http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
LKB1 pathway variant and the prognosis of non-small cell lung cancer after surgical resection
이용훈,( Sook Kyung Do ),( Shin Yup Lee ),( Hyo-gyoung Kang ),( Jin Eun Choi ),( Mi Jeong Hong ),( Jang Hyuck Lee ),( Eung Bae Lee ),( Yangki Seok ),( Ji Yun Jeong ),( Kyung Min Shin ),( Won Kee Lee ),( 대한결핵 및 호흡기학회 2018 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.126 No.-
This study was conducted to investigate the associations between polymorphisms of genes involved in LKB1 pathway and the prognosis of patients with non-small cell lung cancer (NSCLC) after surgical resection. Twenty-three single nucleotide polymorphisms (SNPs) in LKB1 pathway were investigated in a total of 782 patients with NSCLC who underwent curative surgery. The association of the SNPs with overall survival (OS) and disease free survival (DFS) were analyzed. Among the 23 SNPs investigated, TSC2 rs30259G>A was significantly associated with survival outcomes in multivariate analyses. The TSC2 rs30259G>A was associated with significantly worse OS and DFS (adjusted hazard ratio [aHR] for OS=1.88, 95% confidence interval [CI]=1.21-2.91, P=0.005; aHR for DFS=1.65, 95% CI=1.15-2.38, P=0.01, under codominant model, respectively). When stratified by tumor histology, the SNP was significantly associated with survival outcomes only in squamous cell carcinoma, but not in adenocarcinoma. This study suggests that TSC2 rs30259G>A may be useful for the prediction of prognosis in patients with early stage NSCLC after curative surgery.