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絞扼性 腸閉鎖時의 代謝 및 組織學的 變化에 關한 實驗的 硏究
李舜濟,金相孝,白樂晥 인제대학교 1983 仁濟醫學 Vol.4 No.4
실험적인 교액성 장폐쇄에서의 혈청단백, 콜레스테를, 전해질 및 병변 장의 조직학적 변화를 시간별로 관찰함. Acute obstruction of small bowel is caused by hernia, adhesions and bands within peritoneal cavity, and that results in accumulation of fluid and gas proximal to the obstruction producing distention of the intestine. Strangulation develops when the circulation to obstructed intestine is impaired by longstanding or "closed loop" obstruction. Strangulation causes loss of blood and plasma from the strangulated segment, which may be particularly severe if the vascular obstruction is predominantly venous. Author investigated the changes of serum protein, cholesterol, electrolytes, and histological findings of strangulated intestine experimentally in the rats. The following results were obtained. 1.Serum protein was slightly decreased after 30 minutes of obstruction, but the sequential changes of serum protein levels showed no significant differences statistically throughout the experimental periods. 2.Serum cholesterol levels were gradually decreased reaching to 97.4mg/dl within three hours of obstruction in conrast with 116.8mg/dl in control group. 3.Serum calcium levels were slightly decreased after obstruction, but there were no significant differences in serum sodium and potassium levels. 4.In the histological investigation, degeneration of mucosal epithelium, submucosal congestion and edema appeared in 30 minutes of intestinal obstruction. Necrosis of mucosal epithelium, degenerative chance of muscle fiber and thrombus formation in the vessels appeared in one hour of obstruction. In the groups of two to three hours after strangulation obstruction, marked thrombus formation and necrotic changes of all intestinal wall were noticed.
결합재의 물리적 성질을 이용한 샌드아스팔트 혼합물의 강도특성 추정
김광우,이순제,이기호,이성훈,이병덕,Kim, Kwang-Woo,Lee, Soon-Jae,Lee, Gi-Ho,Lee, Sung-Hoon,Lee, Byung-Duck 한국도로학회 2002 한국도로포장공학회 논문집 Vol.4 No.1
This study was performed to estimate the high-speed direct tensile strength(DTS1), low-speed direct tensile strength(DTS2) , indirect tensile strength(ITS) resilient modulus(MR) and stiffness index(SI) of sand asphalt mixture based on the absolute viscosity, kinematic viscosity, penetration, softening point and PG grade of binder. DTS2 showed higher correlation with the physical properties than other properties of mixture, and the next was DTS1, ITS, SI and MR in order. Among binder properties, PG grade showed the highest relation with DTS2. Therefore. it was found that the high DTS mixture could be made when the binder with a high PG grade was used. However, since the individual physical property showed a relatively low correlation, various properties were used together in regression analysis. The estimation models of DTS and ITS were over 0.99, respectively. R2 of MR and SI estimation models were over 0.91 and 0.93, respectively. It was concluded that mechanical properties could be estimated with a high coefficient of determination from those physical properties. 본 연구에서는 아스팔트 바인더의 절대점도, 동점도, 침입도, 연화점, PG 고온등급을 이용하여 샌드아스팔트 흔합물의 고속 직접인장강도(DTS1), 저속 직접인장강도(DTS2), 간접인장강도(ITS), 회복탄성계수(MR), 강성지수(SI)를 추정하기 위한 연구를 수행하였다. 여러 가지 혼합물의 특성 중 DTS2가 가장 상관성이 높게 나타났으며 그 다음이 DTS1, ITS, SI, MR 순인 것으로 나타났다. 바인더 성질 중에는 PG 등급이 DTS2와 가장 높은 상관 관계를 보여 PG 고온등급이 높은 바인더를 사용하면 직접인장강도가 어느 정도 우수한 혼합물을 얻을 수 있음을 알 수 있었다. 하지만 각각의 물리적 성질만으로는 신뢰도가 낮아 종합적으로 여러 물성을 이용하여 상관성을 분석하였다. 그 결과 직접 및 간접인장강도는 결정계수가 0.99 이상인 모델을 얻을 수 있었다. 그리고 MR, SI 값의 추정치 모델도 R2이 0.91 및 0.93 이상이어서 상당한 신뢰성을 가지고 물성으로부터 역학적 특성을 추정할 수 있음을 보여준다.
이창우,이순제,우창수,강신정,김윤희,신기순 한국통합생물학회 2018 Animal cells and systems Vol.22 No.3
The medial habenula (MHb) plays an important role in nicotine-related behaviors, such as aversion and withdrawal. The MHb is composed of distinct subregions with unique neurotransmitter expression and neuronal connectivity. Here, we showed that nicotine and substance P (SP) differentially regulate neuronal excitability in subdivisions of the MHb (ventrolateral division, MHbVL; dorsal division; MHbD and superior division: MHbS). Nicotine remarkably increased spontaneous neuronal firing in the MHbVL and MHbD, but not in the MHbS, which was consistent with different magnitudes of whole-cell inward currents evoked by nicotine in each subdivision. Meanwhile, SP enhanced neuronal excitability in the MHbVL and MHbS. Although the MHbD is composed of SP-expressing neurons, they did not respond to SP. Neurons in the MHbVL increased their firing in response to bath-applied nicotine, which was attenuated by neurokinin receptor antagonists. Furthermore, nicotine addiction and withdrawal attenuated and augmented excitatory SP effects in the MHbVL, respectively. On the whole, we suggest that MHb-involving nicotine-related behaviors might be associated with SP signaling in MHb subdivisions.
김현환,이순제,이문섭 한국도로학회 2015 한국도로학회논문집 Vol.17 No.3
PURPOSES : This paper presents a description of the current issues facing road managers regarding the surface-type conversion of lowvolume roads for cost savings. METHODS: The paper reviews previous works conducted toward this end, acknowledges gaps in the current research, and lays out what information is needed for further studies. RESULTS : If the cost to maintain an unsurfaced road is less than the cost of maintaining a surfaced road, then there is potential for cost savings for the management agency. However, the problem is bigger than simply maintaining the roads that already exist. If unsurfaced roads prove to be more economical than surfaced roads, then the cost to convert from a surfaced to an unsurfaced roadway, and vice versa, when necessary, must also be examined. CONCLUSIONS : No other studies have addressed the un-surfacing of a road for cost savings, and it is therefore unknown whether substantial savings can be realistically obtained by converting from a surfaced to an unsurfaced road. To determine whether a conversion policy would be a viable option, additional data and research are needed.
김영삼,윤지현,이순제,정운규,김광우 한국도로학회 2016 한국도로학회 학술발표회 논문집 Vol.2016 No.06
최근 아스팔트 포장에 빈번히 발생하는 포트홀을 보수함에 있어서 포트홀 부위를 사전 가열하기 위하 여 적외선 방출 하향식 가스히터 장비(이하 적외선 가스히터)를 사용한 공법이 사용된다. 이 보수 공법은 포트홀 발생부위 일정 구역을 적외선 가스히터로 가열하고 가열된 부분을 굴착하고 신규 아스팔트 혼합물 (New asphalt mix: NAM)과 컷백아스팔트를 넣고 비벼서 고르게 펼친 후 다지는 것이다. 이때 최종 포 설된 혼합물(보수 혼합물, Repaired asphalt mix: RAM)은 기존 포트홀 부위에서 회수된 혼합물(RAP from pothole: RFP)보다 더 회생된 상태이어야 한다. 이를 위해서는 추가되는 NAM의 노화도가 낮아야 하고, 사전가열에 의해 표변부위가 타서 노화도가 심해지는 현상이 없어야 한다. 하지만 현재 대부분 현 장의 실정은 포트홀 보수 혼합물(RFP)의 노화특성, NAM의 운반 시간에 따른 단기노화도의 변화, 적회선 heating에 따른 표면 혼합물 노화 특성변화, 최종 보수된 혼합물(RAM)의 노화도 및 회생 정도 등에 대한 정보를 모른 상태로 수행된다. 이에 본 연구에서는 일부 포트홀에 실제 보수된 혼합물의 노화정보를 GPC 를 이용하여 수집하고 최종 포설된 RAM의 상태를 절대점도로 추정하여 평가하였다. 이를 위해 RFP의 노 화특성, 운반시간에 따른 NAM의 노화특성 변화, 사전가열의 영향 등이 RAP에 미치는 영향을 평가하고 필요한 개선 방안을 일부 제시하였다.