이장하 형제의 보고서

이장하 현대기독교역사연구소 2003 자료총서 Vol.5 No.0

성결해진 한국인

이장하 현대기독교역사연구소 1999 성결교회와 신학 Vol.3 No.-

비스포스포네이트 연관 악골 괴사증 환자에서 유경 협부 지방 피판을 이용한 치료

이장하,김민근,김성곤,박영욱,박상욱,박영주,Lee, Jang-Ha,Kim, Min-Keun,Kim, Seong-Gon,Park, Young-Wook,Park, Sang-Wook,Park, Young-Ju 대한악안면성형재건외과학회 2013 Maxillofacial Plastic Reconstructive Surgery Vol.35 No.3

Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a disease characterized by jaw necrosis and delayed wound healing in patients who had received bisphosphonates. Buccal fat pad (BFP) can be used as a pedicled flap in the posterior region of the oral cavity. BFP pedicle flap needs simple surgical technique and it shows less donor site morbidity and aesthetic problem than other vascularized flap. BFP pedicled flap was fed by 3 arteries-facial, internal maxillary, and transverse facial artery. Osteomyelitis was generally related with poor blood supply. Thus, rich blood supply of BFP pedicle flap can have a potential advantage to BRONJ patients. In this case report, we presented 3 BRONJ patients treated by BFP pedicle flap after sequestrectomy.

Al 허니콤 판재의 기계적 성질

이장하,신광선 대한금속재료학회 1993 대한금속재료학회 학술대회 개요집 Vol.1993 No.1

2006~2010년도 국내 노지재배 고추의 바이러스병 발생현황

이장하,홍진성,주호종,박덕환,Lee, Jang Ha,Hong, Jin Sung,Ju, Ho-Jong,Park, Duck Hwan 한국유기농업학회 2015 韓國有機農業學會誌 Vol.23 No.1

2006년부터 2010년까지 국내 고추 노지재배 포장을 대상으로 경상남도와 제주도를 제외한 강원도 11개 지역 등 전국에 걸쳐 총 83개 지역을 중심으로 바이러스 이병체를 채집하여 연차별 고추 발생 바이러스의 발병률, 바이러스 종류 및 감염 형태를 조사하였다. 2006년부터 2010년까지의 고추에서의 평균 단독 감염률은 46.6%, 복합 감염률은 48.0%로 조사되어 고추 생산에 있어서 가장 큰 위해요소는 바이러스 발병으로 나타났다. 바이러스별로는 CMV가 평균 34.8% 발병률로 가장 우점 바이러스로 조사되었다. 반면 BBWV2는 낮은 발병율을 보여주었으며, TSWV는 충남과 전남지역에 국한되는 것으로 조사되었다. 따라서 고추 노지재배 시 발생하는 바이러스의 위해도를 발병률에 따라 구분하면 CMV, PMMoV, 그리고 PepMov 순으로 조사되었다. 또한 복합 감염의 발생도 모든 조사지역 시료에서 검출되었으며, 이에 대한 감염 별 바이러스 종류와 발생률을 분석하였다. 복합 감염에서 가장 빈번하게 검출된 바이러스는 CMV로, CMV+BBWV2, CMV+PepMoV, CMV+PMMoV의 복합 감염형태가 검출률이 높게 나타났다. 따라서 고추의 유기농 재배 생산에 가장 큰 위협요인으로 작용하는 바이러스의 적절한 대책마련을 위한 지속적인 바이러스 모니터링과 3종 이상의 복합 감염 위해성을 판단하기 위한 추가 연구가 필요하다고 사료된다. In this study, viral disease samples were obtained between 2006 and 2010 from pepper fields in 11 major pepper-growing districts in Gangwon-do, and in 83 areas from other provinces, with the exception of Gyeongsangnam-do and Jeju island in Korea. In order to assess the type of infection, field surveys were conducted with regard to viral disease severity and virus type, based on typical symptoms on leaves. The means of single and mixed-virus infections were 46.6% and 48.0%, respectively, during those periods, suggesting that viruses are the agents that most severely decrease pepper production in field cultivation in Korea. In terms of single infection, Cucumber mosaic virus (CMV) was the most prevalent virus based on its disease severity ratings (34.8%). Next, Pepper mild mottle virus (PMMoV) and Pepper mottle virus (PepMoV) were shown to cause severe viral diseases in pepper, with disease severities of around 5-10%. On the other hand, Tomato spotted wilt virus (TSWV) occurs in a limited area in Chungcheongnam-do and Jeollanam-do. Thus, the viral disease caused by CMV, PMMoV, and PepMoV in pepper can be severe, and these virus types should remain considered critical reasons for decreased pepper production in field cultivation in Korea. In addition to single infection, mixed infections are frequently observed in collected pepper samples from all areas. The ratios of mixed infection were therefore studied to evaluate the disease severity of mixed infections and to define individual virus types. These data showed that different types of viruses were present, and CMV was the most abundant virus for mixed infection, as in the case of single infection. Among mixed infections, the highest disease severity was seen with CMV+Broad beam wilt virus 2 (BBWV2), followed by other types of mixed infection such as CMV+PepMoV and CMV+PMMoV. However, further work is needed to reduce the severe damage caused by viruses and to assess mixed infection types involving three or more viruses.

2006~2010년도 국내 노지재배 고추의 바이러스병 발생현황

이장하,홍진성,주호종,박덕환 한국유기농업학회 2015 韓國有機農業學會誌 Vol.23 No.1

2006년부터 2010년까지 국내 고추 노지재배 포장을 대상으로 경상남도와 제주도를 제외한 강원도 11개 지역 등 전국에 걸쳐 총 83개 지역을 중심으로 바이러스 이병체를 채집하여 연차별 고추 발생 바이러스의 발병률, 바이러스 종류 및 감염 형태를 조사하였다. 2006년부터 2010년까지의 고추에서의 평균 단독 감염률은 46.6%, 복합 감염률은 48.0%로 조사되어 고추 생산에 있어서 가장 큰 위해요소는 바이러스 발병으로 나타났다. 바이러스별로는 CMV가 평균 34.8% 발병률로 가장 우점 바이러스로 조사되었다. 반면 BBWV2는 낮은 발병율을 보여주었으며, TSWV는 충남과 전남지역에 국한되는 것으로 조사되었다. 따라서 고추 노지재배 시 발생하는 바이러스의 위해도를 발병률에 따라 구분하면 CMV, PMMoV, 그리고 PepMov 순으로 조사되었다. 또한 복합 감염의 발생도 모든 조사지역 시료에서 검출되었으며, 이에 대한 감염 별 바이러스 종류와 발생률을 분석하였다. 복합 감염에서 가장 빈번하게 검출된 바이러스는 CMV로, CMV+BBWV2, CMV+PepMoV, CMV+PMMoV의 복합 감염형태가 검출률이 높게 나타났다. 따라서 고추의 유기농 재배·생산에 가장 큰 위협요인으로 작용하는 바이러스의 적절한 대책마련을 위한 지속적인 바이러스 모니터링과 3종 이상의 복합 감염 위해성을 판단하기 위한 추가 연구가 필요하다고 사료된다. In this study, viral disease samples were obtained between 2006 and 2010 from pepper fields in 11 major pepper-growing districts in Gangwon-do, and in 83 areas from other provinces, with the exception of Gyeongsangnam-do and Jeju island in Korea. In order to assess the type of infection, field surveys were conducted with regard to viral disease severity and virus type, based on typical symptoms on leaves. The means of single and mixed-virus infections were 46.6% and 48.0%, respectively, during those periods, suggesting that viruses are the agents that most severely decrease pepper production in field cultivation in Korea. In terms of single infection, Cucumber mosaic virus (CMV) was the most prevalent virus based on its disease severity ratings (34.8%). Next, Pepper mild mottle virus (PMMoV) and Pepper mottle virus (PepMoV) were shown to cause severe viral diseases in pepper, with disease severities of around 5-10%. On the other hand, Tomato spotted wilt virus (TSWV) occurs in a limited area in Chungcheongnam-do and Jeollanam-do. Thus, the viral disease caused by CMV, PMMoV, and PepMoV in pepper can be severe, and these virus types should remain considered critical reasons for decreased pepper production in field cultivation in Korea. In addition to single infection, mixed infections are frequently observed in collected pepper samples from all areas. The ratios of mixed infection were therefore studied to evaluate the disease severity of mixed infections and to define individual virus types. These data showed that different types of viruses were present, and CMV was the most abundant virus for mixed infection, as in the case of single infection. Among mixed infections, the highest disease severity was seen with CMV+Broad beam wilt virus 2 (BBWV2), followed by other types of mixed infection such as CMV+PepMoV and CMV+PMMoV. However, further work is needed to reduce the severe damage caused by viruses and to assess mixed infection types involving three or more viruses.

AI 허니콤 판재의 기계적 특성

이장하(J.H.Lee),이명호(M.H.Rhee),신광선(K.S.Shin) 한국자동차공학회 1993 한국자동차공학회 춘 추계 학술대회 논문집 Vol.- No.-

Aluminum honeycomb panels have excellent specific strength and impact energy absorption property and thus have a great potential as light-weight structural materials. In this study, aluminum honeycomb panels were fabricated from 5052 aluminum alloy core and face sheets using adhesive films. The mechanical properties of these panels were<br/> characterized using compressive and tensile tests.<br/> The compressive<br/> <br/> strengths were found to be 4.91 I\1Pa and 2.51 I\1Pa for the panels with the cell sizes of 1/8 inch and 3/16 inch, respectively. The excellent energy absorption property of the honeycomb panel was caused by<br/> repetitive buckling of the core and the cushion strength was found to be 43% - 50% of the maximum compressive strength. The bond strength between the core and face sheets was determined from the tensile tests and found to be about 170 I\1Pa regardless of the cell size.<br/>

성결해진 한국인

이장하 ( J. H. Li ) 현대기독교역사연구소 2003 자료총서 Vol.5 No.0

치수 석회화 변성과정에서 단백분해효소 및 단백분해효소 억제제의 역할

김진우,김현희,이상신,이영준,이장하,김연숙,이석근,문혁수,이종헌 대한구강악안면병리학회 2003 대한구강악안면병리학회지 Vol.27 No.2

As pulp calcification occurs at least fifty percent of total teeth, the focal calcification in pulp chamber usually appears in all age groups. However, the pulp calcification is one of the important pathologic changes affecting the pulp vitality. In order to elucidate the mechanism of pulp calcification during the retrogressive degeneration of pulp tissue we performed an immunohistochemical study for proteases (MMP-3, MMP-10, and cathepsin-G), antiproteases (TIMP-1, α1- AT) and proteins involving tissue protection (TGase-2 and HSP-70). In the normal pulp tissue MMP-3 and MMP-10 were weakly expressed, but cathepsin-G and TIMP-1 were rarely expressed. Around the calcifying tissue of MMP-3, MMP- 10, and α1-AT were predominant, but TIMP-1 and cathepsin-G were sparsely expressed. On the other hands, TGase-2 and HSP-70 were condensed in the proximal fibrous tissue. These data suggest that the pulp calcification is related to retrogressive pulp degeneration, which could be resulted in the incomplete digestion of the degenerated stromal tissue by different proteases. We presume that the aberrant protease digestion of chronic pulpal pathosis, i.e., sclerotic fibrosis, chronic pulp degeneration, etc., may enhance the dystrophic calcification in dental pulp.

내병성 고추 육성을 위한 marker assisted breeding

이흥렬,안혜정,심동보,최순호,이장하,양희범,강병철,남석현,한지학 한국육종학회 2013 한국육종학회 심포지엄 Vol.2013 No.07

전통육종과 marker assisted selection(MAS)를 함께 활용하는 방법이 최근 국내 상업육종에서 활발히 사용되고 있다. 식물 유전학의 빠른 발달과 차세대 유전체 염기서열 분석(NGS) 기술이 발전함에 따라, 대량 분자표지를 저렴한 가격에 확보할 수 있는 시대가 되었기 때문이다. 본 연구에서는 고추의 전사체 정보를 이용하여 SNP를 분석하고 Fluidign probe를 자동으로 디자인할 수 있는 파이프라인을 작성하였다. 또한 SNP를 calling하기 위해 총 6개의 accession(5개의 C. annuum과 1개의 C. chinense)의 전사체 염기서열을 Illumina 플랫폼으로 분석하였고, reference 염기서열은 고추 EST DB를 사용하였다. 분석한 SNP의 유전적 위치를 알기 위하여, UC-DAVIS의 고밀도 고추 유전자 지도와 연계하였다. Fluidigm probe를 design할 수 있는 조건으로 SNP를 filtering한 결과, short read의 depth가 10 이상을 기준으로 총 567개의 SNP를 분석하였고, 총 412개의 probe를 디자인하였다. 제작한 412개의 porbe와 논문에 공개된 SSRs, COSII 분자표지들, 2개의 고추 내병성 형질을 이용하여, 현재 내병성 고추 품종을 육성하기 위한 marker assistant breeding(MAB)을 진행 중에 있다.