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혈액투석 환자에서 혼수로 발현된 cefepime에 의한 비경련성 간질 중첩증
이초이 ( Cho I Lee ),홍미진 ( Mi Jin Hong ),홍성철 ( Sung Chul Hong ),박중희 ( Jung Hee Park ),박유진 ( Eugene Park ),한장수 ( Jang Soo Han ),김영진 ( Young Jin Kim ),이종호 ( Jong Ho Lee ),박정환 ( Jung Hwan Park ),송종오 ( Jong 대한신장학회 2011 Kidney Research and Clinical Practice Vol.30 No.5
Cefepime-induced nonconvulsive status epilepticus (NCSE) in end-stage renal disease (ESRD) patients receiving hemodialysis has only rarely been reported. Here we report a case of cefepime-induced NCSE presenting as coma in a patient with ESRD on hemodialysis. A 73-year-old man, who had been receiving maintenance hemodialysis, developed aphasia and coma during cefepime therapy for epidural abscess. Emergent eletroencephalography (EEG) revealed evidence of NCSE. The abnormal EEG findings were resolved and comatose mentality was completely recovered after cessation of cefepime and administration of anticonvulsive drugs. Cefepime-induced NCSE should be considered if neurological symptoms including comatose mentality develops during cefepime therapy in a patient with renal failure.
이응준 ( Eung Jun Lee ),윤현성 ( Hyun Sung Yoon ),이초이 ( Cho I Lee ),이윤석 ( Yun Serk Lee ),홍성노 ( Sung Noh Hong ),이선영 ( Sun Young Lee ),성인경 ( In Kyung Sung ),심찬섭 ( Chan Sup Shim ) 대한소화기학회 2013 대한소화기학회지 Vol.62 No.4
Cytomegalovirus (CMV) infections are usually diagnosed in immunocompromised patients. A 74-year-old male without any significant medical history visited our center because of abdominal pain and diarrhea which began about a month ago. Abdominal computed tomography revealed segmental enhanced bowel wall thickening on jejunum and single-balloon enteroscopy showed multiple geographic shaped ulcerations covered with exudates on proximal jejunum. Biopsy samples taken during endoscopic examination demonstrated necrotic fibrinopurulent tissue debris and benign ulcer. Nested-PCR analysis of CMV DNA from jejunal tissue was positive. The patient was finally diagnosed with CMV jejunitis and was treated by intravenous ganciclovir for 14 days after which, abdominal pain and diarrhea improved. Our case shows that CMV jejunitis can occur in an immunocompetent adult as multiple jejunal ulcers which can be diagnosed using a single-balloon enteroscope. (Korean J Gastroenterol 2013;62:238-242)
이상헌 ( Sang Heon Lee ),홍성철 ( Sung Chul Hong ),김소미 ( So Mi Kim ),박중희 ( Jung Hee Park ),이정화 ( Jung Hwa Lee ),박유진 ( Eu Gene Park ),김해림 ( Hae Rim Kim ),한장수 ( Jang Soo Han ),홍미진 ( Mi Jin Hong ),이초이 ( Cho I 대한류마티스학회 2011 대한류마티스학회지 Vol.18 No.4
저자들은 피부근염 환자에서 경화부종이라는 드문 피부병변이 동반되어, 메토트렉세이트와 사이클로스포린 투여로 근육염 및 피부 경화부종이 호전된 예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Dermatomyositis (DM) is rare systemic inflammatory disease with typical skin manifestations and muscular involvement. Various skin lesions can accompany this disease, such as Gottron`s sign, Heliotrope rash, mechanic`s hands, V sign and shawl sign. Scleredema is a very rare skin manifestation in DM. We report a case of DM in a 63-year-old woman, who had scleredema on her thighs. A diagnosis of DM was established by clinical manifestation, elevated muscle enzyme levels, electromyogram measures, and muscle biopsy findings. She was successfully treated with the immunosuppressants methotrexate, cyclosporine, and steroids (low dose).
여성진 ( Sung-jin Yeo ),이초이 ( Cho-i Lee ),최용호 ( Yong-ho Choi ),김장군 ( Jang-goon Kim ),박현범 ( Hun-beom Park ) 한국정보처리학회 2014 한국정보처리학회 학술대회논문집 Vol.21 No.2
데스크탑,테블릿,스마트폰등 다양한 인터넷 접근방법과 크롬,사파리,파이어폭스등 다양한 브라우저가 사용됨에 따라 이런 여러 가지 인터넷 환경에 대응하기 위해 W3C에서는 HTML5를 권고하고 있으며 이에 따른 표준화를 진행하고 있다. 전 세계적으로 HTML5로의 전환을 빠르게 확산시키려는 움직임을 보이고 있으나 선도 기업을 제외한 공공기관 및 민간 기업에서는 전문 인력 부족,학습 비용투자 둥 여러 가지 문제로 인해 전환속도가 미흡한 실정이다. 본 논문에서는 HTML5에 대한 국내외 표준화 및 시장현황에 대해 기술하고,이를 기반으로 WYSIWYG HTML5 저작도구를 설계하였다.
투석전 만성신부전 환자에서 Epoetin-α와 Darbepoetin-α의 2주 1회 요법의 조혈효과 비교
김소영 ( So Young Kim ),최혜진 ( Hae Jin Choi ),최혜진 ( Hye Jin Choi ),이초이 ( Cho Ee Lee ),윤선웅 ( Seon Ung Yun ),박정환 ( Jung Hwan Park ),이종호 ( Jong Ho Lee ),송종오 ( Jong Oh Song ),조영일 ( Young Il Jo ) 대한신장학회 2010 Kidney Research and Clinical Practice Vol.29 No.5
Purpose: It is very important to correct renal anemia by erythropoiesis stimulating agents (ESA) be-cause anemia is associated with poor outcomes in chronic kidney disease (CKD) patients. We investigated whether once-biweekly (Q2W) treatment with epoetin- (EPO-) is as effective as Q2W darbe-poetin- (DA-α) in CKD patients who are not on dialysis. Methods: Fifteen CKD patients not receiving dialysis with renal anemia (M:F 6:9, age 60.1±7.2 years, eGFR-MDRD 15.7±6.4 mL/min/1.73m2, DM 46.7%) were enrolled. All patients received Q2W subcutaneous DA-α(40μg) for 10 weeks. After 6 weeks of wash-out period, patients were switched to Q2W subcutaneous EPO- (10,000 IU) for 10 weeks. Results: There were no significant differences in baseline parameters, such as hemoglobin (Hb), serum ferritin, and transferrin saturation, between before DA- therapy and before EPO-α therapy. Hb levels significantly increased after completion of ESA therapy (DA-α, 9.8±0.4 vs. 10.4±0.6 g/dL, p=0.001; EPO-α, 9.6±0.7 vs. 10.2±0.4 g/dL, p=0.003). After completion of ESA therapy, Hb levels did not reveal significant differences between two groups (p=0.123). Erythropoietin resistance index (8.2±1.6 vs. 8.4±1.5 IU/kg weight/g hemoglobin/week, p=0.136) and % increase of Hb (106.7±5.5 vs. 106.8±6.4%, p= 0.776) were not significantly different between DA-α therapy and EPO-α therapy. There were no signi-ficant adverse effects observed during study periods. Conclusion: These findings indicate that Q2W high dose (10,000 IU) of EPO-α therapy in CKD patients who are not on dialysis may be effective in maintaining Hb levels as Q2W DA-α therapy.