who was definitely diagnosed byechocardiography.

측두와에 발생한 피부모양기형낭종

이학승,최승석,안희창,이장현 대한두개안면성형외과학회 2010 Archives of Craniofacial Surgery Vol.11 No.1

Purpose: Dermoid cysts are benign neoplasms that are derived from both ectoderm and mesoderm. Approximately 7 percent of all dermoid cysts occur in the head and neck,as most common sites are the lateral ends of the eyebrows,the midline in the nasal root and neck. Rarely they can be found in the frontal sinus, temporal bone, maxilla and the floor of the mouth. Dermoid cysts in the temporal fossa are extremely rare. We experienced a characteristic dermoid cyst that occupied the temporal fossa. Methods: A 16-year-old man had a progressive enlarging mass on the left eyebrow. Computerized tomographic scan showed a bulging mass in the temporal fossa, and it had the density similar to that of fat. The size of the mass was 3 × 3 × 2 cm, and it was composed of high density of fat with clear margin. There was no bony invasion, but the mass was fixed on bone. Results: We performed the surgery through coronal incision under general anesthesia. Because the mass was closely connected with temporal fat pads, we removed this mass with some portion of temporal fat pads, avoiding damage to the facial nerve. The postoperative course was ordinary without complication. Conclusion: The reports about dermoid cyst on the temporal fossa is uncommon. However, if there is a mass in the temporal fossa which has the density similar to that of fat in CT scan, we should consider the possibility of dermoid cyst. We suggest that excision through coronal incision with bewaring temporal fat pad can induce good result. (J Korean Cleft Palate Craniofac Assoc 11: 65, 2010)

경부 대상포진 감염과 연관된 횡격막 신경 마비

이학승,박현영,조광호 대한신경과학회 2007 대한신경과학회지 Vol.25 No.2