쌍강탕(雙降湯)이 고(高)cholesterol 식이(食餌)로 유발(誘發)된 고지혈증(高脂血症) 백서(白鼠)에 미치는 영향(影響)

이재휘,임승민,안정조,조현경,김윤식,설인찬,유호룡,Lee, Jae-Hwi,Lim, Seung-Min,An, Joung-Jo,Jo, Hyun-Kyung,Kim, Yoon-Sik,Seol, In-Chan,Yoo, Ho-Rhyong 대한한방내과학회 2008 大韓韓方內科學會誌 Vol.29 No.2

Objective : Ssanggang-tang(SGT) is noted as an effective method to treat hyperlipidemia in China. The main purpose of this study was analysis of the effects of Ssanggang-tang(SGT) on rats induced with caused hyperlipidemia. Methods : We observed 3 experimental groups: normal, control, and SGT. Rats were provided a normal diet in the normal group, and the other groups were provided a hyperlipidemic diet to induce hyperlipidemia. After 2 weeks, SGT was treated in the SGT group. For 6 weeks, values related to hyperlipidemia were observed in the 3 experimental groups. Results : SGT decreased some values related to hyperlipidemia like total cholesterol, low density lipoprotein cholesterol(LDL cholesterol), triglyceride, acetocoenzyme A acetyltransferase(ACAT), and 3-hydroxy-3-methylglutaryl coenzyme A reductase(HMG-CoA reductase). However, it showed no effect on weight change or high density lipoprotein cholesterol(HDL cholesterol). Conclusion : These results suggest that SGT might be effective in treatment and prevention of hyperlipidemia.

화습탕으로 호전된 화폐상 습진 환자 치험 5례 증례보고

이재휘,방현진 대한한방안이비인후피부과학회 2019 한방안이비인후피부과학회지 Vol.32 No.1

Objectives : The purpose of this study is to report the clinical effect of Hwaseup-tang for nummular eczema patients. Methods : This study was conducted with five nummular eczema patients who have visited Ryoum Korean Medicine Clinic. They were treated with Hwaseup-tang and acupuncture. In order to evaluate the results of these treatments, we observed the itching condition of the patients and took photographs of the lesions. Results : After Hwaseup-tang medicine treatment, the nummular eczema lesions of five patients were remarkably disappeared and their itching condition was also improved rapidly. Conclusions : These five cases indicate that Hwaseup-tang may be effective in the treating of nummular eczema patient, although the number of cases was limited to five.

Mechanism of Oxygenation of 2,6-Di-tert-butylphenol Derivative

이재휘,조종인,정석원,함승욱 대한화학회 2006 Bulletin of the Korean Chemical Society Vol.27 No.1

백당으로 가교된 폴리아크릴산 하이드로겔의 In vitro 점막부착력 평가

이재휘,김선영,이은석,이민석,김형수,최영욱 한국약제학회 2006 Journal of Pharmaceutical Investigation Vol.36 No.2

안면부 종창을 동반한 Henoch-Scho¨nlein 자반증 1례

이재휘,서무규,임문환,박성기,김태우,이창연 동국대학교 경주대학 1991 東國論集 Vol.10 No.-

We experienced a case of Henoch-Scho‥nlein purpura with are manifestation of facial swelling in a 7-year-old boy.

한약제의 장관흡수에 관한 생물약제학적 연구(Ⅱ) : 우황이 삼칠인삼 중 조사포닌의 소장흡수에 미치는 영향 Effect of Bezoar on the Small Intestinal Absorption of Crude Saponin in San-Chi Ginseng

이재휘,최영욱,김종갑 중앙대학교 약학연구소 1992 약학 논총 Vol.6 No.-

The influence of bezoar on the small intestinal absorption of crude saponin in the San-Chi ginseng were studied using Schanker's loop circulation method in situ and compared with dissolution rate and partition coefficient in vitro. It was observed that the dissolution of crude saponin in pH 6.5 phosphate buffer solution was enhanced by the addition of bezoar and reached to plateau by 60 min. And small intestinal absorption of crude saponin was also increased proportionally to the amount of bezoar added.

Formulation of Microemulsion Systems for Transdermal Delivery of Aceclofenac

이재휘,Yoonjin Lee,Jongseok Kim,윤미경,최영욱 대한약학회 2005 Archives of Pharmacal Research Vol.28 No.9

An O/W microemulsion system was developed to enhance the skin permeability of aceclofenac. Of the oils studied, Labrafil? M 1944 CS was chosen as the oil phase of the microemulson, as it showed a good solubilizing capacity. Pseudo-ternary phase diagrams were constructed to obtain the concentration range of oil, surfactant, Cremophor? ELP, and co-surfactant, ethanol, for micoemulsion formation. Eight different formulations with various values of oil of 6-30%, water of 0-80%, and the mixture of surfactant and co-surfactant (at the ratio of 2) of 14-70%. The in vitro transdermal permeability of aceclofenac from the microemulsions was evaluated using Franz diffusion cells mounted with rat skin. The level of aceclofenac permeated was analyzed by HPLC and the droplet size of the microemulsions was characterized using a Zetasizer Nano-ZS. Terpenes were added to the microemulsions at a level of 5%, and their effects on the skin permeation of aceclofenac were investigated. The mean diameters of the microemulsions ranged between approximately 10~100 nm, and the skin permeability of the aceclofenac incorporated into the microemulsion systems was 5-fold higher than that of the ethanol vehicle. Of the various terpenes added, limonene had the best enhancing ability. These results indicate that the microemulsion system studied is a promising tool for the percutaneous delivery of aceclofenac.

악관절 조영술을 이용한 악관절 장애 환자의 임상적 연구

이재휘 동국대학교 경주대학 1991 東國論集 Vol.10 No.-

This is a retrospective study based on a series of 42 arthrographic examinations of temporomandibular joint in 32 temporomandibular disorder patients following up one year treated as patient at Dept. of Dentistry. Oral & Maxillofacial Surgery, Pohang Hospital, College of Medicine, Dongguk University. The Results obtained were as follows : 1. The mean age of temporomandibular disorder was 31.2 years old, and the ratio of Male/Female was 1 : 22. The first and second decades were the highest age groups in incidence as 59.4%. 2. We could not find any difference of TMJ site in temporomandibular disorder, and the bilateral arthrographic examination was 31.3%. 3. The patients complained temporomandibular pain was 71.9%, and the patients complained headache was 68.8% in clinical symptoms of temporomandibular disorder. 4. In duration of clinial symptoms of temporomandibular disorder, 56.3 could have more than 1 year. 5. In result of arthrographic examinations, MPD Syndrome was 19.0%, Internal Derangement was 81.0%. 6. The first decade was the highest age group in MPD Syndrome, and the second decade was the highest age group in Internal Derangement. 7. As result of arthrogram according to clinical symptoms in temporomandibular disorder, normal arthrogram was high in Group Ⅴ, arthrogram of anterior displacement was high in Group Ⅱ and Ⅳ, arthrogram of perforation was high in Group Ⅶ. 8. The conservative treatment was 59.4%, and the surgical operation was 40.6% in the treatment of temporomandibular disorder. 9. The success rate of conservative treatment was 89.5%, the success rate of arthroscopic surgery was 62.5%, and the success rate of meniscoplasty was 80.0%.

두부방사선 계측에 따른 한국성인 정상교합자의 최대 교합력에 관한 연구

이재휘,송영복 아주대학교 1997 아주의학 Vol.2 No.1

The purpose of this study was to obtain values of maximum occlusal force after lateral and posteroanterior cephalometric analysis. The normal values of lateral and posteroanterior cephalometric analysis were set up with 118 Korean adults with normal occlusion(63 males and 55 females), and the maximum occlusal forces were measured by occlusal force system(MPM 3000). The results obtained with Korean adults with normal occlusion were as follows; 1) The values of maximum occlusal force were : incisor region 15.1 ㎏ in male and 13.3 ㎏ in female; canine legion 21.2 ㎏ in male and 19.0 ㎏ in female; premolar region 29.5 ㎏ in male and 29.4 ㎏ in female; molar region 48.3 ㎏ in male and 36.2 ㎏ in female. 2) There were significant differences between right and left sides and between male and female in incisor, canine, and molar regions except premolar region(p< 0.05). The maximum occlusal forces in male were significantly greater than in female except premolar region of right side, and they were more stronger in right side than in the left except canine, premolar, and molar regions of male. 3) The lateral and posteroanterior cephalometric measurements representing facial skeletal morphology, particularly mandibular morphology, correlated well with the values of maximum occlusal force in premolar and molar regions(p< 0.05).

악관절의 천공성 전방 관절원판 전위에 관한 연구

이재휘,배정수 東國大學校 1992 東國論叢 Vol.31 No.-

This is a retrospective study by arthrographic, clinical, surgical, and histopathologic examination based on a series of 38 patients, 40 joints having anterior meniscal displacement with perforation of the 278 patients, 336 joints who had diagnosed as TMJ internal derangement by use of TMJ arthrography at department of Oral & Maxillofacial Surgery, Pohang Hospital, College of Medicine, Dongguk University. 1. In the 278 patients, 336 joints who had diagnosed as internal derangement, anterior meniscal displacement with perforation was 11.9% in 38 patients, 40 joints. 2. The false positive finding that occurred by arthrography of anterior meniscal displacement with perforation could be prevented by two times of diagnostic and preoperative with accumulating experience and accurate technique, and arthrography was very valuable in diagnosis of meniscal perforation. 3. The radiographical condyle morphology of anterior meniscal displacement with perforation was all abnormal and small condyle was the highest group in incidence as 40.0%. 4. The ratio of Male/Female in anterior meniscal displacement with perforation was about 1:5, the mean age was 43.6 years old, over 30 years old was 84.3%, and we could not find any difference of TMJ site in meniscal perforation. 5. In the clinical symptoms of anterior meniscal displacement with perforation, crepitus was 94.8%, pain was 73.9%, and limitation of mouth opening was 41.9%. Therefore, we could know that crepitus is diagnostic criterion in meniscal perforation. 6. The mean of preoperative mouth opening in anterior meniscal displacement with perforation was 3.14mm and the mean of postoperative mouth opening was 37.9mm. Therefore, preoperative limitation of mouth opening was largely resolve. 7. In the location of meniscus perforation, posterior attachment was the highest group in incidence as 75.0% and the mean size of meniscal perforation was 6.8mm in diameter. 8. All of anterior meniscal displacement with perforation was treated by surgical operation. The meniscoplasty was 70.0% and the meniscectomy was 30.0%. In the postoperative prognosis, the meniscoplasy was 85.8% in the meniscectomy was 83.3% in success rate. 9. In the histopathologic staging of removed soft tissue of anterior meniscal displacement with perforation, Grade 5 Degeneration was the highest group in incidence as 35.0% and the mean Grade was 4.4 Grade. The Grade 4, 5, 6 Degeneration were 75.0% of all, and so interstitial hyalinization and cartilaginous metaplasia were abundant.