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이용수,하정윤,김교한,권태엽 대한치과재료학회 2011 대한치과재료학회지 Vol.38 No.3
a 본 실험에서는 시판 중인 일반소환 매몰재와 급속소환 매몰재를 사용한 경우의 금관의 정확도를 확인하기 위해 패턴레진과 플라스틱 링(링리스 방법)을 사용해서 변연 적합성, 표면 거칠기, 경화 시 최대 온도, 열팽창을 측정하였다. 시편은 일반소환과 급속소환 각각 5개씩 준비하였다. 실험 결과 변연 적합성에서 일반소환과 급속소환 사이에 유의한 차이를 나타내지 않았다. Bellavest를 급속소환할 때 변연적합성이 가장 우수하였다. 오히려 급속소환을 사용 시 표면 거칠기가 더 우수한 경우가 있었다. CB-Plus가 표면 거칠기에서 가장 우수하였다. 경화 시 최대 온도와 열팽창은Moldavest가 가장 우수하였다. 또한 두 방법 모두에서 크랙의 발생이 관찰되지 않았다. 이전 연구에서는 크랙의 문제로 인해 메탈 링 중심으로 연구가 이루어졌지만, 본 연구는 소환 시간을 줄이면서도 동일한 품질을 얻을 수 있는 급속소환 방법이 유용하게 사용될 수 있다는 것을 제시한다.
Arachidonic Acid Activates K+-Cl−-cotransport in HepG2 Human Hepatoblastoma Cells
이용수 대한약리학회 2009 The Korean Journal of Physiology & Pharmacology Vol.13 No.5
K+-Cl−-cotransport (KCC) has been reported to have various cellular functions, including proliferation and apoptosis of human cancer cells. However, the signal transduction pathways that control the activity of KCC are currently not well understood. In this study we investigated the possible role of phospholipase A2 (PLA2)-arachidonic acid (AA) signal in the regulatory mechanism of KCC activity. Exogenous application of AA significantly induced K+ efflux in a dose-dependent manner, which was completely blocked by R-(+)-[2-n-butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H- inden-5-yl]oxy]acetic acid (DIOA), a specific KCC inhibitor. N-Ethylmaleimide (NEM), a KCC activator- induced K+ efflux was significantly suppressed by bromoenol lactone (BEL), an inhibitor of the calcium- independent PLA2 (iPLA2), whereas it was not significantly altered by arachidonyl trifluoromethylketone (AACOCF3) and p-bromophenacyl bromide (BPB), inhibitors of the calcium-dependent cytosolic PLA2 (cPLA2) and the secretory PLA2 (sPLA2), respectively. NEM increased AA liberation in a dose- and time-dependent manner, which was markedly prevented only by BEL. In addition, the NEM- induced ROS generation was significantly reduced by DPI and BEL, whereas AACOCF3 and BPB did not have an influence. The NEM-induced KCC activation and ROS production was not significantly affected by treatment with indomethacin (Indo) and nordihydroguaiaretic acid (NDGA), selective inhibitors of cyclooxygenase (COX) and lipoxygenase (LOX), respectively. Treatment with 5,8,11,14- eicosatetraynoic acid (ETYA), a non-metabolizable analogue of AA, markedly produced ROS and activated the KCC. Collectively, these results suggest that iPLA2-AA signal may be essentially involved in the mechanism of ROS-mediated KCC activation in HepG2 cells.
춘계학술대회 : 포스터발표 ; 비알코올성 지방간을 가진 한국 남성에서 ALT 증가와 Adipokine과의 연관성
이용수,조용균,유태우,오세용,박정호,김홍주,박동일,손정일,전우규,김병익,이원영,오기원 대한간학회 2005 Clinical and Molecular Hepatology(대한간학회지) Vol.11 No.3(S)
배경/목적: 비알코올성 지방간질환(nonalcoholic fatty liver disease, NAFLD)은 단순 지방증과 지방간염을 포함하며, 간경변증 및 말기 간질환으로 진행할 수 있다. 최근 지방세포에서 분비되는 adiponectin, resistin, leptin 같은 adipokine과 비알코올성 지방간의 위험인자로 알려진 비만, 당뇨병과 고지혈증 등 대사성 증후군 사이에 밀접한 관련성이 있음이 알려져 있다. 본 연구에서는 비알콜성 지방간으로
이용수,김정근,김정석 한국보건통계학회 1983 한국보건정보통계학회지 Vol.8 No.1
Activities of MCH require efficient information system for better planning, organization, Monitoring and evaluation of services and for determining such factors as acceptability, utilization and accessibility. The information system for MCH is composed of sub-systems corresponding to each component of MCH activities. Despite the rapid progress in some aspects of MCH activities such as family planning, the most important component of services has not been developed in this country. The biological characteristic of the population is the one component not given attention to the governmental effort. As to the causes of infant mortality, infectious disease has been decreasing steadily, while rate of congenital malformations rises by the year. The prevention of various disabilities and handicaps including congenital malformations is, therefore, a vital component to the development of a better health service. In this paper, an effort is made in terms of the development of information systems for taking preventive measures to decrease disabilities and handicaps. A health examination system for pregnant women, infants, and pre-school children, a surveillance system for congenital malformation, a genetic counselling system, and the mass-screening examination for inborn errors of metabolism has been examined. Also, several functional modules and MCH information sub-systems have been established for practical use in the future.