음이온성 지질을 포함한 지질나노입자의 제조 및 물리적 특성

이정은,김은혜,임덕휘,정석현,정규성,신병철,Lee, Jung-Eun,Kim, Eun-Hye,Lim, Deok-Hwi,Jung, Suk-Hyun,Jeong, Kyu-Sung,Shin, Byung-Cheol 대한화학회 2008 대한화학회지 Vol.52 No.3

한약 치료를 시행한 트리메틸아민뇨증 환자 1례 증례보고

이정은,한성준,이엄지,이재형,남성욱,하나연,김진성,Lee, Jung-eun,Han, Seong-jun,Lee, Eom-jee,Lee, Jae-hyung,Nam, Seong-uk,Ha, Na-yeon,Kim, Jin-sung 대한한방내과학회 2016 大韓韓方內科學會誌 Vol.37 No.2

Objective: This case reports on the efficacy of herbal medicine treatment for trimethylaminuria.Method: A 29-year-old female Korean patient with trimethylaminuria received herbal medicine treatment for three months. We evaluated her symptoms with the methacholine challenge test and OralChroma.Results: The odor intensity shown in the methacholine challenge test demonstrated improvement.Conclusion: Herbal medicine treatment could improve trimethylaminuria symptoms.

부모의 양육태도가 섭식장애의 발병과 심각도에 미치는 영향

이정은,이정현,정영철,박준영,남궁기,박동화,김경란,Lee, Jung Eun,Lee, Jung-Hyun,Jung, Young-Chul,Park, Jun Young,Kee, Namkoong,Park, Dong Wha,Kim, Kyung Ran 한국정신신체의학회 2015 정신신체의학 Vol.23 No.1

연구목적 한국에서 신경성 식욕부진증과 신경성 폭식증을 진단받은 환자 군에서 부모 양육태도의 차이와 각 아형에서 부모 양육태도의 차이가 발병 나이와 섭식장애 증상의 심각도에 미치는 영향을 알아보고자 하였다. 방 법 167명의 섭식장애 환자(신경성 식욕부진증, N=49 ; 신경성 폭식증, N=118)를 대상으로 하였다. 자가보고식 설문지인 부모 양육행동 척도(Parental Behavior Inventory, PBI)를 시행하여 환자가 인식하는 부모님의 양육행동을 측정하였으며, 섭식장애 검사 개정판(The Eating disorder Inventory-2, EDI-2)를 통하여 증상의 심각도를 평가하였다. 결 과 신경성 식욕부진증 환자를 발병 나이에 따라 분류하였을 때, 16세 이후에 발병한 군보다 16세 이전에 조기 발병한 경우 낮은 아버지의 애정, 높은 아버지의 합리적 설명, 낮은 어머니의 과잉간섭을 보고하였다. 섭식장애 증상의 심각도(EDI-2)는 신경성 식욕부진증과 신경성 폭식증에서 어머니의 애정, 합리적 설명과 음의 상관관계를 나타내었다. 단계별 회귀분석을 시행하였을 때, 아버지의 애정, 어머니의 과잉기대와 합리적 설명이 신경성 식욕부진증의 발병 나이에 중요한 영향을 준다는 것을 확인할 수 있었으며, 두 집단에서 모두 어머니의 애정이 높을 수록 EDI-2의 점수가 낮은 것으로 나타났다. 결 론 섭식장애 환자의 평가 및 치료에서 가족의 기능과 인식된 부모의 양육태도가 중요한 역할을 할 수 있겠다. 본 연구 결과는 아버지의 양육방식이 섭식장애 발병나이에 미치는 영향을 밝힘으로써 이제까지 상대적으로 부족하게 평가되었던 아버지 역할의 중요성을 확인하였다. 이뿐 아니라, 섭식장애 증상의 심각도와 어머니의 애정과의 관련성을 확인함으로써 가족 기능에 대한 평가가 치료에 필수적임을 입증하였다. 앞으로 본 연구 결과에 대한 해석 및 적용을 위한 후속 연구들이 필요하겠다. Objectives:To determine the influence of parental behaviors on the onset and severity of eating disorders, this study compared aspects of perceived parental styles, according to eating disorder subtypes and age at onset in Korean women with eating disorders. Methods:One hundred and sixty-seven patients with eating disorders[Anorexia Nervosa (AN), N=49; Bulimia Nervosa(BN), N=118] were recruited for this study. Perceived parent behaviors were assessed with Parental Behavior Inventory(PBI) self-rating scale. The study subjects also completed the Eating Disorder Inventory -2 (EDI-2) to assess the severity of eating disorder symptoms. Results:In anorexia nervosa, early onset group(<16 years) reported low paternal affection and high paternal rational expression, low maternal interference than group with age at onset over 16 years. The severity of eating disorder symptoms was negatively associated with mother affection and rational expression in two subtypes of eating disorder(AN and BN). On stepwise regression analysis, paternal affection and maternal over-protection were associated with age of onset only in AN group and maternal affection was associated with the severity of symptoms in both groups of eating disorder. Conclusions:Considering the role of family function and perceived parental styles could help improve the management of eating disorders. These results emphasize the importance of fathers' role in the eating disorder on the age of onset, a relatively unexplored area of eating disorder research. Also, we investigated the importance of mothers' affection on the severity of symptoms.

커플모래놀이치료가 대학생의 자아분화와 이성관계만족에 미치는 효과

이정은(Jung0-Eun Lee),박지영(Ji-yeong Park),박부진(Boo-Jin Park) 가정과삶의질학회 2013 가정과삶의질연구 Vol.31 No.6

지속가능발전목표(SDGs) 이행을 위한 지속가능한 식생활 교수·학습 과정안 개발

이정은,유난숙,Lee, Jung Eun,Yu, Nan Sook 한국가정과교육학회 2022 한국가정과교육학회지 Vol.34 No.3

The purpose of this study was to identify learning topics linked to Sustainable Development Goals(SDGs) in the dietary life unit of middle school technology and home economics textbooks and to develop teaching-learning plans and learning materials to verify the feasibility and field suitability. This study was carried out through analysis, design, development, and evaluation stages, and the results are as follows. First, in the analysis stage, the dietary life contents of the five home economics textbooks written based on the 2015 revised curriculum were analyzed, and dietary life-related goals were extracted from the 169 SDG targets to reorganize the learning topics linked to the contents of the textbooks. Second, in the design stage, the overall goal of the entire class was set and each session was designed by selecting the learning goals, learning topics, and learning contents, reflecting the SDGs related to the session to be developed. Based on the analyses of textbooks and the SDGs related to dietary life, the themes of 'desirable eating habits of adolescents', 'food production', 'food distribution', and 'food consumption and disposal' were extracted. Third, in the development stage, a total of 11 teaching-learning plans and student worksheets were developed, and an evaluation sheet was developed for expert verification. Fourth, in the evaluation stage, the feasibility and field suitability of the teaching-learning plans were verified by 5 home economics teachers. Learning goals, learning contents, connectivity to related SDGs, and feasibility of teaching-learning plan were evaluated, and based on the assessment results, teaching-learning plans were revised.

간질발작(癎疾發作)환자 치험 1예

이정은,황지호,임도희,한영주,배한호,정인철,박양춘,Lee, Jung-Eun,Hwang, Ji-Ho,Lim, Do-Hee,Han, Young-Joo,Bae, Han-Ho,Jeong, In-Chul,Park, Yang-Chun 대한한방내과학회 2005 大韓韓方內科學會誌 Vol.26 No.2

Epilepsy is a neurological condition that from time to time produces brief disturbances in the normal electrical functions of the brain, Normal brain function is made possible by millions of tiny electrical charges passing between nerve cells in the brain and to all parts of the body. They may affect a person's consciousness, bodily movements or sensations for a short time. These physical changes are called epileptic seizures. These clinical data, gathered an epileptic seizure whose main symptom was convulsion, was analyzed. This clinical report pertains to a 51 year-old man who suffered an epileptic seizure and after effects of weakness. He was treated with ChongsimOndamTang(淸心溫膽湯). The cheif symptom, epileptic seizure, disappeared and general conditions improved after Korean medical treatments, so this is reported as a potential treatment.

구강작열감증후군 환자의 미각 이상과 비기허증(脾氣虛證)의 상관관계

이정은,박재우,김진성,Lee, Jung-eun,Park, Jae-woo,Kim, Jin-sung 대한한방내과학회 2017 大韓韓方內科學會誌 Vol.38 No.4

Objectives: This study evaluated the correlation between taste function and spleen qi deficiency in patients with burning mouth syndrome (BMS) and compared subgroups of BMS (i.e., dysgeusia and non-dysgeusia subgroups). Methods: This study included 60 participants categorized into two groups: a BMS group and healthy control (HC) group. Taste threshold was measured within six levels using solutions of four basic taste qualities. Subjects' Oral Health Impact Profiles (OHIPs-14) and Spleen qi Deficiency Questionnaire (SQDQ) scores were analyzed. Results: Taste thresholds for sweet (sucrose) and salty (NaCl) tastes were significantly lower in the BMS group than in the HC group, but sour (citric acid) and bitter (quinine HCl) tastes showed no significant differences between groups. In the dysgeusia and non-dysgeusia subgroups, no significant differences in the four basic taste thresholds were found. SQDQ scores were significantly higher in the BMS group compared to the HC and in the dysgeusia group compared to the non-dysgeusia group. OHIPs-14 and SQDQ scores for the BMS group were significantly and positively correlated. Conclusions: Spleen qi deficiency is related to taste function and can be used to treat BMS patients with taste dysfunction.

그래픽 하드웨어를 이용한 분자용 보로노이 다이어그램 계산

이정은,백낙훈,김구진,Lee, Jung-Eun,Baek, Nak-Hoon,Kim, Ku-Jin 한국정보처리학회 2012 정보처리학회논문지 A Vol.19 No.4

본 논문에서는 주어진 단백질 분자에 대해 3차원 보로노이 다이어그램을 계산하는 알고리즘을 제안한다. 분자는 반경이 서로 다른 구의 집합으로 표현되며, 각 구의 반경은 원자의 반데르바스 (van der Waals) 반경에 대응한다. 보로노이 다이어그램은 3차원 공간을 복셀(voxel)의 집합으로 분할한 뒤, 보로노이 다이어그램을 포함하는 복셀을 보수적으로 추출함으로써 구성된다. 분자의 계층적 성질을 이용하여 BVH(bounding volume hierarchy)를 구성하고, CUDA 프로그래밍을 통하여 그래픽 하드웨어 가속을 활용함으로써 계산 시간 효율성을 높인다. 공간이 최대 $2^{24}$개의 복셀로 분할될 경우, 단일 코어 CPU로 구현하는 알고리즘에 비해 계산 속도가 323배 가량 향상 되었다. We present an algorithm that computes a 3 dimensional Voronoi diagram for a protein molecule in this paper. The molecule is represented as a set of spheres with van der Waals radii. The Voronoi diagram is constructed in the 3D space by finding the voxels containing it. For the feasibility of the computation, we represent the molecule as a BVH (bounding volume hierarchy), and our system is accelerated by modern graphics hardware with CUDA programming support. Compared to single-core CPU implementations, experimental results show 323 times faster performance in the computation time, when the space is partitioned into $2^{24}$ voxels.

Phase II Study of Induction Irinotecan + Cisplatin Chemotherapy Followed by Concurrent Irinotecan + Cisplatin Plus Twice-Daily Thoracic Radiotherapy

이정은,박희선,정성수,김주옥,조문준,김진환,이충식,김선영,Lee, Jeong Eun,Park, Hee Sun,Jung, Sung Soo,Kim, Ju Ock,Cho, Moon June,Kim, Jin Hwan,Lee, Choong Sik,Kim, Sun Young The Korean Academy of Tuberculosis and Respiratory 2007 Tuberculosis and Respiratory Diseases Vol.63 No.2

배경: Irinotecan hydrochloride는 topoisomerase I inhibitor로서 소세포 폐암에 효과적인 약제로 알려져 있다. Irinotecan은 cisplatin과 더불어 방사선감작물질로 작용하기도 한다. 본 연구는 이전에 치료받은 경험이 없는 제한성 병기의 소세포 폐암 환자에서 irinotecan과 cisplatin(IP)의 방사선 동시화학요법의 효과를 평가하기 위하여 시행되었다. 방법: 2002년 12월부터 2004년 11월까지 충남대학교 병원에서 새로이 제한성 병기의 소세포 폐암으로 진단된 24명의 환자들을 대상으로 하였다. Irinotecan $60mg/m^2$을 제 1일과 제 8일째 투여하였고 cisplatin $60mg/m^2$을 제 1일째 투여하였으며 매 3주 간격으로 시행되었다. 제 3차 항암화학요법을 시작하는 날과 동시에 과다 분할방사선 치료(twice-daily thoracic irradiation; 45 Gy total)을 시작하였다. 예방적 전 뇌 방사선 조사(Prophylactic cranial irradiation)가 방사선 동시화학요법이 끝난 후 완전반응(complete response)을 나타낸 환자에서 시행되었다. 제 2차 항암요법과 제 6차 항암요법이 끝난 후에 흉부 전산화 단층촬영과 기관지경 등을 통한 병기의 재평가가 이루어졌다. 결과: 병기의 재평가는 19명의 환자에게 이루어졌다. 중앙 추적관찰기간은 12.5개월이고 전체 99회의 항암치료가 시행되었다. 평균 한 환자당 5.2회의 항암치료가 시행되었다. 실제 용량강도는 cisplatin $19.6mg/m^2$/week과 irinotecan $38.2mg/m^2$/week이었다. 9명의 환자가 완전반응을 보였고 10명의 환자가 부분반응(partial response)을 보여서 전체 반응률은 95%였다. 3에서 4도의 혈액학적 독성은 백혈구 감소증(35% of cycles), 빈혈(7% of cycles), 혈소판 감소증(7% of cycles) 등으로 나타났다. 3에서 4도의 비 혈액학적 독성은 설사(5% of cycles)였다. 3에서 4도의 방사선 식도염(10% of patients)을 제외하고는 과다 분할 방사선 치료를 이용한 방사선 동시 화학요법의 기존의 방법과 독성 면에서는 큰 차이가 없었다. 치료와 관련된 사망은 관찰되지 않았다. 평가가 가능한 환자들에서 1년 생존율과 2년 생존율은 각각 89% (16/18)와 47% (9/18)였다. 결론: 3주 간격으로 시행된 irinotecan과 cisplatin을 이용한 과다분할 방사선 동시 요법은 제한성 병기의 소세포 폐암 환자에서 부작용은 높지 않으면서 효과적인 치료법으로 고려될 수 있을 것이다. Background: Irinotecan hydrochloride, a topoisomerase I inhibitor, is effective against small-cell lung cancer. Irinotecan also can act as a potential radiation sensitizer along with cisplatin. To evaluate efficacy and toxicity of irinotecan plus cisplatin (IP) with concurrent thoracic radiotherapy, we conducted a phase II study of IP followed by concurrent IP plus hyperfractionated thoracic radiotherapy in patients with previously untreated limited-stage small-cell lung cancer. Methods: Twenty-four patients with previously untreated small-cell lung cancer were enrolled onto the study since November 2004. Irinotecan $60mg/m^2$ was administered intravenously on days 1 and 8 in combination with cisplatin $60mg/m^2$ on day1 every 21 days. From the first day of third cycle, twice-daily thoracic irradiation (total 45 Gy) was given. Prophylactic cranial irradiation was given to the patients who showed complete remission after concurrent chemoradiotherapy. Restaging was done after second and sixth cycle with chest CT and/or bronchosocpy. Results: Up to November 2004, 19 patients were assessable. The median follow-up time was 12.5 months. A total of 99 cycles (median 5.2 cycles per patient) were administered. The actual dose intensity values were cisplatin $19.6mg/m^2$/week and irinotecan $38.2mg/m^2$/week. Among the 19 patients, the objective response rate was 95% (19 patients), with 9 patients (47%) having a complete response (CR). The major grade 3/4 hematological toxicities were neutropenia (35% of cycles), anemia (7% of cycles), thrombocytopenia (7% of cycles). Febrile neutropenia was 4% of cycles. The predominant grade 3/4 non-hematological toxicities was diarrhea (5% of cycles). Toxicities was not significantly different with concurrent administration of irinotecan and cisplatin with radiotherapy, except grade 3/4 radiation esophagitis (10% of patients). No treatment-related deaths were observed. The 1-year and 2-year survival rate of eligible patients was 89% (16/18) and 47% (9/18), respectively. Conclusion: Three-week schedule of irinotecan plus cisplatin followed by concurrent IP plus hyperfractionated thoracic radiotherapy is an effective treatment for limited disease small-cell lung cancer, with acceptable toxicity.

ISO 15489 개정판의 주요 특징에 관한 연구

이정은,윤은하,Lee, Jung-eun,Youn, Eun-ha 한국기록학회 2018 기록학연구 Vol.0 No.57

기록을 둘러싼 업무환경의 변화, 조직의 변화, 시스템의 변화 등은 기록 에 대한 개념을 변화시켰다. 2001년도에 제정된 기록관리 국제표준인 ISO 15489 역시 이에 조응하기 위해 15년 만에 개정을 이루었다. 본 연구는 2016년에 개정된 기록관리 국제표준인 ISO 15489를 통해 급변하는 디지털 혁명 속에서 기록을 바라보는 개념의 변화를 살펴보고자 하였다. ISO 15489의 개정 배경 및 개정 전·후의 조항을 검토하고, 확장된 기록의 개 념을 살펴봄으로써 구체적으로 개정판이 추구하는 바를 알아보고자 한다. A new digital work environments, organizational changes, and system changes surrounding the records have changed the concept of records. ISO 15489, the international standard for records management established in 2001, has also been amended in 15 years to accommodate this. The study examines the characteristics of the revised ISO 15489, its elements and concept, in 2016. By comparing the old and new elements of ISO 15489 in detail, we intend to understand the nature of the revision and the basic framework of new standard.