발열성 과립구 감소증 환자에서 Ceftazidime을 포함한 병합요법과 Piperacillin과 Amikacin 병합요법의 비교

이여민,유진홍,신완식,강문원,한치화,박종원,김춘추,김동집 대한화학요법학회 1989 대한화학요법학회지 Vol.7 No.2

To assess the clinical efficacy of ceftazidime cootaining regimen relative to standard combination antibiotic therapy for the treatment of the febrile granulocytopenic patients, we studied a randomized trial comparing ceftazidime containing regimen with a combination of piperacillin and amikacin. Among 40 evaluable cases of fever and granulocytopenia, 20 were treated with ceftazidime plus amikacin or piperacillin, and the other 20 were treated with piperacillin plus amikacin. The clinical response rates in assessable patients were 66.7% for caftazidime containing regimen and 55.6% for standard combination therapy. The bacteriological clearance rates were 62.5% for ceftazidime containing regimen and 54.5% for standard combination regimen. Efficacy against pseudomonas species appeared to be excellent in ceftazidime containing regimen. Results of therapy according to initial granulocyte count and to the site of infection showed no significant difference in success fate between ceftazidime containing regimen and piperacillin plus amikacin. We conclude that combination antibiotic therepy with ceftazidime will be a good alternative to the other combination antibiotic therapy for the febrile granalocytopenic patients, especially in the hospitals which pseudomonas species are predominant pathogens.

Efffects of Fluoxetine on ATP-induced Calcium Signaling in PC12 Cells

이여민,김희정,홍선화,김명준,민도식,이덕주,김명석,조양혁,한상준,윤신희 대한약리학회 2004 The Korean Journal of Physiology & Pharmacology Vol.8 No.1

Fluoxetine, a widely used anti-depressant compound, has several additional effects, including blockade of voltage-gated ion channels. We examined whether fluoxetine affects ATP-induced calcium signaling in PC12 cells by using fura-2-based digital calcium imaging and assay for [3H]-inositol phosphates (IPs). Treatment with ATP (100μM) for 2 min induced [Ca2+]i increases. The ATP-induced [Ca2+]i increases were significantly decreased by removal of extracellular Ca2+ and treatment with the inhibitor of endoplasmic reticulum Ca2+ ATPase thapsigargin (1μM). Treatment with fluoxetine for 5 min blocked the ATP-induced [Ca2+]i increase concentration-dependently. Treatment with fluoxetine (30μM) for 5 min blocked the ATP-induced [Ca2+]i increase following removal of extracellular Ca2+ and depletion of intracellular Ca2+ stores. While treatment with the L-type Ca2+ channel antagonist nimodipine for 10 min inhibited the ATP-induced [Ca2+]i increases significantly, treatment with fluoxetine alone blocked the ATP-induced responses. Treatment with fluoxetine also inhibited the 50 mM K+-induced [Ca2+]i increases completely. However, treatment with fluoxetine did not inhibit the ATP-induced [3H]-IPs formation. Collectively, we conclude that fluoxetine inhibits ATP-induced [Ca2+]i increases in PC12 cells by inhibiting both an influx of extracellular Ca2+ and a release of Ca2+ from intracellular stores without affecting IPs formation.

식도 정맥류 경화용법후 발생한 장간막 정맥 혈전증 1예

이여민,방춘상,강혜정,최명규,안병민,정인식,정규원,선희식,정환국 大韓消化器病學會 1989 大韓消化器病學會誌 Vol.21 No.3

낭창성 신염 환자의 임상추적 고찰

김호연,윤영석,양진모,방병기,이여민,강숙영 대한신장학회 1988 Kidney Research and Clinical Practice Vol.7 No.2

Systemic lupus erythematosus is a disease of unknown origin, characterized by major alterations of hurnoral or cellular immunity. Lupus nephritis, one of most critical manifestations of outcome in systemic lupus erythematosus, is characterized by various clinical course, histologic and immunologic patterns. 1) In 156 patients with systemic lupus erythematosus, 11 patients were men and 145 patients were women (M: F=l:13.2). Their age at onset of the disease ranged mainly in the 2nd and 3rd decades. 2) In 156 patients systemic lupus erythematosus, lu pus nephritis occurred in 96 patients(61.5%). 3) On admission, positive rates of anti-DNA antibody showed 68.4%, ANA: 71.8%, and ENA antibody: 63.3%. 4) On the basis of morphologic features, the renal lesions were categorized as follows: mesangial proliferative lupus nephritis 2, tocal proliferative lupus nephritis 8, diffuse proliferative lupus nephritis 14, membranons lupus nephritis 5 and interstitial nephriti a one. 5) In the only steroid therapeutic group, rate of complete remission and no-response were 53.6%, 46.4% respectively. In the steroid and cyclophosphamide com- bination therapeutic group, rate of complete remission and no-response were 60.9%, 39.1% respectively. 6) The cause of death in 10 patients with lupus nephritis were reviewed. Unknown (30%), renal failure (20%), suicide (20%), sepsis (10%), pulmonary hemorrage (10%), CUA (10%) were noted.

Helicobacter pylori에 감염된 생쥐에서 위염에 대한 위산의 역할

김성수 ( Sung Soo Kim ),이여민 ( Yeo Min Lee ),김형근 ( Hyung Keun Kim ),김진일 ( Jin Il Kim ),채현석 ( Hiun Suk Chae ),정인식 ( In Sik Chung ),박두호 ( Doo Ho Park ) 대한소화기학회 2007 대한소화기학회지 Vol.50 No.6

목적: 위산이 H. pylori 감염에 의한 위염 진행을 억제할 수 있는지 알아보고자 대상 및 방법: C57BL/6 생쥐 28마리에 H. pylori (SS1 균주)를 감염시켰다. 7마리씩 4군으로 나누어 I군은 처치 없이 관찰하고, II군은 위투여(sham injection), III군은 펜타가스트린 125μg/kg, IV군은 펜타가스트린 250μg/kg을 일주일에 3회 피하 주사하여, 7개월 후 위 점막 pH를 측정하고, 위 점막의 H. pylori 군집도, 호중구 활성도, 만성 염증, 위선 위축의 변화를 관찰하였다. 결과: H. pylori 군집도는 체부와 전정부 모두 군 간에 차이가 없었다. 호중 구 활성도는 체부에서 타군에 비해 IV군이 현저히 낮았으며(I군, 1.71; II군, 1.0; III군, 2.71; IV군, 0.29, p<0.05), 전정 부에서는 군 간에 차이가 없었다. 만성 염증 세포의 침윤정도는 체부에서 III군에 비해 IV군이 현저히 낮았으나(1.86 vs. 1.0, p<0.05), 전정부에서는 군 간에 차이가 없었다. 위축 정도는 군 간에 통계적인 차이가 없었다. 대상 위 점막의 평균산도 3.2를 기준으로 고위산분비군과 저위산분비군으로 나누어 비교했을 때 체부에서 고위산분비군은 저위산분비군에 비해 H. pylori 군집도(1.4 vs. 2.4; P=0.04), 호중구 활성도(0.9 vs. 2.3; p=0.018) 및 만성 염증 세포의 침윤 정도(1.2 vs. 1.8; p=0.011) 모두 유의하게 낮았다. 결론: 위산은 위내 H. pylori에 의한 위염 확산을 억제하는 데 중요한 역할을 하는 것으로 생각한다. Background/Aims: This study was designed to investigate the role of gastric acid in the extent of H. pylori-induced gastritis. Methods: Twenty eight mice were innoculated with live H. pylori. They were allocated into four groups. Mice in group I received no treatment, group II mice were treated with sham injection, group III received 125μg/kg body weight of pentagastrin, while group IV received 250μg/kg body weight of pentagastrin subcutaneously three times a week. After 7 months, the mucosal pH, H. pylori density, neutrophils and monocytes infiltration, and the degree of atrophy were assessed in the stomach. Results: In the gastric body, the densities of H. pylori were not different among groups. The degree of neutrophil infiltration was significantly lower in group IV compared to other groups (p<0.05). The degree of monocyte infiltration was also significantly lower in group IV than group III (p<0.05). In the gastric antrum, there was no significant difference of the H. pylori density, neutrophil and monocyte infiltration, and degree of atrophy among the groups. The mice with the gastric mucosal pH lower than mean of 3.2 had significant lower level of H. pylori density (1.4 vs. 2.4, p=0.04), and infiltration of neutrophils (0.9 vs. 2.3, p=0.018), and monocytes (1.2 vs. 1.8; p=0.011) than the those with mucosal pH above 3.2 in the body of stomach. Conclusions: Gastric acid plays a role in suppressing the proximal propagation of H. pylori-induced gastritis to the body of stomach. (Korean J Gastroenterol 2007;50:363-369)

융모성선자극 호르몬 생산성 골외 점액상 연골육종 1 예

이종욱,박동준,김철민,이중달,강문원,이여민,윤종일,박철휘 대한내과학회 1991 대한내과학회지 Vol.40 No.1

We experienced a case of human chorionic gonadotrophin-producing (HCG) extraskeletal myxoid chondrosarcoma occurred on the left buttock in 65-year-old man, which metastasized to the right lung and pleura. Microscopically, the tumor and pleural malignant cells were characterized by lobular configurations and were sparsely cellular with background of myxoid matrix. The cells were small, round, and undifferentiated with eosinophilic cytoplasm. They were strongly positive for S-100 protein and elevated level of HCG in serum and pleural fluid. he present study documents a very rare case of HCG-producing extraskeletal myxoid chondrosarcoma with pleural metastasis.

Coagulase 음성 포도상구균에 의한 원내감염 균혈증의 임상적 고찰

이봉수(Bong Soo Lee),김태룡(Tae Ryong Kim),유석환(Suk Whan Yoo),이경혜(Gyeong Hye Lee),이여민(Yeo Min Lee),임규택(Gyu Taek Lim),조석구(Suk Ku Cho),신완식(Wan Shik Shin),강문원(Moon Won Kang) 대한내과학회 1991 대한내과학회지 Vol.40 No.2

N/A During a 3 year period from July 1986 to June 1989, 1, 230 of 11,238 cases had positive blood culture, and coagulase-negative staphylococcus (CNS) was present in 370 cases (30.1%) at St. Mary`s hospital. In a retrospective study 345 cases were examined, 125 (36.2%) were true CNS bacteremia, and 75 of 125 cases (60% of CNS bacteremia) were nosocomial in origin (defined as those in which the first positive blood culture was obtained 48 hr after admission). There was a significant annual increase in nosocomial bacteremia and little relation in age-related incidences. The most common undelying diseases were hematologic or neoplastic diseases, mainly acute leukemia, followed by gastrointestinal or liver diseases. The common medical procedures frequently related to bacteremia were cytotoxic chemotherapy, catheterization, and steroid. The most frequent clinical features were fever and leukocytosis. The main sources of bacteremia were the respiratory tract, infected wounds, injured mucosa, and catheter; however the sources were unknown in over half of the cases. The overall mortality was 25.3%, and mortality was especially high in adults over 50 years of age. Mortality due to sepsis was similar to mortality from aggravating underlying diseases, and most of the expired patients had fatal underlying diseases. In antimicrobial susceptibility, the prominent feature was resistance to many commonly used antimicrobial agents. However there was no resistance to vancomycin.

식도 정맥류 경화요법후 발생한 장간막 정맥 혈전증

정규원(Kyu Won Chung),정환국(Whan Kook Chung),선희식(Hee Sik Sun),정인식(In Sik Chung),안병민(Byung Min Ahn),김승남(Seung Nam Kim),이여민(Yeo Min Lee),방춘상(Choon Sang Bang),강혜정(Hye Jung Kang),최명규(Myung Kyu Choi),이용각(Yong K 대한소화기학회 1989 대한소화기학회지 Vol.21 No.3

Although there has not been a satisfactory treatment for esophageal variceal bleeding, recently clinicians take interests in endoscopic sclerotherapy. But several complications were also reported after endoscopic sclerotherapy. One of these was mesenteric venous thrombosis which developed more prevalently when the sclerotherapy used in combination of vasopressin infusion. We experienced one case of mesenteric venous thrombosis after esophageal sclerotherapy with vasopressin infusion for control of esophageal variceal bleeding.

State Industrial Promotion and Law

이용식 한국제도∙경제학회 2019 제도와 경제 Vol.13 No.3

This paper examines state industrial promotion in the context of ‘law and development’. Economists have argued since the 18th century on the economic efficiency of government involvement in the economy. While state-led development policies in some of the most successful development cases, such as South Korea, Taiwan, Singapore, and more recently, China, have been effective, many have doubted the wisdom of government involvement in the economy. Where the availability of information is limited and the financial market is imperfect (which are the inherent conditions of less-developed countries), the government can provide useful initiatives in productive industrial pursuits, as demonstrated in the cited successful development cases. Adoption and management of industrial promotion policies are indeed a hallmark of developmental states. However, industrial promotion by the state, which might be useful in the early stages of economic development, may not be sustained indefinitely, and at some point those industries promoted by the state would have to sustain themselves in the market environment without continuing government support. This paper attempts to clarify the conditions for successful state industrial promotion as well as the legal frameworks that enable the government to provide effective assistance to meet the development needs, which may vary in different stages of economic development. In the legal analysis, the paper applies the recently-developed “General Theory of Law and Development”.