Simultaneous Assessment of Left Ventricular Function and Coronary Artery Anatomy by Third-generation Dual-source Computed Tomography Using a Low Radiation Dose

이지원,Kyung Jin Nam,김진유,정연주,이지원,So Min Park,Soo Jin Lim,추기석 한국심초음파학회 2020 Journal of Cardiovascular Imaging (J Cardiovasc Im Vol.28 No.1

BACKGROUND: To assess left ventricular function and coronary artery simultaneously by third-generation dual-source computed tomography (CT) using a low radiation dose. METHODS: A total of 48 patients (36 men, 12 women; mean age 57.0 ± 9.5 years) who underwent both electrocardiography-gated cardiac CT angiography (CCTA) using 70–90 kVp and echocardiography were included in this retrospective study. The correlation between left ventricular end-diastolic volume (LVEDV), left ventricular end-systolic volume (LVESV), and left ventricular ejection fraction (LVEF) measured using CCTA and echocardiography was determined. The quality of coronary artery images was analyzed using a 4-point scale (1, excellent; 4, poor). The effective radiation dose of CCTA was calculated. RESULTS: Mean heart rate during the CT examination was 59.9 ± 9.9 bpm (range 38–79) and the body mass index of 48 patients was 24.5 ± 2.6 kg/m2 (range 17.0–29.4). LVEDV, LVESV, and LVEF measured using CCTA and echocardiography demonstrated a fair to moderate correlation (Pearson correlation coefficient: r = 0.395, p = 0.005 for LVEDV; r = 0.509. p < 0.001 for LVESV; r = 0.551, p < 0.001 for LVEF). Average image quality score of coronary arteries was 1.0 ± 0.1 (range 1–2). A total of 99.0% (783 of 791) of segments had an excellent image quality score, and 1.0% (8 of 791) of segments had a good score. Mean effective radiation dose was 2.2 ± 0.7 mSv. CONCLUSIONS: Third-generation dual-source CT using a low tube voltage simultaneously provides information regarding LV function and coronary artery disease at a low radiation dose. It can serve as an alternative option for functional assessment, particularly when other imaging modalities are inadequate.

Predictive Value of Cardiac Magnetic Resonance Imaging-Derived Myocardial Strain for Poor Outcomes in Patients with Acute Myocarditis

이지원,정연주,이지원,이남경,이혜원,김진유,최범성,추기석 대한영상의학회 2017 Korean Journal of Radiology Vol.18 No.4

Objective: To evaluate the utility of cardiovascular magnetic resonance (CMR)-derived myocardial strain measurement for the prediction of poor outcomes in patients with acute myocarditis. Materials and Methods: We retrospectively analyzed data from 37 patients with acute myocarditis who underwent CMR. Left ventricular (LV) size, LV mass index, ejection fraction and presence of myocardial late gadolinium enhancement (LGE) were analyzed. LV circumferential strain (EccSAX), radial strain (ErrSAX) from mid-ventricular level short-axis cine views and LV longitudinal strain (EllLV), radial strain (ErrLax) measurements from 2-chamber long-axis views were obtained. In total, 31 of 37 patients (83.8%) underwent follow-up echocardiography. The primary outcome was major adverse cardiovascular event (MACE). Incomplete LV functional recovery was a secondary outcome. Results: During an average follow-up of 41 months, 11 of 37 patients (29.7%) experienced MACE. Multivariable Cox proportional hazard regression analysis, which included LV mass index, LV ejection fraction, the presence of LGE, EccSAX, ErrSAX, EllLV, and ErrLax values, indicated that the presence of LGE (hazard ratio, 42.88; p = 0.014), together with ErrLax (hazard ratio, 0.77 per 1%, p = 0.004), was a significant predictor of MACE. Kaplan-Meier analysis demonstrated worse outcomes in patient with LGE and an ErrLax value ≤ 9.48%. Multivariable backward regression analysis revealed that ErrLax values were the only significant predictors of LV functional recovery (hazard ratio, 0.54 per 1%; p = 0.042). Conclusion: CMR-derived ErrLax values can predict poor outcomes, both MACE and incomplete LV functional recovery, in patients with acute myocarditis, while LGE is only a predictor of MACE.

논문(論文) : 대화분석 방법을 활용한 상호작용적인 말하기 연습활동 -고급 단계 중국어 워크북을 중심으로

이지원 한국중문학회 2015 中國文學硏究 Vol.0 No.61

This study aims to provide a general framework for incorporating a conversation-analytic approach into the design ofworkbooks for foreign language learners of spoken Chinese. Examining the speaking component of current Chinese language workbooks reveals that certain interactional elements of naturally-occurring Chinese conversation are largely missing. This paper proposes the integration of four major conversational properties into workbook study: turn-taking practices, sequencing practices, overall conversational structure, and sociolinguistic elements of spoken conversation. By learning interactional speaking skills, Chinese language learners can be more creative in their target language. Having such skills will also enhance learners’ sense of competence by helping them to construct conversational turns in ways similar to naturally-occurring speech. This creativity and confidence can work to teach speaking skills more effectively since learners will be able to apply more of what they are learning in organic conversation.

Phenethyl Isothiocyanate Induced Apoptosis via Down Regulation of Bcl-2/XIAP and Triggering of the Mitochondrial Pathway in MCF-7 Cells

이지원,조민경 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.12

Although isothiocyanates have been shown to inhibit carcinogen-induced tumorigenesis, no studies have been made to determine their therapeutic potential for the treatment of breast cancer. In the present study, we evaluated the apoptotic activities of phenethyl isothiocyanate (PEITC) in human breast cancer MCF-7 cells. Exposure to PEITC potently reduced cell viability. In addition, DNA fragments and TUNEL positive nuclei were detected in PEITC-treated cells. Furthermore, PEITC induced apoptosis via activation of caspases 7 and 9 and the cleavage of PARP, and these effects were reversed by treatment with the caspase inhibitor, Z-VAD-fmk. PEITC also caused a decrease in the levels of Bcl-2 with a concomitant increase in Bax levels, which resulted in the release of cytochrome c. XIAP suppression and Smac translocation also contributed to the PEITC-induced apoptosis. However, PEITC did not increase the expressions of p53 and p21. Taken together, the results of this study demonstrate that PEITC significantly induces apoptosis via a mitochondrial pathway. Specifically, PEITC induced a change in the Bax/Bcl-2 ratios, XIAP levels and Smac translocation that was conjunction with the release of cytochrome c and following caspase activation. Therefore, PEITC has the potential for use as a therapeutic agent for the treatment of breast cancer.

足太陽膀胱經(족태양방광경)의 背수穴(배수혈) 車鍼刺戟(차침자극) 이 신생아의 생리적 통증반응에 미치는 효과

이지원,김양희 한국아동간호학회 2006 Child Health Nursing Research Vol.12 No.1

=The Effect of Roller Acupuncture Stimulation on Baesu Spots of Joktaeyang Bangkwang Kyeong in the Reaction to Physiologic Pain in Neonates

[Special Report 3] 저물가 시대의 역설_장바구니 물가 뜨겁다 뜨거워

이지원 더스쿠프 2020 더스쿠프 Vol.- No.408-409

문화유산에 프로그램 경험 및 유적지 방문이 국제문화재산업전의 참가의도에 미치는 영향 - 브랜드확장 관점에서의 관여도 조절효과를 중심으로 -

이지원,윤은주,황희곤 한국무역전시학회 2021 무역전시연구 Vol.16 No.3

본 연구는 ‘문화유산박람회’라는 MICE 행사를 중심으로 브랜드 확장의 이론적 개 념을 적용하여 문화유산 및 문화재를 모 브랜드로 보고 문화유산박람회를 확장 브랜드 로 보았을 때 문화유산의 경험이 문화유산박람회라는 MICE 확장 브랜드 참가의도에 유의한 영향을 미치는지 그리고 평소 문화유산의 중요성을 높게 인식하는 고관여도가 조절적 역할을 하는지 살펴보고자 하였다. 이를 위해 문화재 및 문화유산에 관심이 있 고, 문화유적지 관광 경험이 있는 사람들을 대상으로 설문을 한 결과 1,717부의 유효한 표본을 수집하였고 가설검증을 위해 SPSS 22.0을 활용하였다. 그 결과, 모 브랜드로서 문화유적지 방문빈도가 높을수록 문화유산박람회 참가의도에 유의한 영향을 미쳤으며 문화재청이 운영하는 프로그램의 참여가 문화유산박람회 참가 의도에 유의한 영향을 미치는 것으로 나타나 가설 1, 2는 지지되었다. 문화재에 대한 중요성 인식의 정도 (관여도)의 조절 역할을 검증한 결과 관여도가 낮을수록 확장브랜 드로서 문화유산박람회 참가의도가 높은 것으로 나타나, 가설 3도 지지되었다. 본 연구 결과의 실무적, 학문적 시사점은 첫째, 브랜드 확장이라는 이론적 개념을 MICE산업에 적용하여 학문적 범위를 확장시켰다는 점과 둘째, MICE 참가의도에 영향 을 미치는 주요 변수로서 MICE 행사의 핵심 서비스 및 상품에 대한 체험이 중요함을 입증함으로서 단순 홍보에서 벗어나 해당 서비스 및 상품에 대한 체험의 기회를 넓히 는 것이 필요하다는 마케팅적 시사점을 제시하였다. This study examined the effect of a cultural heritage program experience and heritage spot visiting experience (as a parent brand) on the visiting intention to ‘Heritage Korea’ (as an extended brand) in addition to the moderating effect of involvement by adapting the ‘Brand Extension’ concept in the MICE industry. For this study, a survey was conducted from the 19th to 26th of Oct, 2020, among tourists who had visited the heritage spot and were interested in cultural heritage. The result (a total of 1,717 samples) showed that both heritage spot visiting experience and cultural heritage program experience positively affect an expo’s visiting intention, supporting H1 and H2. In addition, the moderating effect of involvement on the expo visiting intention has been found, supporting H3. The theoretical and practical implications are as follows: First, it broadened the research framework by connecting the brand extension strategy into the MICE industry, which was rarely studied. Secondly, it proved that the MICE host needs to focus on how to give the opportunity of experience on the generic contents and theme to the visitor, rather than focusing on the MICE event experience itself. Thus, it suggested for executives to try to promote generic content besides event promotion.

[PART 2_Special Report 3] 비주얼로 본 10년 물가_10년 전보다 무거워진 장바구니 탓에…

이지원 더스쿠프 2020 더스쿠프 Vol.- No.408-409

[Company Insight] 하이트진로|테라에 밀린 하이트 활용법_‘노병’은 죽지 않는다지만…

이지원 더스쿠프 2020 더스쿠프 Vol.- No.408-409

반항하는 몸 : 90년대 폴란드 여류 작가들의 비판 예술과 페미니즘

이지원 한국외국어대학교(글로벌캠퍼스) 동유럽발칸연구소 2003 동유럽발칸연구 Vol.12 No.1

The year 1989, year of the dramatic political transformation in the former socialist block including Poland. The following nineties became a decade of the reconstitution and redefinition of the national, and individual identity, and also brought radical changes to Polish art scene. An emerging generation of women artists made their presence felt and it is interesting that they are showing a strong thematic affinity among themselves. Many works of Katarzyna Kozyra, Alicja Żeborwska, Zofia Kulik, Barbara Konopka etc., are concerning the 'body'. It is anything novel in Polish art history, because we can see two precedents in well known Szapocznikowa's and Abakanowicz's works. These new women artists rather adopted the very Polish tradition of 'sztuka krytyczna (Critic Art)'. What they are criticizing through the 'body' is diverse. The problem of identity and women's self-identity, the social concept of beauty and body, the question of seeing and being seen, and the socially imposed regulations over 'body', especially on female 'body'. These women artists succeeded to voice their concern internationally, with Katarzyna Kozyra getting the special award in Venice Biennale in 1999, Their approaches can be regarded as the negotiating of a personal freedom that has once been repressed by the totalitarian government of the past and the Catholic church and conservative politicians of the present. These women artists were representing current social and cultural issues, which became a part of important social debate. They made distinction in Polish art history also, with their brave breakthrough with Polish locality and ethnic symbolisms with 19th century messianism afront, which had plagued the country's intelligentsia for centuries. 자유화 이후, 정치 경제적이고 사회적인 변화는 폴란드 미술계에도 많은 영향을 미쳤다. 90년대의 혼란기에 예술가의 정체성과 그 역할에 대해 고민하던 작가들에게서 자주 등장하는 주제는 ‘몸’인데, 이는 공산주의 시대부터 지속되어오던 폴란드 고유의 비판 예술 (sztuka krytyczna)의 한 흐름으로 보아야 할 것이다. 90년대 이전 작품활동을 하던 작가들 중 샤포츄니코바 (A. Szpocznikowa)는 ‘몸’을 전체주의 사회에서 용납되지 않는 개인성의 상징으로 내세웠으며, 이후 80년대에 유명해진 아바카노비츠 (M. Abakanowicz)는 껍질로의 ‘몸’을 보여주며 사회 안에서의 개인성의 말살을 비판한 바 있다. 90년대 작가들에게 ‘몸’은 또 다른 여러 가지 의미를 지닌다. 코지라 (K. Kozyra)는 ‘몸’을 통해 볼 수 있는 것과 없는 것, 보여지지 않는 것과 보여지는 것의 문제를 묻고, 아름다움, 또는 사회적 미의 기준이 ‘몸’을, 특히 여성의 ‘몸’을 어떻게 권력에 종속시켰는가를 19세기 유명 작품의 패러디로 말한다. 졔브롭스카(A. ebrowska)는 여성의 ‘몸’과 쾌락을 다루며 사회적 금기를 깨는 작품들을 통하여 자유화 이후의 폴란드에서 개인의 자유를 억압하는 새로운 권력 기관으로 등장한 보수적 정치세력과 교회를 비판한다. 이들 젊은 작가들은 지엽적이고 특수한 폴란드의 역사성에 매달렸던 구세대의 작가들과는 달리, 보다 보편적이고 주제를 다루면서도 폴란드의 현실 상황에 충실하다. 여성 예술가들의 자의식이 작품을 통해 묻고 있는 ‘몸’의 정체성은 단지 페미니스트 미술사학에서만 의미를 가지는 것은 아니다. 사회를 통해 정의되어 온 ‘몸’에 대한 토론은 그들 자신과 그들이 살고 있는 급변하는 폴란드의 정체성을 찾기 위한 것이기 때문이다.‘Twoje ciało to pole walki | Your body is a battlefield’-바바라 크뤼거, 1995년 바르샤바에서 열린 Anti-ciało (Anti-body) 전 퍼포먼스에서