Synthesis of conductive monodisperse hybrid particle

이예진,최순자 한국고분자학회 2010 한국고분자학회 학술대회 연구논문 초록집 Vol.2010 No.4

Adalimumab 치료 후 발생한 Myopathy 1예

이예진,정기헌 대한건선학회 2019 대한건선학회지 Vol.16 No.1

Adalimumab is a human monoclonal antibody against tumor necrosis factor alpha (TNF-α), which blocks the activity of TNF-α receptor. TNF-α inhibitors have been chosen as a therapeutic option in these diseases. A 43-year-old woman with a 19-year history of severe plaque psoriasis and psoriatic arthritis had been treated with adalimumab for 3 years. She was presented with pain in both arms and shoulders. On the basis of laboratory results, imaging studies, and histopathologic findings, we ruled out other possible differential diagnosis. After the cessation of adalimumab treatment and starting systemic corticosteroid treatment, the pain was relieved. Herein, we report a rare case of myopathy after adalimumab therapy.

LAO (Linear Alpha Olefin) 생산을 위한 Fischer-Tropsch 합성반응에서 공정변수가 촉매 성능에 미치는 영향

이예진,이경우,박형진,노연희,천동현,임근배,안상현,윤민혜 한국공업화학회 2021 한국공업화학회 연구논문 초록집 Vol.2021 No.1

지속가능한 디자인 수업이 중학교 3학년의 공동체의식에 미치는 영향

이예진,김효정 한국초등미술교육학회 2021 미술교육연구논총 Vol.64 No.-

The purpose of this study is to confirm the effect of sustainable design class on learners' sense of community. For this research, the educational value was examined through literature research and prior research on sustainable design classes and community consciousness. Community consciousness and sustainable design art dealt with in the art curriculum of the 2015 revised curriculum were identified, and the contents and perspectives on sustainable design presented in each textbook were analyzed through related units. Accordingly, learning objectives and evaluation plans were designed, and flow charts and detailed guidance plans for teaching-learning processes were prepared. The inspection tool of the study utilized a Korean community consciousness inspection tool developed by Jeong Jin-kyung (1999). Accordingly, a sustainable design class was conducted for art clubs of B Middle School in Daejeon to examine the sense of community before and after. Pre- and post-inspection data were statistically processed using the SPSS Ver 21.0 statistical package program, and the corresponding sample t-test was verified and analyzed to produce meaningful results. Also, the effectiveness of the program was confirmed through positive results of class satisfaction. To sum up the results of the study, the entire area and sub-items of community consciousness in the third year of middle school were statistically improved, indicating that sustainable design classes were meaningful in fostering community consciousness. The qualitative analysis of class satisfaction showed high satisfaction with the class compared to before class. As a result, this study has proven that sustainable design classes have had a significant impact on cultivating learners' sense of community. 본 연구는 지속가능한 디자인 수업이 학습자의 공동체의식에 미치는 영향을 확인하는 것을 목적으로 한다. 이를 위해 지속가능한 디자인 수업과 공동체의식에 대한 문헌조사 및 선행연구를 통해 교육적 가치를 살펴보고, 연구의 필요성과 방향을 정리하였다. 2015 개정 교육과정의 미술 교과에서 다루는 공동체의식과 지속가능한 디자인 미술을 확인하고, 중학교 미술 교과서의 지속가능한 디자인 관련 단원을 통해 각 교과서마다 제시하는 지속가능한 디자인에 대한 내용과 관점을 분석하였고, 지속가능한 디자인을 수록한 교과서 중 사회적·경제적·환경적 관점과 관련된 도판이 포함된 교과서를 중심으로 분석하였다. 이를 바탕으로 지속가능한 디자인 수업의 주제를 ‘플라스틱 줄이는 지속가능 한 패키지디자인 제작하기’로 설정하였다. 이에 따라 학습목표와 평가계획을 설계하고 교수-학습 과정의 흐름도와 세부 지도안을 작성하였다. 연구의 검사 척도는 정진경(1999) 이 개발한 한국 공동체의식 검사 척도를 활용하여 대전광역시에 소재한 B중학교의 미술동아리을 대상으로 지속가능한 디자인 수업을 실시한 전과 후의 공동체의식에 대한 검사를 시행하였다. 사전·사후에 실시한 검사 자료는 SPSS Ver 21.0 통계 패키지 프로그램을 활용하여 통계처리 하였으며, 대응표본 t-test로 검증분석 하여 본 프로그램의 유의미한 결과를 도출하였다. 또한, 수업만족도의 긍정적인 결과를 통해 프로그램의 효과성을 확인하였다. 연구결과를 종합하여 정리하자면, 중학교 3학년 공동체의식의 전체 영역과 하위항목은 사후 결과가 통계적으로 향상되어 지속가능한 디자인 수업이 공동체의식의 함양에 있어 유의미한 것을 알 수 있었다. 수업만족도의 질적 분석 결과로는 수업 전과 비교해볼 때 본 연구의 수업에 대한 높은 만족도를 확인할 수 있었다. 따라서 본 연구는 지속가능한 디자인 수업이 학습자의 공동체의식을 함양시키는 데 있어 유의미한 영향을 미쳤음을 검증하였다.

Characterization and Prognostic Significance of Cutaneous Adverse Events to Anti-Programmed Cell Death-1 Therapy

이예진,김학태,원종현,장성은,이미우,최지호,이우진 대한의학회 2019 Journal of Korean medical science Vol.34 No.26

Background: Anti-programmed cell death-1 (PD-1) immunotherapy using antibodies such as nivolumab or pembrolizumab has shown promise for treating various types of cancer. In this study, we reviewed the frequency and spectrum of cutaneous adverse events (AEs) caused by PD-1 antibodies and their possible correlation with treatment response. Methods: We reviewed records of all patients from a single institution treated with either nivolumab or pembrolizumab from August 1, 2014 to April 1, 2017. Results: Of 211 patients included in the study, 134 (63.5%) were treated with nivolumab and 77 (36.5%) with pembrolizumab. Thirty-five patients (16.4%) developed cutaneous AEs. Cutaneous AEs were significantly associated with longer treatment cycles (P = 0.001). The prevalence of cutaneous AEs did not differ between nivolumab (17.2%) and pembrolizumab (15.6%). Patient age, gender, baseline Eastern Cooperative Oncology Group scale and underlying malignancy were not associated with development of cutaneous AEs. Median time until onset of cutaneous AEs was 50.0 days (range, 1–378 days). Anti-PD-1 therapy was tolerable in most of patients with grade 1 (65.2%) and grade 2 (23.9%) cutaneous AEs. Pruritus (32.6%) and eczema (21.7%) were the most commonly reported cutaneous AEs. In lung cancer patients, cutaneous AEs were not associated with better treatment outcomes after adjusting for the number of treatment cycles. Conclusion: Both pembrolizumab and nivolumab exhibited tolerable cutaneous safety profiles in a variety of cancer patients undergoing anti-PD-1 therapy. Cutaneous AEs of anti-PD-1 therapy were not associated with antibody type, underlying malignancy, patient characteristics, or improved response.

기내배양 홍띠 단계별 재분화체의 기관분화 관련 유전자 발현과 ISSR에 기반한 유전적 안정성 분석

이예진,깅인진,배창휴 한국자원식물학회 2023 한국자원식물학회지 Vol.36 No.5

적 요화본과 식물 홍띠(Imperata cylindrica ‘Rubra’)의 기관분화관련 유전자의 동태와 기내재생체의 유전적 안정성을 조사하고자 기관분화 단계별 재분화체를 작성하여 기관분화 관련 유전자 발현과 ISSR 마커 기반 변이성을 조사하였다. 5종류 총 15개체의 기관분화 단계별 재분화체에서 캘러스 발생 유전자인 FIE 는 모식물체 1번을 제외한 14개의 식물체에서 모두 발현되었으며, 뿌리 발생 유전자인 WOX11도 15개의 모든 단계별 재분화체에서 발현하였다. 체세포 발생 유전자인 LEC1B는 15개 식물체에서 모두 발현하였으나 비교적 약하게 발현하였다. 7종류 총21개체의 기관분화 단계별 재분화체 및 재분화식물체에 대하여ISSR 분석한 결과, 유전적 다형성은 기관분화 단계별 재분화체및 순화 재분화체(실내포트 재배식물체 4.1%, 노지 재배식물체4.3%, 기내배양 홍띠(적색)식물체 4.2%, 녹색신초 발생 캘러스5.6%, 캘러스 1.4%)에서 대조구인 모식물체(1.4%)와 같거나 높게 나타났다. 또한, 유전적 유사도 지수는 0.747~1.0 사이에 분포하며, 평균 0.868로 나타났다. 군집분석 결과 유전적 유사도지수 0.809에서 기외 식물체(모식물체, 실내재배 및 노지재배재분화 녹색 식물체)와 기내식물체 및 재분화 과정상의 분화체(기내배양 중인 홍띠 식물체, 녹색 신초, 적색신초 발생 캘러스, 캘러스)는 독립적인 2개 그룹으로 유집되었다. 이상의 결과는화본과 식물의 기내배양 시 재분화 과정에서 일어나는 일련의유전학적 기초자료를 제공해 준다. Abstract - The in vitro organogenesis is one of important issues in plant embryology, and somaclonal variations are existing in calli and/or regenerants induced from a process of the organogenesis with in vitro circumstances. In this study, expressions of organogenesis-related genes were evaluated and genetic stability of regenerants derived from the process of in vitro organogenesis were measured using ISSR markers in Imperata cylindrica ‘Rubra’, Poaceae. The expressions of organogenesis-related genes were detected all of regenerants at the process of the organogenesis. All ISSR markers produced with an average of 71 bands per in vitro-cultured regenerants, and the scorable bands were varied from two to eight with an average of 5.14 bands per a primer. The polymorphism rates of the in vitro regenerants were higher than that of mother plants (1.4%), showing 4.1% (pot-cultured regenerants), 4.3% (field-cultured regenerants), 4.2% (in vitro-cultured regenerants), 5.6% (calli with green shoots) and 1.4% (calli), respectively. The genetic similarity matrix (GSM) among all accessions ranged from 0.747 to 1.0 with a mean of 0.868. GSM of the regenerants showed differences (from 0.972 to 1.00) compared with that of mother plants (0.991). According to the clustering analysis, two independent groups were divided into; the one is mother plants and regenerants cultured at room and open field, the other is regenerants cultured in vitro. The results give a new insight for understanding the dynamics of organogenesis in monocot plant. Key words – Genetic similarity matrix (GSM), In vitro organogenesis, Organogenesis-relate

Pulmonary Histoplasmosis Identified by Video-Assisted Thoracic Surgery (VATS) Biopsy: a Case Report

이예진,강혜린,송진화,신수임,이상민 대한의학회 2018 Journal of Korean medical science Vol.33 No.2

Histoplasmosis is a common endemic mycosis in North, Central, and South America, but Korea is not known as an endemic area. We treated an immunocompetent Korean patient who had histoplasmosis. A 65-year-old Korean man presented with multiple pulmonary clumps of tiny nodules in the both lungs. He had been diagnosed 40 years earlier with pulmonary tuberculosis (TB) and a fungus ball had been diagnosed 4 years earlier. He denied any history of overseas travel. The patient visited our hospital with dyspnea, blood-tinged sputum, and weight loss, which had appeared 2 months earlier. The patient underwent video-assisted thoracic surgery (VATS) lung biopsy. The biopsy sample showed necrotizing granuloma and the presence of multiple small yeast-like fungi. Tissue culture confirmed Histoplasma capsulatum, and he was finally diagnosed with pulmonary histoplasmosis. Therapy was initiated with 200 mg itraconazole orally once per day. The symptoms disappeared 1 week after the start of treatment. After 4 months, low-dose chest computed tomography showed improvement in the ground glass opacity and size of the lung lesions. In conclusion, we report a case of an immunocompetent patient who developed histoplasmosis in Korea. When a patient shows unexplainable progressive infiltrative lung lesions, histoplasmosis should be considered as one of differential diagnoses although Korea is not an endemic area.

A genome-wide association study on the risk variations for differential lung function decline trajectories

이예진,최승호,권성연,이윤환,이정규,허은영,정희순,김덕겸 대한결핵 및 호흡기학회 2018 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.126 No.0

Low FEV1 in early adulthood and accelerated decline in FEV1 are important in the genesis of COPD. We aimed to identify unique genetic loci that contribute to accelerated decline in FEV1 and low FEV1 in early adulthood based on some postulations. Genotyping was performed using Koreanchip for the samples of GENIE cohort including participants received health screening examination at Seoul National University Hospital healthcare system Gangnam Center (SNUH-GC) between February 2014 and October 2016. We estimated FEV1 at 25 and 65 years by extrapolation using FEV1 decline for middle age period for the GENIE cohort. Based on the estimated FEV1 at 25 years old, the study population were stratified according to the presence or absence of COPD at 70 years. The genome-wide associations between genetic variants and low FEV1 in early adulthood or rapid decline of FEV1 were tested using multivariate linear regression models. Only one single-nucleotide polymorphisms (SNP) approaching genome-wide significance for an association with low FEV1 in early adulthood (rs55829010, P=8.82 x10-8). This is near the genes RBFOX3 on chromosome 17, which is associated with small airway epithelial epigenetic changes. As for the candidate genetic loci for rapid decline of FEV1, genome-wide significant variants were not found although top list SNPs included rs911288 of PRIMA1. Despite the limited cases, a novel candidate loci (in or near the genes RBFOX3) that may play a role in low FEV1 in early adulthood causing COPD in Koreans. Further analyses in larger populations or longitudinal cohorts are needed.

상황인식과정에서의 시선 이동에 관한 성별 특성

이예진,정광태,이현철 대한산업공학회 2021 대한산업공학회 춘계학술대회논문집 Vol.2021 No.6

In this study, gender characteristics of gaze movements were analyzed in the process of judging a system status through information on the HMI (Human-Machine Interface) screen. Gaze entropy was used as a method to analyze gaze movement in the process of situation awareness. LOCA(Loss of Coolant Accident), SGTR(Steam Generator Tube Rupture), SLB(Steam Line Break), and LOV(Loss of Voltage) which are the accident situation of a nuclear power plant were used as task scenarios for the experiment. Subjects judged the accident situation by looking at the six indicators displayed on the HMI screen showing the accident situation. A total of 20 college students (10 males and 10 females) with no experience in operating a nuclear power plant participated as subjects. In order to measure the gaze data, the subjects performed an experiment while wearing an eye tracker. For all tasks, Shannon entropy did not show a significant difference between men and women, but Markov entropy showed a significant difference between men and women, and it was found that women’s Markov entropy was higher. In conclusion, there was no significant difference between men and women in the ratio of viewing the necessary information elements for situation awareness, but it was found that women had more gaze movements between necessary information elements than men.

Postextubation respiratory events in patients admitted to the intensive care unit: a prospective pilot study using overnight respiratory polygraphy

이예진,이진우,이상민,조재영 대한중환자의학회 2020 Acute and Critical Care Vol.35 No.4

Background: Before the main trial in which respiratory polygraphy will be used to evaluate postextubation sleep apnea in critically ill patients, we performed a prospective pilot study to ensure that any issues with the conduct of the trial would be identified. Methods: In the present study, 13 adult patients who had received mechanical ventilation for ≥24 hours were prospectively recruited. Among the patients, 10 successfully completed respiratory polygraphy on the first or second night after extubation. Data regarding the types and doses of corticosteroids, analgesics, sedatives, and muscle relaxants as well as the methods of oxygen delivery were recorded. Results: During the night of respiratory polygraphy, all 10 patients received supplemental oxygen (low-flow oxygen, n=5; high-flow oxygen, n=5), and seven patients received intravenous corticosteroids. Three of the 10 patients had a respiratory event index (REI) ≥5/hr. All respiratory events were obstructive episodes. None of the patients receiving high-flow oxygen therapy had an REI ≥5/hr. Two of the seven patients who received corticosteroids and one of the other three patients who did not receive this medication had an REI ≥5/hr. Although low- or high-flow oxygen therapy was provided, all patients had episodes of oxygen saturation (SpO2) <90%. Two of the three patients with an REI ≥5/hr underwent in-laboratory polysomnography. The patients’ Apnea-Hypopnea Index and REI obtained via polysomnography and respiratory polygraphy, respectively, were similar. Conclusions: In a future trial to evaluate postextubation sleep apnea in critically ill patients, pre-stratification based on the use of corticosteroids and high-flow oxygen therapy should be considered.