한냉담마진 1례

이영현,김유영,강석영 대한알레르기학회 1981 천식 및 알레르기 Vol.1 No.2

Expression and Possible Role of Phospholipase C $\beta1$ and $\gamma1$ in Mouse Oocyte Maturation and Preimplantation Embryo Development

이영현,금동호,심찬섭,서판길,김경진,Lee, Young-Hyun,Geum, Dong-Ho,Shim, Chan-Seob,Suh, Phan-Gil,Kim, Kyung-Jin The Korean Society of Developmental Biology 1998 발생과 생식 Vol.2 No.1

Phospholipase C (PLC)는 다양한 세포주에서 세포내 신호전달에 중요한 역할을 한다고 알려져 있으나, 생쥐 난자성숙 과정과 착성전 배아발생 과정에서 PLC의 역할과 발현은 아직 연구된 바 없다. 본 연구에서는 난자성숙과 착상전 배아발생 과정에서 생쥐의 PLC \beta 1과 \gamma 1의 유전자 발현을 조사하기 위하여 한 개의 난자 혹은 배아에서 추출된 total RNA를 사용하여 경쟁적 RT-PCR 방법으로 mRNA를 정량하였다. PLC \gamma 1의 유전자 발현을 조사하기 위하여 한 개의 난자 혹은 배아에서 추출된 total RNA를 사용하여 경쟁적 RT-PCR 방법으로 mRNA를 정량하였다. PLC \gamma 1의 유전자는 전혀 발현하지 않았다. 수정후 PLC \betta 1과 \gamma 1의 유전자 발현은 상실기 배아에서 증가하기 시작하여 포배기 배아에서는 현저히 증가하였다. 난자성숙과 착상전 배아발생 과정에서 protein kinase C(PKC) 신호전달체게에 의한 PLC의 역할을 조사하기 위하여 PKC의 억제제인 sphingosin, PKC의 촉진제인 $diC_{8}$, 그리고 PLC의 억제제인 U73122의 효과를 조사하였다. Spihingosine은 처리후 1시간 이내에 대조군에 비해 20% 정도의 난자성숙을 촉지하였으나 U73122는 유효한 효과를 보이지 않았다. U73122는 상실기 배아의 compaction을 억제하였으나 $diC_{8}$에 의하여 부분적으로 극복되었다. 이상의 결과는 PLC \beta 1과 \gamma 1 유전자가 생쥐의 착상전 발생단계에서 특이젖으로 발현하고 있으며, 난자성숙과 착상전 초기배아에서 PKC-PLC 신호전달체계가 관여하고 있으리라 사료된다. It has been wel known that phospholipase C(PLC) plays an important role in the intracellular signaling in a variety of cell types. However, involvement of PLC in mouse oocyte maturation and preimplantation embryo development remains unknown. The present study examined the expression patterns of the mouse PLC \beta 1 and \gamma 1 during oocyte maturatio and preimplantation embryo development study examined the expression patterns of the mouse PLC \beta 1 and \gamma 1 during oocyte maturation and preimplantation embryo development by the competitive reverse transcription-polymerase chain reaction (RT-PCR method). PLC \gamma 1 mRNA (0.1 fg) was readily detected in germinal vesicle (GV)-stage oocyte and its level was reduced as meiotic resumption proceeded. PLC-\beta 1 mRNA (<0.1 fg) as detected at low level at GV-stage oocytes and scarcely detected at germinal vescle breakdown (GVBD)-stage oocytes. After fertilization, both PLC \beta 1 and \gamma 1 mRNA levels began to increase at morula-stage embryos (0.2 fg) and were more prominent in blastocyst-stage embryos(1 fg). to elucidate the possible involvement of PLC via protein kinase C(PKC) pathway during oocyte maturation and preimplantation embryo development , the effects of sphingosine (PKC inhibitor), sn-$diC_{8}$(PKC activator) anc U73122 (PLC ingibitor) were examined. Treatment of GV-stage oocytes with sphingosine (20 \mu M) facilitated the meiotic resuption by 10-20 over the control within 1 h as judged by GVBD, whereas U73122 failed to show any significant effect. U73122 (10 \mu M) effectively blocked the compaction of morula, while sn-$diC_{8}$(50 \mu M). In summary, the present study shows that the mouse PLC \beta 1 and \gamma 1 are expressed in a developmental stage-specific manner and PLC-PKC pathway may be involved in early preimplantation embryo development.

레일건 가속특성 분석

이영현,김성호,이병하,Lee, Young-Hyun,Kim, Seong-Ho,Lee, Byung-Ha 한국군사과학기술학회 2021 한국군사과학기술학회지 Vol.24 No.5

To accelerate a launch mass with a low level of pressure as possible in a railgun, it is required to hold supplied current nearly constant during launch phase. We obtained the discharging conditions for required current shaping by modeling and analysis of circuit equations coupled to acceleration equation of the launch mass. The acceleration characteristics of the railgun in the conditions were analyzed by comparing experimental and theoretical results.

꿈보다 해몽이구나

이영현 샘터사 1999 월간 샘터 Vol.30 No.1

단일 수술자에 의한 초기와 중기에 시행한 무지외반증에 대한 Scarf 절골술의 결과 비교

이영현,남일현,이태훈,안길영,이용식,황성현,이경진,Lee, Yeong-Hyeon,Nam, Il-Hyun,Lee, Tae-Hun,Ahn, Gil-Yeong,Lee, Yong-Sik,Hwang, Sung-Hyun,Lee, Kyung-Jin 대한족부족관절학회 2020 대한족부족관절학회지 Vol.24 No.4

Purpose: This study evaluated the results of two groups-the early group and midterm group-comparatively in the treatment of hallux valgus using a scarf osteotomy. Materials and Methods: From January 2005 to December 2009 (Group 1) and from January 2010 to December 2013 (Group 2), this study compared hallux valgus cases treated by a scarf osteotomy by a single surgeon with at least a five-year follow-up. Results: The average ages of Group 1 and Group 2 were 50.5 and 51.7 years old, respectively. The average follow-up of Groups 1 and 2 were 7.4 and 6.2 years, respectively. Groups 1 and 2 had 86 cases (53 patients) and 93 cases (64 patients) with at least a five-year follow-up, respectively. The average hallux valgus angle (HVA) and 1-2 intermetatarsal angle (IMA) of Group 1 were improved from 31.3° and 13.9° preoperatively to 11.3° and 6.8° at the final follow-up, respectively (p<0.001). The average HVA and 1-2 IMA of Group 2 were improved from 31.7° and 13.4° preoperatively to 8.9° and 6.6° at the final follow-up, respectively (p<0.001). The mean American Orthopaedic Foot and Ankle Society (AOFAS) score of both groups increased from 48.5 and 45.0 points preoperatively to 73.7 and 82.4 points at the final follow-up, respectively. The numbers of patient-assessed subjective satisfaction of Groups 1 and 2 at the final follow-ups were as follows: excellent, 27 and 36 (31.4%, 38.7%); good, 34 and 49 (39.5%, 52.7%); fair, 13 and 5 (15.1%, 5.4%); poor, 12 and 3 (13.9%, 3.2%); respectively. Neither troughing nor stress fractures occurred in both groups. Conclusion: Scarf osteotomy for treating hallux valgus is an excellent surgical method with a relatively low incidence of complications. The results in Group 2 were better than those in Group 1, showing that more surgical experience and evolution of the techniques provided better results.

닭고기 가공제품의 냉온저장

이영현 한국식품과학회 1986 식품과학과 산업 Vol.19 No.4

단축 Scarf 절골술을 이용한 무지 강직증의 치료

이영현,안길영,남일현,이태훈,이용식,김대근,이영훈,Lee, Yeong Hyeon,Ahn, Gil Yeong,Nam, Il Hyun,Lee, Tae Hun,Lee, Yong Sik,Kim, Dae Geun,Lee, Young Hoon 대한족부족관절학회 2016 대한족부족관절학회지 Vol.20 No.4

Purpose: To evaluate the effect of shortening scarf osteotomy on pain relief and range of motion (ROM) of the first metatarsophalangeal joint in hallux rigidus patients. Materials and Methods: Twenty-three cases of 19 patients who had been treated with shortening scarf osteotomy for the hallux rigidus between January 2007 and December 2013 were reviewed. The mean follow-up period was 21.4 months, and the mean age was 59.2 years. The first metatarsal bone was shortened until the ROM of the first metatarsophalangeal joint was greater than $80^{\circ}$ or $40^{\circ}$ of dorsiflexion. The length shortened by scarf osteotomy was measured. The authors also measured and compared the joint interval difference of the standing foot using an anteroposterior radiography. Moreover, the difference of ROM of the first metatarsophalangeal joint between the preoperative and final follow-up periods was also compared. The clinical results were evaluated and compared using the American Orthopaedic Foot and Ankle Society (AOFAS) scoring system and visual analogue scale (VAS) score. Results: The mean shortening length was about 6.5 mm (range, 4~9 mm). The joint space has been increased to 1.8 mm, and the ROM of the first metatarsophalangeal joint has also been increased to $18.4^{\circ}$ after the operation. In three cases, the postoperative ROM has been decreased to less $10^{\circ}$. The AOFAS score has been improved from 41.7 (range, 32~55) to 86.2 (range, 65~95), and the VAS score was also decreased from 3.7 (range, 3~5) to 1.3 (range, 0~3). Two cases have shown no decrease in pain even after the operation. Conclusion: Shortening scarf osteotomy was found to decrease joint pain by decompressing the pressure of the first metatarsophalangeal joint. This osteotomy also helped improve the ROM of the first metatarsophalangeal joint. Shortening scarf osteotomy can be considered one of the effective methods for joint preservation.

급성 심장성뇌경색 환자에서 관찰된 경동맥혈전의 독특한 이중초음파소견

이영현,양지혜,손영민,김범생,조아현 대한뇌졸중학회 2012 Journal of stroke Vol.14 No.3

In patients with acute ischemic stroke, carotid duplex ultrasonography has been used to assess atherosclerotic lesions at the extracranial carotid artery. We reported a unique sonographic finding of carotid artery thrombus in a patient with acute cardioembolic stroke and atrial fibrillation. An 81-year-old woman with atrial fibrillation was presented with dysarthria and left side hemiparesis. She had undergone surgical thrombectomy and angioplasty for her right brachial artery occlusion four days before the stroke onset. Diffusion-weighted MRI revealed multiple territorial infarctions suggestive of acute cardio-embolic stroke. CT angiography showed an occlusion of the right common carotid artery. On B-mode ultrasonography, longitudinal intraluminal tortuous cylinderic oscillating thrombus was observed on the right distal common carotid artery to the proximal internal carotid artery. This case illustrates a unique ultrasonographic finding of acute cardiogenic thrombus in the extracranial carotid artery.

원발성 한랭담마진 2례

이영현,김유영,강석영 대한천식알레르기학회 1981 천식 및 알레르기 Vol.1 No.2

Cold urticaria is a kind of physical aller gy and its clinic al picture is char acterized by local and systemic symptoms which were provocated by cold exposure. Two cases of primary col d urticaria w a.s reported with brief review of literature. The first case presented in this paper is a wo- men, who has urtic aria of 20 ye srs duration. The symptom was noticed after cold exposure. This patient shows typical ice cube test r esults but the response of therapeutic trial including cold desens- itization and antihistamines was poor The second case has urticaria cf 3 years duration and which was provocated by cold exposure. Cold desensitization was started and successful resurts was noticed. This patient is now symptom free and no urticari a is provocated by cold w ater (OC temperature) exposure. We ca nnot find any etiologic f zctors in both cases.

Pulmonary Embolism -내과적 치료 및 예방-

이영현 대한결핵 및 호흡기학회 1997 워크샵 Vol.8 No.-