The Effect of Ethanol on the Physical Properties of Neuronal Membranes

윤일희,Moon-Kyoung Bae,Dong-Keun Jeong,No-Soo Park,Cheol-Ho Lee,Bong-Hye Cho,Hye-Ock Jang 한국분자세포생물학회 2005 Molecules and cells Vol.19 No.3

Intramolecular excimer formation of 1,3-di(1-pyrenyl) propane(Py-3-Py) and fluorescence polarization of 1,6-diphenyl-1,3,5-hexatriene (DPH) were used to evaluate the effect of ethanol on the rate and range of lateral and rotational mobilities of bulk bilayer structures of synaptosomal plasma membrane vesicles (SPMVs) from the bovine cerebral cortex. Ethanol increased the excimer to monomer fluorescence intensity ratio (I′/I ) of Py-3-Py in the SPMVs. Selective quenching of both DPH and Py-3-Py by trinitrophenyl groups was used to examine the range of transbilayer asymmetric rotational mobility and the rate and range of transbilayer asymmetric lateral mobility of SPMVs. Ethanol increased the rotational and lateral mobility of the outer monolayer more than of the inner one. Thus ethanol has a selective fluidizing effect within the transbilayer domains of the SPMVs. Radiationless energy transfer from the tryptophans of membrane proteins to Py-3-Py was used to examine both the effect of ethanol on annular lipid fluidity and protein distribution in the SPMVs. Ethanol increased annular lipid fluidity and also caused membrane proteins to cluster. These effects on neuronal membranes may be responsible for some, though not all, of the general anesthetic actions of ethanol.

수행평가로 인한 학습자의 과학에 대한 인식 변화

윤일희 경북대학교 사범대학부속 중등교욱연구소, 2001 중등교육연구 Vol.48 No.-

The Effect of Dibucaine.HCI on the Physical Propertieis of Neuronal Membranes

윤일희,장혜옥,현철호,윤진혁,강용규,박성민,박영식,박준섭,옥진석,이동훈,배문경 한국광과학회 2005 Journal of Photosciences Vol.12 No.2

On the Characteristics of Meteorological Drought over the South Korea

윤일희,Lee, Byung-Gil,김희종 한국지구과학회 2006 韓國地球科學會誌 Vol.27 No.7

Meteorologists define a drought as a period of common dry weather. This may sound straightforward, but it is not so in reality. In this study, we attempted to identify meteorological drought conditions over South Korea. To evaluate the temporal and spatial variability of drought, we calculated two commonly used drought indices, the percent of normal precipitation (PNP) and the Palmer drought severity index (PDSI) calculated from fifty-eight meteorological stations below the Korean Meteorological Administration (KMA). The yearly precipitation has been growing gradually, and the amplitude between maximum and minimum also grow more explicitly from 1960's. According to the analysis of percentile anomaly of monthly precipitation, major drought duration was 1927~1929, 1937~1939, 1942~1944, 1967~1968, 1976~1977, 1982~ 1983, 1988, and 1994~1995. The severe drought occurred most frequently in Mokpo, Daegu, Jeonju, Busan, and Gangneung; it tended to occur more frequently in south sector than in mid sector of Korea and in south west sector than in south east sector. According to the analysis of seasonal distribution, extreme droughts occurred frequently in winter at Seoul, Gangneung, Jeonju, Daegu, and Busan. Severe droughts in summer were formed frequently at Seoul, Gangneung, and Mokpo, while that for spring at Jeonju, Daegu, and Busan. The results of PDSI distribution for the 1994~1995 drought period were one of the most severe and widely spreaded droughts; it occurred most frequently in the south sector of South Korea. The comparison of time series between PDSI and Normal Percent showed that they exhibit a strong compatibility for the entire study period; it implies that both drought indices are useful method to indicate drought severity.

초창기 과학학회의 설립 및 활동에 관한 연구

윤일희,Yoon, Ill-He 경북대학교 과학교육연구소 2017 科學敎育硏究誌 Vol.41 No.2

이 연구의 목적은 초기 대표적인 과학학회의 설립과정과 그들의 활동에 대해서 살펴보는데 있다. 이를 위하여 대학 도서관 자료, 온라인 데이터베이스, 구글 학술 검색, 위키피디아 등에서 자료 검색을 실시하여 연구 대상 과학학회 설립 및 활동과 관련한 문헌들을 수집하였다. 이들 학회의 설립과 활동 분석을 위해 32편의 수집된 문헌, 선행연구 및 과학사 서적 등을 대상으로 내용 분석을 실시하였다. 연구 결과를 정리하면 다음과 같다. 과학적인 방법을 수행하기 위한 과정에서 실험의 중요성의 부각은 필연적으로 실험기기의 제작 또는 구입에 대한 비용의 증대로 귀결되었다. 따라서 과학자들은 독자적인 연구를 넘어, 공동체를 구성함으로써 최신의 정보를 교환하고, 상호 협력에 의해서 과학실험을 수행할 필요성에 직면하게 되었다. 이러한 필요성은 과학학회의 창립을 유발시키게 되었다. 초기 과학학회의 설립은 부유한 후원자가 전적으로 학회운영을 부담하는 경우, 학회 회원들이 회비를 거두어 운영하는 경우, 국가가 정부기관으로 설립하는 경우 등으로 구분할 수 있었다. 이 연구의 결과는 미래의 과학학회에 대해 시사점을 제공할 것이다. The purpose of this study is to review the foundation of the representative early scientific societies and their major activities. The documents, books, and literature related to this study were collected through internet websites (e.g., google scholar, wikipedia) and analyzed by the qualitative content analysis method. The result of this study shows that requirement for the necessary resources to acquire or to prepare the instruments for the experiment is significantly increased with the rising importance of the experiments to conduct the scientific methods. As a consequence, scientists faced urgent necessities to conduct scientific experiments with cooperation and exchange of the newest information by establishing a community beyond the independent and individual research activity. Establishment of the scientific societies is the result of these necessities. At the beginning of the scientific societies, the resources are provided by either wealthy patron or member contribution or public through foundation of government organization. This study provides the implications for future scientific societies.

Effects of Dimyristoylphosphatidylethanol on the Structural Parameters of Neuronal Membranes

윤일희,Hye-Ock Jang,Hyang-Gun Shin 한국분자세포생물학회 2004 Molecules and cells Vol.17 No.3

한반도에서 발생하는 중규모 대류계에 의한 집중호우의 종관적 특징 분석

윤일희 경북대학교 사범대학부속 중등교욱연구소, 2002 중등교육연구 Vol.50 No.-

Role of Regulatory T Cells in Transferable Immunological Tolerance to Bone Marrow Donor in Murine Mixed Chimerism Model

윤일희,김용희,김유선,신준섭,박정규 대한의학회 2013 Journal of Korean medical science Vol.28 No.12

Constructing a bone marrow chimera prior to graft transplantation can induce donor-specific immune tolerance. Mixed chimerism containing hematopoietic cells of both recipient- and donor-origin has advantages attributed from low dose of total body irradiation. In this study, we explored the mechanism of mixed chimerism supplemented with depletion of Natural Killer cells. Mixed chimerism with C57BL/6 bone marrow cells was induced in recipient BALB/c mice which were given 450 cGy of γ-ray irradiation (n=16). As revealed by reduced proliferation and cytokine production in mixed leukocyte reaction and ELISpot assay (24.6 vs 265.5), the allo-immune response to bone marrow donor was reduced. Furthermore, the induction of transferable immunological tolerance was confirmed by adoptive transfer and subsequent acceptance of C57BL/6 skin graft (n=4). CD4+FoxP3+ regulatory T cells were increased in the recipient compartment of the mixed chimera (19.2% → 33.8%). This suggests that regulatory T cells may be therapeutically used for the induction of graft-specific tolerance by mixed chimerism.

최정산 위성추적소의 천체관측 환경에 관한 조사 연구: II. 천문 관측환경에 대한 기상학적 연구

윤일희,안병호,강용희,윤태석,Yun, Il-Hui,An, Byeong-Ho,Kang, Yong-Hui,Yun, Tae-Seok 한국천문학회 1996 天文學論叢 Vol.11 No.1

The climatological characteristics at the Choejung-san site were statistically analyzed using monthly normals for the various meteorological elements at Taegu meteorological station for 30 years from January 1960 to December 1990. Various synoptic weather conditions were classified by the estimated geostrophic wind speeds and direction determined using the 850 hPa geopotential height field for 10 years from December 1980 to November 1989. Also the analysis of number of clear days were monthly and seasonally performed using the satellite infrared image data which were obtained from GMS 5 for 5 years from December 1990 to November 1995. The results reveal that the meteorological environments of astronomical observation at Choejung-san site were very good conditions during three hours after midnight except for summer season.

대구상공에서의 대기 오염 물질 확산에 관한 연구

윤일희,민경덕,박동재 한국환경과학회 1994 한국환경과학회지 Vol.3 No.3

Meteorological parameters in the atmospheric boundary layer and the vertical and horizontal dispersion parameters were determined by analyzing the data obtained by the special upper-air observations of one clear day for each season from October 1991 to August 1992. The concentration of the atmospheric pollutants over Taegu was analyzed by using the application of the Gaussian diffusion model. In the diurnal variation of diffusion of atmospheric pollutants, vertical diffusion due to turbulence is active in daytime while horizontal diffusion due to wind is active in nighttime. The mean concentration of pollutants in the side of downwind is higher during the daytime than the nighttime. Thus, the height of the mixed-layer at the nighttime considered as the most important parameter of the mean concentration of pollutants. In the seasonal variation of diffusion of atmospheric pollutants, vertical diffusion due to strong solar radiation is active in summer case day, and horizontal diffusion due to strong wind is active in winter case day. In winter case day, the mean concentration of pollutants in the side of downwind is maximum in the daytime. However, in summer case day, that is maximum in the nighttime.