http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
이정필,한호섭,황수진,최지영,박종섭,김태진 대한부인종양학회 2013 Journal of Gynecologic Oncology Vol.24 No.3
Objective: The purpose of this study was to investigate whether selective cyclooxygenase (COX) inhibitors promote paclitaxel-induced apoptosis in taxane-resistant ovarian cancer cells by suppressing MDR1/P-glycoprotein (P-gp) expression. Methods: Taxane-resistant ovarian cancer cells were cultured with paclitaxel alone or combined with a selective COX inhibitors. The expression patterns of MDR1/P-gp and the ability of COX inhibitors to inhibit growth of taxane-resistant ovarian cancer cells were measured. The efficacy of prostaglandin E2 (PGE2) supplementation was measured to evaluate the mechanisms involved in suppressing MDR1 gene expression. Results: P-gp was upregulated in taxane-resistant ovarian cancer cells compared to paired paclitaxel-sensitive ovarian cancer cells. An 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay showed that selective COX inhibitors significantly enhanced the cytotoxic effects of paclitaxel in taxane-resistant ovarian cancer cells via a prostaglandin-independent mechanism. These increased apoptotic effects were further verified by measuring an increased percentage of cells in sub-G1 stage using flow cytometry. Selective COX inhibitors suppressed MDR1 and P-gp expression. Moreover, combined treatment with paclitaxel and selective COX inhibitors increased poly (ADP-ribose) polymerase (PARP) cleavage in taxane-resistant ovarian cancer cells. Conclusion: Selective COX inhibitors significantly promote paclitaxel-induced cell death in taxane-resistant ovarian cancer cells in a prostaglandin-independent manner. COX inhibitors could be potent therapeutic tools to promote paclitaxel sensitization of taxane-resistant ovarian cancers by suppressing MDR1/P-gp, which is responsible for the efflux of chemotherapeutic agents.
Cam-Shift 알고리즘을 이용한 경비드론 융합서비스 기법
이정필,이재욱,이근호 한국융합학회 2016 한국융합학회논문지 Vol.7 No.5
최근 첨단산업이 발달함에 따라 일상생활의 다양한 부분에서 드론의 이용이 급격하게 발전되어 지고 있 다. 드론은 기술성과 기능성의 증가 및 여러 생활방식에 맞춰 활용이 가능한 분야에 대한 접목이 쉬운 장점을 가지 고 있다. 또한 드론 서비스에 대한 다양화를 통하여 카메라와 CCTV같은 영상처리를 할 수 있는 매체를 융합해 사람 대신 경비를 할 수 있는 자동화 시스템이 도입되어 질 예정이다. 이러한 무인경비 기술을 설계하여 기존 드론 응용기술력을 강화하는 새로운 융합적 경비드론 서비스 기법을 제안하고자 한다. 제안하는 기법에는 OpenCV 기술 및 객체 추적 알고리즘인 CAM-Shift 알고리즘을 통해 초기 윈도우와 탐색 윈도우에서 객체를 중심으로 물체를 탐색 및 영역을 설정하여 안전의 유무를 판단하고 보안성에 대하여 드론에 접목시킬 수 있는 추가적인 인증수단인 생체인증기술을 설계한다. 이를 통해 기동성 및 실시간 영상 처리에 대한 기술의 분석이 지속적으로 증가될 수 있는 드론을 이용하여 무인 경비를 하는데 있어서 효율성이 높은 경비드론 융합서비스 모델에 대한 내용을 제안한다. Recently, with the development of high-tech industry, the use of the drones in various aspects of daily life is rapidly advancing. With technical and functional advancements, drones have an advantage of being easy to be utilized in the areas of use according to various lifestyles. In addition, through the diversification of the drone service converged with image processing medium such as camera and CCTV, an automated security system that can replace humans is expected to be introduced. By designing these unmanned security technology, a new convergence security drone service techniques that can strengthen the previous drone application technology will be proposed. In the proposed techniques, a biometric authentication technology will be designed as additional authentication methods that can determine the safety incorporated with security by selecting the search and areas of an object focusing on the objects in the initial windows and search windows through OpenCV technology and CAM-Shift algorithm which are an object tracking algorithm. Through such, a highly efficient security drone convergence service model will be proposed for performing unmanned security by using the drones that can continuously increase the analysis of technology on the mobility and real-time image processing.