http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
자가탁주(自家濁酒)와 땅콩버터에 대한 Aflatoxins 오염도의 검색
윤여표,오유진,여신구,홍진태 한국식품위생안전성학회 1986 한국식품위생안전성학회지 Vol.1 No.2
In order to detect the aflatoxins in home-made Takju and peanut butter, the samples were collected in Chungbuk region and cleaned up Sep-pak silica cartridge. Aflatoxins were detected by thin layer chromatographic and high performance liquid chromatographic behavior. Determination was carried out by thin layer densitometer. The results were as follows; 1. Aflatoxin B; was detected in 78% of the home-made Takju, and the highest concentration was 1.2 ppb and average 0.36 ppb. 2. Aflatoxins were not detected in any peanut butter smaples. 3. Clean-up method by Sep-pak silica cartridge was more efficient and economical than column chromatography of AOAC method.
Effects of Diazinon on the Murine Host Defense System
윤여표,이세창,홍진태,김관회 한국식품위생안전성학회 1992 한국식품위생안전성학회지 Vol.7 No.2
Diazinon which is one of the most heavily used organophosphate pesticide in Korea, was examined for its effects on the marine host defense system. Immunotoxicological assay parameters adopted in this study were carbon clearance for macrophage function, susceptibility to tumor challenge, and pathotoxicological indicators. Subchronic exposure of pesticide to rodents resulted in the suppression of immune functions, enhancement of susceptibility to tumor challenge, and moderate histological changes of lymphoid organ without any significant alterations of clinical status.
PCB ( Aroclor 1254 ) 가 한국산 담수어류에 (淡水魚類) 미치는 영향
윤여표,이성규,김용화,강원식,지연태,이세창 ( Yeo Pyo Yun,Sung Kyu Lee,Yong Hwa Kim,Won Seek Kang,Youn Tae Chi,Se Chang Lee ) 한국하천호수학회 1994 생태와 환경 Vol.27 No.3
The purpose of this study was to elucidate the adverse effects of Aroclor 1254 on domestic freshwater fish. The acute toxicity in terms of LC_(50)(mg/L) in 96 hours was evaluated for the freshwater fish, Oryzias latipes, Cyprinus carpio and Misgurnus anguillicaudatus. 96-hr LC_(50) values(that concentration kills half of the firth in 96 hours) were 0.053mg/L for newly hatched Oryzias latipes but above 200mg/L for adult Oryzias latipes. Concentrations of Aroclor 1254 above 100mg/L were not lethal to Misgurnus anguillicaudatus but half of Cyprinus carpio were dead after 96 hours in 100mg/L concentration. To assess the danger of Aroclor 1254 to aquatic invertebrates, bioassays were conducted with Daphnia magna. Fifty percent of hatched Daphnia magna died at 0.048mg/L concentration after 96 hours. It is suggested from this study that further study on Aroclor 1254 or other PCBs should be focussed en the mortality of the fish larvae with chronic exposure at low concentrations.
간장장해와 Ketosis시에 Cytochrome P450IIE의 Regulatory Mechanism에 관한 연구
윤여표,강원식,이세창,손동환 한국환경보건학회 1993 한국환경보건학회지 Vol.19 No.3
In order to elucidate the alteration of drug-metabolizing enzymes and mechanism in the animal with hepatic injury and ketosis, the regulation of P450IIE was studied in the rats with heaptic injury caused by CCl$_4$ and with ketosis caused by streptozotocin and high-fat diet. P450IIE expression in liver was examined by the combination of enzyme activities, Western immunoblot, and mRNA Northern blot analyses using specific polyclonal antibody and cDNA probe for P450IIE. Enzyme activity and amounts of immunoreactive P450IIE were rapidly decreased in a time-dependent manner after a single dose of CCl$_4$ . However, the decreases in P450IIE enzyme activity and immunoreactive protein by CCl$_4$ were not accompanied by a decline in its mRNA level. The data thus suggested a post-translational reduction of P450IIE by CCl$_4$. The enzyme activities (aniline hydroxylase) in hepatic microsomes were elevated about 2-3-fold by streptozotocin and feeding with a high fat diet. This increases in enzyme activities were also accompanied by 3-fold increases in immunoreactive P450IIE protein and its mRNA. Our data thus indicated that P450IIE induction during the ketosis appears to be due to pretranslational activation.
윤여표,임일호,이정석,김대병,허문영 한국식품위생안전성학회 1996 한국식품위생안전성학회지 Vol.11 No.1
The genotoxicity of combinations of four p-oxybenzoic acids (methyl paraben, ethyl paraben, isopropyl paraben, butyl paraben) and benzoic acid had been evaluated. The in vitro Ames test using Salmonella typhimurium (TA 98, TA 100, TA 1535, TA 1537) and the in uiuo micronucleus assay using mouse peripheral blood were performed. Methyl paraben plus benzoic acid, ethyl paraben plus benzoic acid, and ethyl paraben plus butyl paraben slightly increased the frequency of micronucleated reticulocytes in the high doses, but were negative in Ames test with Salmonella typhimurzum with and without rat liver microsomal activation. The other combinations tested were negative in Ames test and did not show any clastogenic effect in micronucleus test. These results suggest that genotoxicity can produced by the combinations of p-oxybenzoic acid.
6 -(4 - 요오드페닐 ) 아미노 - 7 - 클로로 - 5 , 8 - 퀴놀린디온의 항진균작용 및 안전성 평가
윤여표,허문영,유충규,이병무,강혜영,이유진 한국식품위생안전성학회 1999 한국식품위생안전성학회지 Vol.14 No.1
6-(4-Iodophenyl)amino-7-chloro-5,8-quinolinedione (RCK9) was evaluated for antifungal activities. The MIC values of RCK9 were determined against A. flavus, C. albicans, C. neoformans and F. oxysporium. The RCK9 showed generally potent antifungal activities against the tested fungi. Acute oral toxicity studies of RCK9 were carried out in ICR mice of both sexes. These acute oral toxicities of RCK9 were low and LDSO values were over 2,850 mg/kg in ICR mice. The genotoxicities of RCK9 had been evaluated. RCK9 was negative in Ames test with Salmonella typhimurium and chromosomal aberration test in CHL cells. The clastogenicity was tested on the RCK9 with in vivo mouse micronucleus assay. RCK9 did not show any clastogenic effect in mouse peripheral blood and was negative in mouse micronucleus assay. The results indicate that RCK9 has no genotoxic potential under these experimental conditions.