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이남헌,윤담희,유화승,조정효,손창규,이연월,조종관,Lee, Nam-Heon,Yoon, Dam-Hee,Yoo, Hwa-Seung,Cho, Jung-Hyo,Son, Chang-Gue,Lee, Yeon-Weol,Cho, Chong-Kwan The Society of Internal Korean Medicine 2005 大韓韓方內科學會誌 Vol.26 No.4
목적 : 본 연구는 100명의 암환자를 대상으로 항암단의 항혈관형성 효과를 측정하기 위하여 고안되었다. 방법 : 100명의 암환자 전체의 치료전후의 VEGF, bFGF 및 혈소판 수치의 변화량을 측정하였고, 병기, 삶의 질 및 암종별로 환자를 나누어 각각의 치료전후의 VEGF, bFGF 및 혈소판 수치의 변화량을 측정하여 통계적 유의성을 살펴보았다. 결과 : 항암단으로 치료한 암환자의 bFGF 수치는 치료전 후 통계적으로 유의성 있게 감소하였다. 특히 유방암 환자에서 bFGF 수치의 감소가 눈에 띄었다. 비록 통계적으로 유의하지는 않았지만 VEGF수치도 항암단으로 치료 후 다소 감소하는 경향을 보였다. 결론 : 따라서 항암단이 암환자 치료에 있어 항혈관형성 약물로써 작용한다고 추론할 수 있다.
한국 인삼의 경쟁력 제고를 위한 국내외 인삼 관련 특허 분석
이남헌,유사라,손창규,Lee, Nam-Hun,Yoo, Sa-Ra,Son, Chang-Gue 대한한방내과학회 2008 大韓韓方內科學會誌 Vol.29 No.2
Objective : To build a basis of patent analysis for development of Korean ginseng as a competitive medical product in the world market. Methods : Survey of all patents related to ginseng or ginseng products in Korea and other rival countries such as the USA, Japan or EU, using KIPRIS. Results : Korea has more patents of ginseng itself , however has fewer patents related to functional goods, higher value-added businesses or medical technologies using ginseng than rival countries. Conclusion : The Oriental medical world should make more effort to verify the pharmacological effects of ginseng, develop high value-added functional products or medical technologies using ginseng and apply for more patents in such fields.
Systematic Review of Randomized Controlled Trials Evaluating the Efficacy and Safety of Ginseng
이남헌,손창규 사단법인약침학회 2011 Journal of Acupuncture & Meridian Studies Vol.4 No.2
This systematic review aims to evaluate the available evidence from randomized clinical trials of the clinical efficacy and safety of ginseng. Systematic literature searches were performed in 13 databases up to March 2009 without language restriction. All randomized clinical trials evaluating the clinical effects or safety of the use of ginseng monopreparations (Panax ginseng or P. quinquefolium) were considered for inclusion. A total of 411 potentially relevant studies were identified and 57 randomized clinical trials were included. The main indications included glucose metabolism, physical performance, psychomotor function, sexual function, cardiac function, pulmonary disease, and cerebrovascular disease. We found strong evidence of a positive effect of ginseng on glucose metabolism, psychomotor function, and pulmonary disease, whereas evidence suggests that ginseng is not effective at enhancing physical performance. However, ginseng generally has a good safety profile and the incidence of adverse effects seems to be low. In conclusion, our review compiles the evidence on the use of ginseng, finding a strong positive potential for glucose metabolism, psychomotor function, and pulmonary disease, but not for physical performance enhancement.
암의 종류 및 증상에 따른 삶의 질 평가 척도에 관한 연구 현황 분석
이남헌,조정효,손창규,유화승,이연월,윤담희,이종훈,방선휘,조종관,Lee, Nam-Heon,Cho, Jung-Hyo,Son, Chang-Gue,Yoo, Hwa-Seung,Lee, Yeon-Weol,Yoon, Dam-Hee,Lee, Jong-Hoon,Bang, Sun-Hwi,Cho, Chong-Kwan 대한한방내과학회 2006 大韓韓方內科學會誌 Vol.27 No.3
Objectives : The objective of this study is to analyze what quality of life(QOL) scales are frequently used in cancer patients and lay a cornerstone to develop new QOL scales adequate for oriental medical anti-cancer treatment in the future. Methods : We searched 151 articles concerned with 'QOL and scale and cancer' from PubMed and classified them according to periods. nations. cancer types and symptoms. Results: 138 articles(91%) were published after 1996. 65 articles(43%) were published in USA. For breast. lung, prostate. esophageal cancer and melanoma. European Organization for Research and Treatment of Cancer-quiality of life questionaire(EORTC-QLQ) was used most frequently to evaluate quality of life. Functional Assessment of Cancer Treatment(FACT) for bladder cancer. Hospital Anxiety and Depression Scale(HADS) for colorectal cancer and of Washington Quality of Life questionnaire(UW-QOL) for Head & Neck cancer were used repeatedly. And for the patients with the symptoms such as bone marrow depression. depression. pain. dyspnea. nausea & vomiting and voice change. the investigators used EORTC-QLQ mainly to evaluate QOL. FACT-An(anemia) for anemia. FACT-BMT(bone marrow transplant) for bone marrow depression were applicated generally. Conclusions It is anticipated that further investigations will be performed to develop adequate QOL scales for oriental medical anti-cancer therapy.
도관적입법(導管滴入法)으로 호전된 장폐쇄증(腸閉鎖症) 환자 치험 2례 보고
이남헌,윤담희,이지영,채은영,유화승,조정효,이연월,손창규,조종관,Lee, Nam-Heon,Yoon, Dam-Hee,Lee, Ji-Young,Chae, Eun-Young,Yoo, Hwa-Seung,Cho, Jung-Hyo,Lee, Yeon-Weol,Son, Chang-Gue,Cho, Chong-Kwan 대한한방내과학회 2004 大韓韓方內科學會誌 Vol.25 No.4
This study was designed to evaluate the effects of retention enema therapy on patients with ileus. We retrospectively analyzed the medical records of two patients with ileus whose main symptoms were nausea, vomiting, constipation and abdominal pain. They were treated with retention enema therapy. After treatment, improvement was seen in nausea, vomiting, constipation and abdominal pain. The results of this study suggests that retention enema therapy is effective for the treatment of ileus.
이남헌,하혜경,이호영,정다영,최지윤,이준경,신현규,Lee, Nam-Hun,Ha, Hye-Kyung,Lee, Ho-Young,Jung, Da-Young,Choi, Ji-Yoon,Lee, Jun-Kyoung,Shin, Hyun-Kyoo 대한한의학방제학회 2008 大韓韓醫學方劑學會誌 Vol.16 No.2
Objective : The purpose of this report was to provide the information about activity and safety of Ojeok-san by analyzing domestic/international papers about Ojeok-san. Methods : Domestic/international papers related to Ojeok-san were reviewed and analyzed. These papers were then classified by year, experimental method and subject. Results : The following results were obtained in this study. 1. The studies of Ojeok-san started from 1984 and has continuously increased. The studies were mainly focused on experimental models rather than clinical studies. 2. By subject, papers related to safety were most common with 5 papers among 20 papers. Besides there were papers related to efficacy of analgesic, anti-hyperlipidemic, anti-blood stasis and treatment for uterine myoma. 3. The papers related to safety were mainly focused on the effect of Okeok-san on liver function, renal function or metal concentration of organs such as blood, brain, liver, kidney and bone. Ojeok-san proved to be safe, but more clinical studies regarding the safety are needed hereafter. 4. Papers related to analgesic, anti-pyretic, anti-phlogistic activities of Ojeok-san were in vivo studies, and other papers were about anti-hyperlipidemic activity, apoptosis inducing activity on uterine myeloma cell line and anti blood static activity on hydrocortisone acetate induced blood statis model. 5. Case reports were about anti-lipidemia, analgesic effect for mastalgia/back pain and anxiety disorder due to climacteric changes. Conclusion : Ojeok-san is being used in various ways with analgesic, anti-pyretic, anti-phlogistic, anti-hyperlipidemic, anti-tumor or anti-blood statis activity. However, mechanism study should be conducted at the molecular biology level and more clinical studies on the efficacy of Ojeok-san are needed.