全南地方 育成豚의 穿孔疥癬蟲症 調査

李採瑢,朴永埈,李政吉,羅炳勝 한국수의공중보건학회 1990 예방수의학회지 Vol.14 No.3

Saanen 젖염소에서 발생한 Pasteurella multocida에의한 유방염 예

이채용,이정치,선재승,이윤경,박하연,김영철 한국임상수의학회 2007 한국임상수의학회지 Vol.24 No.3

Neurobehavioral Tests for Occupational Screening의 타당도 평가 : 파킨슨병 환자들의 검사 성적

이채용,Lee, Chae-Yong 대한예방의학회 1997 예방의학회지 Vol.30 No.3

이 연구는 최근 개발된 컴퓨터를 이용한 정신운동 기능 검사법인 Neurobehavioral Tests fur Occupational Screening(NTOS)의 타당도 평가를 위해 시도되었다. 일개 종합병원 신경과에 등록된 파킨슨병 환자 12명과 신경독성물질에 폭로된 적이 없는 근로자 21명을 대상으로 NTOS의 단순반응시간 검사, 2가지 선택반응시간 검사, 양 손의 수지타진검사를 실시하였다. 평균 단순반응시간은 근로자군은 245 msec, 환자군은 378 msec였으며, 2가지 선택반응시간은 근로자군은 444 msec, 환자군은 671 msec 로 나타나 T 검정에서 유의한 차이를 보였다. 주로 쓰는 손의 수지타진검사는 68.6회를 나타내었고, 파킨슨병 환자군은 51.6회, 주로 쓰지 않는 손은 각각 60.9회, 43.1회로 유의한 차이를 보였다. 환자군과 근로자군의 연령과 학력차이를 통계적으로 보정하고 두군에서 차이가 나는지를 알아보기 위해 공분산분석을 실시한 결과, 단순반응시간, 선택반응시간, 수지타진이 유의한 결과를 보였다. 이상으로 볼 때, NTOS는 정신운동기능의 장애를 발견할 수 있는 도구라고 생각된다. 그러나 선택반응 시간 검사의 실수 횟수 같이 상대적으로 민감하지 못한 지표에 대한 고려가 필요하며, 혼란변수를 연구 설계에서 조정할 수 있는 큰 규모의 연구와 정신운동기능의 잠재적 장애를 보이는 집단에 대한 연구들이 추후에 있어야 할 것이다. Validation and Standardization of neurobehavioral instrument in Korean occupational setting has not been studied ever. This study tried to validate the newly developed computerized psychomotor tests, Neurobehavioral Tests for Occupational Screening (NTOS). Male patients with Parkinson's disease(n=12) and male workers who never exposed to occupational neurotoxic materials and didn't have neurologic disease(n=21), performed some tests from NTOS; simple reaction time, choice reaction time(2 choice), and finger tapping(both hands). In simple analysis, difference between patient group and worker group was significantly great. Adjusted for age and education years, simple reaction time and finger tapping(both hand) were statistically significantly different between two groups(p<.05). Choice reaction time was also different(p<.1) but error frequency of choice reaction time test was not. Generally, this results showed NTOS could detect impairment of psychomotor function. But insensitive results of choice reaction time was partly due to small sample size and confounding variables and so required future study and refinement at improvement of NTOS.

견모낭충증(犬毛囊蟲症)의 동거감염(同居感染)에 관한 연구(硏究)(I)

이채용,이정길,서계원,Lee, Chai-yong,lee, Chung-gil,Seo, Gyeo-won 대한수의학회 1992 大韓獸醫學會誌 Vol.32 No.3

In order to obtain basic data concerning the treatment of canine demodicosis, 8 Doberman Pinschers were infected with Demodex canis. The clinical signs, were examined after infection, and their hematological and blood chemical values were determined, along with four non-infected control dogs of same breed. The number of white blood cells, especially the number of band neutrophils was significantly higher(p<0.01) in the infected than in the non-infected control dogs. This result indicated that the first episode of secondary infection should be treated with an appropriate antibiotics based on the culture and sensitivity test. The red blood cell counts, packed cell volume, hemoglobin contents, and serum albumin levels were significantly lower (p<0.01~0.001) in the infected than in the non-infected control dogs. These results suggested that the infected dogs had an anemia due to malnutrition. Thus, the infected dogs should be on a well balanced, high protein diet.

Psychosocial Wellbeing Index의 신뢰도 및 타당도

이채용,이종영,Lee, Chae-Yong,Lee, Jong-Young 대한예방의학회 1996 예방의학회지 Vol.29 No.2

정상적으로 일상생활을 영위하는 사람들을 대상으로 스트레스 수준을 가늠하고, 스트레스에 대한 조정기전을 밝히고자 하는 목적으로 개발된 사회 심리적 건강 측정 도구(PWI)의 신뢰도 및 타당도를 평가하기 위하여, 의과 대학생을 대상으로 4주간격으로 두 차례의 설문 조사를 실시하였다. 내적 일치도를 나타내는 Crohnbach's $\alpha$계수가 0.93의 값을 보였다. 4주의 간격을 둔 검사-재검사 신뢰도는 1차조사의 성적과 2차조사의 성적 사이 Pearson상관계 수가 0.72의 값을 보였다. 탐색적 인자 분석을 통해 고유값 1이상의 인자는 13개였다. 인자의 수를 4개로 지정하여 주축인자법과 직교 회전법으로 분석하여 인자 구조를 비교한 결과 첫번째 인자는 거의 일치하였으나, 3번째와 4번째 인자는 거의 일치하지 않았다. 확증적 인자분석을 통해 선행 연구의 4인자 모형과 이 연구의 탐색적 분석 결과에 나타난 4인자 모형의 적합도를 구한 결과 RMR값이 0.1미만인 것을 제외하고는 모든 적합도 지수가 부적합하게 나왔다 각 인자를 측정 변수로 간주하고 그 하부에 이론 변수로서 단일 인자가 존재하는 것으로 구성한 일차원적 단일 인자 모형에 대한 적합도는, 비록 이 모형이 오차 항의 상관성을 지닌 것이긴 하나 적합한 지수를 많이 보여, PWI가 2차원적 측정 구조를 가졌을 가능성을 제시하였다. To study reliability and validity of PWI, this newly developed self-administered questionnaire which measures stress, was given to medical students. All respondent(133) were followed 4 weeks later and 92 were retested. Cronbach's $\alpha$ coefficient of data was 0.93. Test-retest reliability measured by Pearson's correlation coefficient was 0.72(P<0.01). Exploratory factor analysis(EFA) performed by principal axis factor method without iteration and by varimax rotation explored 13 principal components(eigenvalues > 1). After exploring 4 factor structure according to previous study results, factor 1 showed good agreement but other factors did not. Confirmatory factor analysis(CFA) showed poor fit of 4 factor model to data. In the further study, it may be considered to model that has unidimensional factor structure.

광주지역에서 도태되는 홀스타인 소 유방의 병변 조사

이채용,김혜라,이정치,김상기,이정길,김종택,Lee, Chai-yong,Kim, Hye-ra,Lee, Jeong-chi,Kim, Sang-ki,Lee, Chung-gil,Kim, Jong-taek 대한수의학회 2003 大韓獸醫學會誌 Vol.43 No.2

Macroscopic investigations were made on the lesions of a total of 101 udders from slaughtered Holstein cows in Gwangju area. Incidence of supernumerary teats was 9.9%. Gross lesions were found in the surface of teats of 29.4% of cows; these lesions comprised papilomatosis (16.0%), fronds (8.9%) and injury at the tip (3.2%). Approximately 95% of the cows had slight to severe teat orifice keratosis. On the mucous membranes of the teat cisterns, fibrosis (22.7%) and congestion (8.9%) were observed. Gross lesions were found in the mammary glands of 68% of cows; these lesions comprised fibrosis (18.8%), serous exudate (4.9%), fatty tissue (4.9%), pus (4.0%), congestion (2.0%).

광주(光州)·전남지역내(全南地域內) 소의 바이러스성 질병(疾病)에 관한 혈청학적(血淸學的) 연구(硏究)

이채용,이정길,남선문,Lee, Chai-yong,Lee, Chung-gil,Nam, Sun-moon 대한수의학회 1995 大韓獸醫學會誌 Vol.35 No.3

Sera from 304 Holsteins or Korean native cattle were collected from slaughterhouse in Kwangju area to study the infection of major virus-borne diseases. Serum antibody titers against infectious bovine rhinotracheitis virus(IBRV), bovine viral diarrhea virus(BVDV), parainfluenza type-3 virus(PI-3V), bovine ephemeral fever virus(BEFV), bovine Ibaraki virus(BIV), bovine Akabane virus(BAKV), bovine rotavirus(BRV), bovine coronavirus(BCV) were measured by serum neutralization tests. Results which obtained were as follows. Sera from 280 cattle(92.1%) contained antibodies against BRV which rate was the highest among the 8 viruses, and serum antibodies against BCV, BVDV, BIV, BAKV, BEFV, IBRV and PI-3V were detected from 266(87.5%), 149(49%), 108(35.5%), 94(30.9%), 80(26.3%), 32(10.5%) and 24(7.9%) cattle, respectively. Prevalence of seropositives to BVDV, BIV, BAKV, BEFV were higher among Holsteins than among the Korean native cattle(P<0.05). Prevalence of antibody titers against BVDV, BIV and BEFV in Korean native cattle were higher among females than males, while more males contained antibodies to BAKV, IBRV and PI-3V than females in their blood(P<0.05). Seropositives to BVDV, BIV, BAKV, BEFV and IBRV in Holsteins were higher among females than males(P<0.05). In Korean native cattle, serum antibody titers against IBRV and PI-3V ranged from 1:2~1:32 and 1:2~1:64, respectively, while serum antibody titers against the rest 6 viruses ranged from $1:2{\sim}1:{\geq}256$. In Holsteins, serum antibody titers against IBRV and PI-3V ranged from 1:2~1:64 and 1:2~1:32, respectively, while serum antibody titers against the rest 6 viruses ranged from $1:2{\sim}1:{\geq}256$.

진돗개에서 ivermectin의 독성 I. 임상증상과 혈액학적 변화 관찰

이채용,오석일,이정길,Lee, Chai-yong,Oh, Seok-il,Lee, Chung-gil 대한수의학회 1997 大韓獸醫學會誌 Vol.37 No.4

Ivermectin is a synthetic derivative of the naturally occurring avermectin $B_{1a}$ (22, 23-dihydroavermectin $B_{1a}$) and $B_{1b}$ (22, 23-dihydroavermectin $B_{1b}$), It is widely used as antiparasitic and pesticidal agents because of its remarkably potent and broad spectrum of antiparasitic activity. Although the drug has shown excellent anthelmintic effects, development of toxicosis in some animals such as the Collie species of dog is well documented. However, no studies have been reported on the toxic effects of the drug in Korean native animals such as the Jindo dog. The toxic effect of ivermectin was evaluated in 25 Jindo dogs divided into five groups which were orally administered with ivermectin at dosage levels of $200{\mu}g/kg$, $300{\mu}g/kg$, $600{\mu}g/kg$ and $2,500{\mu}g/kg$ of body weight, respectively. Toxic signs were not observed in the groups receiving $200{\mu}g/kg$ and $300{\mu}g/kg$ B.W. ivermectin. One dog developed mild clinical signs of toxicosis in the group receiving $600{\mu}g/kg$ dosage of ivermectin. In the group with $2,500{\mu}g/kg$ dosage, all dogs developed mild (salivation, drooling, vomiting, mydriasis, and/or confusion) and/or moderate (ataxia and tremors) clinical signs of toxicosis. Hematologic changes were not observed in the groups receiving $200{\mu}g/kg$, $300{\mu}g/kg$ and $600{\mu}g/kg$ B.W. ivermectin. In the groups receiving $2,500{\mu}g/kg$ B.W., total erythrocyte counts, total and differential leukocyte counts and hemoglobin levels were not affected by drug. Aspartate aminotransferase levels were increased after administration of ivermectin, while serum cholesterol and blood glucose levels were decreased.

Demodex canis 감염이 화학적으로 유발된 지연형 피부과민증에 미치는 영향

이채용,함현우,이정길,서계원,Lee, Chai-yong,Ham, Hyeon-woo,Lee, Chung-gil,Seo, Kye-won 대한수의학회 1995 大韓獸醫學會誌 Vol.35 No.4

To observe the effect of Demodex canis infection on the cellular immune response and hematological profile, 8 Doberman pinschers experimentally infected with D cains and 4 uninfected control dogs were sensitized with 2, 4-dinitro-chlorobenzene(DNCB) on the skin and were challenged with DNCB 14 days after the initial sensitization to elicit allergic contact dermatitis. Histological and hematological changes of these dogs were then observed. Macroscopic changes of skin challenged with DNCB in D canis-infected dogs included significantly reduced area of allergic reaction(p<0.05) than in uninfected control group. Infiltration of inflammatory cells in the D canis-infected group was also significantly reduced(p<0.05) than in the uninfected control group. These changes indicated that the cell-mediated immune response of the animals was suppressed by the infection with D canis. Total white blood cell count in dogs infected with D canis was increased when dogs were sensitized with DNCB (p<0.01). The result appeared to be caused by stress due to D canis infection, secondary bacterial infection and decreased efficacy of general body defense system. Blood eosionophils were increased in D canis-infected dogs which appreared to be caused by the allergic contact dermatitis. Blood chemistry analysis revealed that total protein and globulin were increased(p<0.05), while albumin level was decreased. This result appeared to be caused by secondary bacterial infection.

Mycobacterium bovis 감염(感染)이 화학적(化學的)으로 유발(誘發)된 지연형(遲延型) 피부과민증(皮膚過敏症)에 미치는 영향(影響)

이채용,이정길,박영준,Lee, Chai-yong,Lee, Chung-gil,Park, Young-jun 대한수의학회 1986 大韓獸醫學會誌 Vol.26 No.2

In order to evaluate the effects of the cell-mediated immunity of the animal in the chronic diseases the guinea pigs and rabbits were inoculated with Mycobacterium bovis. After 6 weeks these animals were sensitized and challenged with 2,4-dinitrochlorobenzene. The cutaneous reactions observed in these animal species were similar each other. Macroscopic and microscopic responses in the animal experimentally infected with M. bovis were markedly reduced compared to those in the control animals. The results indicated that the cell-mediated immunity of the animals was depressed by infection of M. bovis.