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토끼에서 Trinitrobenzene Sulfonic Acid ( TNBS ) 로 유발시킨 급성 대장 손상에 대한Warfarin의 영향
김학산,김동준,윤윤보,최은수,손행종(Haeng Jong Sohn),전원호(Won Ho Jeon),김광일 대한소화기학회 1994 대한소화기학회지 Vol.26 No.3
N/A Inflammatory bowel disease is a group of chronic inflammatory disorders of unknown etiolo- gy involving the gastrointestinal tract. Wakefield et al suggested that Crohns disease is medi- ated by multifocal gastrointestinal infarction and recently Gaffney reported that marked im- provement in the patients with ulcerative colitis were noticed during treatment with heparin. This study was performed to find out, whether intrarectal infusion of TNBS 50mg into t.he rab- bit causes acute colitis or not, and whether warfarin pretreatment. Prevent.s colonic damage in duced by TNBS or not. The rabbits were randomly assigned to one of two groups, warfar in pretreated(N=6) and non treated(N=6). Warfarin solution was infused through the ear vein of the rabbit and TNBS 50mg was instilled into the colon of the rabbit. The rabbits were sacri ficed and the degree of colonic damage was recorded as visual analogue scale and microscopic findings. The results showed that intrarectal infusion of TNBS 50mg caused acut.e necrotic co litis, but warfarin pretreatment did not prevent TNBS induced acute colitis.(Korean J Gastro- enterol 1994; 26: 458 464)
아스피린 - 과민성 천식 : Lysine - aspirin 기관지유발시험의 진단적 유용성
박해심,김윤정,김희연,남동호,윤윤보 대한천식알레르기학회 1997 천식 및 알레르기 Vol.17 No.2
Aspirin(ASA) and NSAIDs can induce bronchoconstriction in 10 20% of adult asthmatics patients. Inhalation of lysine ASA(L ASA) has been described as an alternative method for diagnosis of ASA sensitive asthma. To further understand the characteristics of ASA sensitive asthma, we studied 38 asthmatic patients with ASA sensitivity (36 intrinsic and 2 extrinsic asthma) proven by L ASA bronchoprovocation test (BPT). Most were female (male to female ratio was 27:73). Twenty (53%) of them had no previous history of adverse reactions when exposed to ASA. Twenty nine (79% ) had rhino sinusitis symptoms. Early asthmatic response was observed in 16 (42% ) patients, late only response in 16(42%), and dual response in 6 (16% ) patients. The threshold of L ASA to provoke a positive response ranged from 11.2 to 180 mg/ml and most (68.3% ) had a positive response after the inhalation of 180 mg/ ml. Concurrent sensitivity to sulfite was noted in 14 (36%) patients, followed by sensitivity to tartrazine in one (3% ) patient. None showed a positive response to sodium benzoate. After the avoidance from ASA / NSAIDs with administration of anti asthmatic medications, symptom and medication scores re- duced in 26(87%) patients among 30 followed patients. They were classified into the improved group'. Four (13%) patients belonged to the not improved group. There were no significant differences in clinical characteristics between the improved and not improved group (p>0.05). In conclusion, L ASA BPT could be considered as a useful method to diagnose ASA sensitive asthma and be used to screen the causative agent for asthmatic patients with intrinsic type, especially in female patients with rhino sinusitis and/or nasal polyp, even though they do not have any history of adverse reactions. Cessation of exposure and proper treatment may allow to reduce symptom and medication scores.