위암 환자들이 경험세계에 대한 현상학적 연구

이명선 서울대학교 간호대학 간호과학연구소 1996 간호학 논문집 Vol.10 No.1

Gastric cancer has been one of the major causes of death in Korea. At the same time, the survival rates of gastric cancer have increased due to the improved medical technology and increased screening examination which are able to find cancer in the early stage. The purpose of this study is to explore and describe the lived experience of gastric cancer patients by eliciting their verbal description of the experience. Participants were persons who were diagnosed with gastric cancer at the hospital and living at home. The first phase of the study included 6 individual in-depth interviews of the patients. They were asked open-ended and descriptive questions in order for them to talk their experience in their own terms. The second phase interview was designed to discuss themes that were emerged from the analysis of previous interviews. Interviews were tape recorded and transcribed verbatim. The transcripts were analyzed by Colaizzi method. Major themes that were emerged from the analysis are "diet control and nutrition," "changes in the role," "emotional distress," "folk medicine," " family's and friends' support," "information seeking," and "spirituality of self-transcendence." The results of this study may help nurses and other health care workers to implement more efficient nursing strategies for gastric cancer patients by deeply understanding their lived experience in everyday life.

산업장 근로자의 스트레스 증상과 작업환경과의 관련성

이명선 慶山大學校 保健福祉硏究所 2000 保健福祉硏究 Vol.4 No.-

There has been a rapid industrial progress in Korea since 1962 by the success of 5-year economic development plan, and the number of industrial work has also made a rapid increase. Consequently, the management of the occupational health for the purpose of promoting the health of industrial workers and improving the working environment is badly needed in these days. Health services on industrial noisy environment have been provided only for noise-induced hearing loss management until now. But gradually, modern diseases and death have come to be related to the stress and mental health, therefore noise-induced mental disorder, like a stress became very important. Thus, this study has been carried out to analyze the relationship between workers' stress symptoms and the perceived working environment and the perceived working conditions. This study included 786 industrial workers selected from 24 factories in chang-won. The results were as follows: 1. For demographic characteristics, most of the workers were males(75.7%), the 20∼29 years old were 34.8% and those who graduated from high school were 56.9%. The workers whose monthly income ranged from 700,000 to 1,500,000 won were 37.9% and who has a religion were 49.0%. 2. For occupational characteristics workers who had worked 1∼5 years in the factories were 35.8%. Those who felt much for them workload were 42.7% and who worked more than 8 hours a day were 74.3%. Those who were dissatisfied with their job and pay were 31.9% and 51.1%. The workers who responded ventilation condition of their worksites were bad were 50.4% and the dissatisfied with working environment of their worksites were 43.8%. 3. For the noise exposure level in worksite, workers who were exposed to 70∼90dB were 37.4%, 90∼100dB were 25.2% and 50∼70dB were 18.8%. 4. Workers' stress symptoms were significantly related to marital status and their monthly income(P<0.05). Workers who were single and had lower monthly income showed higher PSI(Psychiatric Symptom Index) scores than those who were married and had higher monthly income. Higher PSI scores were also significantly related to the night-work, workload, dissatisfaction with their job, and bad relationship with their bosses or co-workers. 5. The higher noise exposure level in worksite from 80dB was, the more severe stress symptoms including PSI subparts wee reported; Anxiety, Anger, Depression, and Cognitive disorder symptom(P<0.001). 6. According to the results of stepwise multiple regression analysis, factors affecting workers' PSI scores were noise exposure level in worksite(R²=0.150), relationship with coworkers, amount of workload, monthly income and relationship with bosses orderly and the total R² of this 6 factors was 0.297.

移植用 Pot가 秋作배추收量에 미치는 影響

李明善 동국대학교 농림과학연구소 1979 農林科學 論文集 Vol.5 No.-

This experiment is conducted to look into the way and effect to minimize an injury in transplantation: 1) Jiffy Pot(L) in the pots used in this experiment produces the best results. 2) Decrease in a yield is a factor in the elimination of pot. 3) Even the case of Jiffy Pot shows a difference in a yield in size. 4) The side using Jiffy Pot shows an increase in a yield by minimizing an injury in transpiantation.

국회 속기록에 나타난 여성정책 시각 : B. 가족계획에 대하여

이명선 이화여대 한국여성연구소 1990 여성학논집 Vol.7 No.-

In recent years, not on]y the interests in grasping the relationship between women and state are increasing in the social and academic contexts, but also some moves are emerging to correct the unequal structure through policies for women. When the very concept of policy for women is nor well defined, the examination of the past policy on women should be carried out in the first place. This study aims to explore and analyze perspectives of decision makers specificaily in relation to the family planning policies. For doing this, stenographed records of a standing committee of the national assembly which covers questions and answers conducted by the legislative and the administrative about the family planning policies are utilized as the basic material. And the analysis was conducted from a feminist perspective, which has an 'objective' to pursue to recover women's rights and to achieve the mutual equality of both sexes, and the records were categorized by concepts of "instrumental" and "objective" policies. The total number of speeches in the records were 142, which were categorized into five sub-themes i.e., birth control, target group for contraception, agents for family planning policy, general policy execution, and directions of the policy. The birth control problem was a focal issue in the 1960's and concentrated on the debates between the administrative and the legislative about the necessity of executing family planning policy. The target group for contraception and agents for the policy drew interests to the similar extent in the 1960's and 1970's. As for the target group, the 1960's showed the process of deciding women as the main target for the policy, while the criticism against the policy was raised by the legislative in the 1970's by those concerned with the excessive expenditure. The issue on the agents for family planning policy showed a concensus between the legislative and the administrative, i. e. employing women as the agents. But, despite hot debates in the 1960's, it shows that the family planning policy was already implemented systematically from the early 1960's. In the meantime, the ideology of son-preference emerged as an impeding factor against the family planning policy in the late 1970's. Especially in the 1980's, revision of the family law toward equality between sexes and diversification for the directions of the policy began to be discussed in connection with the improvement of women's status, health of mother-child, and so forth. Based on the content analyses of the legislation records, the family planning policy was ptoved to be an instrumental policy seen from a feminist perspective First, as shown in the discussion on birth control, the policy attempted to control women's reproduction for the national economic development without considering women's interests per se. Second, women played the role as a traget and/or a deliverer of the policy in the front, not as a participant of any capacity in decision making. This means that women were used instrumentally as a target group for policy goals rather than for women's own health, satisfaction, and welfare. However, discussions on the revision of the family law and the change of direcitions of the policy raised in relation to the son-preference ideology in the 1980's suggest the possibility that the family planning policy can be changed into an "objective policy" from original "instrumental one. In this process the legislative rather than the administrative, particularly the activities of women members of the National Assembly, was noteworthy. This move should be, of course, followed by fundamental changes of overall perspectives of the policy and political support as well in order for it nor to became a passing phenomenon. In sum, this study finds that in the family planning policy, the most typical one among the recent policies greatly affected women, women were no more than instrumental means, and criticizes that it did never functioned as a genuine policy for women i.e. as an "objective policy". Also this study points out problems of the existing policies on women and it will serve as an important material for re-establishing a viewpoint for the future policy. However, this study has a limitation because of the character of the data limited to the stenographed record of the National Assembly, and it was beyond its scope to deal with how the discussions were reflected on the actual administration or what the results and effects were. Consequently, further study on the process of executing the family planning program as an instrumental policy and of the influences and effects on women needs to follow.

산업재해에 의한 휴업기간에 영향을 미치는 관련요인 분석

이명선 梨花女子大學校 韓國生活科學硏究院 1993 韓國生活科學硏究院 論叢 Vol.52 No.-

학교환경위생정화구역 내 유해업소의 타당성과 재분류

이명선 경산대학교 보건복지연구소 2000 保健福祉硏究 Vol.5 No.-

The purpose of this study is to provide the basic data for making up a desirable school education environment, based upon reclassifying the harmful stores according to their harmfulness degree, by investigating and analyzing the realities and proprieties of the students-related stores within school environment hygiene purification zone. The results were as follow: 1) Of the stores, which groups of students, teachers, and parents cognized as harmful, the prostituted quarters, the sex utensil handling store, the street lewd article dealer, and the corrupt barbershop respectively ranked high, in sequence, in the estimation of harmfulness degree. Actually, however, rather than in the places whose harmfulness degrees were estimated high, did students commit misconducts in the easy-to-enter stores around the school, such as the electronic game room, the video room, the singing room, the loding facilities, the street lewd article dealer, the billiard halls. That is, through this study, it was found out that students' misconducts were likely to be raised in the places around the school which they could approach easily. Among there stores, teacher and parent groups indicated the electronic game room, the PC room, the roller-skating rink, and the singing room as the facilities, which might be licensed to do business within the relative purification zone, though the discussion of the Purification Committee. But, on the other hand, they pointed out the amusement & liquor store, the lodging facilities, the special bathhouse, and the video appreciation room as the categories, which had to be prohibited from doing business, because juveniles committed many misconducts here. Most of them answered that under the existing law and regulations, these categories might be licensed to do business, only through the discussion of the Purification Committee, but the amusement & liquor store, the lodging facilities, and video appreciation room were the places where students experienced so many misconducts. In consideration of the fact that it had a high degree of harmfulness in estimation, but also could exert a bad influence upon juveniles' sound growth and development, an absolute majority of teachers and parents indicated the special bathhouse as the business category to be forbidden to do business activities. 2) By the School health Law, it is provided that any business behaviors or facilities should be licensed to be carried out or installed, only through the discussion of the School Environment Hygiene Purification Committee, so long as they do not have a bad influence upon learning and school health hygiene. As found out by this study, however, any after-management or control is nearly not exercised, now. Accordingly, as it is very difficult to inflict punishment or have control after licensing any behaviors or facilities to be carried out or be installed, the more powerful legal criteria must be prepared against the behaviors and facilities absolutely to be forbidden within the relative purification zone, instead of the discussion of the Purification Committee. Pointed out as the behaviors or facilities which might be permitted within the relative purification zone, through discussion, by teacher and parent groups, the electronic game room, the PC room, the roller-skating rink, the singing room, and the cartoon room should be permitted through the discussion of the Purification Committee; these behaviors or facilities need to be managed and controlled constantly in order to prevent juveniles' misconducts and make these behaviors or facilities be executed or operated soundly. As mentioned above, because it is a very crucial sensitive matter to discuss and decide which categories of businesses to permit or which categories of businesses to forbid, within the purification zone, the Purification Committee must be organized by school unit so that the peculiarities of each zone and the circumstances of each school can be reflected fully. In addition, it is desirable to form the Purification Committee so that its representative and specialized nature may be made higher and the wider popular will may be converged, in discussion, through the participation of all the representatives engaged in a wide variety of fields, such as the academic world, the vocational organization, the parents, and the juveniles-related institution.

잔디원의 維持管理에 關한 硏究 : 發生하는 雜草의 生態學的 特性에 關하여

李明善 동국대학교 대학원 1980 연구논집 Vol.10 No.

밤增産을 爲한 肥種別 施肥效果에 關한 硏究 : B₂O₃및 MgO의 效果分析 effect of B₂O₃&MgO contained in compound fertilizers application

李明善 尙志大學校 1983 論文集 Vol.4 No.-

In present time, the total area of the chestnut plantation reach about 200,000 hectars in Korea. For this reason, this study, which is an experiment of the fertilization by some kind of fetrilizers in the Chestnuts plantation with 4 years-old Eungi, was carried out from 1979 to 1981 by way of contribute an in crease of the wiban-and hilly country-in come. The experiment was designed by randomized Sampling method and treated with seven fertilizer, such as un-fertilized, Mixture of single fertilized(urea, fused Super phosphate, potassium chloride) compound fertilized double amounts compound fertilized, compound fertilized with boron & magnesium, compound fertilized with boron, and double amounts compound fertilized with boron. The ingredients ratio of these fertilizers were prcpared as N.P.K=16-16-13, N.P.K.Mg : B=16-16-13-4-0.7 and N.P.K. B=16-16-13-0.7 and fertilizing-level should be devided as the standard-treatment and the double-treatment. The Growth, the beared-cone number, the dropped cone number, the ripened-cone number, the must number and yield-amount and weight were investigated in annually. The results of investigations are as follows, ① In the Growth, it showed the high significant difference on 5∼1 percent between. un-fertilized & fertilized, and standard level fertilized & double amount level fertilized, but non significant difference between the same fertilizer-level. ② The total number of cones, immediately after flancering and bearing in the late springtime, also showed the significante-difference on 1 percent between the un-fertilized is fertilized And the total number of cones in the compound-fertilized with boron between the same fertilizing-level is much but not so much. ③ The number of dropped-cone are ranhed as order of un-fertilized(44∼62%), Simple-fertilized(24∼46%), compound-fertilized, and the same of compound-fertilized with boron and magnesium and compound-fertilized unith boron(0.2∼4%) ④ The amount and weight of yield, as the number of ripend cone and the number of nuts, showed that the compound-fertilized with boron and the compound-fertilized with boron and magnesium increase more 160∼600 percent and 200∼700 percent than the compound-fertilized. ⑤ Especially, in 1980 the insolation-amount shorted from an abnomal climate, the growth and the amount of yield in the compound-fertilized with boron and magenesium are good. And the growth in the compound-fertilized with magnesium & more 150 percent than the compound-fertilized and the compound-fertilized with boron, and the amount of yield is more 700 percent than compound fertilized and more 120 percent than the compound-fertilized with boron. The growth and the amount of yield in the compound-fertilized with out magnesium decrease than that in 1979. It was to be considered that the magnesium-fertilizer could be highly contributed to an assimilation on the green plants, in case of the insolation is shorted. As about a results, the exclusive-use of compound-fertilizer on the chestnut plantation will be come available to be used three-elements fertilizer with boron and magenesium (N.P.K.Mg-B-16-16-13-4-0.7) for the protection of dropped-cone and on increase of nuts yield. Therefore, in future, this fertilizer has to spread and encourage to the possessors of the chestnuts plantation for the yield-increase.

인체 자궁암세포에서 cisplatin과 산삼배양근추출물에 의한 apoptosis유도

이명선,Lee, Myeong-Seon 한국현미경학회 2010 Applied microscopy Vol.40 No.3

인체 자궁암 세포 HeLa에 항암제 cisplatin (CDDP)과 산삼배양근 추출물(ETCMG)을 투여하여 세포 성장률, 형태, 전기영동에 의한 DNA fragmentation, 세포주기 분석을 통하여 apoptosis 유도를 확인하였다. ETCMG 2, 4, 6mg/mL, CDDP $4{\mu}g/mL$의 농도로 24시간 투여한 후 세포의 성장에 미치는 영향을 분석하고, ETCMG를 항암제로서 효과가 입증되어있는 CDDP와 복합투여하여 비교한 결과 apoptosis비율은 대조군에 비하여 ETCMG의 농도가 증가할수록 농도에 비례하여 현저히 증가하였고 (p<0.05), CDDP와 ETCMG를 복합투여한 경우에 ETCMG를 단독으로 투여한 경우 보다 apoptosis비율이 매우 높은것으로 나타났다(p<0.05). 세포의 형태를 도립현미경과 투과전자현미경으로 관찰한 결과, 대조군은 세포의 정상적인 형태를 유지하고 있는 반면에 CDDP와 ETCMG를 각각 처리한 암세포는 세포의 성장이 현저히 억제되었고, 염색질의 응축과 apoptotic body가 관찰되었다. 세포의 성장억제가 apoptosis에 의한 것인지를 확인하고자 DNA를 분리하여 전기영동한 결과, HeLa 세포에서 ETCMG의 농도가 증가할수록 ladder가 뚜렷이 관찰되었고, CDDP를 복합 처리한 것 역시 ETCMG의 농도에 비례하여 ladder가 선명하게 나타났다. Flow cytometry (FC)에 의한 세포주기 분석 결과, ETCMG를 농도별로 처리한 경우에 apoptosis를 나타내는 Sub-$G_1$기의 양이 농도에 비례하여 증가하였고, 항암제인 CDDP와 복합 투여한 경우에 Sub-$G_1$기 DNA양이 눈에 띠게 증가한 것으로 나타났다. 이상의 실험 결과를 종합하면, ETCMG는 인체 자궁암에서 항암효과를 가지고 있으며, 항암제 CDDP의 단독 투여보다는 ETCMG와 함께 사용하는 경우에 암 치료제로서의 상승효과가 있는 것으로 사료된다. Mountain ginseng is a perennial crop rarely found in the deep mountains of Korea. The medicinal effect of the mountain ginseng is well known as a panacea in traditional Chinese medicine for a long time. But scientific studies to elucidate the medicinal effect of the mountain ginseng have never been made on account of lack of sample. Recently an improved method of adventitious root culture system through the use of bioreactor has been developed in Panax ginseng that seems to be a reliable way of commercialization of root derived secondary metabolites. This experiment was conducted to evaluated chemotherapeutic effect against human cervical cancer cells by cisplatin (CDDP) and extract of tissue cultured mountain ginseng (ETCMG). CDDP and ETCMG-induced apoptotic cell death in human cervical cancer cell line, HeLa was confirmed by the analysis of cell growth, morphological changes, DNA fragmentation, flow cytometry showed that ETCMG is an inducer of apoptosis and synergizes with CDDP. These results suggest that ETCMG present evidence of anticancer effect and could have a possibly natural therapeutic potential in cervical cancer patients.

인체 암세포에서 산삼배양근에 의한 apoptosis 유도

이명선 청주대학교 산업과학연구소 2008 産業科學硏究 Vol.25 No.2

Ginseng has been used for traditional medicine in China, Korea, Japan and other countries for the treatment of various disease. Recently an improved method of adventitious root culture system throμgh the use of bioreactor has been developed in Panax ginseng that seems to be a reliable way of commercialization of root derived secondary metabolites. This experiment was conducted to evaluate anticancer effect against human colon carcinoma HCT-116 cells by adventitious root cultures of Panax ginseng C. A. Meyer. Flowcytometric analysis showed that extracts of adventitious root cultures of Panax ginseng C. A. Meyer(CBN) initially arrested the cell cycle at the G1/S boundary, but consequently induced apoptosis as evidenced by generating as apoptotic peak. The induction of apoptosis was confirmed by the results of DNA fragmentation assays and alteration in cell morphology after treatment of the cells with CBN. These results sμggest that CBN present evidence of anticancer effect and could have a possibly natural therapeutic potential in colon cancer patients.