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Two Series of Familial Cases With Unclassified Interstitial Pneumonia With Fibrosis
이은,서주희,Hyoung-Young Kim,유진호,송진우,박영수,장세진,도경현,권지원,박성우,Jeong-hwan Park,홍수종 대한천식알레르기학회 2012 Allergy, Asthma & Immunology Research Vol.4 No.4
Several children presenting with mild symptoms of respiratory tract infection were diagnosed with unclassified interstitial pneumonia with fibrosis. Their clinical and radiological findings were similar to those of acute interstitial pneumonia, but there were some differences in the pathological findings. Unclassified interstitial pneumonia with fibrosis is characterized by histological findings of centrilobular distribution of alveolar damage and bronchiolar destruction with bronchiolar obliteration. This report describes two different series of familial cases of unclassified interstitial pneumonia with fibrosis, which developed almost simultaneously in the spring. Some of the individual cases showed rapidly progressive respiratory failure of unknown cause, with comparable clinical courses and similar radiological and pathological features, including lung fibrosis. Each family member was affected almost simultaneously in the spring, different kinds of viruses were detected in two patients, and all members were negative for bacterial infection, environmental and occupational agents, drugs, and radiation. These findings implicate a viral infection and/or processes related to a viral infection, such as an exaggerated or altered immune response, or an unknown inhaled environmental agent in the pathogenesis of unclassified interstitial pneumonia with fibrosis.
Differences of Photographs Inducing Craving Between Alcoholics and Non-alcoholics
이은,남궁기,이충헌,안석균,이병욱 연세대학교의과대학 2006 Yonsei medical journal Vol.47 No.4
Many researchers have used cue reactivity paradigm to study alcohol craving. But the difference of craving response to drinks between alcoholic patients and social drinkers was little evaluated. To investigate characteristics of alcohol-related visual cues which induce alcohol craving in alcoholism, we examined the response of subjects to alcohol-related cues considering qualitative aspects. The authors developed 27 photographs related to alcohol as candidate visual cues. Thirty five patients with alcohol dependence, 35 heavy drinkers and 35 social drinkers were shown these pictures and asked to rate these 6 pictures in order of inducing alcohol craving the most. ‘A glass of Soju' and ‘A Party scene' were chosen as the alcohol-related visual cues which induced craving the most in the patients and heavy drinkers, respectively. The results suggest that the patients with alcohol dependence are more absorbed by alcohol without drinking context such as an atmosphere or situation involving drinking. Heavy drinkers may experience craving in anticipation of being in a drinking situation.
한국형 양극성 장애 약물치료 알고리듬 2010 : 급속 순환
이은,박원명,윤보현,민경준,김원,신영철,주연호,서정석,안용민,이정구,김병수,전덕인 대한우울조울병학회 2011 우울조울병 Vol.9 No.2
Objectives : Bipolar disorder is an illness with significant morbidity and mortality that contributes to disturb social function. Our objective for this study is to revise Korean Medication Algorithm Project for Bipolar Disorder 2006 for rapid cycling. Methods : The questionnaires to survey the expert opinion of medication for rapid cycling were completed by the review committee consisting of 70 Korean expert psychiatrists. We classified the experts’ opinion to 3 categories based on the lowest category in which the confidence interval fall (6.5≤ for first-line and 3.5≤ for second-line treatment). Results : The first-line treatment is the combination of a mood stabilizer and an atypical antipsychotic. Combination of two mood stabilizers was preferred as next strategy. The first-line medications in all cases are valproic acid, lithium, quetiapine, and olanzapine. For the treatment of depressive phase, lamotrigine is the first-line medication. Conclusion : Compared to the surveys in 2006, the preference for lamotrigine and atypical antipsychotics has increased while that of carbamazepine and antidepressant has decreased. (J of Kor Soc for Dep and Bip Disorders 2011;9:103-108)
이은,심정연,홍수종,이소연,송대진,강미진,양송이,권지원,김효빈,유호성,홍경모,정영호,이승화,최길용,신혜림,홍서아,김형영,서주희,김병주,김우경,장광천 대한천식알레르기학회 2015 Allergy, Asthma & Immunology Research Vol.7 No.2
Purpose: The complex interplay between environmental and genetic factors plays an important role in the development of asthma. Several studieshave yielded conflicting results regarding the 2 asthma-related risk factors: antibiotic usage during infancy and/or a history of bronchiolitis duringearly life and the development of asthma. In addition to these risk factors, we also explored the effects of Toll-like receptor 4 (TLR4) polymorphismon the development of childhood asthma. Methods: This cross-sectional study involved 7,389 middle school students who were from 8 areas ofSeoul, Korea, and completed the International Study of Asthma and Allergies in Childhood questionnaire. The TLR4 polymorphism rs1927911 wasgenotyped in 1,395 middle school students from two areas using the TaqMan assay. Results: Bronchiolitis in the first 2 years of life, antibiotic exposureduring the first year of life, and parental history of asthma were independent risk factors for the development of asthma. When combined, antibioticuse and a history of bronchiolitis increased the risk of asthma (adjusted odds ratio [aOR]: 4.64, 95% confidence interval [CI]: 3.09-6.97, P valuefor interaction=0.02). In subjects with CC genotype of TLR4, antibiotic exposure and a history of bronchiolitis during infancy, the risk of asthma wasincreased, compared to subjects without these risk factors (aOR: 5.72, 95% CI: 1.74-18.87). Conclusions: Early-life antibiotic exposures and a historyof bronchiolitis are risk factors for asthma in young adolescents. Polymorphisms of TLR4 modified the influence of these environmental factors. Reducing antibiotic exposure and preventing bronchiolitis during infancy may prevent the development of asthma, especially in genetically susceptiblesubjects.