http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
胎兒赤芽球症生成機轉에 있어서의 交叉反應性抗體에 關한 硏究
李三悅 中央醫學社 1941 中央醫學 Vol.10 No.2
In 1960, the first proven case among Korean babies of Rh-sensitized and five cases 4 ABO-sensitized erythroblastosis fetalis were reported by the present author. Attention was paid to the fact that all of those ABO-cases happened exclusively in group-O mothers. Seeking the explanation of this phenomenon, the author was interested in the role of the so-called "Cross-reacting antibody", which importance in 'tithe' development of ABO-erythroblastosis fetalis was postulated by Wiener and Zuelzer (1955). Employing the technique of antibody-absorption and elution introduced by Dodd (1952) the author made the following observations using both clinical materials of Korean population and experimental animal materials. 1. Antibody responses to a same antigen stimulation was greater in group-O persons than in any other group persons, and this was true in both natural and immune antibody productions. 2. Group-O persons might possess a so-called cross-reacting antibody, anti-C, in addition to the ordinary anti-A and anti-B; and its frequencies among Koreans were 70 to 77%a in male and 65 to 80'% in pregnant female. 3. The cross-reacting antibody reacted better at 37C than at 4 C and better in colloidal medium than in saline medium. 4. The cross-reacting antibody reacted best with an indirect Coombs technique among the ordinary three titration techniques; and in this regard this antibody belonged to an incomplete antibody. 5. In contrast to immune anti-A or anti-B sera, the cross-reacting antibody was neutralized by soluble group specific substances but this phenomenon did not happen on an immune animal origin cross-reacting antibody. 6. It was demonstrated that blood-free placental emulsion absorbed hemagglutinins in vitro including the cross-reacting antibody; and the same phenomenon appeared to occur in vivo as demonstrated in a group-A fetal placenta delivered from a group-O mother. ; These observations were discussed to find the possible role of the cross-reacting antibody in the pathogenesis of ABO-erythroblastosis fetalis and the author reached the conclusion that the reasons why ABO-erythroblastosis fetalis is apt to occur in eases of group-O mothers would be: they are prone to produce more hemagglutinins than any other group persons, in general, and they produce so-called cross-reacting antibody readily, which would not be possibly produced in any other group persons. Furthermore, the cross-reacting antibody possesses many immunohematologically advantageous characteristics which would induce an erythroblastosis fetalis. On the other hands the reasons why all group-O mothers do not develop erythroblastosis fetalis in their heterospecific pregnancies would be the cross-reacting antibody is absorbed by placenta, a fact which is quite different from that in the cases of Rh-antibodies, and the cross-reacting antibody is neutralized by soluble group specific substances in the fetus. These fetal protective mechanisms would weaken the offending potency of the cross-reacting antibody.