少陰人 補中益氣湯의 效能에 關한 實驗的 硏究

尹相協,朴東遠,?基遠 慶熙大學校韓醫科大學韓醫學硏究所 1987 慶熙韓醫大論文集 Vol.10 No.-

만성(慢性)기침 환아(患兒)의 원인질환(原因疾患)에 관(關)한 임상적(臨床的) 고찰(考察)

윤상협,최인화,Yoon Sang-Hyub,Choi In-Hwa 대한한방소아과학회 1998 대한한방소아과학회지 Vol.12 No.1

Chronic cough is one of the most common respiratory symptoms, especially in children. And it can be the sale presenting manifestation of bronchial asthma. Although most coughs are self limiting, chronic cough often proves to be a frustrating problem. It is commonly defined as a persistent or recurrent cough exceeding 3weeks duration. The post nasal syndrome has been determined to be the most common cause of chronic cough, followed by asthma, chronic bronchitis, gastroesophageal reflux and bronchiectasis. This study was performed at both City-Oriental Medicine Hospital and Pundang Cha Oriental Medicine Hospital from January,1,1998 to November 31,1998, and 114 children with chronic cough persisting for longer than 3 weeks were evaluated. We investigated the clinical findings and evaluated the etiology in children with chronic cough syndrome including: type of cough (with or with out sputum and daily onset) and associated signs & symptoms. The results were as follows: The most common cause of chronic cough was asthma with sinusitis (27.2%); The second and third were post nasal drip syndrome(22.8%) and bronchial hypereactivitic cough(14.9%). The other causes included asthma, paranasal sinusitis, bronchitis and rhinitis. Therefore, in the diagnostic and therapeutic approach to this symptom, it should be considered that the cause of this type of cough is either bronchus and pulmonary disease or that associated with another problem, especially sinusitis, gastroesophageal reflux and allergic disease. Also, in infants and toddlers, congenital abnormaly should be considered.

담즙 역류가 동반된 위 운동성 장애의 기능성 소화불량증에 대한 한방치료 경험 2례

윤상협 대한한방내과학회 2020 大韓韓方內科學會誌 Vol.41 No.6

Objectives: The aim of this study was to determine the therapeutic effects of a traditional Korean treatment on the symptom improvement and loss of bile juice in cases of functional dyspepsia of gastric dysmotility complicated by bile juice reflux. Methods: Dyspeptic symptoms, gastric motility (electrogastrography and bowel sound analysis), and gastric mucosa (gastroendoscopy) were evaluated. The treatment consisted of Banwhasashim-tang (extract) used as a herbal drug. Both ST36 electrical stimulation and simple immersion stimulation of CV11, 12, and 13 in the abdomen were also applied. Results: Dyspeptic symptoms, including a foreign body sensation in the throat, indigestion, and upper abdominal pain, were all relieved by the treatment and gastric myoelectrical activity and gastric pyloric function were improved. Bile juice disappeared from the gastric mucosa. Conclusion: The traditional Korean treatment was effective at relieving dyspeptic symptoms and bile juice reflux by improving the pyloric sphincter function.

위장질환 환자의 양도락에 대한 경락학설과 자율신경이론의 연관성에 대한 연구 (위 운동장애형 소화불량증과 위궤양 환자의 증례를 대상으로)

윤상협,Yoon, Sang-Hyub 대한한방내과학회 2010 大韓韓方內科學會誌 Vol.31 No.4

It has been shown that bilateral decrease of point H4,5,6 in Ryodoraku test is related with gastric dysmotility. This suggested that the system of Kyung-Rak related with anatomical gastric disease may not be the Stomach Meridian, in the view that the system of Kyung-Rak is similar to that of Ryodoraku, and which was not consistent with classical contents of Kyung-Rak principle. Therefore, this paper was done to investigate whether bilateral decrease of point H4,5,6 is a general sign of common gastric disease in Ryodoraku test and to study its relation between Kyung-Rak principle and autonomic nervous system as a mediator explaining Ryodoraku response. As shown in the results of this study, different electrical response of Ryodoraku between patients with dyspepsia of gastric dysmotility and gastric ulcer revealed discrepancy of location indicating anatomical stomach between Kyung-Rak principle and Ryodoraku and instability of explanation of autonomic nerve theory to Ryodoraku. Thus, it presented the possibility that artificial application of Kyung-Rak principle against Ryodoraku may destroy its originality in the clinical field. To correctly use Ryodoraku in the diagnosis or evaluation of disease, Ryodoraku test should be used according to Nakatani's suggestion and clinical indication of which is limited to the diseases complicated with dysfunction of the autonomic nervous system.

양도점의 전기적 반응에 대한 교감신경작용과 경락 배열과 실질장기의 불일치는 양도락의 경락 관련성을 배제한다.(위 운동장애형 기능성 소화불량증 환자의 양도점 H4,5,6의 반응을 중심으로)

윤상협,Yoon, Sang-Hyub 대한한방내과학회 2011 大韓韓方內科學會誌 Vol.32 No.2

Objectives : The purpose of this study was to investigate two subjects: the diagnostic value of bilateral lowering of electrical activity at point H4,5,6 of Ryodoraku and the mechanism for Ryodoraku phenomena. Methods : Electrical activities of Ryodoraku test and electrogastrography recorded simultaneously and monitored continuously from 16 cases of functional dyspeptic patients were collected and their variations were grouped by the topics of discussion which were peculiarity, stability, lagging, alterability, and anomaly. Ryodoraku recordings obtained from 6 patients with different gastrointestinal diseases and 1 normal healthy person were used as control. The results are discussed with Nakatani's suggestion, theory of sympathetic nerve and Meridian Principle, respectively. Finely, coincidence of stomach arrangement between anatomy and meridian system in Ryodoraku was also evaluated. Results : Time-course variation showed a regular relationship between the typical pattern of Ryodoraku at point H4,5,6 and gastric myoelectrical activity. However, an irregular relationship and atypical pattern of Ryodoraku occasionally appeared. A literature search suggested that electrical response at the Ryodoraku point H4,5,6 may be dependent on an afferent sympathetic spinal reflex transmitted from the stomach. However, there was no evidence for making clear whether bilateral lowering of electrical activity at this point was induced by hypofunction of local sympathetic nerve in the skin itself or of signals transmitted from the gastric sympathetic nerve or not. The coincidence of 19% could not provide a visceral arrangement of the stomach between anatomy and meridian systems. Conclusions : Bilateral lowering of electrical activity at Ryodoraku point H4,5,6 has value as a diagnostic index for gastric dysmotility of functional dyspepsia. This phenomenon is associated with spinal reflex transmitted from the afferent sympathetic nerve in the stomach but not that of meridian function.

Intraluminal Suture Technique에 의한 실험적 뇌허혈-재관류가 혈압, 국소뇌혈류량, 뇌경색 및 뇌부종 형성에 미치는 영향

윤상협,류재환 경희대학교 1994 慶熙醫學 Vol.10 No.2

와송의 수종 암세포에 대한 항암작용 연구

윤상협,류봉하,류기원,김진성,Yoon, Sang-Hyub,Ryu, Bong-Ha,Ryu, Ki-Won,Kim, Jin-Sung 대한한방내과학회 2005 大韓韓方內科學會誌 Vol.26 No.2

Background: Cancer reseach is done in earnest world-wide, because cancer is one of most threatening diseases to humans. Orostachyos Herba is a widely used herb that has long been in use in Korea as an anti-inflammatory and anti-cancer therapy. The purpose of this study is to verify any anti-cancer effects on stomach and liver cancer in vitro. Materials & Methods: AGS and KATO III stomach cancer cells and Hep3B and HepG2 liver cancer cells, all obtained from Korean Cell Line Bank, were used. The boiled extract of Orostachyos Herba(20 and 40 microliters) were injected into cultures and observed at 0 hours, and at 24-hour intervals up to 96 hours. The destruction of stomach and liver cancer cells was measured through Trypan blue exclusion testing. The suppression on viability of stomach and liver cancer cells was observed, and anti-cancer mechanisms was examined by analyzing the cell cycle. Results: In morphologic change, AGS, KATO III, HepG2 and Hep3B showed some of the withdrawn and floating appearance that is typical in cellular imparment. AGS, KATO III, HepG2 and Hep3B showed more destruction of stomach cancer cells in each test group than in the control group to a statistically significant degree. Analysis of the cell cycle after introduction of Orostachyos Herba showed very little inhibition of divisions of all cell lines. Conclusions: This experiment suggests that Orostachyos Herba has some anti-tumor effects on stomach and liver cancer cells. Progressive research on Orostachyos Herba and it's anti-tumor effects will be needed to determine its practicability as a cancer treatment.

기능성소화불량과 만성 위축성 위염이 병발된 여성 환자에 대해 한방치료 경험 1례

윤상협 대한한방내과학회 2019 大韓韓方內科學會誌 Vol.40 No.4

Objective: The aim of this study was to introduce gastric dysmotility as a common cause in patients with concurrent functional dyspepsia and chronic atrophic gastritis. Method: Dyspeptic symptoms, the Rydoraku score, gastric motility (electrogastrography, bowel sound analysis), gastric mucosa (gastroendoscopy), and blood and blood chemistry were all evaluated. For the treatment method, Pyengwi-san (solution) and Banwhasashim-tang (extract) were used as herbal drugs. Both ST36 electrical stimulation and simple immersion stimulation of CV11, 12, and 13 in the abdomen were applied. Results: Dyspeptic symptoms including indigestion, headache, and insomnia were all relieved. Gastric myoelectrical activity and gastric pyloric function were additionally improved. The condition of the gastric mucosa was changed from atrophic to erosive. Other side-effects of the treatment were not noted. Conclusion: The traditional Korean treatment showed effectiveness in the relief of dyspeptic symptoms and mucosal improvement of chronic atrophic gastritis. Gastric dysmotility is a common cause of the condition being concurrent with both functional dyspepsia and chronic atrophic gastritis without Helicobacter pylori infection.

류마티스 관절염의 수술적 치료

윤상협,김신윤 대한의사협회 2010 대한의사협회지 Vol.53 No.10

Alarge number of patients who are diagnosed with rheumatoid arthritis undergo a chronic and progressive course. Surgical treatment is often needed for these patients, who have not responded to medical treatment. The aim of surgical intervention in rheumatoid arthritis is to restore function and quality of life by preventing joint destruction, correcting deformity, relieving pain, and making cosmetic improvements. There are many surgical options, including synovectomy,osteotomy, arthrodesis, resection arthroplasty, joint replacement, surgeries for the treatment of the tendon involved (repair, transfer, graft), and cervical spine surgery (fusion or decompression). The selection of the optimal surgical option requires consideration of not only the articular status and the degree of regional deformity involved, but also the physical status and age of the patient. In addition, timely surgical intervention is important because a delay of surgery often results in poorer functional outcomes and an increase in postoperative complications. Early referral to orthopedic treatment can provide better functional outcomes for patients with rheumatoid arthritis. Precise prediction of the disease progress and selection of the optimal treatment option are needed for excellent results to be expected. Therefore, a cooperative and multidisciplinary treatment strategy should be made among the relevant teams, such as physical medicine,rheumatology, orthopedics, physical therapy, occupational therapy, social work, and psychology.

기능성(機能性) 소화불량증(消化不良症) 환자(患者)의 식후(食後) 심하비만과 pyloric valve의 기능장애(機能障碍);장음과 위전도를 중심으로

윤상협,Yoon, Sang-Hyub 대한한방내과학회 2007 大韓韓方內科學會誌 Vol.28 No.4

Background & Object : Postprandial epigastric fullness is one of common symptoms in functional dyspepsia, but its pathophysiological mechanism has still been unknown. In this study, its association between postprandial epigastric fullness and pyloric valve disturbance was studied through analysis of bowel sounds and electrogastrography. Methods : Bowel sounds and electrogastrography were recorded together for fasting 15 min and postprandial 40 min. Parameters of bowel soundincluding motility index, sound to sound interval, standard deviation of sound to sound interval, sounds per minute, % of bowel sound, sound length, intensity, dominant frequency of sounds, and postprandial / fasting ratio of dominant frequency of sounds were analyzed with a specialized program. By electrogastrography, regularity of slow waves and power ratio were obtained. Results : Significances of bowel sounds appeared in motility index (p=0.046), dominant frequency of fasting (p=0.048), postprandial (p=0.003), and the ratio of postprandial/fasting (p=0.000); those of EGG parameters were shown in postprandial regularity of slow waves (p=0.006) and power ratio (p=0.011). Conclusion : Pyloric valve disturbance was a cause of postprandial epigastric fullness in patients with functional dyspepsia. Analysis of bowel sound might be useful in diagnosing its existence.