가미오령산(加味五?散)이 Streptozotocin으로 유발된 흰쥐의 당뇨병성(糖尿病性) 신증(腎症)에 미치는 영향

이연경,강석봉,Lee, Yeon-Kyeong,Kang, Seok-Bong 대한한방내과학회 2012 大韓韓方內科學會誌 Vol.33 No.4

Objectives : The object of this study was to observe the effects of Gamioryung-san (GOS), which consists of 22 types of herbs, on streptozotocin (STZ)-induced diabetic nephropathy rats. Methods : Three different dosages of GOS were orally administered once a day for 28 days from 3 weeks after STZ treatment. Six groups, each of 8 rats per group were used. Changes on the body weights, blood glucose levels, serum BUN and creatinine levels, urine volumes, and UAER were observed with changes on the kidney malondialdehyde contents and glutathione, dismutase and catalase contents. In addition, histopathology of kidney, pancreas, thymus and spleen were observed. The results were compared with antioxidant silymarin 100 mg/kg, of which the effects on STZ -induced diabetes and related complications are already confirmed. Results : As a result of treatment of GOS 800, 400 or 200 mg/kg for 28 days, STZ-induced decreases of body weights, hyperglycemia, atrophic changes of pancreatic islets with decreases of insulin-immunoreactive cells and decreases of glucagon -immunoreactive cells were inhibited dose-dependently. Increases in kidney weight, serum BUN and creatinine levels, urine volumes, UAER, vasodilated atrophic glomerulus and abnormal tubules were inhibited dose-dependently. Also increases of kidney MDA contents and decreases of GSH contents, SOD and CAT activities, decreases of thymus and spleen weights, and atrophic changes at histopathological observation were also inhibited. The effects of GOS 400 mg/kg showed similar effects to silymarin 100 mg/kg. Conclusions : These results suggest that 400 mg/kg of GOS retarded the STZ-induced diabetic nephropathies as similarly to silymarin 100 mg/kg, through modulations of oxidative stress and immune systems.

대분청음(大分淸飮)이 Cisplatin으로 유발(誘發) 된 흰쥐의 급성신부전(急性腎不全)에 미치는 영향(影響)

이연경,윤경민,장수영,강석봉,Lee, Yeon-Keong,Yoon, Kyeong-Min,Jang, Su-Yeong,Kang, Seok-Bong 대한한방내과학회 2009 大韓韓方內科學會誌 Vol.30 No.4

Purpose : This study was to observe the nephroprotective effects of the traditional prescription, Daebuncheong-eum (DBCE). DBCE has generally been used for treating various renal diseases, including renal failure. Methods : Three different dosages of DBCE extract were orally administered once a day for 28 days. At the 23rd day after DBCE extract treatment, cisplatin was also treated. Then, 5 days after cisplatin treatment, all rats (6 groups of 8 rats each) were sacrificed. Changes on the body weight, kidney weight, serum BUN and creatinine levels were observed, along with changes to the kidney MDA and GSH contents. The results were compared with captopril 100mg/kg, from which the effects on cisplatin-induced acute renal failures have already been confirmed. Results : Cisplatin induced ARF are induced by oxidative stress and related lipid peroxidation in the present study. However, these ARFs and inhibition of antioxidant effects induced by cisplatin were dose-dependently reduced by treatment of all three different dosages of DBCE extracts. Conclusion : This study suggests that DBCE extracts show favorable effects on cisplatin-induced rat ARF.

네 방향 스캔 방법을 이용한 QR코드 파인더 인식

이연경,유훈,Lee, Yeon-Kyung,Yoo, Hoon 한국정보통신학회 2012 한국정보통신학회논문지 Vol.16 No.6

본 논문에서는 네 방향으로 스캔 방향을 늘려 QR코드 파인더를 인식하는 방법을 제안한다. QR코드 인식의 첫 과정은 파인더 인식이다. 만약 파인더를 인식하지 못한다면 QR코드를 인식 할 수 없다. 기존의 QR코드 인식방법은 정면에서 촬영하지 않으면 QR코드를 인식하지 못한다는 문제점을 가지고 있다. 이러한 문제점을 극복하기 위해서 네 방향으로의 스캔과 후보군 영상을 사용하여 정확하게 파인더의 위치를 찾는다. 또한 모폴로지 연산을 이용하여 파인더의 위치를 다시 추려낸다. 제안된 방법을 입증하기 위해 기존의 인식 방법과 비교 실험을 수행하였고 그 결과 제안한 방법이 기존 방법보다 QR코드 파인더 인식률에서 우수함을 입증하였다. This paper describes a method to detect QR-code finders by four-direction scanning. The finder recognition is the first step in the QR-code recognition. If the finder is missing, QR-code recognition fails. The existing QR-code recognition method has a problem that the recognition performance decreases for perspectively distored images. To overcome the problem, we introduce four-direction scanning and a candidate set image to accurately detect QR-code finders. Using morphological operations detect the QR-code finder in the candidate set image robustly. To show the effectiveness of our method, we compared our method with the well-known existing method. The experimental result indicates that the proposed method is superior to the existing method in terms of the finder recognition performance.

목방기약침(木防己藥鍼)이 관절염(關節炎)에 미치는 영향(影響)

이연경,이병렬,Lee, Yeun-kyung,Lee, Byung-ryul 대한침구의학회 2001 대한침구의학회지 Vol.18 No.4

Objective : The purpose of this study is to observe the effect of Aqua-acupuncture with Stephania Tetrandra Solution (ST-AS) on arthritis. Methods : The author performde several experimental items : that isgene expression and secretion of IL-$1{\beta}$, IL-6, TNF-${\alpha}$, MMP-2, production of ROS, paw thickness, DTH, weight of spleen, expression of CD4+, CD8+, CD19+ in the spleen, production of IL-6, TNF-${\alpha}$, examination of histology. Results : The obstain results are summarized as follows. 1. IL-$1{\beta}$, IL-6, TNF-${\alpha}$ gene expression of hFLS were significantly inhibited in treatmentgroup, and gene expression of MMP-2 was not inhibited in treatmentgroup. 2. The secretion amount of IL-$1{\beta}$, IL-6, TNF-${\alpha}$ were significantly inhibited in treatmentgroup. 3. Expression of P-38 MAP kinase and production of ROS were inhibited in treatmentgroup. 4. Treatmentgroup were significantly inhibited the incidence of arthritis, hind paw edema, the index of arthritis and DTH of CIA (collagen II-induced arthritis) mice. 5. Treatmentgroup were significantly decreased splenetic weight and the number of CD4+, CD8+, CD19+ activated cells and secretion aroout of IL-6, TNF-${\alpha}$ of CIA (collagen II-induced arthritis) mice.. 6. Treatmentgroup were expressed form of new bone, synoviumin, new margine in histology imperison to controlgroup. Conclusions : Taking all these observations into account, ST-AS injection is considered to be effective in treating arthritis and put to practical use in future arthritis clinic.

새로운 소비자, 새로운 시장, 할랄 보충제

이연경,Lee, Yeon Kyung 한국식품과학회 2015 식품과학과 산업 Vol.48 No.2

기능성 정보 전달 방법 및 소비자 태도에 따른 건강기능식품 광고 효과 분석

이연경,김지연,권오란,황인경,Lee, Yeonkyung,Kim, Ji Yeon,Kwon, Oran,Hwang, In-Kyeong 한국식품영양학회 2016 韓國食品營養學會誌 Vol.29 No.6

본 연구에서는 소비자 중심적인 건강기능식품 기능성 전달방법을 도출하기 위하여 이미지, 원료 및 기능성에 대한 설명, 기능성을 설명하는 도표, 특허 정보, 권위자의 설명 등 다양한 전달 방법들이 소비자의 광고 평가에 미치는 영향을 분석하였다. 또한 소비자들이 이미 가지고 있었던 건강기능식품에 대한 인식들이 광고 평가에 미치는 영향에 대하여 살펴 보았다. 이미 수행된 정성조사(Focus group interview)에서는 실제 사용되던 건강기능식품 광고 50여건을 소비자에게 제시하고, 기능성과 관련하여 소비자의 광고 인식에 미치는 방법들을 찾아내었다. 이렇게 찾은 방법들에 대하여 보다 넓은 범위에서 검증하기 위하여, 이를 바탕으로 6가지의 광고안들을 개발하여 정량 조사를 수행하였다. 6가지 광고안은 각각 정인지 이미지+원료에 대한 설명+기능성을 설명하는 도표, 정인지 이미지+원료에 대한 설명, 정인지 이미지, 오인지 이미지, 오인지 이미지+특허 정보, 오인지 이미지+권위자의 설명을 반영하여 제작되었다. 정량 조사의 대상은 서울 및 수도권 거주자 30~60대 총 300명이었으며, 대인면접법으로 한 사람당 4가지 광고안을 평가하도록 하여 광고안 당 200개의 평가 결과가 나올 수 있도록 하였다. 광고에 대한 평가는 광고 위계 효과 모형에서 제시되는 인지-감정-행동 세 가지 요소가 모두 반영될 수 있도록 '광고가 시선을 끄는가', '광고가 얼마나 이해하기 쉽다고 생각하는가', '제품 기능에 대한 정보가 충분한가', '광고의 메시지에 공감이 가는가', '광고를 통해 제품의 효능/효과를 얼마나 신뢰하는가', '광고를 본 후 구입하고 싶은 생각이 드는가'의 6가지 항목을 질문하였다. 또한 광고에 대한 평가와 함께 소비자들이 건강기능식품에 대하여 가지고 있는 태도를 '건강하기 위해서는 건강기능식품을 꼭 섭취해야 한다고 생각한다', '건강기능식품의 효능/효과에 대해 신뢰한다', '건강기능식품을 구입하기 전에 많은 정보를 수집한 후 구입한다', '평소 건강기능식품 광고들을 관심있게 본다', '건강기능식품 광고에서 전달하는 효능/효과에 대해 신뢰한다' 이렇게 5가지 문항을 통하여 조사하였다. 건강기능식품에 대한 소비자의 태도를 t-검정 및 일원분산분석을 이용하여 분석한 결과, 성별에 따른 차이로서 '광고관심도'에 대해서는 유의적인 차이를 보이지 않았으나, '섭취필수도', '효과신뢰도', '구입 전 정보수집도' 및 '광고내용신뢰도'에 대해서는 여성이 남성보다 유의하게 긍정적인 태도를 취하고 있는 것으로 나타났으며, 연령에 따른 분석 결과로서는 모든 항목에 대하여 40대와 50대 연령층이 30대와 비교하여 보다 긍정적인 태도를 취하고 있음을 알 수 있었다. 제시된 6가지 광고에 대하여 광고 효과를 분산분석한 결과, 단순히 이미지만을 제시한 광고안들에 비하여 원료와 기능성에 대한 정보가 함께 제시된 광고안들의 효과가 유의적으로 높게 평가되어 즉, 원료 및 기능성에 대한 설명, 그래프 형태의 시험 결과 제시, 특허, 권위자의 설명은 인지, 정서, 행동 모든 측면에서 광고 효과를 높일 수 있는 것으로 확인되었다. 하지만 소비자들은 오인지 이미지에 대하여 인지하지 못하여 이에 따른 광고 평가의 영향은 없는 것으로 나타났다. 다른 변수들과의 상호작용을 살펴보기 위하여 이원분산분석을 수행한 결과, 이러한 경향은 성별, 연령과 서로 상호작용을 가지지 않았으며, 성별과 연령 The purpose of this study was to find efficient and customized tools for delivering the benefit of health functional foods (HFFs). Delivery tools which could influence the impact of advertising were images, explanations of ingredients, diagrams of health benefit, patents, and comments from authority. Six advertisements were developed using these tools: "A": relevant image + explanation of ingredients + scientific diagram of efficacy; "B": relevant image + explanation of ingredients; "C": relevant image; "D": irrelevant image; "E": irrelevant image + explanation of ingredient + patent; "F": irrelevant image + explanation of ingredient + comments from authority. To analyze the consumer perceptions on HFFs and advertisement effects, 300 respondents were requested to answer a questionnaire comprising of the following questions: 5 questions of attitudes (necessity of HFFs, trust in HFFs, gathering information, watching advertisements and trust in advertisement claims) and 6 questions on the 6 developed advertisements (attention, understanding, sufficiency of information, sympathy, trust, and purchase). Scoring was done as per the 5 Likert scale. There was a higher proportion of females and the elderly, as compared to males and youngsters. The overall consumer attitudes were positive. Explanation of ingredients, scientific diagram of health benefit, patents and expert comments were helpful factors in increasing the advertisement evaluation by consumer, but the images were not. Advertisement evaluation of consumer did not differ with gender and age. However, differences were observed between some of the consumer attitudes (necessity of HFFs, trust in HFFs, gathering information and trust in advertisements claim) and advertisement evaluations (attention, understanding, sympathy and purchase). Our results indicate that for consumers utilizing the HFFs, advertisements with concrete tools such as diagrams, patent, and expert comments are more helpful. However, for consumers who do not have interest in HFFs, the scientific information was irrelevant. We believe that to maximize the effect of health information in advertisements, consumers should be segmented, and customized tools for each segment needs to be developed.

서울 상업용도지역 내 주거 기능 회복의 필요성과 방향 -서울 역사도심과 뉴욕 맨해튼을 중심으로-

이연경,이경민,최원우,신중호,김도년,Lee, Youn-Kyung,Lee, Kyung-Min,Choi, Won-Woo,Shin, Jung Ho,Kim, Do-Nyun 국제문화기술진흥원 2022 The Journal of the Convergence on Culture Technolo Vol.8 No.6

The purpose of this study is to present the problems of urban ecosystem imbalance in Seoul and the need to restore housing functions through comparison with Manhattan, New York, which grew earlier than Seoul and has been striving to solve urban problems and restore urban ecosystems. The residential status in urban commercial use areas was investigated through analysis of the total amount of residential space, characteristics of each type of residential building, and distribution of residential buildings. Through this, it can be seen that most of the space in Seoul's historic city center is biased toward commercial roads, and there are significantly insufficient high- and high-density mixed-use buildings suitable for urban dwellings compared to Manhattan's. In addition, it can be seen that the complex building in the historical city center of Seoul is located adjacent to the outskirts of the target site. In conclusion, Seoul's historical city center does not provide an appropriate residential space for creating an urban ecosystem, and it is necessary to come up with measures to restore housing functions.

1차원 Cu(II)배위 고분자의 합성 및 구조: [Cu(bdcH)₂(bipyen)] (bdc=1,3-benzenedicarboxylate; bipyen=trans-1,2-bis (4-pyridyl)ethylene)

이연경,이순원,Lee, Yeon Gyeong,Lee, Sun Won 대한화학회 2002 대한화학회지 Vol.46 No.5

당뇨병 및 소갈(消渴)의 최신 연구 동향 -2003년에서 2007년까지 한의학술논문을 중심으로-

이연경,최규호,신현철,강석봉,Lee, Yeon-Kyeong,Choi, Geu-Ho,Shin, Hyun-Cheol,Kang, Seok-Bong 대한한의학방제학회 2007 大韓韓醫學方劑學會誌 Vol.15 No.2

At this moment, because there're lots of necessity to have an attention on diabetus mellitus (DM), in this article searched over all the Korean oriental medical academic journals about DM from 2003 to 2007, Method: Through data base system that Daegu Haany University affiliated information center & Korean Studies Information Center manage, selected 60 articles worthy to look up that are searched by the keyword 'DM' & '消渴'. Result and Conclusion: 5 articles of observing 'DM' & '消渴' itself academically, 29 articles of experimental study, 8 articles of clinical research study and 18 articles of case report. For experimental study, mostly it were concerning type II DM modeled rat medicated herb and its effect, so there were only a few type I experimental study. For observing articles, generally the causes, pathology, treatments, acupuncture methods and medication et al., variable studies were done. In clinical research, diverse categories were subject, which is to prove the efficacy of medication, acupuncture, physical therapy and diet supplements. And in case reports, focused not only on improvement in blood sugar level but also its complications.

이중 문턱 값과 적분영상을 이용한 2차원 바코드 영상의 적응적 이진화

이연경,유훈,Lee, Yeon-Kyung,Yoo, Hoon 한국정보통신학회 2012 한국정보통신학회논문지 Vol.16 No.11

본 논문에서는 2차원 바코드 영상을 위한 적응적 이진화 방법을 제안한다. 적응형 이진화 방법은 조명의 영향을 최소화하여 이진화를 수행하는 기술이다. 적응적 이진화 방법은 주로 문서 영상에 맞게 발전되어 왔다. 기존 방법들은 적응적 이진화에서 사용되는 박스에 대한 크기 설정 문제를 가지고 있다. 이 문제로 기존 방법들은 이차원 바코드 영상 인식에 적용하기에 부적절하다. 문제점을 극복하기 위해 먼저 박스크기와 기존 방법들의 문제점을 분석하고, 이를 기반으로 적분영상을 사용한 새로운 적응형 이진화 방법을 소개한다. 제안한 방법의 성능 입증을 위해 기존의 방법과 속도, 성능 비교 실험을 수행하였고 실험 결과는 기존 방법보다 우수함을 입증하였다. In this paper, we propose an adaptive thresholding method to binarize two-dimensional barcode images. Adaptive thresholding methods that minimize light effects convert an original image into a binary image. The methods are applied to document image binarization. The methods, however, have problems of determining box size used in adaptive thresholding. thus, they inappropriate to use in recognition of two-dimensional barcode images. To overcome the problem, we analysis the problem and propose a new adaptive threshold method using the integral image. To show the effectiveness of our method, we compared our method with the well-known existing methods in terms of visual quality and processing time. The experimental result indicates that the proposed method is superior to the existing method.