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LC/TOFMS를 이용한 생체시료의 내인성 대사체 분석법 개발
이인선,김진호,조수열,심선보,박혜진,이진희,이지현,황인선,김성일,이정희,조수현,최돈웅,조양하 한국식품위생안전성학회 2010 한국식품위생안전성학회지 Vol.25 No.4
Metabolomics aims at the comprehensive, qualitative and quantitative analysis of wide arrays of endogenous metabolites in biological samples. It has shown particular promise in the area of toxicology and drug development, functional genomics, system biology and clinical diagnosis. In this study, analytical technique of MS instrument with high resolution mass measurement, such as time-of-flight (TOF) was validated for the purpose of investigation of amino acids, sugars and fatty acids. Rat urine and serum samples were extracted by selected each solvent (50% acetonitrile, 100% acetonitrile, acetone, methanol, water, ether) extraction method. We determined the optimized liquid chromatography/time-of-flight mass spectrometry (LC/TOFMS) system and selected appropriated columns, mobile phases, fragment energy and collision energy, which could search 17 metabolites. The spectral data collected from LC/TOFMS were tested by ANOVA. Obtained with the use of LC/TOFMS technique, our results indicated that (1) MS and MS/MS parameters were optimized and most abundant product ion of each metabolite were selected to be monitorized; (2) with design of experiment analysis, methanol yielded the optimal extraction efficiency. Therefore, the results of this study are expected to be useful in the endogenous metabolite fields according to validated SOP for endogenous amino acids, sugars and fatty acids.
이인선,조성우,권정남 대한침구의학회 2010 대한침구의학회지 Vol.27 No.6
Objectives : This study was undertaken in order to establish the composite principles of fomulas through the of Sa-am acupuncture therapy and the theory of sovereign, minister, assistant and courier. Methods : We analyzed the formula construction of Sa-am acupuncture therapy, and applied the theory of sovereign, minister, assistant and courier that was referred to in the preface of 『Essential Rhymes on Acupuncture and Moxibustion by Master Sa-am』 to the analysis of formula construction. Results & Conclusions :1. Sa-am acupuncture therapy was acupuncture and moxibustion method that inherited and developed progress contents of Chinese traditional acupuncture and moxibustion. 2. The theory of sovereign, minister, assistant and courier was based on the idea that acupuncture and herbal medicine had the same origins. 3. Formula constructions of Sa-am acupuncture therapy were formed complicatedly, but reflected the theory of sovereign, minister, assistant and courier. 4. The supplementing acupuncture point that is Chunbu-point in other merdian became Sovereign, the draining acupuncture point that is Chunbu-point in other merdian became Minister, and the supplementing and draining acupuncture points in same merdian became Assistant and Courier that mean leading merdian points.
메타인지를 활용한 쓰기가 베트남어 모어 화자의 한국어 글쓰기에 미치는 영향
이인선 인문사회 21 2023 인문사회 21 Vol.14 No.3
연구 목적: 이 연구는 메타인지를 활용한 쓰기가 베트남어 모어화자의 한국어 글쓰기에 미치는 영향을 알아보고자 하였다. 연구 방법: 연구방법은 6회의 글쓰기를 실시하였고, 쓰기 메타인지 검사, 쓰기 수행검사, 쓰기 자기 모니터링을 통해서 글쓰기 과정 중에 변화를 알아보았다. 연구 내용: 이 논문의 연구내용은 녹화된 글쓰기 과정을 자기 모니터링하면서, 메타인지를 활용하여 글쓰기를 할 수 있도록 하였다. 결론 및 제언: 메타인지를 활용하는 반복적인 글쓰기 훈련을 통해서 메타인지전략을 학습하고 한국어 글쓰기 수행을 향상시킬 수 있었다. 추후 연구에서는 자기 모니터링 과정에서 동료 피드백 활용하기, 계획하기 과정에서 프로토콜 분석하기 등으로 베트남어 모어화자의 한국어 글쓰기 능력을 증진시킬 수 있는 다양한 연구를 시도하고자 한다.
이인선,최승준,서초롱,김준성 대한영상의학회 2019 대한영상의학회지 Vol.80 No.5
Purpose The aim of this study was to compare the measurements of diameter and volume of hepatic metastases from CT images with the overall survival and tumor response, in patients with unresectable liver metastases of colorectal cancer treated with a targeted agent. Materials and Methods We recruited 43 patients with unresectable liver metastases of colorectal cancer, in whom targeted therapy was used as the first-line treatment. Three-dimensional quantification of the volume of hepatic metastases was performed for each patient. An independent survival analysis using the Response Evaluation Criteria in Solid Tumors guidelines was performed and compared to the volumetric measurement. Overall survival was evaluated using the Kaplan-Meier analysis and compared to the Cox proportional hazard ratios (HRs) following univariate and multivariate analyses. Results In patients classified as non-progressing and progressing by the volumetric criteria, the median overall survival time was 21 months [95% confidence interval (CI): 491.25–768.75] and 11 months (95% CI: 0–949.42), respectively (p = 0.001). Using a multivariate analysis, we found that volumetric response (HR: 3.467; p = 0.002) was a significant factor affecting the overall survival in patients with liver metastases of colorectal cancer. Conclusion Volumetric assessment of liver metastases could be an alternative predictor of the overall survival of patients with liver metastases of colorectal cancer treated with a targeted agent.
이인선,이광오 한국인지및생물심리학회 2011 한국심리학회지 인지 및 생물 Vol.23 No.2
Two experiments were conducted to investigate the effects of oral reading on word recognition. Experiment 1 aimed to examine how naming and lexical decision performances differ as a function of pre-task treatment: oral reading, silent reading, and non-verbal mental rotation. The results of Experiment 1 revealed no significant effect of oral reading on naming and lexical decision. In Experiment 2, how individual differences in subvocalization during reading modulates effects of oral reading was explored. For this, subvocalizers and non-subvocalizers were divided according to their scores in the articulatory suppression task. The results showed that subvocalizers performed naming better after a 10-minute oral reading practice. But, for lexical decision, subvocalizers did better in the silent reading condition, whereas non-subvocalizers did better in oral reading condition. The results from the two experiments were explained in terms of facilitaions in lexical access. 낭독이 단어 인지에 미치는 효과를 조사하기 위해서 두 개의 실험을 실시하였다. 실험 1에서는 사전처치(낭독, 묵독, 심적회전)에 따라 명명과 어휘판단의 수행이 어떻게 달라지는지 조사하였다. 실험 1의 결과, 낭독의 효과는 유의하게 나타나지 않았다. 실험 2에서는 개인의 독서습관(음운변환 대 음운무변환)에 따른 낭독의 효과를 조사하였다. 실험 2의 결과, 음운무변환자가 음운변환자보다 명명에서 더 큰 낭독 효과를 보여주었다. 한편, 어휘판단에서는, 음운변환자는 묵독 조건에서, 음운무변환자는 낭독 조건에서, 수행이 더 좋았다. 이러한 결과는, 낭독의 효과가 음운변환과 관련한 독서습관에 따라 달라질 수 있음을 시사한다.