http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
유혜현,백승훈,박연경,이승호,김창민,이경순,박만기,박정일 영남대학교 약품개발연구소 2002 영남대학교 약품개발연구소 연구업적집 Vol.11 No.-
This study is to establish the quality control method of Codonopsis Radix, the root of Codonopsis lanceolate (S. et Z.) Trautv. 1,2,3,4-Tetrahydro-β-carboline-3-carboxylic acid(1) isolated from this plant was adequate as an analytical marker. Content of 1 in Codonopsis Radix, determined by HPLC, was 0.0012±0.0005% (n=13). Total ash was 5.0±2.7%, and loss on drying was 11.9±1.3%.
설명간호사실 운영 활성화를 통한 외래 환자 만족도 증진
유혜현,김현미,배미형,김민정,우정인,이은영 한국의료QA학회 2009 한국의료질향상학회지 Vol.15 No.1
문제: 본원의 외래 상황은 진료의가 짧은 시간 내에 많은 환자를 진료해야 하고, 진료 환자 모두에게 충분히 만족하도록 설명해주는 것은 매우 어려운 실정이었다. 2007년의 의료기관 본 평가에 앞서 병원 자체 평가 결과 외래환자의 설명 만족도는 57점으로 저조하였다. 목적: “이해하기 쉽게 설명하는 서울대학교 병원” 이라는 슬로건 하에 설명간호사 제도를 운영하기 시작하여, 설명간호사실 운영 활성화를 통한 외래 환자 만족도를 향상시키고자 한다. 의료기관: 서울시 종로구에 소재한 대학병원 질 향상 활동: 설명간호사실 방문율 증가 및 one-stop service care을 실현할 수 있는 방안을 모색하였고, 검사 시행 이유, 귀가 후 주의사항ㆍ검사 결과, 검사일정ㆍ외래 진료 안내 브로셔 및 표준화된 교육 자료를 개발하였다. 또한 설명간호사의 역할 및 업무의 확립을 위한 업무기술서를 개발 및 설명간호사실 환경을 개선하였다. 개선효과: 설명간호사실의 방문율이 내과는 2배, 신경과는 3배 정도 증가하였다. 표준화된 교육 자료 개발로 설명 요구도를 충족시켰고, ‘환자의 알 권리‘와 ‘설명을 들을 권리’를 보장하였다. 업무기술서 개발로 설명간호사의 업무 및 역할을 확립하였으며 설명간호사실의 환경 개선으로 개인 신상 비밀을 보호받을 권리를 보장하였다. 외래 설명만족도가 2007년 57점에서 2008년 74점으로 향상되었다. 설명간호사실 자체 설문조사에서도 97%가 만족한다고 답하였고, 100% 모두 재방문 의사를 보였다. one-stop service care를 제공함으로써 외래가 복잡하다는 부정적인 이미지를 긍정적인 이미지로 변화시켰다
유혜현,Kevin Kyungsik Choe,Shaheed Ur Rehman,최민선 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.7
Complementary and alternative therapies are quickly gaining importance because they are perceived to be free of side effects due to their natural origin. However, herbal remedies are complex mixtures of bioactive entities, which may interact with prescription drugs through pharmacokinetic or pharmacodynamic mechanisms and sometimes result in life-threatening consequences. In particular, diabetes patients are often treated with multiple medications due to different comorbidities, and such patients use antidiabetic medications for their entire lives; thus, it is important to make the public aware of herb interactions with antidiabetic drugs. In this paper, we summarize the reports available on the interaction of herbal remedies with oral hypoglycemic agents and describe mechanisms, preclinical or clinical evidence, importance, and management strategies.
Ultra-fast Generic LC-MS/MS Method for High-Throughput Quantification in Drug Discovery
김소희,유혜현,차은주,정은숙,김호준,김동현,이재익 사단법인 한국질량분석학회 2013 Mass spectrometry letters Vol.4 No.3
An ultra-fast generic LC-MS/MS method was developed for high-throughput quantification of discovery pharmacokinetic(PK) samples and its reliability was verified. The method involves a simple protein precipitation for sample preparationand the analysis by ultra-fast generic LC-MS/MS with the ballistic gradient program and selected reaction monitoring (SRM)mode. Approximately 290 new chemical entities (NCEs) (over 10,000 samples) from 5 therapeutic programs were analyzed. The calibration curves showed good linearity in the concentration range of 1, 2 or 5 to 2000 ng/mL. No significant ion suppressionwas observed in the elution region of all the NCEs. When approximately 300 plasma samples were continuously analyzed,the peak area of internal standard was constant and reproducible. In the repeated analysis of samples, the plasma concentrationsand the area under the curve (AUC) were consistent with the results from the first analysis. These results showed that the presentultra-fast generic LC-MS/MS method is reliable in terms of selectivity, sensitivity, and reproducibility and could be useful forhigh-throughput quantification and other bioanalysis in drug discovery.
김경아,유혜현,Wan Gu,Dae-Hyung Yu,Ming Ji Jin,Hae-Lim Choi,Kathy Yuan,Laetitia Guerin-Deremaux,김동현 고려인삼학회 2014 Journal of Ginseng Research Vol.38 No.3
Background: There is limited understanding of the effect of dietary components on the absorption ofginsenosides and their metabolites into the blood. Methods: This study investigated the pharmacokinetics of the ginseng extract and its main constituentginsenoside Rb1 in rats with or without pretreatment with a prebiotic fiber, NUTRIOSE, by liquidchromatography tandem mass spectrometry. When ginsenoside Rb1 was incubated with rat feces, itsmain metabolite was ginsenoside Rd. Results: When the intestinal microbiota of rat feces were cultured in vitro, their ginsenoside Rd-formingactivities were significantly induced by NUTRIOSE. When ginsenoside Rb1 was orally administered torats, the maximum plasma concentration (Cmax) and area under the plasma drug concentrationetimecurve (AUC) for the main metabolite, ginsenoside Rd, were 72.4 31.6 ng/mL and 663.9 285.3 mg$h/mL, respectively. When the ginseng extract (2,000 mg/kg) was orally administered, Cmax and AUC forginsenoside Rd were 906.5 330.2 ng/mL and 11,377.3 4,470.2 mg$h/mL, respectively. When ginsengextract was orally administered to rats fed NUTRIOSE containing diets (2.5%, 5%, or 10%), Cmax and AUCwere increased in the NUTRIOSE receiving groups in a dose-dependent manner. Conclusion: These findings reveal that intestinal microflora promote metabolic conversion of ginsenosideRb1 and ginseng extract to ginsenoside Rd and promote its absorption into the blood in rats. Its conversionmay be induced by prebiotic diets such as NUTRIOSE.