산업재해에 의한 안외상에 대한 역학적 고찰

이지은,김수영,이승욱,이상준,Ji Eun Lee,MD,Soo Young Kim,MD,Seung Uk Lee,MD,Sang Joon Lee,MD 대한안과학회 2013 대한안과학회지 Vol.54 No.1

Purpose: To investigate the epidemiological and clinical characteristics of industrial ocular trauma for treatment application and prevention. Methods: A retrospective survey of 207 eyes from 206 patients who visited Gosin University Gospel Hospital from January 1, 1998 to December 31, 2007 was performed. The age, sex, diagnosis, causes, injury site, primary ocular surgery, duration of hospitalization and treatment, and initial and final visual acuities were reviewed using the United States Eye Injury Registry (USEIR) form based on the Birmingham Eye Trauma Terminology (BETT). Results: The trauma incidence was higher in males (95.65%) in their forties (50.24%). The mean patient age was 41.5 years. Separately counted lesions were presented as a proportion to total injured eyes. The most common diagnosis of industrial ocular traumas was global injuries (124.1%), orbital wall fractures (6.3%), adnexal trauma (5.3%) and optic nerve injuries (3.4%). The most common cause of ocular injuries was flying iron piece (28.67%), and the cornea was the most frequent injured site (69.1%). In 43% of the patients, surgical treatments were performed and the most common surgery was primary closure of the cornea or sclera (82.02%), followed by vitrectomy (30.33%). The average of initial and final visual acuity (log MAR) was 1.2 and 0.93, respectively. In 69.7% of all patients, the final visual acuity was improved or stabilized compared to the initial status. Conclusions: Flying objects are still the most frequent cause of industrial ocular trauma and in approximately 70% of all patients, the final visual outcome improved or stabilized compared to the initial status. These types of ocular traumas can be significantly reduced by wearing protector shields along with educational safety programs.

건강행위 이행율에 따른 대사증후군 발생 위험요인 변화

이지은,이은주,Lee, Ji Eun,Lee, Eun Joo 한국데이터정보과학회 2017 한국데이터정보과학회지 Vol.28 No.3

본 연구는 일개 보건소 대사증후군 관리프로그램에 참여한 대상자의 건강행위 이행율에 따른 대사증후군 위험인자의 변화정도를 평가하기 위해 수행되었다. 대상자는 K도 G시 일개 보건소의 대사증후군 관리 프로그램에 자발적으로 참여한 168명이며, 자료수집은 2015년 1월부터 6월까지 이루어졌다. 연구결과 대상자의 건강행위 이행율은 프로그램 적용후 3개월과 6개월에 각각 약 62%, 66%이었으며, 건강행위의 실천개수가 많을수록 대상자의 대사증후군 발생위험도는 더 낮아졌다. 또한 건강행위 실천개수가 적더라도 건강행위를 지속적으로 하는 고이행군의 경우 대사증후군 위험인자가 유의하게 더 낮아지는 결과가 나타났다. 이로써 대사증후군의 관리에는 건강행위 실천개수도 중요하지만, 적은 실천개수 일지라도 꾸준히 지속적으로 건강행위를 실천하는 것이 중요하다고 할 수 있다. 따라서 대사증후군의 예방 및 관리를 위해서는 단기간 많은 건강행위를 하는 것보다 적은 개수라도 꾸준히 건강행위를 실천할 수 있도록 하는 전략을 개발하는 것이 필요하다는 것을 제안하는 바이다. The purpose of this study was to identify the changes in the risk factors of metabolic disease by compliance rate and numbers of health behaviors performed in the people who voluntarily participated in the metabolic disease management program implemented in a public health care center. Data were collected from a total of 168 people, January to June of 2015. Data were analyzed by paired t-test and ANOVA with post hoc test. The compliance rates were about 62% and 66% at 3 and 6 months respectively after implementing the program. Although the numbers of health behaviors performed was small, the participants with high compliance rate had significantly lower risk factors of metabolic disease after 6 months. Therefore the compliance rate is critically important to manage metabolic disease and enhancing compliance rate of health behaviors should be developed and investigated in the future studies.

덱사메타존과 디클로페낙이 각막실질세포에 미치는 영향

이지은,이승욱,김종환,이종수,Ji-Eun Lee,M,D,Seung-Uk Lee,M,D,Jong Hwan Kim,M,D,Jong Soo Lee,M,D 대한안과학회 2005 대한안과학회지 Vol.46 No.1

Purpose: To evaluate the inhibitory effect of dexamethasone and diclofenac on the proliferation of cultured human keratocytes, and to investigate the apoptotic response and the cellular morphologic changes associated with dexamethasone and diclofenac in vitro. Methods: Human corneal keratocytes were exposed to 0.05, 0.1, 0.2, 0.4, 0.8, 1.6, and 3.2 mM concentration of dexamethasone and diclofenac for 4, 24, and 48 hours. MTT based calorimetric assay, flow cytometric analysis, fluorescent micrograph, inverted phase-contrast micrograph, and electron microscopy were used to evaluate the results. Results: The inhibitory effect of human keratocyte proliferation increased at higher concentrations and longer exposure times of dexamethasone and diclofenac (p<0.05). In flow cytometry, the maximal apoptotic response developed at 0.4 mM concentration of dexamethasone and 1.6 mM concentration of diclofenac after 4 hours. Apoptotic cells were demonstrated in fluorescent micrograph. Dexamethasone-treated cases showed a more damaged appearance, more swollen rather than spindle shaped, with greater detachment from the bottom of the dish and the chromatin of the nuclear remnant condensed along the nuclear periphery with cytoplasmic vesication and cytoplasmic blebs formation, and partial disruption of the nuclear membrane compared with diclofenac. Conclusions: The apoptotic response of dexamethasone and diclofenac is associated with the inhibitory effect of human corneal keratocyte proliferation. For inhibition of cellular proliferation of human corneal keratocytes, dexamethasone may be more effective at lower concentration and shorter exposure time than diclofenac.

각막궤양에서 양막이식술 후 발생한 각막혼탁 감소를 위한 각막문신

이지은,이승욱,김지홍,전종배,엄부섭,이종수,Ji Eun Lee,Seung Uk Lee,Ji Hong Kim,Jong Bae Jun,Boo Sup Oum,Jong Soo Lee 대한안과학회 2006 대한안과학회지 Vol.47 No.9

Purpose: To report on the cosmetic efficacy of corneal tattooing using India ink in cases where amniotic membrane grafting was performed to promote corneal wound healing in corneal ulcers. Methods: Amniotic membrane grafting of corneal ulcers was carried out in three patients with no expectation of visual recovery. After corneal reepithelization, a 30 G needle filled with India ink was placed into the amniotic membrane space between the regenerated corneal epithelium and the stromal bed, and the ink was then carefully injected. Results: The staining of corneas to the appropriate opacity with India ink was successful in all cases. There were no significant complications during the mean follow up period of 17 months. All the patients were well satisfied with the corneal staining. Conclusions: When corneal opacity occurs subsequent to an amniotic membrane graft for a corneal ulcer, this corneal tattooing with an intrastromal injection of India ink into the amniotic membrane space might be a very useful method to achieve a good cosmetic result.

(R)-(-)-Linalool 유도체의 합성과 향취에 관한 고찰

이지은,김지은,안철진,Lee, Ji-Eun,Kim, Ji-Eun,Ahn, Chuljin 대한화학회 2021 대한화학회지 Vol.65 No.6

수소화-탈수소화법을 이용한 탄탈륨 스크랩으로부터 탄탈륨 분말 제조 연구

이지은,이찬기,박지환,윤진호,Lee, Ji-eun,Lee, Chan Gi,Park, Ji Hwan,Yoon, Jin-Ho 한국자원리싸이클링학회 2018 資源 리싸이클링 Vol.27 No.5

For recylcing of high purity tantalum (Ta) scrap, We investigated manufacture of tantalum powder using hydride-dehydride (HDH) process. Tantalum had excellent properties such as ductile, hardness and high melting point. Usually these properties made difficult to make a powder. In this study, Tantalum powder was manufactured using Tantalum hydride via hydridation. Tantalum hydride was formed at $500^{\circ}C$, 5 hr/$700^{\circ}C$, 3 hr and it is easy to make a tantalum hydride powder because hydrogen in the tantalum act as a defect dislocation and lattice expansion. The powder was pulverized to a size of less than $10{\mu}m$ under a condition of 1300 rpm, 30 min using a ring mill, and tantalum powder with less than 50 ppm hydrogen was prepared through dehydridation in an Ar and low vacuum atmosphere.

신증후군 환아에서 스테로이드 유발 대사성 골질환에 대한 Alendronate의 치료 효과

이지은,이현옥,백경훈,이숙향,진동규,Lee Ji-Eun,Lee Hyun-Ok,Paik Kyung-Hoon,Lee Suk-Hyang,Jin Dong-Kyu 대한소아신장학회 2004 Childhood kidney diseases Vol.8 No.1

목 적 : 소아 신증후군에서 스테로이드 장기투여에 따른 대사성 골질환은 흔한 합병증 중의 하나이다. 저자들은 성인에서의 스테로이드 유발성 골다공증 치료에 유효한 bisphosphonate(alendronate)를 투여하여 소아 신증후군에서 스테로이드 유발 대사성 골질환에 대한 치료효과에 대해 전향적으로 평가하고자 하였다. 방 법 : 신증후군 이환 기간이 2년된 5-8세의 환자 58명에게 DEXA로 골밀도를 측정하여 요추 골밀도가 Z-score -1 이하인 환아 30명(51.7%)을 대상으로 선정한 후 이들을 alendronate 주 1회 투여군, calcitriol 투여군, 약제 비투여군등의 세 군으로 분류하여 1년간 연구하였다. 치료 6개월, 1년에 요추 L1-L4 골밀도를 측정하였고 치료 전과 치료 1년 후 생화학적 검사를 측정하였다. 각 군간 평균 연령, 기저 요추 골밀도, 스테로이드 축적량, 골밀도% 변화율, 요추 골밀도 Z-score를 측정 분석하였다. 결 과 : 총 30명 환자에서 기본 요추 골밀도 측정시 환아의 나이는 $7.4{\pm}1.7$세였고 신증후군 이환기간은 $2.2{\pm}1.2$년이었다. Z-score로 진단된 골밀도 감소증은 23명(76.7%), 골다공증은 7명(23.3%)이었다. 각 생화학적 변수들은 치료 전후로 차이가 없었으며, 군 간에도 유의한 차이가 없었다(P>0.05). 빈번 재발형 신증후군과 스테로이드 의존형 신증후군은 22명(73.3%)으로 드문 재발형 신증후군 8명(26.6%)에 비해 대사성 골질환의 빈도가 높았다. 골밀도 변화율은 alendronate 군에서 치료 1년에 8.56%였고, calcitriol군은 5.79% 증가를 보였으며, 비투여군은 1.9%증가를 보였다. Z-socre 변화는 alendronate 군과 calcitriol 군에서만 호전되었고, 비투여군에서는 감소하였다. 골밀도 증가율은 각 군간 유의한 차이를 보였지만(P=0.0002), alendronate 군과 비투여군, calcitriol 군과 비투여군 간에 있었고(P<0.05), alendronate 군과 calcitriol 군간에는 유의한 차이가 없었다. Alendronate 투여시 약복용을 중단할 만큼의 심각한 부작용은 발현되지 않았다. 결 론 : 소아 신증후군 환자에서 고용량의 스테로이드를 투여해야 하는 경우 대사성 골질환의 발생 위험이 높기 때문에 정기적인 골밀도 측정이 필요하며, 그 평가 도구로는 요추 골밀도 Z-score가 유용함을 알 수 있었다. 또한 신증후군 환아의 스테로이드 유발 대사성 골질환에서 alendronate 주 1회 경구투여는 요추 골밀도를 증가시키는 효과적인 치료법이었다. Purpose : Children with nephrotic syndrome(NS) are under high risk for metabolic bone disease(MBD) as a complication of long-term glucocorticoid therapy. We prospectively evaluated the effect of oral bisphosphonate(alendronate) therapy in children with NS, which has proven efficacy in adult patients with glucocorticoid induced MBD. Methods : Among 58 children with NS, aged 5 to 8 years and haying a disease duration of more than 2 years, 30(51.7%) were enrolled to meet the selection criteria, less than -1.0 Z-scores of lumbar spine bone mineral density(BMD) by dual energy X-ray absorptiometry (DEXA). These 30 children were divided into three groups and each were assigned to receive alendronate, calcitriol, and no-medication, respectively for one year. Lumbar spine BMD was followed up every 6 months and the biochemical indexes were measured before and 1 year after the treatment. There were no significant difference among groups with respect to the average age, the initial BMD, and the cumulative steroid doses. Analysis of the treatment efficacy was done by the % change of BMD and by the changes in Z-scores of lumbar spine BMD. Results : Mean age and disease duration of patients at the initial lumbar spine BMD evaluation was $7.4{\pm}1.7$ years and $2.2{\pm}1.2$ years, respectively. Twenty-three of 30 children(76%) had osteopenia, and seven(23%) had osteoporosis. There was no difference in the biochemical values among the groups, before and 1 year after the treatment(P<0.05). Twenty two children(73.3%) with frequent relapsing or steroid dependant NS had more frequent MBD, compared to the 8 children(26.6%) with infrequent relapsing NS. The one year % changes of BMD were 8.56 in alendronate group, 5.79 in calcitriol group, and 1.9 in no-medication group. The changes in Z-score of lumbar spine BMD increased in the alendronate group and the calcitriol group, but not in the no-medication group. One year % changes of BMD were different among groups(P=0.0002). Significant differences were found between the alendronate and the no-medication group, and between the calcitriol and the no-medication group(P<0.05). There was no difference between the alendronate and the calcitriol group. No serious adverse effect was observed in the alendronate group. Conclusion : Children with NS receiving high dose steroids are under the high risk of BMD and should undergo regular BMD evaluation. Z-score of lumbar spine BMD was a useful parameter in diagnosing low bone mass in children. Alendronate weekly oral therapy was effective and relatively safe in increasing the lumbar spine BMD in children with NS having steroid induced MBD.

미세변화형 신증후군(MCNS)으로부터 국소성 분절성 사구체 경화증(FSGS)으로 이행된 환아의 임상양상

이지은,육진원,이의성,김지홍,김병길,정현주,Lee Ji Eun,Yook Jinwon,Lee Eui Seong,Kim Ji Hong,Kim Pyung-Kil,Chung Hyun Joo 대한소아신장학회 2000 Childhood kidney diseases Vol.4 No.1

목 적 :소아의 원발성 신증후군 중 $85\%$이상을 차지하는 미세변화형 신증후군(MCNS)은 스테로이드 치료로 완전 관해가 잘 오는 예후가 양호한 질환이다. 반면 국소성 분절성 사구체 경화증(FSGS)은 치료에 잘 반응하지 않고 신부전으로의 진행 및 신이식 후의 재발률이 높아 장기 예후가 나쁜 것으로 알려져 있다. 신생검상 MCNS로 진단된 환아 중 여러 약물 요법에 반응이 불량하거나 증세의 악화가 있어 추적 관찰하며 시행한 2차 신생검상 FSGS로 조직 소견의 변화를 보이는 경우가 드물게 있어 본 저자들은 이들의 임상 양상의 특징을 비교 고찰하여 MCNS로부터 FSGS로 이행될 수 있는 위험 요인을 알아보고자 본 연구를 시행하였다. 대상 및 방법 : 1988년 1월부터 1999년 5월까지 세브란스 병원 소아과에서 신장생검 상 미세변화형 신증후군 및 국소성 분절성 사구체 경화증으로 진단받고 치료 중인 환아 296명을 대상으로 하였다. 조직 병리 소견상 미세변화형 신증후군을 보인 군(MCNS군), 국소성 분절성 사구체 경화증을 보인 군(FSGS군)및 MCNS로부터 FSGS로 이행된 군(이행군)등 3개 군으로 나누어 이들 각 군의 임상 양상 차이를 비교하였다. 결 과 : 대상 환아는 MCNS군 241명($81.4\%$), FSGS군 47명($15.9\%$), 이행군 8명($2.7\%$)으로 총 296명 이었으며, 평균 발병 연령은 MCNS군 $6.0{\pm}2.6$세, FSGS군 $7.2{\pm}4.3$세, 이행군 $8.3{\pm}2.6$세였고, 남녀비는 MCNS군 3.7:1, FSCS군 1.8:1, 이행군 3:1이었다. 내원 당시의 혈뇨, 고혈압, 24시간 뇨단백량, 혈청 알부민, 혈청 콜레스테롤, 혈청 크레아티닌 등을 비교하였으며, 이중 이행군:FSGS군 간의 비교에서 24시간 뇨단백량 $686:342mg/m^2/hr$(P<0.05), 혈청 알부민 1.92:2.47g/dL(P<0.05), 혈청 콜레스테를 494:343 mg/dL(P<0.05)으로 의미있는 차이를 보였고, 이외에는 이행군과 FSGS군 또는 MCNS군과의 사이에 의미있는 차이를 보이지는 않았다. 스테로이드 치료에 전혀 반응을 보이지 않는 경우는 MCNS군 $13.3\%$,이행군 $12.5\%$,FSGS군 $59.6\%$로 FSGS군이 의미있게 많았으며(P<0.05), 스테로이드 이외의 면역억제제 치료가 필요했던 경우는 MCNS군 $58.5\%$, 이행군 $100\%$, FSGS군 $80.8\%$로 MCNS군에 비해 이행군과 FSGS군이 의미있게 높았다(P<0.05). 평균재발횟수는 MCNS군 $0.84{\pm}0.21$회/6개월, 이행군 $1.07\pm}0.53$회/6개월로 의미있는 차이는 없었으며, 관해에서 첫 재발까지의 기간 역시 MCNS군 6.94${\pm}$1.92개월, 이행군 $6.71{\pm}4.89$개월, FSGS군 $5.27{\pm}12.48$개월로 각 군간의 의미있는 차이는 없었다. 결 론 : 미세변화형 신증후군에서 치료 경과중 국소성 분절성 사구체 경화증으로 이행된 예는 전체 MCNS의 249명중 8명으로 $3.2\%$였다. 이들의 임상양상의 특징을 비교 고찰한 결과 이행여부를 예측할 수 있는 위험요인은 없었다. 미세변화형 신증후군으로 진단된 환아 중에서 스테로이드 치료에 반응이 없거나 자주 재발하는 경우, 또는 강력한 면역치료에도 관해가 오지 않는 경우 등에는 신장 조직 생검을 재시행하여 국소성 분절성 사구체 경화증으로의 이행 여부를 확인해야 하겠다. Purpose: MCNS is found in approximately $85\%$ of the idiopathic nephrotic syndrome in children and shows good prognosis with initial steroid therapy. However in FSGS, there is poor prognosis with initial therapy and shows higher rate of progression to chronic renal failure and relapse after kindney transplantation. We have experienced 8 patients who were diagnosed as MCNS on initial renal biopsy and then progressed to FSGS on follow-up biopsy. So we have investigated their clinical course and risk factors for transition of MCNS to FSGS. Methods: We conducted a retrospective study with a review of histopathologic findings and clinical manifestations of 296 cases of MCNS and FSGS that were diagnosed from January 1988 to May 1999. We classified them into 3 groups according to the histopathologic finding; MCNS, FSGS, MCNS progressed to FSGS in follow-up biopsy. Results: The number of children was 296 cases comprising 241 cases($81.4\%$) showing MCNS, 8 cases($2.7\%$) transition group, 47 cases($15.9\%$) FSGS. The mean onset age was $6.0{\pm}2.6$years in MCNS, transition group $8.3{\pm}2.3$years, FSGS $7.2{\pm4.3$years, and the gender (M:F) ratio was 3.7:1 in MCNS, 3:1 in transition group, 1.8:1 in FSGS. Comparing the presence of initial hematuria, hypertension,24 hour urine protein, serum albumin, serum creatinine, there were significant difference between the transition group and the FSGS group in the following points; 24hour urine protein $684:342mg/m^2/hr$(P<0.05), serum albumin 1.92: 2.47g/dL(P<0.05), serum cholesterol 494:343mg/dL(P<0.05). Refractoriness to steroid therapy was 13.3$\%$ in MCNS. $12.5\%$ in transition group, $29.6\%$ in FSGS; significantly higher in FSGS(P<0.05). Immunosuppressant therapy was performed in $58.5\%$ of MCNS, $100\%$ in transition group, $80.8\%$ in FSGS; transition group showed significantly higher .ate(P<0.05) comparing with MCNS. Mean number of relapse and duration from onset to first relapse showed no significance difference between these groups. Conclusion: 249 patients with MCNS have been followed and $3.2\%$ (8 patients) of them has shown change in pathologic diagnosis from MCNS to FSCS. The risk factor for transition could not be found. Our results point to the need for a follow-up biopsy to certify the possibility of transition to FSCS in some MCNS cases with refractory cases to steroid therepy, frequent relapsing cases, or in case of no remission in spite of vigorous immunosuppressant therapy.

A change of sinus floor level related to the amount of grafted material after bone added osteotome sinus floor elevation (BAOSFE) technique: A radiographic retrospective study

이지은,박소민,이종빈,방은경,Lee, Ji-Eun,Park, So-Min,Lee, Jong-Bin,Pang, Eun-Kyoung The Korean Dental Association 2017 대한치과의사협회지 Vol.55 No.11

Purpose: The purpose of this article is to evaluate a change o bone level on the sinus floor by a bone added osteotome sinus floor elevation (BAOSFE) technique, according to the amount of deproteinized bovine bone mineral (DBBM). And Changes in augmented bone height after BAOSFE procedure were also assessed for 6 months after the implant procedure. Materials and Methods: Forty eight single implants were placed in the posterior maxilla using BAOSFE technique. The implantation sites were classified into two groups according to the amount of grafted DBBM, 0.25 group (0.25g) and 0.5 group (0.5 g). Panoramic views or cone-beam computed tomography (CBCT) were taken at the time of implant placement with BAOSFE and after at least 6 months to assess the bone level changes in the elevated sites with DBBM. Results: Alveolar bone level around all implants was stable clinically and radiographically during the follow-up. Mean augmented bone height was $5.21{\pm}0.94mm$ in 0.25 group and $6.92{\pm}1.19mm$ in 0.5 group. Statistically significant difference in augmented bone height was found in the comparison between the 0.25 group and 0.5 group at the time of surgery. There was a positive correlation between the length of the implant protruding into the maxillary sinus and the augmented bone height. After 6 months, mean reduction of augmented bone height was $0.50{\pm}0.34mm$ in 0.25 group and $0.41{\pm}0.30mm$ in 0.5group. There was no specific correlation between the reduction of augmented bone height and amount of grafted DBBM. Conclusion: Within the limit of this study, the amount of grafting materials and the protrusion length of implant into the maxillary sinus affect the amount of the augmented bone height.

유용 미생물 제제 이용 발효 유채박 비료 제조 및 시용 효과

이지은,박원,김광수,이영화,권다은,문윤호,차영록,강용구,Lee, Ji-Eun,Park, Won,Kim, Kwang-Soo,Lee, Yong-Hwa,Kwon, Da-Eun,Moon, Youn-Ho,Cha, Young-Lok,Kang, Yong-Ku 한국작물학회 2019 한국작물학회지 Vol.64 No.1

Rapeseed meal, which is a byproduct of rapeseed oil extraction, improves crop productivity by supplying nutrients to the soil. The present study aimed to manufacture fermented rapeseed meal compost using two effective microbial agents and evaluate their efficiency as fertilizer. To types of fermented rapeseed meal, manufactured using either a bio-carrier or microbial agent, showed no differences in pH, electrical conductivity (EC), and total nitrogen content. However, the contents of $NH_4-N$ and $NO_3-N$ as inorganic nitrogen were increased by 5.6 times and 1.5 times, respectively, after 5 d of fermentation. Rapeseed meal fermented for 5 d was applied to tomato a basal fertilizer and after eight weeks, the plant height increased in all fermented rapeseed treatments compared to that in the chemical fertilizer treatment, and also the quantum yield of photosystem II (PS II) showed the same trend. The total nitrogen content of tomato leaves treated with a microbial fermented rapeseed meal was twice as high as that of that treated with a chemical fertilizer. It was confirmed that the increase in the tomato height was an effect of the rapeseed meal containing inorganic nitrogen, which can easily be absorbed by plants. From these results, it is considered that fermented rapeseed meal manufactured with an effective microbial agent for 5 d showed the highest inorganic nutrient content and greatest growth enhancement in tomato.