방송과 통신위성

윤병일,Yun, Byeong-Il 한국과학기술단체총연합회 1984 과학과 기술 Vol.17 No.7

지능형 실시간경매시스템에 관한 연구

윤병일,이재원 한국경영정보학회 1999 한국경영정보학회 학술대회논문집 Vol.1999 No.-

전립선특이항원치 4.0ng/ml 이상인 환자에서 전립선용적과 나이에 따른 전립선암의 발견율

윤병일,김수진,조혁진,홍성후,손동완,이지열,황태곤,김세웅 대한남성과학회 2010 The World Journal of Men's Health Vol.28 No.1

Purpose: We retrospectively investigated the changes of prostate cancer detection rate according to patients prostate volume, age with prostate-specific antigen (PSA) levels of above 4.0ng/ml. Material and Methods: Data were collected from 663 patients who underwent 10 core prostate biopsy for elevated PSA above 4.0ng/ml. The biopsy-proven cancer patient group was compared to the non-cancer patient group according to age, PSA, prostate volume and PSAD. Prostate cancer detection rate was calculated according to prostate volume (less than 40 vs 40 or more 40ml) and age (less than 60, 60-69, 70-79, 80 or more years old). Also we compared prostate cancer detection rate according to PSA levels (4-10 vs 10-20ng/ml). Results: Among the 663 patients who underwent prostate biopsy, prostate cancer was detected in 134 patients (20.2%). There were no stastically difference in mean age, mean prostate volume, and mean PSAD except mean PSA (13.9 vs 11.9ng/ml) between cancer and non-cancer groups. The cancer detection rate in small prostate was significantly higher than large prostate (23.5% vs 16.0%). The cancer detection rate was significantly increased with age: from 14.5% for below 60 year-old patients to 30.3% for the 80 or more year-old patients. There was no significant difference in cancer detection rate between the two PSA groups (19.0 vs 20.5%). Conclusion: Prostate cancer detection rate was higher in old patients and patients with small prostate volume. The older age group and the patients with small prostate volume was considered as the important factors to decide whether biopsy of prostate is needed.

햄스터 oval cell의 간흡충감염 후 담관암으로의 분화에 관한 세포병리학적 연구

윤병일,김방현,김대용 한국수의병리학회 2002 한국수의병리학회지 Vol.6 No.1

Oval cell is considered as facultative precursor cells for both hepatocytes and biliary cells, as well as origin of hepatocellar and cholangiocellular carcinoma (CCC) during carcinogenesis or toxic liver injury. To clarify the cellular origin or differentiation of cholagiocarcinogenesis, the fate of carcinogen-induced oval cells was pathologically and phenotypically chased in Syrian golden hamster liver after Clonorchis sinensis (CS) infection which would give rise to a promoting effect. Two week treatment of hamsters with 0.005% diethylnitrosamine (DEN) followed by 2 week treatment of 1% 2-acetylaminofluorene (AAF) under choline deficient diet resulted in massive proliferation of BrdU labeled and PCNA positive oval cells showing various distinct morphology, histochemical and immunohistochemical phenotypes for GGT, cytokeratin 19 and OV-6. Oval cells also frequently form ductular-like structures or phenotypically show hepatocyte-like characteristics. After CS infection, the oval cells showed sequential morphological changes to atypical proliferating bile ductules and all hamsters thereafter developed well differentiated and anaplastic CCC at 16 week after CS infrection. In electron microscopy, some bile ductules were constructed by intermediate oval cells and bile ductular cells surrounded by thick basement membrane. The results of this study strongly suggest that CCC developed in the present study were originated from hepatic stem-like oval cells, supporting the theory of stem cell origin of cancers. In addition, this hamster model would be valuable for the molecular mechanistic study during chemical-triggered cholangiocarcinogenesis.

단일기관의 방사선과와 비뇨기과에서 시행한 경직장 초음파유도하 전립선생검 후 임상적 및 병리적 결과에 대한 고찰

윤병일,김수진,조혁진,홍성후,손동완,이지열,황태곤,김세웅 대한남성과학회 2010 The World Journal of Men's Health Vol.28 No.1

Purpose: Many centers rely on radiologists to detect prostate cancer by transrectal ultrasound guided prostate biopsy. In this study we evaluated transrectal ultrasound guided prostate biopsy by radiologist or urologist, and compared prostate cancer detection rate, pathologic results and pain scrore. Material and Methods: In all, 259 consecutive patients had transrectal ultrasound guided prostate biopsy by one radiologist (group 1) and one urologist (group 2). The indication for prostate biopsies were a raised or rising prostate specific antigen (PSA) level or abnormal digital rectal examination (DRE). All data were collected prospectively. Results: Both group showed comparable demographic data in age, PSA, prostate volume. But pain score showed higher in urologist group (p<0.05). Prostate cancer was detected in 73 patients (28.1%). Radiologist detected prostate cancer in 38 patients (29.2%) and urologist detected prostate cancer in 35 patients (27.1%) (p=0.70). Both groups showed comparable cancer detection rates in PSA of <4, 4-10 and >10 ng/ml. Both groups had similar Gleason score (6.8±0.7 vs 6.7±0.8) and number of cancer cores (3.0±1.7 vs 3.9±2.3). Group 1 showed significantly low visual analogue pain scale compared with Group 2 (2.9±1.9 vs 4.0±2.1)(p<0.05). Conclusion: Transrectal ultrasound guided prostate biopsy showed equally reliable datas whether performed by radiologist or urologist. The urologist can effectively perform transrectal ultrasound guided prostate biopsy like radiologist in detecting prostate cancer. Also we recommend to perform anesthesia to relieve pain before prostate biopsy and furthermore future studies with more patients with more datas are needed.

복강경하 근치적 전립선적출술이 요실금 및 하부요로증상의 변화에 미치는 영향

윤병일,황태곤,김준철 대한비뇨의학회 2008 Investigative and Clinical Urology Vol.49 No.2

Purpose: The definition of continence after radical prostatectomy has not been established. We examined the continence rate and changes in voiding and storage symptoms after laparoscopic radical prostatectomy(LRP). Materials and Methods: Fifty-seven patients were enrolled and followed for more than 12 months after a LRP. Postoperative evaluation of urinary incontinence was performed by interview, and was classified as completely dry, intermittent(occasional dribbling only), using only 1 pad/day, using more than 1 pad/day, and no control. Pre- and post-operative International Prostate Symptom Scores(IPSS) were compared(Total, each criterion, and quality of life, voiding, and storage symptom subscores). Results: Sixty seven percent of patients were completely dry and 17% of patients were classified as intermittent. Those using 1 pad/day, more than 1 pad/day, or no control accounted for 2%, 9%, and 5%, respectively. Pre- and post-operative total IPSS and quality of life scores were not different, but urgency and nocturia scores increased(p<0.05). The voiding subscore decreased and the storage subscore increased after LRP(p<0.05), suggesting aggravation of storage symptoms after LRP. Conclusions: We need to determine which definition of continence is most clinically useful. It is important to assess lower urinary tract symptoms, especially storage symptoms, as well as urinary incontinence after LRP. (Korean J Urol 2008;49:134-138) Purpose: The definition of continence after radical prostatectomy has not been established. We examined the continence rate and changes in voiding and storage symptoms after laparoscopic radical prostatectomy(LRP). Materials and Methods: Fifty-seven patients were enrolled and followed for more than 12 months after a LRP. Postoperative evaluation of urinary incontinence was performed by interview, and was classified as completely dry, intermittent(occasional dribbling only), using only 1 pad/day, using more than 1 pad/day, and no control. Pre- and post-operative International Prostate Symptom Scores(IPSS) were compared(Total, each criterion, and quality of life, voiding, and storage symptom subscores). Results: Sixty seven percent of patients were completely dry and 17% of patients were classified as intermittent. Those using 1 pad/day, more than 1 pad/day, or no control accounted for 2%, 9%, and 5%, respectively. Pre- and post-operative total IPSS and quality of life scores were not different, but urgency and nocturia scores increased(p<0.05). The voiding subscore decreased and the storage subscore increased after LRP(p<0.05), suggesting aggravation of storage symptoms after LRP. Conclusions: We need to determine which definition of continence is most clinically useful. It is important to assess lower urinary tract symptoms, especially storage symptoms, as well as urinary incontinence after LRP. (Korean J Urol 2008;49:134-138)

간흡충감염을 통한 oval cell의 분화 및 간암발생연구를 위한 햄스터모델의 확립

윤병일,이재현,주경환,김대용 한국실험동물학회 1997 한국실험동물학회 학술발표대회 논문집 Vol.1997 No.-

한국인에서 전립선 생검의 기준으로 전립선특이항원 절단치 2.5 ng/ml가 적절한가?

윤병일,조혁진,홍성후,손동완,이지열,황태곤,김세웅,김수진 대한남성과학회 2009 The World Journal of Men's Health Vol.27 No.3

Purpose: Currently many clinicians have recommendsprostate biopsy when the level of prostate specific antigen (PSA) is higher than 4.0 ng/ml. However, recently the prostate cancer detection rates werereported to be about 20% at PSA level 2.5 to 4.0 ng/ml. Therefore, an increasing amount of hospitals have recommends lowering the PSA cut off level to 2.5 ng/ml. We retrospectively evaluated the prostate cancer detection rate and pathologic characteristics of patients with PSA level of 2.5 to 4.0 ng/ml and we compared this with the patients who had PSA level in the range of 4.1 to 10.0 ng/ml. Material and Methods: We analyzed the data of 515 patients who received prostate biopsy in the range of PSA level 2.5 to 10 ng/ml. The clinical characteristics, cancer detection rate and pathologic findings of the biopsy were compared between the PSA 2.5-4.0 ng/ml group and PSA 4.1-10.0 ng/ml group. Results: Cancer detection rates in patients who underwent biopsy were 18.1% and 22.4% at PSA 2.5 to 4.0 and 4.1 to 10.0 ng/ml, respectively. Mean Gleason scores were found 6.4±0.5 and 6.6±0.7 and high grade cancers with Gleason score 7 or more were found in 50% and 58.4% of patients with cancer with PSA 2.5 to 4.0 and 4.1 to 10.0 ng/ml, respectively. There were no significant difference between the 2 groups in cancer detection rates and pathologic findings on biopsy including mean Gleason score and high grade cancers with Gleason score 7 or more between two groups. Conclusion: There were no significant difference in cancer detection rates and pathologic findings between PSA 2.5-4 ng/ml group and PSA 4.1-10 ng/ml group. These results suggest that a lower PSA cutoff should be considered as an indication for prostate biopsy in the Korean population.

싸이클로헥센 증기 공정에 의한 산소량이 적은 실리콘카바이드 섬유의 개발

윤병일,최우철,김명주,김재성,김정일,강홍구,Yoon, Byungil,Choi, Woo Chul,Kim, Myeong Ju,Kim, Jae Sung,Kim, Jung il,Kang, Hong Gu 한국군사과학기술학회 2017 한국군사과학기술학회지 Vol.20 No.5

A chemical vapor curing method(CVC) was developed to cure polycarbosilane(PCS) fibers by using cyclohexene vapour as a non-oxygen active reactant, instead of air in oder to prepare the silicon carbide(SiC) fiber with low oxygen content. A cross-linked PCS fibers by cyclohexene vapor showed a completely different variation in IR spectra in comparison to the air-cured PCS fiber. CVC method resulted in less than 3 wt% in oxygen content. In this experiment conditions, The average tensile strength and modulus of SiC fiber obtained by CVC had 1995 MPa and 183 GPa respectively, which is higher than that of SiC fiber prepared by air-curing process.

평수기 한강하구 염하수로 인근의 낙조 우세 및 조석 평균 흐름의 정량적 분석

윤병일,우승범 한국해양환경·에너지학회 2012 한국해양환경공학회 학술대회논문집 Vol.2012 No.5