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실험적(實驗的) 당뇨병(糖尿病)에 대(對)한 옥천산(玉泉散) 및 파채자의 효과(效果)
이창근,Lee, Chang-Geun,Lee, Bong-Kyo 대한한방내과학회 1994 大韓韓方內科學會誌 Vol.15 No.2
In order to investigate the effects of Okchunsan (Sample A), Gamiokchunsan (Sample B) and Spinacia oleracea L. (semen: Sample C) on streptozotocin-induced diabetic rats, the experimal study was performed on the levels of glucose, insulin, total cholesterol, triglyceride, total protein, albumin, blood urea nitrogen (BUN), electrolytes $(Na^+,\;Ka^+,\;Cl^-)$, GOT and GPT in serum, hemoglobin, hematocrit, urine volume, glucose and protein in urine, body weight, liver and kidney weight. The results were obtained as follows: 1. Serum glucose levels were significantly decreased in Sample A. B and C group and serum insulin levels were increaseclin Sample A and B group. 2. Serum total cholesterol levels were recovered as the normal value in Sample A, B and C group and serum triglyceride levels were decreased in Sample A and C group. 3. Serum total protein levels were increased in Sample C group, BUN levels were decreased in Sample A and C group. 4. Serum $Na^+\;and\;Cl^-$ levels were increased, $K^+$ levels were decreased in Sample A, B and C group. 5. Serum GOT and GPT levels were remarkedly decreased in Sample A, B and C group. 6. Urine volume, urine glucose and protein levels were decreased in Sample A, B and C levles. 7. Body Weight showed a tendancy of increasing in Sample A, B and C group. 8. Levels of serum albumin, hemoglobin, nematocrit, liver and Kidney weight were not significantly changed. According to above results, Okchunsan, Gamiokchunsan and spinacia oleracea L. (Semen) were expected to be applied to the treatment of diabetes mellitus and its complications.
이창근,윤정방,Lee, Chang Geun,Yun, Chung Bang 대한토목학회 1987 대한토목학회논문집 Vol.7 No.4
직립원통형 액체저장탱크가 지진하중을 받을 때, 벽면 유연성이 벽면에 작용하는 유동압력에 미치는 영향에 대해 연구하였다. 탱크 구조물은 환(ring)형 유한요소를 사용하여 이상화하였으며, 유동에 대한 해는 Laplace 방정식을 이용하여 구하였다. 쉘-유체계의 운동방정식은 자유표면거동과 벽면유연성의 상관효과까지 포함하여 구성하였으며, 이에 따른 쉘 거동과 자유표면거동에 대한 자유진동모우드를 해석하는 방법이 개발되었다. 예제해석으로는, 구조적 특성이 다른 몇개의 저장탱크에 대해, 응답스펙트럼 해석법과 시간영역 해석법을 사용하여 동적응답을 구하였고, 그 결과들을 비교 분석하였다. In this paper the liquid sloshing effects in vertical storage tanks under earthquake loadings are studied. The study focuses on the investigation of the effect of the flexibility of the tank wall on the hydrodynamic forces exerted on it. The tank structure is modelled using finite elements. The motion of the liquid is expressed by the Laplace equation. The equation of motion of the fluid shell system is formulated including the coupling effect between the shell motion and the sloshing motion. A procedure is developed to obtain the natural frequencies and the mode shapes of the sloshing motion as well as the shell vibration. Dynamic analyses have been carried out for several tanks with different dynamic characteristics utilizing the time history method as well as the response spectra method.
저췌(猪膵)를 가미한 세당환변방(世糖丸變方)이 Streptozotocin으로 유발된 흰쥐의 실험적 당뇨에 미치는 영향
이창근,소경순,정찬길,Lee, Chang-Geun,Soh, Kyeong-Sun,Jeong, Chan-Gil 대한약침학회 2007 Journal of pharmacopuncture Vol.10 No.3
Objectives We performed this study in order to investigate the effects of Sedang-Hwan(世糖丸) and modified Sedang-Hwan(世糖丸變方)on the diabetes mellitus. Methods We injected a vein with 65mg/kg of streptozotocin(STZ) on the rats. And then administered Sedang-Hwan(Sample 1 group); 18.7mg/kg/day, modified Sedang-Hwan; 16.5mg/kg/day(Sample 2 group) to Sample groups and observed the body weight, glucose and insulin levels. Results 1. The Sample 1, 2 groups showed a high suppressive effect of body weight loss compared to Control group. 2. The Sample 1, 2 groups’ glucose level showed a effective in lowering level compared to Control group. 3. The sample 1, 2 groups showed a higher insulin level than Control group. Conclusions Conclusively, modified Sedang-hwan was recognized to have decrease effect of serum glucose of the diabetic rats induced by streptozotocin. It is also required to study on the further detailed mechanism of decrease effect of serum glucose by modified Sedang-hwan.