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결장 및 직장암에서 Ki- 67 Index의 임상적인 의의
양형태(Hyeong Tae Yang),윤대근(Dae Kun Yoon),장우영(Woo-Young Jang),최규성(Gyu-Seong Choi),강희준(Hee Jun Kang),전성은(Seong Eun Cheon),박성길(Sung Gil Park),김종현(Jong Hyun Kim),전욱(Wook Chun),허준(Jun Hun),김도헌(Do Hern Kim),이 대한외과학회 2007 Annals of Surgical Treatment and Research(ASRT) Vol.72 No.4
Purpose: Monoclonal antibody Ki-67 has been employed to evaluate the growth fraction of various tumors. The purpose of this study is to determin the prognostic value of the Ki-67 index for colorectal cancer. Methods: The Ki-67 index was investigated by counting the immunohistochemically stained cells. We described this as the permillage. We reviewed the test results of 36 colorectal cancer patients and we compared the Ki-67 index with other clinical factors. Results: There was no correlation between the Ki-67 index and the other established risk factors, and only the number of invaded lymph nodes and their degree of differentiation were related with the Ki-67 index. Conclusion: The Ki-67 index is an important marker of the growth fraction of tumor. The pattern of tumor growth is determined not only by the growth fraction, so the discovery of other parameters that can reflect tumor growth and the Ki-67 index can help the patients with respect to their prognosis & treatment.