지주막하출혈 환자에서 아세타졸아미드 부하 뇌혈류 SPECT의 유용성

이석모,배상균,염하용,문재곤 고신대학교(의대) 고신대학교 의과대학 학술지 2000 고신대학교 의과대학 학술지 Vol.15 No.1

Background : We obtained basal and acetazolamide-enhanced cerebral perfusion SPECT to evaluate the vascular reserve capacity in patients with subarachnoid hemorrhage. Methods : Basal cerebral perfusion SPECT was obtained following the injection of 555 MBq (15 mCi) of Tc-99m HMPAO. For acetazolamide-enhanced SPECT, acetazolamide was injected 20 minutes prior to the injection of Tc-99m HMPAO on separate day. The result of acetazolamide response was compared with the clinical outcomes. Results : Fourteen patients (male : 5, female : 9, mean 50 years old) with subarachnoid hemorrhage were included. We obtained SPECT study in 4 patients preoperatively and delayed operation in 2 patients because of diagnosing vasospasm. The 7 patients among 8 patients with normal response to acetazolamide revealed good outcome. But 3 patients among 5 patients with poor response to acetazolamide didn't recover. The response to acetazolamide correlates with the clinical outcome (p<0.05), but Hunt& Hess grade and Fisher grade do not correlated with outcome. Conclusion : Acetazolamide-enhanced cerebral perfusion SPECT is considered as a useful tool to diagnose the vascular reserve state and to aid the treatment plan.

Hydroxyapatite orbital implant의 peg drilling 시기 결정을 위한 정량적 혈관화 측정 증례보고

이석모,염하용 대한핵의학회 1997 핵의학 분자영상 Vol.31 No.4

진해만의 빈산소 수괴 형성에 관한 수치실험

이석모,최우정,박청길 한국수산학회 1994 한국수산과학회지 Vol.27 No.4

鎭海灣은 貧酸素로 인한 수산생물의 생산성 저하가 현저하다. 본 연구에서는 鎭海灣의 수질환경개선 및 회복을 위해서 貧酸素 水塊의 形成防止가 무엇보다도 중요하다고 생각되어 해수유동 및 물질순환 모델을 이용하여 貧酸素 水塊 形成狀態를 재현하였고, 주요 오염부하가 용존산소에 미치는 영향의 정도를 예측하여 어장환경 관리방안을 도출한 결과는 다음과 같다. 저층의 용존산소 농도분포는 水溫 및 密度成層과 밀접한 관계를 가지고 변동하였고 수온성층이 가장 강했던 6∼7월에 양식어장이 밀집된 鎭海灣 西部海域과 馬山灣 해역에서 2.0㎎/ℓ이하의 貧酸素水塊가 형성되었다. 해수유동 모델에 의한 M₂분조 계산결과 漲潮時流向의 主流는 加德水路를 통하여 서쪽으로 이동하였고 일부는 馬山灣으로 유입되었으며, 落潮時는 반대 방향이었다. 最强流速은 加德水路 부관에서 발생하였고 鎭東灣, 고현성만, 元門灣등의 鎭海灣 西部海域과 馬山灣에서는 5㎝/sec이하로 微弱하였다. 恒流는 만 중앙부와 칠천도 사이에서 반시계방향의 還流가 형성되는 것이 특징적이었으며, 馬山灣이나 당황만 입구 부근에서는 표층의 경우 南向의 흐름이 나타났고, 저층에서는 北向의 흐름이 형성되었다. 물질순환 모델의 補正結果 상관성은 0.85이상을 보였고 相對誤差는 28%이하의 범위내에서 여름철의 貧酸素 水塊를 재현하였다. 각종 오염부하가 용존산소에 미치는 영향의 정도와 범위를 시뮬레이션을 통하여 예측한 결과 SOD가 전지역에 걸쳐 가장 큰 영향을 나타내었고, 馬山灣의 유입부하도 용존산소 분포에 큰 영향을 미쳤으나 馬山灣내 局限되어 나타났으며, 양식생물에 의한 부하는 영향도 적었고 鎭海灣 酉部海域에 局限되었다. 貧酸素 水塊가 강하게 형성되는 馬山灣과 鎭海灣 西部海域의 貧酸素 水塊 형성방지를 위해 효율적인 오염저감 대책으로서 馬山灣의 경우 유입 COD부하와 SOD를 저감해야하며, 鎭海灣 西部海城의 경우 SOD가 主가 되어야 함을 알 수 있었다. 회복시켜야 할 용존산소 농도를 海城Ⅱ等級인 5.0㎎/ℓ의 농도를 유지시키기 위해서는 馬山灣의 경우 유입되는 COD 부하를 50%, SOD를 70%로 低減해야 하며, 鎭海灣 西部海域의 경우 SOD를 95%, 양식생물 오염부하를 90%까지 低減해야 되는 것으로 나타났다. Jinhae Bay once was a productive area of fisheries. It is, however, now notorious for its red tides; and oxygen deficient water-masses extensively develop at present in summer. Therefore the shellfish production of the bay has been decreasing and mass mortality often occurs. Under these circumstances, the three-dimensional numerical hydrodynamic and the material cycle models, which were developed by the Institute for Resources and Environment of Japan, were applied to analyze the processes affecting the oxygen depletion and also to evaluate the environment capacity for the reception of pollutant loads without dissolved oxygen depletion. In field surveys, oxygen deficient water-masses were formed with concentrations of below 2.0㎎/ℓ at the bottom layer in Masan Bay and the western part of Jinhae Bay during the summer. Current directions, computed by the M₂ constituent, were mainly toward the western part of Jinhae Bay during flood flows and in opposite directions during ebb flows. Tidal currents velocities during the ebb tide were stronger than that of the flood tide. The comparision between the simulated and observed tidal ellipses showed fairly good agreement. The residual currents, which were obtained by averaging the simulated tidal currents over 1 tidal cycle, showed the presence of counterclockwise eddies in the central part of Jinhae Bay. Density driven currents were generated southward at surface and northward at the bottom in Masan Bay and Jindong Bay, where the fresh water of rivers entered. The material cycle model was calibrated with the data surveyed in the field of the study area from June to July, 1992. The calibrated results are in fairly good agreement with measured values within relative error of 28%. The simulated dissolved oxygen distributions of bottom layer were relatively high with the concentration of 6.0∼8.0㎎/ℓ at the boundaries, but an oxygen deficient water-masses were formed within the concentration of 2.0㎎/ℓ at the inner part of Masan Bay and the western part of Jinhae Bay. The results of sensitivity analyses showed that sediment oxygen demand(SOD) was one of the most important influence on the formation of oxygen depletion. Therefore, to control the oxygen deficient water-masses and to conserve the coastal environment, it is an effective method to reduce the SOD by improving the polluted sediment. As the results of simulations, in Masan Bay, oxygen deficient water-masses recovered to 5.0㎎/ℓ when the 50% reduction in input COD loads from Masan basin and 70% reduction in SOD was conducted. In the western part of Jinhae Bay, oxygen deficient water-masses recovered to 5.0㎎/ℓ when the 95% reduction in SOD and 90% reduction in culturing ground fecal loads was conducted.

하계 동해남부해역의 자정능력 평가

이석모 부산수산대학 해양과학연구소 1987 연구논문집-부산수산대학교 해양과학공동연구소 Vol.19 No.-

뇌 동정맥기형 환자 수술시 휴식/아세타졸아마이드 뇌혈류 SPECT의 예후 예측력

이석모,김한규,문재곤,배상균,염하용,황도윤 대한핵의학회 2000 핵의학 분자영상 Vol.34 No.5

After surgical operation in patients with arteriovenous malformation (AVM), normal pressure perfusion breakthrough (NPPB) is one of the major complications. Brain perfusion SPECT with acetazolamide stress was known to be useful to evaluate the vascular reserve in several neurological and neurosurgical conditions. The authors performed acetazolamide brain perfusion SPECT in patients with AVM and compared the brain perfusion in the post-operative clinical courses. The acetazolamide brain perfusion SPECT was helpful in defining the prognosis of the patients with AVM. We describe 4 patients with AVM who had acetazolamide brain perfusion SPECT to examine the prognosis.

지주막하출혈 환자에서 아세타졸아미드 부하 뇌혈류 SPECT의 유용성

이석모,배상균,염하용,문재곤 고신대학교 의학부 2000 高神大學校 醫學部 論文集 Vol.15 No.1

Background We obtained basal and acetazolamide-enhanced cerebral perfusion SPECT to evaluate the vascular reserve capacity in patients with subarachnoid hemorrhage. Methods Basal cerebral perfusion SPECT was obtained following the injection of 555MBq (15mCi) of Tc-99m HMPAO. For acetazolamide-enhanced SPECT, acetazolamide was injected 20 minutes prior to the injection of Tc-99m HMPAO on separate day. The result of acetazolamide response was compared with the clinical outcomes. Results Fourteen patients (male:5, female:9, mean 50 years old) with subarachnoid hemorrhage were included. We obtained SPECT study in 4 patients preoperatively and delayed operation in 2 patients because of diagnosing vasospasm. The 7 patients among 8 patients with normal response to acetazolamide revealed good outcome. But 3 patients among 5 patients with poor response to acetazolamide didn't recover. The response to acetazolamide correlates with the clinical outcome (p<0.05), but Hunt & Hess grade and Fisher grade do not correlated with outcome. Conclusion Acetazolamide-enhanced cerebral perfusion SPECT is considered as a useful tool to diagnose the vascular reserve state and to aid the treatment plan.

골스캔에서 냉소로 보인 급성골수염

이석모,배상균,조명래 대한핵의학회 2000 핵의학 분자영상 Vol.34 No.6

Acute osteomyelitis is usually shown as a localized area of increased activity (hot uptake) in the infectious focus on bone scintigraphy. In our patient, absence of radioactivity (cold lesion) was noted in the distal metaphyseal and diaphyseal regions of his right femur. Initial x-ray was interpreted as normal except for mild soft tissue swelling in the right thigh. The lesion was confirmed as an acute osteomyelitis with subperiosteal abscess on surgery. Staphylococcus aureus was the etiologic organism. We describe a case of acute osteomyelitis in a one-year-old boy shown as a cold lesion on bone scan.

방사성옥소 전신스캔을 위해 유발된 갑상선기능저하증 동안의 신기능 변화

이석모,배상균,염하용 대한핵의학회 1999 핵의학 분자영상 Vol.33 No.5

낙동강조사월보 1997년 제11호(1997년 12월)

이석모 부산연구원 1997 낙동강연구 Vol.- No.11

지주막하출혈 환자에서 아세타졸아미드 부하 뇌혈류 SPECT의 유용성

이석모,배상균,염하용,문계곤 고신대학교 의학부 2000 고신대학교 의학부 학술지 Vol.15 No.1