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오요탕(五拗湯) 및 신출산(神朮散)이 GUINEA PIG의 기관지(氣管支) 평활근(平滑筋)에 미치는 영향(影響)
이시형,Lee, Si-Hyeong 대한한방내과학회 1993 大韓韓方內科學會誌 Vol.14 No.1
This study was carried out to investigate the effect of Oyootang and Shinchulsan extract on the contractile force of the isolated guinea pig trachea smooth muscle and elucidate its mechanism The result were obtained as follow: 1. The isolated trachea smooth muscle was suspended in the organ bath with oxygenated kerb's Henseleit bicarbonate buffer solution at $37^{\circ}C$, and the developed tension by the drug was recorded with isometric tranducer(Nacro F-60). The resting tension was approximately 0.5g 2. The contractile response of the trachea smooth muscle of the isolated guinea pig by histamine $10^{-4}M$ was significantly inhibited by Oyootang and Shinchulsan extract. 3. The contractile response of the trachea smooth muscle of the isolated guinea pig by acetylcholine $10^{-4}M$ was considerably inhibited by Oyootang and Shinchulsan extract. 4. The contractile response of the trachea smooth muscle of the isolated guinea pig by histamine $10^{-4}M$ was significantly inhibited by Oyootanghabshinchulsan extract. 5. The contractile response of the trachea smooth muscle of the isolated guinea pig by acetylcholine $10^{-4}M$ was significantly inhibited by Oyootanghabshinchulsan extract. 6. The contractile response of the trachea smooth muscle of the iso-lated guinea pig by histamine $10^{-4}M$ was significantly inhibited by Oyootang, Shinchulsan and its constituent herbs extract. 7. The contractile response of the trachea smooth muscle of the iso-lated guinea pig by acetylcholine $10^{-4}M$ was significantly inhibited by Oyootang, Shinchulsan and its constituent herbs extract.
석진한,심철웅,최현배,이시형,Seok, Jin-Han,Sim, Cheol-Ung,Choi, Hyun-Bae,Lee, Si-Hyeong 대한한의정보학회 2012 大韓韓醫情報學會誌 Vol.18 No.1
Pulse diagnosis has been highly valued in many East Asian medical books, since "Huangdaineijing(黃帝內經)" published. Gigoo-inyoung pulse method(氣口人迎脈法) is one of the four pulse diagnostic methods originally written in"Huangdaineijing(黃帝內經)". At the late 3rd century, "Maijing(脈經)" redefined the positions of Gigoo-inyoung pulse(氣口人迎脈). According to "Maijing(脈經)", both spots were 1fen(分) in front of guan(關) but Gigoo on the right hand and Inyoung on the left hand. At the middle of 13th century, "Maekgyolejijangbyungsikdoseol(脈訣指掌病式圖說)" had detailed view points about the manner of reading Gigoo-inyoung pulse. "Maekgyolejijangbyungsikdoseol(脈訣指掌病式圖說)" explained clearly the position of 1fen(分) in front of guan(關) by sketch of wrist. The location indicated the border of cun(寸) and guan(關). It also explained clearly corresponding certain cun-guan-chi(寸關尺) with Gigoo-inyoung pulse by sketch. "Euihackipmoon(醫學入門)" is a comprehensive book on medicine written by Lee-Cheon(李?) in Ming(明) dynasty. In this book, pulse diagnosis is the most emphasized method among the four techniques of diagnosis(四診). Furthermore, it introduces detailed information about Gigoo-inyoung pulse method(氣口人迎脈法) in "Gigoo-inyoungmaekgyole(氣口人迎脈訣)". Lee-Cheon concured in the theory of "Yeongruegumbang(永類鈐方)" and "Maekgyolejijangbyungsikdoseol(脈訣指掌病式圖說)" and put a short essay about Gigoo-inyoung pulse named "Gigoo-inyoungmaekgyole(氣口人迎脈訣)" quoted from the two books. Therefore, throughout many chapters of "Euihackipmoon(醫學入門)", Gigoo-inyoung pulse is used in order to distinguish internal damage(內傷) and external contraction(外感). "Maekgyolejijangbyungsikdoseol(脈訣指掌病式圖說)" and "Euihackipmoon(醫學入門)" understood Gigoo-inyoung pulse commonly by corresponding certain cun-guan-chi(寸關尺) with Gigoo-inyoung pulse. Therefrom, Gigoo-inyoung pulse can distinguish seven emotions(七情) of internal damage(內傷) or six excesses(六淫) of external contraction(外感).
Bee Venom과 Sweet Bee Venom이 지방세포 대사에 미치는 영향
김민기,이시형,신조영,김강산,조남근,임태진,권기록,Kim, Min-Ki,Lee, Si-Hyeong,Shin, Jo-Young,Kim, Kang-San,Cho, Nam-Guen,Rhim, Tae-Jin,Kwon, Ki-Rok 대한약침학회 2007 Journal of pharmacopuncture Vol.10 No.3
Objectives The purpose of this study was to investigate the effects of Bee Venom and Sweet Bee Venom to the primary cultured preadipocyte, adipocytes, and localized fat tissue. Methods Decreased preadipocyte proliferation and decreased lipogenesis are mechanisms to reduce obesity. So, preadipocytes and adipocytes were performed on cell cultures using Sprague-Dawley Rats and treated with 0.01-1mg/ml Bee Venom and Sweet Bee Venom. And porcine skin including fat tissue after treated Bee Venom and Sweet Bee Venom according to the dosage dependent variation are investigated the histologic changes after injection of these Pharmacopuncture. Result Following results were obtained from the preadipocyte proliferation and lipolysis of adipocyte and histologic investigation of fat tissue. 1. Bee Venom and Sweet Bee Venom showed the effect of decreased preadipocyte proliferation depend on concentration. 2. Bee Venom and Sweet Bee Venom showed the effect of decreased the activity of glycerol-3-phosphate dehydrogenase(GPDH) significantly. 3. Bee Venom was not showed the effect of lipolysis, but Sweet Bee Venom was increased in low dosage and decreased in high dosage. 4. Investigated the histologic changes in porcine fat tissue after treated Bee Venom and Sweet Bee Venom, we knew that these Pharmacopuncture was activated nonspecific lysis of cell membranes depend on concentration. Conclusion These results suggest that Bee Venom and Sweet Bee Venom efficiently induces decreased proliferation of preadipocyte and lipolysis in adipose tissue.
『醫學入門ㆍ臟腑條分』中 腎臟에 작용하는 藥物에 관한 硏究
이석재(Lee Seok-jae),맹학영(Maeng Hack-young),금경수(Keum Kyung-soo),황우준(Hwang Woo-jun),이시형(Lee Si-hyeong) 대한한의학원전학회 2009 대한한의학원전학회지 Vol.22 No.2
In this dissertation, I will focus on the channel entry[歸經] and the effect and the treatment [效能主治] in oriental medicine texts from ancient to modern times in order to classify the medicines of the kidney. Medicines that effected the Kidney through working on any other viscera were as follows: Fossilia Ossis Mastodi(龍骨), Schizandrae Fructus(五味子), Nelumbinis Semen(蓮肉), Ostreae Testa(牡蠣), Polygalae Follium(小草), Angelicae Gigantis Radix(當歸), Albizzae Cortex(合歡), Thujae Semen(栢子仁) and Bambusae Calulis in Liquamen(竹瀝). This study was dedicated to researching the medicines related to the kidney and making efficient use of these medicines.